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Beyer, Eric C.

One or more keywords matched the following properties of Beyer, Eric C.

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keywords	Connexins
overview	Dr. Beyer is a physician scientist who practices pediatric hematology/oncology and has a broad background in basic laboratory and translational research. His laboratory has spent more nearly 30 years investigating intercellular communication (as mediated by the channels contained within gap junctions) and how its disruptions contribute to disease. These studies encompass basic investigations including identification and cloning of the subunit proteins, characterization of structure-function physiological relationships, determination of pathways of biosynthesis and degradation. Dr. Beyer's laboratory has also been pursuing translational examinations of the roles of these proteins in diseases including cataracts, deafness, arrhythmias, cancer, and premature labor. The group has spent many years studying the connexins expressed in the eye lens. They are elucidating the process of cataract development by studying mouse and cell culture models that mimic the pathologies seen in human families with connexin mutants and inherited cataracts. Dr. Beyer has investigated the roles of cardiac connexins in normal cardiac conduction and in the pathogenesis of arrhythmias. He is studying the roles of circulating extracellular vesicles in the vascular pathologies that underlie the crises of patients with sickle cell disease. He has mentored many students and post-doctoral fellows within his laboratory.

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Connexins

overview

Dr. Beyer is a physician scientist who practices pediatric hematology/oncology and has a broad background in basic laboratory and translational research. His laboratory has spent more nearly 30 years investigating intercellular communication (as mediated by the channels contained within gap junctions) and how its disruptions contribute to disease. These studies encompass basic investigations including identification and cloning of the subunit proteins, characterization of structure-function physiological relationships, determination of pathways of biosynthesis and degradation. Dr. Beyer's laboratory has also been pursuing translational examinations of the roles of these proteins in diseases including cataracts, deafness, arrhythmias, cancer, and premature labor. The group has spent many years studying the connexins expressed in the eye lens. They are elucidating the process of cataract development by studying mouse and cell culture models that mimic the pathologies seen in human families with connexin mutants and inherited cataracts. Dr. Beyer has investigated the roles of cardiac connexins in normal cardiac conduction and in the pathogenesis of arrhythmias. He is studying the roles of circulating extracellular vesicles in the vascular pathologies that underlie the crises of patients with sickle cell disease. He has mentored many students and post-doctoral fellows within his laboratory.

One or more keywords matched the following items that are connected to Beyer, Eric C.

