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Alegre, Maria-Luisa

One or more keywords matched the following properties of Alegre, Maria-Luisa

Property	Value
keywords	Transplant Rejection
overview	My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.

Property

Value

keywords

Transplant Rejection

overview

My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.

One or more keywords matched the following items that are connected to Alegre, Maria-Luisa

Item Type	Name
Concept	Graft vs Host Disease
Concept	Graft Survival
Concept	Graft Rejection
Concept	Graft Enhancement, Immunologic
Concept	Graft vs Host Reaction
Concept	Transplants
Academic Article	Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Academic Article	Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
Academic Article	Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article	Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article	Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.
Academic Article	Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.
Academic Article	Secondary lymphoid organs are important but not absolutely required for allograft responses.
Academic Article	Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts.
Academic Article	CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Academic Article	Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Academic Article	Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL.
Academic Article	Role of natural killer cell subsets in cardiac allograft rejection.
Academic Article	Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article	Cellular mechanisms underlying acute graft rejection: time for reassessment.
Academic Article	Overexpression of program death-1 in T cells has mild impact on allograft survival.
Academic Article	Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.
Academic Article	Toll-like receptor signaling in transplantation.
Academic Article	Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signaling.
Academic Article	The multiple facets of toll-like receptors in transplantation biology.
Academic Article	Toll-like receptors (TLRs) in transplantation.
Academic Article	TLR signals promote IL-6/IL-17-dependent transplant rejection.
Academic Article	Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome.
Academic Article	Bacterial infections, alloimmunity, and transplantation tolerance.
Academic Article	IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Academic Article	The inside story of dendritic cell immunotherapy.
Academic Article	Commensal microbiota determine intestinal iTreg.
Academic Article	Role of T cell-nuclear factor ?B in transplantation.
Academic Article	The impact of infection and tissue damage in solid-organ transplantation.
Academic Article	"Tip-toeing" to an assay for transplantation tolerance?
Academic Article	Literature watch implications for transplantation. The anti-infectious role of the IL-17 pathway.
Academic Article	TLR engagement prevents transplantation tolerance.
Academic Article	Attenuation by targeting the B- and T-cell attenuator.
Academic Article	An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity.
Academic Article	Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors.
Academic Article	Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells.
Academic Article	Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Academic Article	A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.
Academic Article	Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.
Academic Article	Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.
Academic Article	Role of T-cell-specific nuclear factor ?B in islet allograft rejection.
Academic Article	CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Academic Article	Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Academic Article	The microbiota, the immune system and the allograft.
Academic Article	IFN-?: The Dr. Jekyll and Mr. Hyde of immunology?
Academic Article	Transplantation tolerance and its outcome during infections and inflammation.
Academic Article	Lessons and limits of mouse models.
Academic Article	Microbes and allogeneic transplantation.
Academic Article	The influence of the microbiota on the immune response to transplantation.
Academic Article	Spontaneous restoration of transplantation tolerance after acute rejection.
Academic Article	High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Academic Article	The composition of the microbiota modulates allograft rejection.
Academic Article	Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection.
Academic Article	Standardizing Mouse Models to Account for Host-Microbial Interactions.
Academic Article	Antigen Presentation in Transplantation.
Academic Article	Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft.
Academic Article	Natural killer cell subsets in allograft rejection and tolerance.
Academic Article	Long-term Maintenance of Sterility Following Skin Transplantation in Germ-free Mice.
Academic Article	Transplantation tolerance after allograft rejection.
Academic Article	Super-MANF to the Rescue: Immunomodulation Improves Retinal Repair and Regenerative Cell Therapy.
Academic Article	Erosion of Transplantation Tolerance After Infection.
Academic Article	Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice.
Academic Article	The Multiple Molecular Paths of Antibody Suppression by TFR Cells.
Academic Article	Dendritic Cell Identification for Dummies.
Academic Article	Ionic Checkpoint: Potassium-Driven T Cell Immunosuppression.
Academic Article	The Tpm Subset of the CD8+ T Cell Memory Family.
Academic Article	Impact of environmental factors on alloimmunity and transplant fate.
Academic Article	Select Effects of IL-13 in Driving Tissue Repair and Fibrosis.
