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A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
Anti-tumor effects of an engineered "killer" transfer RNA.
Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin.
Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
Gene expression in local stroma reflects breast tumor states and predicts patient outcome.
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.
Limited inhibition of multiple nodes in a driver network blocks metastasis.