| Item Type | Name |
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Concept
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DNA Damage
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Concept
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DNA Polymerase II
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Concept
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DNA-Binding Proteins
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Concept
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DNA Polymerase I
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Concept
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DNA Repair
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Concept
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DNA Mutational Analysis
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Concept
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DNA, Neoplasm
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Concept
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DNA
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Concept
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DNA Topoisomerases, Type II
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Concept
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DNA Adducts
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Concept
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DNA Modification Methylases
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Concept
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Sequence Analysis, DNA
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Concept
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DNA, Complementary
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Concept
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DNA Repair Enzymes
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Concept
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DNA Breaks, Double-Stranded
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Concept
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DNA Glycosylases
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Concept
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DNA Copy Number Variations
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Concept
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DNA Methylation
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Concept
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O(6)-Methylguanine-DNA Methyltransferase
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Concept
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DNA Mismatch Repair
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Concept
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DNA, Single-Stranded
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Concept
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DNA Primers
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Academic Article
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Supplemental dietary calcium fails to alter the acute effects of 1,2-dimethylhydrazine on O6-methylguanine, O6-alkylguanine-DNA alkyltransferase and cellular proliferation in the rat colon.
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Academic Article
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Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Academic Article
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Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.
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Academic Article
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O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
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Academic Article
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Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
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Academic Article
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Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
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Academic Article
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Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
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Academic Article
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O6-benzylguanine and its role in chemotherapy.
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Academic Article
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Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity.
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Academic Article
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O6-alkylguanine-DNA alkyltransferase in cutaneous T-cell lymphoma: implications for treatment with alkylating agents.
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Academic Article
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Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
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Academic Article
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Inactivation of O6-alkylguanine-DNA alkyltransferase by 8-substituted O6-benzylguanine analogs in mice.
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Academic Article
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Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and analogues in nonhuman primates.
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Academic Article
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Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
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Academic Article
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Silence is golden: gene hypermethylation and survival in large-cell lymphoma.
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Academic Article
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Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.
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Academic Article
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A phase II trial of oral temozolomide in patients with metastatic renal cell cancer.
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Academic Article
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Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
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Academic Article
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Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
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Academic Article
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Debenzylation of O(6)-benzyl-8-oxoguanine in human liver: implications for O(6)-benzylguanine metabolism.
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Academic Article
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Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity.
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Academic Article
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Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
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Academic Article
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Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells.
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Academic Article
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Molecular mechanisms of resistance and toxicity associated with platinating agents.
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Academic Article
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Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
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Academic Article
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Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
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Academic Article
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Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.
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Academic Article
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Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.
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Academic Article
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Etoposide pathway.
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Academic Article
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Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
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Academic Article
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Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
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Academic Article
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Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.
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Academic Article
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A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter.
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Academic Article
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Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
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Academic Article
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An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
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Academic Article
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Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Sequential therapy with dacarbazine and carmustine: a phase I study.
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Academic Article
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Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.
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Academic Article
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Pharmacokinetics and metabolism in rats of 2,4-diamino-6-benzyloxy-5- nitrosopyrimidine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
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Academic Article
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Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer.
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Academic Article
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Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells.
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Academic Article
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Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.
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Academic Article
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Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
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Academic Article
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Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine.
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Academic Article
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Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
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Academic Article
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Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts.
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Academic Article
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Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents.
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Academic Article
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Sequence specificity of guanine alkylation and repair.
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Academic Article
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Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase.
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Academic Article
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Use of a dodecadeoxynucleotide to study repair of the O4-methylthymine lesion.
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Academic Article
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Extent of formation of O4-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver O6-alkylguanine-DNA-alkyltransferase.
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Academic Article
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Specificity of O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli.
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Academic Article
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Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
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Academic Article
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Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts.
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Academic Article
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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
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Academic Article
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Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
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Academic Article
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Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.
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Academic Article
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Repair of O-alkylpyrimidines in mammalian cells: a present consensus.
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Academic Article
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Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
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Academic Article
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Activity of temozolomide in the treatment of central nervous system tumor xenografts.
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Academic Article
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Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.
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Academic Article
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Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells.
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Academic Article
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Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli.
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Academic Article
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Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.
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Academic Article
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Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents.
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Academic Article
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Depletion of O6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine.
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Academic Article
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Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase.
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Academic Article
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Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo.
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Academic Article
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Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
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Academic Article
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Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Academic Article
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Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene.
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Academic Article
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O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
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Academic Article
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Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.
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Academic Article
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The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
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Academic Article
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O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
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Academic Article
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Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.
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Academic Article
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Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Academic Article
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Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies.
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Academic Article
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Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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O6-methylguanine-DNA methyltransferase activity and promoter methylation status in pediatric rhabdomyosarcoma.
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Academic Article
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Allelic loss at the GPx-1 locus in cancer of the head and neck.
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Academic Article
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A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.
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Academic Article
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Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
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Academic Article
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Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.
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Academic Article
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Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
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Academic Article
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O6-benzylguanine-mediated enhancement of chemotherapy.
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Academic Article
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Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
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Academic Article
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Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
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Academic Article
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Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits.
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Academic Article
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Genetic variants in cytosolic 5'-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia.
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Academic Article
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The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2.
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Academic Article
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Multicenter phase II trial of temozolomide in mycosis fungoides/sezary syndrome: correlation with O6-methylguanine-DNA methyltransferase and mismatch repair proteins.
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Academic Article
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Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine.
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Academic Article
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Use of oligodeoxynucleotides containing O6-alkylguanine for the assay of O6-alkylguanine-DNA-alkyltransferase activity.
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Academic Article
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Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
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Academic Article
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Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
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Academic Article
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Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
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Academic Article
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Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.
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Academic Article
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The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
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Academic Article
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Characterization of CpG sites that escape methylation on the inactive human X-chromosome.
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