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Sisodia, Sangram S.

One or more keywords matched the following items that are connected to Sisodia, Sangram S.

Item Type	Name
Concept	Endopeptidases
Concept	Aspartic Acid Endopeptidases
Concept	Serine Endopeptidases
Academic Article	Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
Academic Article	The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry.
Academic Article	Beta-amyloid precursor protein cleavage by a membrane-bound protease.
Academic Article	Neuroscience. An accomplice for gamma-secretase brought into focus.
Academic Article	Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Academic Article	Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing.
Academic Article	Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.
Academic Article	Biomedicine. A cargo receptor mystery APParently solved?
Academic Article	Gamma-secretase: never more enigmatic.
Academic Article	gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?
Academic Article	Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein.
Academic Article	Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
Academic Article	Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Academic Article	Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
Academic Article	Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
Academic Article	Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC).
Academic Article	Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
Academic Article	Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
Academic Article	A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.
Academic Article	Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Academic Article	Presenilin attenuates receptor-mediated signaling and synaptic function.
Academic Article	Presenilin 1 in migration and morphogenesis in the central nervous system.
Academic Article	Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.
Academic Article	Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.
Academic Article	Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
Academic Article	Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.
Academic Article	The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.
Academic Article	Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.
Academic Article	Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating ?-Secretase Activity.
Academic Article	Negative evidence for a role of APH1B T27I variant in Alzheimer's disease.

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Endopeptidases