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Grdina, David
One or more keywords matched the following properties of Grdina, David
PropertyValue
keywords Adaptive Responses, Genomic Instability, Radioprotectors, Amifostine, Radiation Biology
overview My research has focused on the development of radio-protective drugs for use in the prevention of radiation-induced genomic instability and subsequent processes leading to cancer development. Specifically, studies are directed at very low dose radiation and select phosphorothioate drug exposures to induce adaptive responses affecting genomic instability development.
One or more keywords matched the following items that are connected to Grdina, David
Item TypeName
Concept Dose-Response Relationship, Radiation
Concept Neoplasms, Radiation-Induced
Concept Radiation Injuries
Concept Radiation-Sensitizing Agents
Concept Radiation Dosage
Concept Radiation Genetics
Concept Radiation Injuries, Experimental
Concept Radiation Tolerance
Concept Radiation Protection
Concept Radiation-Protective Agents
Concept Radiation Effects
Concept Radiation, Ionizing
Concept Acute Radiation Syndrome
Academic Article Attenuation of G2-phase cell cycle checkpoint control is associated with increased frequencies of unrejoined chromosome breaks in human tumor cells.
Academic Article Reversion of radiosensitivity in azacytidine-treated XRS5 cells does not result in full radioprotection by WR-1065.
Academic Article Antimutagenic effects of amifostine: clinical implications.
Academic Article The inhibition of radiation-induced mutagenesis by the combined effects of selenium and the aminothiol WR-1065.
Academic Article Regulation of thymus PCNA expression is altered in radiation-sensitive wasted mice.
Academic Article The isoquinoline sulfonamide H7 attenuates radiation-mediated protein kinase C activation and delays the onset of x-ray-induced G2 arrest.
Academic Article Chemical protection and cell-cycle effects on radiation-induced mutagenesis.
Academic Article WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.
Academic Article Misoprostol, a PGE1 analog, protects mice from fission-neutron injury.
Academic Article Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.
Academic Article Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines.
Academic Article Further evidence that the radioprotective aminothiol, WR-1065, catalytically inactivates mammalian topoisomerase II.
Academic Article Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells.
Academic Article Amifostine: mechanisms of action underlying cytoprotection and chemoprevention.
Academic Article Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine.
Academic Article Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine.
Academic Article Radiation-induced DNA double-strand break frequencies in human squamous cell carcinoma cell lines of different radiation sensitivities.
Academic Article Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells.
Academic Article Inhibition of spontaneous metastases formation by amifostine.
Academic Article Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice.
Academic Article Radioprotectants: current status and new directions.
Academic Article Protection by WR-151327 against late-effect damage from fission-spectrum neutrons.
Academic Article Relationships between cytoprotection and mutation prevention by WR-1065.
Academic Article Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003.
Academic Article Association of WR-1065 with CHO AA8 cells, nuclei, and nucleoids.
Academic Article Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo.
Academic Article Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC).
Academic Article The effect of chemical radiation protectors on cell cycle progression after gamma or neutron irradiation.
Academic Article Delayed radioprotection by nuclear transcription factor kappaB -mediated induction of manganese superoxide dismutase in human microvascular endothelial cells after exposure to the free radical scavenger WR1065.
Academic Article Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha.
Academic Article Cellular radiosensitivity in V79 cells is linked to alterations in chromatin structure.
Academic Article Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine.
Academic Article Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.
Academic Article WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.
Academic Article Variation in radiation sensitivity during the cell cycle of two human squamous cell carcinomas.
Academic Article Amifostine reduces lung vascular permeability via suppression of inflammatory signalling.
Academic Article Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells.
Academic Article Accumulation of CHO cells in G2 phase following exposure to WR-1065.
Academic Article The inherent cellular radiosensitivity of epithelial ovarian carcinoma.
Academic Article Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells.
Academic Article Radiation protectors: the unexpected benefits.
Academic Article Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs.
Academic Article Pathological effects of the radiation protector WR-151327 in mice.
Academic Article The increase in radioresistance of Chinese hamster cells cultured as spheroids is correlated to changes in nuclear morphology.
Academic Article Halogenated pyrimidines as radiosensitizers for high-LET radiation.
Academic Article Protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid against induction of altered hepatocyte foci in rats treated once with gamma-radiation within one day after birth.
Academic Article SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine.
Academic Article The effect of 2-[(aminopropyl)amino] ethanethiol (WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cells.
Academic Article Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino]ethanethiol.
Academic Article Radioprotectors: current status and new directions.
Academic Article Inhibition of topoisomerase II alpha activity in CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065).
Academic Article SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells.
Academic Article The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair.
