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One or more keywords matched the following properties of Long, Manyuan
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overview Since my doctoral study in California in the early 1990s, I have been focusing on the study of a new and major scientific problem: How does a gene originate and evolve? The approaches I have developed and are being used to investigate the new gene problem include theoretical, computational, and molecular experimental approaches. We are currently exploring following scientific issues: Phenotypic effects and functions of new genes; Evolution of gene functions in development; Evolutionary analysis of gene interactions with new genes; Sex selection and sexual conflict on new genes: De novo gene origination. Our scientific works have been recorded in ~200 publications of research reports, commentaries, reviews, interviews and popular science articles with numerous reports of news media. 110 research articles are selected below. Most of their pdf files can be found in the lab website. Besides, five books and monographs were also published: 2021. How Do New Genes Originate and Evolve? Genes. With E. Beltran 2020. Walter Gilbert: Selected Works. 614 pages. World Scientific, Singapore. With W. Gilbert. 2019. Evolution of Genes and Genomes. 174 pages. Science China Life Science. With B. Shen 2010. Darwin’s Heritage Today. 385 pages. Higher Education Press. With H. Gu and Z. Zhou 2003. Origin and Evolution of New Gene Functions. Volume 10, Contemporary Issues in Genetics and Evolution. 202 pages. Kluwer Academic Publishers. The Netherlands. Our works have generated scientific and societal impacts: Scientific impacts: Our works were conferred a prestigious award as The John Simon Guggenheim Memorial Fellowship for Natural Sciences in 2022, as one of 3 scientists in biology and one of 180 fellows selected from thousands of tenured professors and noted artists from natural sciences, humanity, social sciences, writers and creative arts in USA and Canada. The American Association for the Advancement of Science (AAAS) summarized my contribution when conferring me with a fellow honor (2014 AAAS Fellow) as “You are being honored: For distinguished contributions to the fields of molecular evolution and genetics, particularly for starting and leading the area of new gene evolution using experimental and computational genomics and molecular biology”. Our discovers have helped shape the new chapters and sections about new gene evolution in major textbooks pf evolutionary biology (e.g. Douglas Futuyma, 2009 and 2005, Evolution, Sinauer, Massachusetts; Michael Lynch, 2007, The Origins of Genome Architecture, Sinauer, Massachesetts; Wen-Hsiung Li, 1997, Molecular Evolution, Sinauer, Massachusetts; Roderic Page and Edward Holmes, 1998, Molecular Evolution. Blackwell Science London). Nature published a News Feature to highlight our discovery of a large number of de novo genes in Oryza (Levy, 2019. Genes from the Junkyard. Nature 574: 314-316). Our study of de novo gene originations in Oryza (Zhang et al, 2018. Nature Ecol Evol 3: 679–690) were also selected as one of 15 studies in 2019 that challenged medical dogma by Medscape. Societal impacts: The New York Times, The New Yorker, Washington Times, Chicago Tribune, Sacramento Bee, The Huffington Post, La Vanguardia, the New Scientist, the Scientist, Discover, La Recherche, Wen Hui Bao, Shanghai Review of Books, and other news media in US, Europe, East Asia reported in various languages his scientific discovers and commentaries. The research results of new gene evolution summarized in a Nature Rev Genet article (Manyuan Long et al, 2003) were cited as major evidence for defense of Amendment I to the United States Constitution in the nationally concerned case of Kitzmiller et al. vs. Dover Area School District in Pennsylvania in 2005. The American Scientist magazine published a feature popular science article by us to discuss de novo gene origination (Mortola and Long, 2021. Turning Junk into Us: How Genes Are Born. May-June Issue.) The Quanta Magazine published two interviews with me to discuss de novo gene origination and evolution of gene essentiality (Callier, 2020. Where do new genes come from. April 9. Callier, 2020. Scientists Find Vital Genes Evolving in Genome’s Junkyard. November 16.