Academic Article	Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.
Academic Article	The Bugs That Keep Us Safe.
Academic Article	Creating a Niche.
Academic Article	Danger, Metabolism and T Cell Memory.
Academic Article	Sweet T Cell Dysfunction.
Academic Article	Preventing PTLD?
Academic Article	What's new in transplantation tolerance?
Academic Article	Gut microbes contribute to variation in solid organ transplant outcomes in mice.
Academic Article	Novel Role of Calcineurin Inhibitors in Curbing T Cells' Sweet Tooth.
Academic Article	The Unbearable Lightness of Breathing.
Academic Article	Timing Is Everything.
Academic Article	Equal Expansion of Endogenous Transplant-Specific Regulatory T Cell and Recruitment Into the Allograft During Rejection and Tolerance.
Academic Article	The outstanding questions in transplantation: It's about time….
Academic Article	Anti-Inflammatory Effects of Nonprofessional Phagocyte.
Academic Article	DC Metabolism Controls Lung T Cell Polarization.
Academic Article	Th17 Cells Changing Colors.
Academic Article	Immune-Electrical Connection.
Academic Article	Making Therapeutic Antibodies in Vitro.
Academic Article	Predicting TCR specificity?
Academic Article	A Cause for Leaky Guts.
Academic Article	Metabolic Control of T Cell Memory.
Academic Article	Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article	Stealing Tregs' Identity (by Deleting NF-?B).
Academic Article	Immune Regulation of Lung Fibrosis.
Academic Article	Mind the GAP, for Tolerance to Gut Bacteria.
Academic Article	The Adaptive NK Cell Response.
Academic Article	The Importance of Inflammation-induced NETS.
Academic Article	Gut Microbiota Can Impact Chronic Murine Lung Allograft Rejection.
Academic Article	B cells, CMV, and stem cell transplant.
Academic Article	Exercise increases skin graft resistance to rejection.
Academic Article	A molecular pathway for indirect presentation?
Academic Article	The pursuit of transplantation tolerance: new mechanistic insights.
Academic Article	A New Ligand for LAG-3.
Academic Article	Outstanding questions in transplantation: An introduction to this minireview series.
Academic Article	Treg Respiration.
Academic Article	Harnessing the commensal microbiota to improve immune responses.
Academic Article	Fifty Shades of Tolerance: Beyond a Binary Tolerant/Non-Tolerant Paradigm.
Academic Article	Neuroimmunology and the control of T cell migration.
Grant	Impact of Microbiota on Alloimmune Responses in Transplantation
Grant	Infections and the Stability of Transplantation Tolerance
Grant	The microbiota and allograft rejection: novel investigations into the consequences of obesity
Academic Article	Lymph node segregation for tolerance or inflammation.
Academic Article	Skin-restricted commensal colonization accelerates skin graft rejection.
Academic Article	Teamwork by IL-10+ and IL-35+ Tregs.
Academic Article	Fibroblasts can have subsets too!
Academic Article	Innate lymphoid cells coming of age.
Academic Article	Impact of the microbiota on solid organ transplant rejection.
Academic Article	Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article	DeTOXifying exhausted T cells.
Academic Article	Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.
Academic Article	Pathogenic Bhlhe40+ GM-CSF+ CD4+ T cells promote indirect alloantigen presentation in the GI tract during GVHD.
Academic Article	The initiation of graft-versus-host disease.
Academic Article	The First International Transplant Science (ITS) Meeting.
Academic Article	In vivo and in vitro differences in CD8+ T cell metabolism.
Academic Article	Giving effector/memory T cells a new (suppressive) purpose.
Academic Article	Exploiting immunometabolism and T cell function for solid organ transplantation.
Academic Article	Immune impact of commensals versus pathobionts.
Academic Article	Liver Protection by ILC1s.
Academic Article	The First ITS Meeting.
Academic Article	The anti-inflammatory function of the apoptotic secretome.
Academic Article	Metabolomic profiling reveals clinically relevant microbiota-linked metabolites.
Academic Article	The COVID-19 pandemic: A community approach.
Academic Article	Influence of the microbiome on solid organ transplant survival.
Academic Article	Taurodeoxycholic acid and valine reverse obesity-associated augmented alloimmune responses and prolong allograft survival.
Academic Article	Toward an understanding of allogeneic conflict in pregnancy and transplantation.
Academic Article	Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation.
Academic Article	Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance.
Academic Article	Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants.
Academic Article	Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival.
Academic Article	Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival.
Concept	Transplant Recipients
Grant	Role of NF-kB Activation in Acute Allograft Rejection
Grant	Mechanisms of TLR-mediated prevention of transplantation tolerance
Grant	Role of NF-kB Activation in Acute Allograft Rejection
Grant	NF-kappaBeta activation T cell function/graft rejection
Academic Article	Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia.
Academic Article	Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection.
Academic Article	Low-affinity CD8+ T cells provide interclonal help to high-affinity CD8+ T cells to augment alloimmunity.
Academic Article	Advancing mouse models for transplantation research.
Academic Article	Coordinated elimination of bacterial taxa optimally attenuates alloimmunity and prolongs allograft survival.
Academic Article	Tiny heroes: Microbiota-modified bile acid metabolites protect against drug-induced gut damage.

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Transplants