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Hanck, Dorothy

One or more keywords matched the following items that are connected to Hanck, Dorothy

Item Type	Name
Concept	Sodium Channels
Concept	Sodium Channel Blockers
Academic Article	Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
Academic Article	Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics.
Academic Article	The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B.
Academic Article	Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms.
Academic Article	Optimization of a mammalian expression system for the measurement of sodium channel gating currents.
Academic Article	Nonequilibrium response spectroscopy of voltage-sensitive ion channel gating.
Academic Article	Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
Academic Article	A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.
Academic Article	Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.
Academic Article	Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin.
Academic Article	Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin.
Academic Article	Augmentation of recovery from inactivation by site-3 Na channel toxins. A single-channel and whole-cell study of persistent currents.
Academic Article	Differences in the binding sites of two site-3 sodium channel toxins.
Academic Article	The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.
Academic Article	Gating of skeletal and cardiac muscle sodium channels in mammalian cells.
Academic Article	The role of the putative inactivation lid in sodium channel gating current immobilization.
Academic Article	Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin.
Academic Article	Heartthrobs.
Academic Article	Lidocaine alters activation gating of cardiac Na channels.
Academic Article	Two components of use-dependent block of sodium current by lidocaine in voltage clamped cardiac Purkinje cells.
Academic Article	Atrionatriuretic peptide and calcium-conducting sodium channels.
Academic Article	Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity.
Academic Article	Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3.
Academic Article	Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation.
Academic Article	Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.
Academic Article	Molecular action of lidocaine on the voltage sensors of sodium channels.
Academic Article	State-dependent mibefradil block of Na+ channels.
Academic Article	Kinetic analysis of single sodium channels from canine cardiac Purkinje cells.
Academic Article	Gating currents associated with Na channels in canine cardiac Purkinje cells.
Academic Article	Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.
Academic Article	Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.
Academic Article	Sodium channels in cardiac Purkinje cells.
Academic Article	Isoform-dependent interaction of voltage-gated sodium channels with protons.
Academic Article	Open sodium channel properties of single canine cardiac Purkinje cells.
Academic Article	Site-3 toxins and cardiac sodium channels.
Academic Article	An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels.
Academic Article	Is there a second external lidocaine binding site on mammalian cardiac cells?
Academic Article	Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel.
Academic Article	The sodium channel as a target for local anesthetic drugs.
Academic Article	Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.
Academic Article	Sodium channel molecular conformations and antiarrhythmic drug affinity.
Academic Article	A direct effect of forskolin on sodium channel bursting.
Academic Article	Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.
Academic Article	Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination.
Academic Article	Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells.
Academic Article	Modification of sodium channel inactivation by alpha-chymotrypsin in canine cardiac Purkinje cells.
Academic Article	Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.
Academic Article	Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells.
Academic Article	Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII.
Academic Article	Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study.
Academic Article	The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels.
Academic Article	Outward stabilization of the voltage sensor in domain II but not domain I speeds inactivation of voltage-gated sodium channels.
Academic Article	Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.
Concept	NAV1.2 Voltage-Gated Sodium Channel
Concept	NAV1.5 Voltage-Gated Sodium Channel
Concept	Voltage-Gated Sodium Channel beta-3 Subunit
Concept	NAV1.3 Voltage-Gated Sodium Channel
Grant	Structure-Function of the Cardiac Sodium Channel
Grant	Drug therapy targeted to the voltage-gated sodium channel

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Sodium Channels