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Rosner, Marsha

One or more keywords matched the following items that are connected to Rosner, Marsha

Item Type	Name
Concept	Insulysin
Academic Article	Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding.
Academic Article	Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation.
Academic Article	Regulation of insulin degradation: expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway.
Academic Article	Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23----q25.
Academic Article	The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition.
Academic Article	Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Academic Article	Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues.
Academic Article	Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line.
Academic Article	Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.
Academic Article	Functional analysis of conserved residues in the active site of insulin-degrading enzyme.
Academic Article	Identification of zinc ligands of the insulin-degrading enzyme.
Academic Article	An evolutionarily conserved TGF-alpha/insulin-degrading enzyme.
Academic Article	Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites.
Academic Article	Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster.
Academic Article	Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster.
Academic Article	Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
Academic Article	Functional human insulin-degrading enzyme can be expressed in bacteria.
Academic Article	Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
Academic Article	Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels.
Academic Article	Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes.
Academic Article	Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme.
Academic Article	Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.
Academic Article	Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.
Academic Article	An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.
Academic Article	Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.
Academic Article	Insulin-Degrading Enzyme Does Not Require Peroxisomal Localization for Insulin Degradation.

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Insulysin