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Sisodia, Sangram S.
One or more keywords matched the following items that are connected to Sisodia, Sangram S.
Item TypeName
Concept Presenilin-2
Concept Presenilin-1
Academic Article Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Academic Article Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Academic Article Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
Academic Article Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Academic Article A vector for expressing foreign genes in the brains and hearts of transgenic mice.
Academic Article Protein topology of presenilin 1.
Academic Article Assessment of normal and mutant human presenilin function in Caenorhabditis elegans.
Academic Article Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.
Academic Article Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.
Academic Article Alzheimer's disease: genetic studies and transgenic models.
Academic Article An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
Academic Article Lack of requirement for presenilin1 in Notch1 signaling.
Academic Article Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
Academic Article Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.
Academic Article Effects of PS1 deficiency on membrane protein trafficking in neurons.
Academic Article Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
Academic Article Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm.
Academic Article Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls.
Academic Article Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.
Academic Article Neuroscience. An accomplice for gamma-secretase brought into focus.
Academic Article Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Academic Article Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine.
Academic Article The value of transgenic models for the study of neurodegenerative diseases.
Academic Article Function and dysfunction of the presenilins.
Academic Article Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains.
Academic Article Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.
Academic Article Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules.
Academic Article Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
Academic Article Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein.
Academic Article Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
Academic Article Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Academic Article Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
Academic Article Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC).
Academic Article Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
Academic Article Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
Academic Article DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes.
Academic Article A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.
Academic Article Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Academic Article True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice.
Academic Article Presenilin attenuates receptor-mediated signaling and synaptic function.
Academic Article Presenilin-1-dependent transcriptome changes.
Academic Article Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
Academic Article Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice.
Academic Article Adult neurogenesis is functionally associated with AD-like neurodegeneration.
Academic Article Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex.
Academic Article Biogenesis of gamma-secretase early in the secretory pathway.
Academic Article Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).
Academic Article Presenilin 1 in migration and morphogenesis in the central nervous system.
Academic Article Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
Academic Article Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
Academic Article P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.
Academic Article Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice.
Academic Article Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Academic Article Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.
Academic Article Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.
Academic Article Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Academic Article Activation and intrinsic gamma-secretase activity of presenilin 1.
Academic Article Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Academic Article Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.
Academic Article Increased expression of PS1 is sufficient to elevate the level and activity of ?-secretase in vivo.
Academic Article BMS-708,163 targets presenilin and lacks notch-sparing activity.
Academic Article Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
Academic Article Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis.
Academic Article A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Academic Article Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
Academic Article Stable association of presenilin derivatives and absence of presenilin interactions with APP.
Academic Article Alzheimer's disease: perspectives for the new millennium.
Academic Article Subcellular localization of presenilins: association with a unique membrane pool in cultured cells.
Academic Article The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.
Academic Article Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.
Academic Article Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells.
Academic Article Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors.
Academic Article Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species.
Academic Article Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
Academic Article Nanoscale organization of Nicastrin, the substrate receptor of the ?-secretase complex, as independent molecular domains.
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  • Presenilin 2