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overview My lab has had a long-standing interest in understanding the basis of immunological tolerance and humoral immunity following allogeneic transplantation. We have been collaborating extensively with Dr. Marisa Alegre in studying how infections prevent the induction of transplantation tolerance or destabilize established tolerance, and understanding the fundamental mechanisms of robust transplantation tolerance. We recently have developed new approaches to track a defined population of endogenous allospecific T (CD4+effectors (Th1 and Tfh), CD4+Tregs and CD8 effector) and B cells (Class I and Class II reactive), and are now asking how each of these subsets of cells behave under conditions of rejection, memory/sensitization and tolerance, with the goal of identifying new biomarkers of tolerance and rejection. We also actively investigating the behavior of memory alloreactive B cells in the setting of transplantation, and in identifying how these cells differ from naïve B cells, with the goal of identifying immunosuppressive and tolerance inducing strategies to control this clinically important subset of cells. We are conducting these studies in experimental rodent models, and also testing our findings in humans. These studies are performed in collaboration with Dr. Roger Sciammas at UCDavis, and the clinical transplant faculty at the University of Chicago and Ohio State University. In addition, we have stretched our research into the prevention of infections through vaccination, with the long-term goal of using this strategy as an indirect but cost-effective means of stabilizing tolerance. Towards this goal, my lab has been collaborating with Dr. Chris Montgomery, a physician scientist in the Department of Pediatrics, to identify sub-unit vaccine candidates and to investigate the immunobiology of protection from Staphylococcus aureus skin infections. My lab also has a strong program of collaborative research with Dr. Joel Collier, a bioengineer at Duke University, to develop of nanoparticulate adjuvant-free vaccines that can elicit protective immune responses with minimal inflammation. Such a vaccine that elicits minimal inflammation may be ideal for tolerant patients, as we now appreciate that inflammation can destabilize established tolerance.

One or more keywords matched the following items that are connected to Chong, Anita S.

Item TypeName
Concept Antigen-Presenting Cells
Concept Bone Marrow Cells
Concept Antigens, Differentiation, B-Lymphocyte
Concept B-Lymphocytes
Concept Clone Cells
Concept Dendritic Cells
Concept Epithelial Cells
Concept Killer Cells, Natural
Concept T-Lymphocytes, Helper-Inducer
Concept Hematopoietic Stem Cells
Concept HeLa Cells
Concept Plasma Cells
Concept Receptors, Antigen, B-Cell
Concept Stem Cells
Concept Th1 Cells
Concept Tumor Cells, Cultured
Concept B-Lymphocyte Subsets
Concept PC12 Cells
Concept 3T3 Cells
Concept CD4-Positive T-Lymphocytes
Concept Lymphocytes, Tumor-Infiltrating
Concept CD8-Positive T-Lymphocytes
Concept Th2 Cells
Concept Jurkat Cells
Concept B-Lymphocytes, Regulatory
Concept Pluripotent Stem Cells
Concept Vero Cells
Concept Insulin-Secreting Cells
Concept T-Lymphocytes, Cytotoxic
Concept Killer Cells, Lymphokine-Activated
Concept HT29 Cells
Concept T-Lymphocytes, Regulatory
Concept Th17 Cells
Concept Cells, Cultured
Concept Kupffer Cells
Concept Lymphocytes
Concept T-Lymphocytes
Academic Article Leflunomide, a novel immunomodulatory agent: in vitro analyses of the mechanism of immunosuppression.
Academic Article Regulation of B cell function by the immunosuppressive agent leflunomide.
Academic Article Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase.
Academic Article Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation.
Academic Article The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms.
Academic Article In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium.
Academic Article Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production.
Academic Article Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts.
Academic Article In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: mechanisms of action.
Academic Article Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide.
Academic Article Differential immune response to carbohydrate epitopes on allo- and xenografts: implications for accommodation.
Academic Article Transcriptional regulation of Fas gene expression by GA-binding protein and AP-1 in T cell antigen receptor.CD3 complex-stimulated T cells.
Academic Article Acute xenograft rejection mediated by antibodies produced independently of TH1/TH2 cytokine profiles.
Academic Article Nondepleting anti-CD4 but not anti-CD8 antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1, 3-galactosyl-transferase knock-out mice.
Academic Article Intact active bone transplantation synergizes with anti-CD40 ligand therapy to induce B cell tolerance.
Academic Article Combination of antilymphocyte globulin and leflunomide leads to superior grafts.
Academic Article Development and characterization of anti-Gal B cell receptor transgenic Gal-/- mice.
Academic Article Allograft tolerance induced by intact active bone co-transplantation and anti-CD40L monoclonal antibody therapy.
Academic Article Direct killing of xenograft cells by CD8+ T cells of discordant xenograft recipients.
Academic Article Role of CD4+ and CD8+ T cells in the rejection of concordant pancreas xenografts.
Academic Article Mouse-heart grafts expressing an incompatible carbohydrate antigen. II. Transition from accommodation to tolerance.
