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One or more keywords matched the following properties of Alegre, Maria-Luisa
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overview My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.
One or more keywords matched the following items that are connected to Alegre, Maria-Luisa
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Concept Graft Survival
Academic Article Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Academic Article Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
Academic Article Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.
Academic Article CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Academic Article Overexpression of program death-1 in T cells has mild impact on allograft survival.
Academic Article Toll-like receptor signaling in transplantation.
Academic Article IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Academic Article A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.
Academic Article Role of T-cell-specific nuclear factor ?B in islet allograft rejection.
Academic Article CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Academic Article Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Academic Article Transplantation tolerance and its outcome during infections and inflammation.
Academic Article Microbes and allogeneic transplantation.
Academic Article Spontaneous restoration of transplantation tolerance after acute rejection.
Academic Article High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection.
Academic Article Erosion of Transplantation Tolerance After Infection.
Academic Article Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.
Academic Article Gut microbes contribute to variation in solid organ transplant outcomes in mice.
Academic Article Exercise increases skin graft resistance to rejection.
Grant Impact of Microbiota on Alloimmune Responses in Transplantation
Grant The microbiota and allograft rejection: novel investigations into the consequences of obesity
Academic Article Impact of the microbiota on solid organ transplant rejection.
Academic Article Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.
Academic Article Exploiting immunometabolism and T cell function for solid organ transplantation.
Academic Article Taurodeoxycholic acid and valine reverse obesity-associated augmented alloimmune responses and prolong allograft survival.
Academic Article Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation.
Academic Article Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival.
Academic Article Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival.
Grant NF-kappaBeta activation T cell function/graft rejection
Academic Article Low-affinity CD8+ T cells provide interclonal help to high-affinity CD8+ T cells to augment alloimmunity.
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  • Graft Survival