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The University of Chicago

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Sisodia, Sangram S.

One or more keywords matched the following items that are connected to Sisodia, Sangram S.

Item Type	Name
Concept	Receptor, Notch1
Academic Article	An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
Academic Article	Lack of requirement for presenilin1 in Notch1 signaling.
Academic Article	Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm.
Academic Article	Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Academic Article	Gamma-secretase: never more enigmatic.
Academic Article	Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
Academic Article	Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Academic Article	Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
Academic Article	Soluble ?-secretase modulators selectively inhibit the production of the 42-amino acid amyloid ß peptide variant and augment the production of multiple carboxy-truncated amyloid ß species.

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Receptor Notch1