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One or more keywords matched the following properties of Liao, James
overview Dr. Liao is the Harold H. Hines Jr. Professor of Medicine and Chief of Cardiology Section at the University of Chicago. He is also the Director of the Physician Scientist Development Program and Principal Investigator of the NIH T32 Cardiovascular Sciences Training Grant. His laboratory has made many important discoveries, which has helped elucidate signaling mechanisms in the vascular wall. Specifically, his laboratory explored molecular pathways which revealed how HMG-CoA reductase inhibitors (or statins) could exert cholesterol-independent or "pleiotropic" effects. This translational work provided a mechanistic basis for the benefit of statin therapy in stroke patients for which he received and was awarded the Cardiovascular Research Prize from the American Heart Association. His laboratory also identified, cloned, and characterized a novel cytochrome P450 epoxygenase, CYP2J2, and its products, epoxyeicosatrienoic acids (EETs), as endothelium-derived hyporpolarizing factors with anti-inflammatory and anti-ischemic properties. In addition, his work also led to the discovery of a novel, rapid, nongenomic effect of steroid hormone receptors. For his research accomplishments, Dr. Liao received the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award from the American Heart Association and the Outstanding Investigator Award from the American Federation for Medical Research. He has served on numerous NIH study sections, advisory committees, and special emphasis panels.
One or more keywords matched the following items that are connected to Liao, James
Item TypeName
Concept Hydroxymethylglutaryl-CoA Reductase Inhibitors
Academic Article Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.
Academic Article Pleiotropic effects of statins. - Basic research and clinical perspectives -.
Academic Article Squalene synthase inhibitor lapaquistat acetate: could anything be better than statins?
Academic Article Statins inhibit Rho kinase activity in patients with atherosclerosis.
Academic Article Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy.
Academic Article Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.
Academic Article Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation.
Academic Article Rho kinase: an important mediator of atherosclerosis and vascular disease.
Academic Article Rapid effects of statins: from prophylaxis to therapy for ischemic stroke.
Academic Article Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol.
Academic Article Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.
Academic Article A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms.
Academic Article Endothelium-dependent effects of statins.
Academic Article Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.
Academic Article Isoprenoid metabolism and the pleiotropic effects of statins.
Academic Article Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF.
Academic Article Does it matter whether or not a lipid-lowering agent inhibits Rho kinase?
Academic Article Mitohormesis: another pleiotropic effect of statins?
Academic Article Pleiotropic effects of statins.
Academic Article Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event.
Academic Article Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
Academic Article Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription.
Academic Article Isoprenoids as mediators of the biological effects of statins.
Academic Article Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells.
Academic Article Safety and efficacy of statins in Asians.
Academic Article Statins and ischemic stroke.
Academic Article Evidence of pleiotropy by statins: leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome predictors.
Academic Article 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1).
Academic Article Statins: potent vascular anti-inflammatory agents.
Academic Article Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment.
Academic Article Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.
Academic Article Rho GTPases, statins, and nitric oxide.
Academic Article Clinical implications for statin pleiotropy.
Academic Article Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.
Academic Article [New findings on the action of HMG-CoA-reductase inhibitors].
Academic Article Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection.
Academic Article Simvastatin decreases IL-6 and IL-8 production in epithelial cells.
Academic Article Statin therapy: having the good without the bad.
Academic Article Statins and myocardial hypertrophy.
Academic Article Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase.
Academic Article Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase.
Academic Article Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.
Academic Article Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection.
Academic Article Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.
Academic Article Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.
Academic Article Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein.
Academic Article Statin therapy is associated with improved patency of autogenous infrainguinal bypass grafts.
Academic Article Drug Insight: statins and stroke.
Academic Article RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
Academic Article Targeting Rho in cardiovascular disease.
Academic Article Lipid management with statins. The lower the better?
Academic Article Targeting eNOS for stroke protection.
Academic Article Direct vascular effects of HMG-CoA reductase inhibitors.
Academic Article Pleiotropic Effects of Statins on the Cardiovascular System.
Academic Article Preservation of NO production by statins in the treatment of heart failure.
Academic Article Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor.
Academic Article Beyond lipid lowering: the role of statins in vascular protection.
Academic Article Statin therapy for cardiac hypertrophy and heart failure.
Academic Article Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase.
Academic Article Simvastatin preserves cardiac function in genetically determined cardiomyopathy.
Academic Article The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.
Academic Article Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Academic Article Long-term statin use and psychological well-being.
Academic Article Emerging views of statin pleiotropy and cholesterol lowering.
Academic Article Challenging Statin Pleiotropy: Preeclampsia.
Grant Endothelial Akt in Vascular Injury
Academic Article Understanding the molecular mechanisms of statin pleiotropic effects.
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  • Hydroxymethylglutaryl CoA Reductase Inhibitors