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Search Results to Barbara Lynne Kee

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overview Transcriptional Control of Innate and Adaptive Lymphoid Development and Transformation The execution of an effective immune response with minimal immune-mediated disease requires appropriate control of the development and function of adaptive and innate components of the immune system. B and T lymphocytes are the cells that mediate adaptive immunity; they are highly antigen specific but require substantial expansion and activation prior to promoting an effective immune response. In contrast, natural killer (NK) cells, innate-like T lymphocytes, and the recently identified innate lymphoid cells (ILCs) are lymphocytes that function in innate immunity; they acquire their effector properties during their development and are poised to rapidly confront invading pathogens. All immune system cells develop from a common hematopoietic stem cell (HSC) whose differentiation pathway is controlled in part by the activation and repression of lineage specific gene programs. Our laboratory is interested in understanding how these transcriptional programs are wired and how alterations in these pathways lead to disease such as autoimmunity, asthma and acute leukemia. The E protein class of basic helix-loop-helix (bHLH) transcription factors and their antagonists, the ID proteins, play fundamental roles in the choice between adaptive and innate lymphoid differentiation and they control the precise effector functions exhibited by these cells. Failure to properly control the activity of these proteins leads to immune deficiencies and cancer. The E protein E2A is required for development of B and T lymphocytes due to direct regulation of critical transcriptional networks that specify these lineages from HSCs and multipotent progenitors. Despite a severe T lymphocyte immune deficiency in E2A-deficient mice, the mice develop a disease similar to T lymphocyte acute lymphoblastic leukemia (T-ALL), and the human disease is characterized by recurrent mutations that affect E protein function. We identified a transcriptional cascade involving the transcription factors Notch1 and LEF1 as being critical for leukemia cell survival and we are working toward an understanding of how these transcription factors contribute to both immune deficiency and leukemogenesis. ID2 and ID3 control the development and effector fate of innate lymphoid cells including NK cells, ILCs and NKT cells. Our laboratory has focused on understanding how ID protein expression is regulated in innate lymphoid cells and how the targets of the E protein transcription factors control adaptive and innate lymphoid cell differentiation. Our recent studies led to the identification of ETS1 as a critical regulator of ID2 that promotes NK cell and ILC differentiation, and we are working toward an understanding of how ETS1 and ID2 cooperate to control NK cell maturation and effector function.

One or more keywords matched the following items that are connected to Kee, Barbara Lynne

Item TypeName
Concept Gene Expression Regulation
Concept Up-Regulation
Concept Gene Expression Regulation, Developmental
Concept Down-Regulation
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Leukemic
Concept Gene Expression Regulation, Neoplastic
Academic Article Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.
Academic Article Transcription factor regulation of B lineage commitment.
Academic Article Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A.
Academic Article Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.
Academic Article DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection.
Academic Article Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity.
Academic Article Extrinsic and intrinsic regulation of early natural killer cell development.
Academic Article Lymphoid development: it's not 'all Greek to us' any more.
Academic Article Helix-loop-helix proteins in lymphocyte lineage determination.
Academic Article E proteins and the regulation of early lymphocyte development.
Academic Article Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.
Academic Article Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors.
Academic Article Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2.
Academic Article Transcriptional regulation of lymphocyte development.
Academic Article The transcriptional regulation of B cell lineage commitment.
Academic Article Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.
Academic Article The TLX1 oncogene drives aneuploidy in T cell transformation.
Academic Article Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1.
Academic Article Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas.
Academic Article Multiple hats for natural killers.
Academic Article Early B-cell factor regulates the expression of Hemokinin-1 in the olfactory epithelium and differentiating B lymphocytes.
Academic Article E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.
Academic Article ID'ing innate and innate-like lymphoid cells.
Academic Article Fingerprinting ikaros.
Academic Article Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota.
Academic Article Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.
Academic Article Sox4 B-lymphocyte progenitors.
Academic Article EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints.
Academic Article Transcriptional and epigenetic regulation of innate-like T lymphocyte development.
Academic Article Transcription factor ID2 prevents E proteins from enforcing a naïve T lymphocyte gene program during NK cell development.
Academic Article Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.
Academic Article Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf.
Academic Article Transcriptional regulation of natural killer cell development and maturation.
Academic Article The transcription factor BCL-6 controls early development of innate-like T cells.
Academic Article It's a Phase That EBF1 Is Going Through.

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