Academic Article 2-[(Aminopropyl)amino] ethanethiol-mediated reductions in 60Co gamma-ray and fission-spectrum neutron-induced chromosome damage in V79 cells.
Academic Article Synergistic induction of altered hepatocyte foci by combined gamma radiation and diethylnitrosamine administered to neonatal rats.
Academic Article Effects of separate and combined treatments with gamma radiation and diethylnitrosamine in neonatal rats on the induction of altered hepatocyte foci and hepatic tumors.
Academic Article Protection against radiation-induced mutagenesis in V79 cells by 2-[(aminopropyl)amino] ethanethiol under conditions of acute hypoxia.
Academic Article Radioprotectors in treatment therapy to reduce risk in secondary tumor induction.
Academic Article Radiation-induced DNA single-strand breaks in the intestinal mucosal cells of mice treated with the radioprotectors WR-2721 or 16-16 dimethyl prostaglandin E2.
Academic Article Radiation response of clonogenic cell populations separated from fibrosarcoma.
Academic Article Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection.
Academic Article Transformation of human epidermal keratinocytes with fission neutrons.
Academic Article The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cells.
Academic Article The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells.
Academic Article Response of selected tumour cell populations separated from a fibrosarcoma following irradiation in situ with fast neutrons.
Academic Article Treatment of artificially-induced pulmonary metastases with fractionated doses of vincristine and/or radiation therapy.
Academic Article Cyclic-radiation response of murine fibrosarcoma cells grown as pulmonary nodules.
Academic Article Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065.
Academic Article Tumor sensitizing effect by misonidazole in a clinically relevant radiation dose range.
Academic Article Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression.
Academic Article Cell cycle redistribution of cultured cells after treatment with chemical radiation protectors.
Academic Article Radiation sensitivity of murine fibrosarcoma cells separated by centrifugal elutriation.
Academic Article Differential protection of radiation-induced DNA single-strand breaks and cell survival by solcoseryl.
Academic Article The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation.
Academic Article The effect of misonidazole in situ on the radiation response of selected tumor subpopoulations.
Academic Article In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis.
Academic Article Response of fibrosarcoma cell subpopulations to small doses of radiation delivered in situ.
Academic Article The effects of cycloheximide and WR-1065 on radiation-induced repair processes: a mechanism for chemoprevention.
Academic Article Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action.
Academic Article Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response.
Academic Article Coactivation of ATM/ERK/NF-kappaB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes.
Academic Article Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry.
Academic Article Protection by WR1065 and WR151326 against fission-neutron-induced mutations at the HGPRT locus in V79 cells.
Academic Article A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327.
Academic Article Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N"-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278).
Academic Article The role of intracellular calcium in the cellular response to ionizing radiation.
Academic Article Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326.
Academic Article Radiosensitivity of mammalian cell lines engineered to overexpress cytosolic glutathione peroxidase.
Academic Article Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons.
Academic Article Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells.
Academic Article Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR 1065.
Academic Article Modification of radiation response in mice by fractionated extracts of Panax ginseng.
Academic Article Effectiveness of AMSA alone or in combination with radiation on murine fibrosarcoma pulmonary nodules.
Academic Article Radiation response of cell populations irradiated in situ and separated from a fibrosarcoma.
Academic Article Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation.
Academic Article Radioprotection by WR-151327 against the late normal tissue damage in mouse hind legs from gamma ray radiation.
Academic Article Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice.
Academic Article CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress.
Academic Article A manganese superoxide dismutase (SOD2)-mediated adaptive response.
Academic Article A survivin-associated adaptive response in radiation therapy.
Academic Article Comparing radiation toxicities across species: an examination of radiation effects in Mus musculus and Peromyscus leucopus.
Academic Article The effects of radiation and dose-fractionation on cancer and non-tumor disease development.
Academic Article NF?B and Survivin-Mediated Radio-Adaptive Response.
Academic Article CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection.
Academic Article Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent.
Academic Article Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs.
Academic Article CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair.
Academic Article The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose.
Academic Article Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity.
Academic Article Altered expression of a metformin-mediated radiation response in SA-NH and FSa tumor cells treated under in vitro and in vivo growth conditions.
Academic Article Andrographis paniculata Diterpenoids Protect against Radiation-Induced Transformation in BALB/3T3 Cells.
Academic Article ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response.
Academic Article TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response.
Academic Article Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells.
Grant Delayed Radioprotection by Thiols
Grant EXPERIMENTAL RADIOTHERAPY--CARCINOGENESIS, AND PROTECTOR
Grant Radiation Protectors and Radiation Therapy Coupled Chemoprevention
Search Criteria
  • Radiation