Item Type	Name
Academic Article	Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle.
Academic Article	Multiple connexins colocalize in canine ventricular myocyte gap junctions.
Academic Article	Connexin expression in the developing avian cardiovascular system.
Academic Article	Gap junction protein phenotypes of the human heart and conduction system.
Academic Article	Multiple connexins confer distinct regulatory and conductance properties of gap junctions in developing heart.
Academic Article	The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195.
Academic Article	Gap junctions.
Academic Article	Connexin43 mediates direct intercellular communication in human osteoblastic cell networks.
Academic Article	Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes.
Academic Article	Cardiac intercellular communication: consequences of connexin distribution and diversity.
Academic Article	Differential expression of gap junction connexins in endocrine and exocrine glands.
Academic Article	The gap-junction protein connexin 56 is phosphorylated in the intracellular loop and the carboxy-terminal region.
Academic Article	Differential regulation of connexin43 and connexin37 in endothelial cells by cell density, growth, and TGF-beta1.
Academic Article	Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37.
Academic Article	Cultured chicken embryo lens cells resemble differentiating fiber cells in vivo and contain two kinetic pools of connexin56.
Academic Article	Cloning and functional expression of a novel gap junction channel from the retina of Danio aquipinnatus.
Academic Article	Gap junctions in the chicken pineal gland.
Academic Article	Functional expression and biochemical characterization of an epitope-tagged connexin37.
Academic Article	Mouse connexin40: gene structure and promoter analysis.
Academic Article	Co-expression of lens fiber connexins modifies hemi-gap-junctional channel behavior.
Academic Article	Differential expression of gap junction proteins in the canine sinus node.
Academic Article	Functional expression and biophysical properties of polymorphic variants of the human gap junction protein connexin37.
Academic Article	Heteromeric connexons formed by the lens connexins, connexin43 and connexin56.
Academic Article	Heterogeneous localization of connexin40 in the renal vasculature.
Academic Article	Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins.
Academic Article	Connexin46 mutations linked to congenital cataract show loss of gap junction channel function.
Academic Article	Mouse connexin37: gene structure and promoter analysis.
Academic Article	Zygotic expression of the connexin43 gene supplies subunits for gap junction assembly during mouse preimplantation development.
Academic Article	Gap junction messenger RNA expression by vascular wall cells.
Academic Article	Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43.
Academic Article	Characterization of gap junction channels in A7r5 vascular smooth muscle cells.
Academic Article	Mouse connexin 45: genomic cloning and exon usage.
Academic Article	Molecular mechanism underlying a Cx50-linked congenital cataract.
Academic Article	Gap junction channels formed by coexpressed connexin40 and connexin43.
Academic Article	PKC isoenzymes in the chicken lens and TPA-induced effects on intercellular communication.
Academic Article	Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages.
Academic Article	Redistribution of connexin45 in gap junctions of connexin43-deficient hearts.
Academic Article	Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts.
Academic Article	Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation.
Academic Article	Cardiac gap junction channels show quantitative differences in selectivity.
Academic Article	Peptide inhibitors of intercellular communication.
Academic Article	In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic B-cells.
Academic Article	Molecular cloning of a rat uterine gap junction protein and analysis of gene expression during gestation.
Academic Article	Functional role of the carboxyl terminal domain of human connexin 50 in gap junctional channels.
Academic Article	Heteromeric mixing of connexins: compatibility of partners and functional consequences.
Academic Article	Loss of function and impaired degradation of a cataract-associated mutant connexin50.
Academic Article	Gap junction synthesis and degradation as therapeutic targets.
Academic Article	Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions.
Academic Article	A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo- or hetero-oligomerization.
Academic Article	Highly restricted pattern of connexin36 expression in chick somite development.
Academic Article	Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5.
Academic Article	Plasma membrane channels formed by connexins: their regulation and functions.
Academic Article	Connexin family of gap junction proteins.
Academic Article	Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis.
Academic Article	Molecular cloning and developmental expression of two chick embryo gap junction proteins.
Academic Article	N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26.
Academic Article	A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts.
Academic Article	Transgenic overexpression of connexin50 induces cataracts.
Academic Article	The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum.
Academic Article	Pathways for degradation of connexins and gap junctions.
Academic Article	Dynamic model for ventricular junctional conductance during the cardiac action potential.
Academic Article	Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells.
Academic Article	Quantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43.
Academic Article	The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation.
Academic Article	A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract.
Academic Article	Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50.
Academic Article	An intact connexin N-terminus is required for function but not gap junction formation.
Academic Article	Connexin40 and connexin43 determine gating properties of atrial gap junction channels.
Academic Article	Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure.
Academic Article	Different domains are critical for oligomerization compatibility of different connexins.
Academic Article	Connexin43: a protein from rat heart homologous to a gap junction protein from liver.
Academic Article	Inducible coexpression of connexin37 or connexin40 with connexin43 selectively affects intercellular molecular transfer.
Academic Article	Cx30.2 can form heteromeric gap junction channels with other cardiac connexins.
Academic Article	Differential expression of three gap junction proteins in developing and mature brain tissues.
