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Sisodia, Sangram

One or more keywords matched the following items that are connected to Sisodia, Sangram

Item Type	Name
Concept	Peptide Fragments
Concept	Peptide Hydrolases
Concept	Peptide Chain Elongation, Translational
Academic Article	Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Academic Article	Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Academic Article	Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
Academic Article	Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Academic Article	Toxicity of synthetic A beta peptides and modeling of Alzheimer's disease.
Academic Article	Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
Academic Article	Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
Academic Article	Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.
Academic Article	Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Academic Article	Familial British dementia: expression and metabolism of BRI.
Academic Article	Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.
Academic Article	Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides.
Academic Article	Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
Academic Article	Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Academic Article	Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
Academic Article	Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
Academic Article	Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Academic Article	Amyloid beta from axons and dendrites reduces local spine number and plasticity.
Academic Article	Activation and intrinsic gamma-secretase activity of presenilin 1.
Academic Article	Amyloid beta amyloidosis in Alzheimer's disease.
Academic Article	Stable association of presenilin derivatives and absence of presenilin interactions with APP.
Academic Article	APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
Academic Article	Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation.
Academic Article	Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species.
Academic Article	Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating ?-Secretase Activity.
Grant	Modulation of ABeta Deposition by Environmental Enrichment

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