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One or more keywords matched the following items that are connected to Sisodia, Sangram S.
Item TypeName
Concept Peptide Fragments
Concept Peptide Hydrolases
Concept Peptide Chain Elongation, Translational
Academic Article Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Academic Article Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Academic Article Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
Academic Article Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Academic Article Toxicity of synthetic A beta peptides and modeling of Alzheimer's disease.
Academic Article Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
Academic Article Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
Academic Article Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.
Academic Article Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Academic Article Familial British dementia: expression and metabolism of BRI.
Academic Article Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.
Academic Article Proteolytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloidogenic peptides.
Academic Article Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
Academic Article Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Academic Article Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
Academic Article Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
Academic Article Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Academic Article Amyloid beta from axons and dendrites reduces local spine number and plasticity.
Academic Article Activation and intrinsic gamma-secretase activity of presenilin 1.
Academic Article Amyloid beta amyloidosis in Alzheimer's disease.
Academic Article Stable association of presenilin derivatives and absence of presenilin interactions with APP.
Academic Article APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
Academic Article Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation.
Academic Article Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species.
Academic Article Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating ?-Secretase Activity.
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