Academic Article	Selectivity of connexin-specific gap junctions does not correlate with channel conductance.
Academic Article	Characterization of gap junctional communication-deficient mutants of a rat liver epithelial cell line.
Academic Article	Expression of multiple gap junction proteins in human fetal and infant hearts.
Academic Article	A mutant connexin50 with enhanced hemichannel function leads to cell death.
Academic Article	Autophagy: a pathway that contributes to connexin degradation.
Academic Article	Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces.
Academic Article	Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization.
Academic Article	Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function.
Academic Article	Characterization of the gap junction protein connexin56 in the chicken lens by immunofluorescence and immunoblotting.
Academic Article	Expression of the gap junction protein connexin43 in embryonic chick lens: molecular cloning, ultrastructural localization, and post-translational phosphorylation.
Academic Article	Selective dye and ionic permeability of gap junction channels formed by connexin45.
Academic Article	Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells.
Academic Article	Chick connexin-56, a novel lens gap junction protein. Molecular cloning and functional expression.
Academic Article	Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties.
Academic Article	Differential expression of two gap junction proteins in corneal epithelium.
Academic Article	Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle.
Academic Article	Bovine connexin44, a lens gap junction protein: molecular cloning, immunologic characterization, and functional expression.
Academic Article	Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40.
Academic Article	Expression of multiple connexins in cultured neonatal rat ventricular myocytes.
Academic Article	Cardiac myocytes express multiple gap junction proteins.
Academic Article	Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium.
Academic Article	Distribution of gap junctions in dog and rat ventricle studied with a double-label technique.
Academic Article	Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50.
Academic Article	Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities.
Academic Article	The molecular basis of anisotropy: role of gap junctions.
Academic Article	The gap junction protein connexin43 is degraded via the ubiquitin proteasome pathway.
Academic Article	Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43.
Academic Article	Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45.
Academic Article	Characterization of the gap junction protein, connexin45.
Academic Article	Expression patterns of mRNAs for the gap junction proteins connexin43 and connexin42 suggest their involvement in chick limb morphogenesis and specification of the arterial vasculature.
Academic Article	Cloning and expression of a Xenopus embryonic gap junction protein.
Academic Article	Formation of gap junctions by expression of connexins in Xenopus oocyte pairs.
Academic Article	Rat uterine myometrium contains the gap junction protein connexin45, which has a differing temporal expression pattern from connexin43.
Academic Article	Distinct behavior of connexin56 and connexin46 gap junctional channels can be predicted from the behavior of their hemi-gap-junctional channels.
Academic Article	Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein.
Academic Article	Gap junction proteins exhibit early and specific expression during intramembranous bone formation in the developing chick mandible.
Academic Article	Connexin 43 and connexin 40 gap junctional proteins are present in arteriolar smooth muscle and endothelium in vivo.
Academic Article	Connexin and gap junction degradation.
Academic Article	Expression of different connexin genes in rat uterus during decidualization and at term.
Academic Article	Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication.
Academic Article	Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels.
Academic Article	Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins.
Academic Article	An aberrant sequence in a connexin46 mutant underlies congenital cataracts.
Academic Article	Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues.
Academic Article	A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor.
Academic Article	Atrial fibrillation-associated connexin40 mutants make hemichannels and synergistically form gap junction channels with novel properties.
Academic Article	Roles and regulation of lens epithelial cell connexins.
Academic Article	Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated.
Academic Article	Gap junction protein connexin43 exacerbates lung vascular permeability.
Academic Article	Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation.
Academic Article	Connexin40 abnormalities and atrial fibrillation in the human heart.
Academic Article	Connexin46fs380 causes progressive cataracts.
Academic Article	The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating.
Academic Article	Are these connexins compatible and does it matter?
Academic Article	Connexin23 deletion does not affect lens transparency.
Academic Article	The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses.
Academic Article	Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins.
Academic Article	Gap junction gene and protein families: Connexins, innexins, and pannexins.
Academic Article	Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice.
Academic Article	Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.
Academic Article	Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice.
Academic Article	Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses.
Academic Article	Characterization of a variant of gap junction protein a8 identified in a family with hereditary cataract.
Academic Article	Connecting Exosomes and Connexins.
Academic Article	The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation.
Academic Article	CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice.
Academic Article	p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency.
Academic Article	ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
Academic Article	Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization.
Academic Article	Do Connexin Mutants Cause Cataracts by Perturbing Glutathione Levels and Redox Metabolism in the Lens?
Academic Article	Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant.
Academic Article	Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation.
Academic Article	Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice.
Academic Article	A crystallin mutant cataract with mineral deposits.

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