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Search Results to Aaron Turkewitz

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One or more keywords matched the following properties of Turkewitz, Aaron

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keywords membrane traffic
overview A network of membrane-bound organelles, interconnected by dynamic vesicular traffic, is a defining hallmark of eukaryotes. Our laboratory studies membrane traffic in the ciliate Tetrahymena thermophila. Our interest in these cells stems from the fact that Tetrahymena is unicellular and offers a host of experimental advantages; the individual cells are remarkably complex and include features that are usually associated with animal cells but absent in fungi. For example, ciliates have a prominent pathway for regulated secretion of polypeptides from specialized vesicles resembling dense core granules. This is in spite of the fact that ciliates are far more distantly related to animals than are most organisms, including yeast, that are commonly studied by cell biologists. We use genetic, cell biological, informatics and biochemical approaches to dissect this and other pathways of membrane trafficking in these remarkable cells.

One or more keywords matched the following items that are connected to Turkewitz, Aaron

Item TypeName
Concept Cell Membrane
Concept Membrane Proteins
Concept Membranes
Concept Membrane Fusion
Concept Membrane Lipids
Concept Coated Pits, Cell-Membrane
Academic Article Granule lattice protein 1 (Grl1p), an acidic, calcium-binding protein in Tetrahymena thermophila dense-core secretory granules, influences granule size, shape, content organization, and release but not protein sorting or condensation.
Academic Article Mutational analysis of regulated exocytosis in Tetrahymena.
Academic Article Core formation and the acquisition of fusion competence are linked during secretory granule maturation in Tetrahymena.
Academic Article Comprehensive analysis reveals dynamic and evolutionary plasticity of Rab GTPases and membrane traffic in Tetrahymena thermophila.
Academic Article Conservation and innovation in Tetrahymena membrane traffic: proteins, lipids, and compartments.
Academic Article Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells.
Academic Article Concentration of transferrin receptor in human placental coated vesicles.
Academic Article Tetrahymena thermophila: a divergent perspective on membrane traffic.
Academic Article A Rab-based view of membrane traffic in the ciliate Tetrahymena thermophila.
Academic Article An evolutionary balance: conservation vs innovation in ciliate membrane trafficking.
Academic Article Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology.
Academic Article An Alveolata secretory machinery adapted to parasite host cell invasion.
Academic Article A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila.

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  • Membranes