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One or more keywords matched the following properties of Kovar, David R.
keywords Cytoskeleton
overview Cells simultaneously assemble and maintain different actin cytoskeleton networks of distinct organizations and dynamics for fundamental processes such as polarization, endocytosis, motility and division. How does a shared pool of actin monomer building blocks self-organize into distinct actin filament networks of specific densities, sizes and function within a common cellular cytoplasm? Our research group is investigating the molecular mechanisms that govern how diverse actin cytoskeleton networks self-organize through (1) competition for a limited supply of actin monomers, (2) network-specific sorting of actin binding proteins, and (3) the effects of different combinations of actin binding proteins on actin filament network organization, dynamics and function. We take advantage of complementary experiments in live cells and with purified components. These interdisciplinary techniques include genetics, time-lapse fluorescence microscopy of cells, biochemistry, biophysics, in vitro reconstitution and multi-color single molecule TIRF microscopy imaging.
One or more keywords matched the following items that are connected to Kovar, David R.
Item TypeName
Concept Actin Cytoskeleton
Academic Article Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.
Academic Article The characterization of ligand-specific maize (Zea mays) profilin mutants.
Academic Article Fluorescently-labeled fimbrin decorates a dynamic actin filament network in live plant cells.
Academic Article Actin and actin-binding proteins in higher plants.
Academic Article The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin.
Academic Article Insertional assembly of actin filament barbed ends in association with formins produces piconewton forces.
Academic Article Progressing actin: Formin as a processive elongation machine.
Academic Article Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo.
Academic Article Cell polarity: formin on the move.
Academic Article Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.
Academic Article A plant-specific kinesin binds to actin microfilaments and interacts with cortical microtubules in cotton fibers.
Academic Article Formin differentially utilizes profilin isoforms to rapidly assemble actin filaments.
Academic Article Signal-mediated depolymerization of actin in pollen during the self-incompatibility response.
Academic Article Role of tropomyosin in formin-mediated contractile ring assembly in fission yeast.
Academic Article Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1.
Academic Article Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation.
Academic Article Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.
Academic Article Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks.
Academic Article The functionally distinct fission yeast formins have specific actin-assembly properties.
Academic Article Molecular details of formin-mediated actin assembly.
Academic Article The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly.
Academic Article Fimbrin and tropomyosin competition regulates endocytosis and cytokinesis kinetics in fission yeast.
Academic Article Three's company: the fission yeast actin cytoskeleton.
Academic Article Latrunculin B has different effects on pollen germination and tube growth.
Academic Article Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.
Academic Article Attachment conditions control actin filament buckling and the production of forces.
Academic Article SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.
Academic Article Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex.
Academic Article Formin-based control of the actin cytoskeleton during cytokinesis.
Academic Article Homeostatic actin cytoskeleton networks are regulated by assembly factor competition for monomers.
Academic Article A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface.
Academic Article HopW1 from Pseudomonas syringae disrupts the actin cytoskeleton to promote virulence in Arabidopsis.
Academic Article The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.
Academic Article Cytoskeletal dynamics: a view from the membrane.
Academic Article Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites.
Academic Article Actin age orchestrates myosin-5 and myosin-6 run lengths.
Academic Article Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites.
Academic Article The F-actin bundler a-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast.
Academic Article Internetwork competition for monomers governs actin cytoskeleton organization.
Academic Article Fascin- and a-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting.
Academic Article Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.
Academic Article When Is "Enough" Enough?
Academic Article Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates.
Academic Article Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly.
Academic Article Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins.
Academic Article Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia cross-linker fascin.
Academic Article Cooperation between tropomyosin and a-actinin inhibits fimbrin association with actin filament networks in fission yeast.
Academic Article Cofilin drives rapid turnover and fluidization of entangled F-actin.
Academic Article Mechanical and kinetic factors drive sorting of F-actin cross-linkers on bundles.
Academic Article Chlamydomonas reinhardtii formin FOR1 and profilin PRF1 are optimized for acute rapid actin filament assembly.
Academic Article Pseudomonas aeruginosa exoenzyme Y directly bundles actin filaments.
Academic Article F-Actin Cytoskeleton Network Self-Organization Through Competition and Cooperation.
Academic Article LIM domain proteins in cell mechanobiology.
Academic Article Stir it up: The role of actin in mitochondrial mixing during mitosis.
Academic Article Formin Cdc12's specific actin assembly properties are tailored for cytokinesis in fission yeast.
Academic Article Mechanism of actin filament nucleation.
Academic Article Actin assembly requirements of the formin Fus1 to build the fusion focus.
Academic Article Acetylation of fission yeast tropomyosin does not promote differential association with cognate formins.
Academic Article Reconstitution of the transition from a lamellipodia- to filopodia-like actin network with purified proteins.
Academic Article Highly flexible PEG-LifeAct constructs act as tunable biomimetic actin crosslinkers.
Academic Article Multi-monoubiquitylation controls VASP-mediated actin dynamics.
Academic Article Arp2/3 complex- and formin-mediated actin cytoskeleton networks facilitate actin binding protein sorting in fission yeast.
Academic Article Prediction of the essential intermolecular contacts for side-binding of VASP on F-actin.
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  • Cytoskeleton