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Dolan, Mary Eileen
One or more keywords matched the following items that are connected to Dolan, Mary Eileen
Item TypeName
Concept Guanine
Academic Article Supplemental dietary calcium fails to alter the acute effects of 1,2-dimethylhydrazine on O6-methylguanine, O6-alkylguanine-DNA alkyltransferase and cellular proliferation in the rat colon.
Academic Article Pharmacokinetics of O6-benzylguanine in rats and its metabolism by rat liver microsomes.
Academic Article Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.
Academic Article O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
Academic Article Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
Academic Article Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
Academic Article O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings.
Academic Article Determination of 8-oxoguanine in human plasma and urine by high-performance liquid chromatography with electrochemical detection.
Academic Article Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
Academic Article O6-benzylguanine and its role in chemotherapy.
Academic Article Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
Academic Article Inactivation of O6-alkylguanine-DNA alkyltransferase by 8-substituted O6-benzylguanine analogs in mice.
Academic Article Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
Academic Article Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.
Academic Article Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
Academic Article Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
Academic Article Debenzylation of O(6)-benzyl-8-oxoguanine in human liver: implications for O(6)-benzylguanine metabolism.
Academic Article Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity.
Academic Article Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
Academic Article Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells.
Academic Article Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
Academic Article Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
Academic Article Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.
Academic Article Role of copper transporters in resistance to platinating agents.
Academic Article Role of GADD34 in modulation of cisplatin cytotoxicity.
Academic Article Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
Academic Article Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
Academic Article Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies.
Academic Article Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.
Academic Article Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Academic Article An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers.
Academic Article Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
Academic Article Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
Academic Article Human liver oxidative metabolism of O6-benzylguanine.
Academic Article Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
Academic Article Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer.
Academic Article Pharmacokinetics of oral O6-benzylguanine and evidence of interaction with oral ketoconazole in the rat.
Academic Article Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
Academic Article Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine.
Academic Article Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
Academic Article Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts.
Academic Article Sequence specificity of guanine alkylation and repair.
Academic Article Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase.
Academic Article Specificity of O6-alkylguanine-DNA alkyltransferase.
Academic Article Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli.
Academic Article Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
Academic Article Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
Academic Article Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
Academic Article Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
Academic Article Activity of temozolomide in the treatment of central nervous system tumor xenografts.
Academic Article Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.
Academic Article Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells.
Academic Article Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli.
Academic Article Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.
Academic Article Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents.
Academic Article Depletion of O6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine.
Academic Article The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.
Academic Article Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase.
Academic Article Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo.
Academic Article 8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.
Academic Article Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
Academic Article Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase.
Academic Article O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
Academic Article Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.
Academic Article The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
Academic Article Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Academic Article O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
Academic Article Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Academic Article Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Academic Article Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies.
Academic Article Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
Academic Article A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.
Academic Article Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
Academic Article O6-benzylguanine-mediated enhancement of chemotherapy.
Academic Article Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
Academic Article Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
Academic Article The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2.
Academic Article Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine.
Academic Article Use of oligodeoxynucleotides containing O6-alkylguanine for the assay of O6-alkylguanine-DNA-alkyltransferase activity.
Academic Article Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
Academic Article Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
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  • Guanine