One or more keywords matched the following items that are connected to Long, Manyuan
Item TypeName
Concept Genome, Insect
Concept Genome, Plant
Concept Genome, Mitochondrial
Concept Genome, Helminth
Concept Genome, Fungal
Concept Genome, Human
Concept Genome-Wide Association Study
Academic Article Intron-exon structures of eukaryotic model organisms.
Academic Article A new function evolved from gene fusion.
Academic Article Retroposed new genes out of the X in Drosophila.
Academic Article The origin of new genes: glimpses from the young and old.
Academic Article Expansion of genome coding regions by acquisition of new genes.
Academic Article Extensive gene traffic on the mammalian X chromosome.
Academic Article Origination of chimeric genes through DNA-level recombination.
Academic Article Natural selection shapes genome-wide patterns of copy-number polymorphism in Drosophila melanogaster.
Academic Article Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes.
Academic Article High rate of chimeric gene origination by retroposition in plant genomes.
Academic Article Age-dependent chromosomal distribution of male-biased genes in Drosophila.
Academic Article General gene movement off the X chromosome in the Drosophila genus.
Academic Article Evolution of genes and genomes on the Drosophila phylogeny.
Academic Article Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome.
Academic Article Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila.
Academic Article Evolutionary patterns of RNA-based duplication in non-mammalian chordates.
Academic Article Adaptive evolution and the birth of CTCF binding sites in the Drosophila genome.
Academic Article Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genes.
Academic Article Mutational bias shaping fly copy number variation: implications for genome evolution.
Academic Article The rapid generation of chimerical genes expanding protein diversity in zebrafish.
Academic Article Highly tissue specific expression of Sphinx supports its male courtship related role in Drosophila melanogaster.
Academic Article Drosophila duplication hotspots are associated with late-replicating regions of the genome.
Academic Article An intronic signal for alternative splicing in the human genome.
Academic Article Extensive structural renovation of retrogenes in the evolution of the Populus genome.
Academic Article Accelerated recruitment of new brain development genes into the human genome.
Academic Article New genes expressed in human brains: implications for annotating evolving genomes.
Academic Article Gene duplication and evolution.
Academic Article gKaKs: the pipeline for genome-level Ka/Ks calculation.
Academic Article High occurrence of functional new chimeric genes in survey of rice chromosome 3 short arm genome sequences.
Academic Article The genome sequence of African rice (Oryza glaberrima) and evidence for independent domestication.
Academic Article A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster.
Academic Article Why rodent pseudogenes refuse to retire.
Academic Article New genes drive the evolution of gene interaction networks in the human and mouse genomes.
Academic Article LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoans.
Academic Article Expressed Structurally Stable Inverted Duplicates in Mammalian Genomes as Functional Noncoding Elements.
Academic Article Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster.
Academic Article Publisher Correction: Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza.
Academic Article Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza.
Academic Article GenTree, an integrated resource for analyzing the evolution and function of primate-specific coding genes.
Academic Article Origination and evolution of orphan genes and de novo genes in the genome of Caenorhabditis elegans.
Academic Article Evolution of genes and genomes: an emerging paradigm in life science.
Academic Article Evolutionary Dynamics of Abundant 7-bp Satellites in the Genome of Drosophila virilis.
Academic Article The yeast splice site revisited: new exon consensus from genomic analysis.
Academic Article Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution.
Academic Article New Genes Interacted With Recent Whole-Genome Duplicates in the Fast Stem Growth of Bamboos.
Academic Article Gene fusion as an important mechanism to generate new genes in the genus Oryza.
Academic Article The Rapid Evolution of De Novo Proteins in Structure and Complex.
Academic Article Human gene age dating reveals an early and rapid evolutionary construction of the adaptive immune system.
Academic Article High quality genome assemblies reveal evolutionary dynamics of repetitive DNA and structural rearrangements in the Drosophila virilis sub-group.
Academic Article High-Quality Genome Assemblies Reveal Evolutionary Dynamics of Repetitive DNA and Structural Rearrangements in the Drosophila virilis Subgroup.
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