Academic Article Cutting Edge: NK cells mediate IgG1-dependent hyperacute rejection of xenografts.
Academic Article Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Academic Article Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors.
Academic Article Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
Academic Article Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.
Academic Article Hyperacute rejection by anti-Gal IgG1, IgG2a, and IgG2b is dependent on complement and Fc-gamma receptors.
Academic Article The multiple facets of toll-like receptors in transplantation biology.
Academic Article TLR signals promote IL-6/IL-17-dependent transplant rejection.
Academic Article Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome.
Academic Article Seeing is believing: how the MIP-luc mouse can advance the field of islet transplantation and ß-cell regeneration.
Academic Article Peripheral deletion of mature alloreactive B cells induced by costimulation blockade.
Academic Article CD4+ T cells are sufficient to elicit allograft rejection and major histocompatibility complex class I molecule is required to induce recurrent autoimmune diabetes after pancreas transplantation in mice.
Academic Article The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele.
Academic Article Memory alloreactive B cells and alloantibodies prevent anti-CD154-mediated allograft acceptance.
Academic Article Expression of complement regulatory proteins in accommodated xenografts induced by anti-alpha-Gal IgG1 in a rat-to-mouse model.
Academic Article Matchmaking the B-cell signature of tolerance to regulatory B cells.
Academic Article Making a B-line for transplantation tolerance.
Academic Article IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Academic Article Experimental models of B cell tolerance in transplantation.
Academic Article Plasma cell densities and glomerular filtration rates predict renal allograft outcomes following acute rejection.
Academic Article Evidence for a dithiol-activated signaling pathway in natural killer cell avidity regulation of leukocyte function antigen-1: structural requirements and relationship to phorbol ester- and CD16-triggered pathways.
Academic Article "Tip-toeing" to an assay for transplantation tolerance?
Academic Article Modulating adaptive immune responses to peptide self-assemblies.
Academic Article Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope.
Academic Article TLR engagement prevents transplantation tolerance.
Academic Article Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide.
Academic Article American society of transplantation symposium on B cells in transplantation: harnessing humoral immunity from rodent models to clinical practice.
Academic Article Cross-linking of CD45 on NK cells stimulates p56lck-mediated tyrosine phosphorylation and IFN-gamma production.
Academic Article Long-term control of alloreactive B cell responses by the suppression of T cell help.
Academic Article Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.
Academic Article Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro.
Academic Article Inactivation of Kupffer cells after prolonged donor fasting improves viability of transplanted hepatic allografts.
Academic Article Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide.
Academic Article Lewis rat pancreas, but not cardiac xenografts, are resistant to anti-gal antibody mediated hyperacute rejection.
Academic Article Multidrug resistance activity in human lymphocytes.
Academic Article Gamma-irradiated peripheral blood mononuclear cells can express LAK activity.
Academic Article Stimulation of IFN-gamma, TNF-alpha, and TNF-beta secretion in IL-2-activated T cells: costimulatory roles for LFA-1, LFA-2, CD44, and CD45 molecules.
Academic Article Monoclonal antibodies anti-CD3, anti-TCR alpha beta and anti-CD2 act synergistically with tumor cells to stimulate lymphokine-activated killer cells and tumor-infiltrating lymphocytes to secrete interferon gamma.
Academic Article Nonimmune lymphocyte-macrophage interaction. I. Quantification by an automated colorimetric assay.
Academic Article Tumor targets stimulate IL-2 activated killer cells to produce interferon-gamma and tumor necrosis factor.
Academic Article Phenotypic and functional analysis of lymphokine-activated killer (LAK) cell clones. Ability of CD3+, LAK cell clones to produce interferon-gamma and tumor necrosis factor upon stimulation with tumor targets.
Academic Article ICAM-1 and LFA-3 enhance the ability of anti-CD3 mAb to stimulate interferon gamma production in interleukin-2-activated T cells.
Academic Article Diverse multidrug-resistance-modification agents inhibit cytolytic activity of natural killer cells.
Academic Article CD54/ICAM-1 is a costimulator of NK cell-mediated cytotoxicity.
Academic Article Receptors that turn on and turn off natural killer cells.
Academic Article IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression.
Academic Article Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin.
Academic Article Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4.
Academic Article Blocking of lymphokine activated killer (LAK) cell mediated cytotoxicity by cell-sized beads bearing tumor cell proteins.
Academic Article Natural killer cell cytotoxicity and the multidrug resistance gene.
Academic Article CD45-cross-linking stimulates IFN-gamma production in NK cells.
Academic Article Impact of immunosuppression on recall immune responses to influenza vaccination in stable renal transplant recipients.
Academic Article Transplantation tolerance and its outcome during infections and inflammation.
Academic Article Lessons and limits of mouse models.
Academic Article Microbes and allogeneic transplantation.
Academic Article Immune complex formation and in situ B-cell clonal expansion in human cerebral cavernous malformations.
Academic Article Transplantation: molecular phenotyping of T-cell-mediated rejection.
Academic Article Memory B cells in transplantation.
Academic Article B cells assist allograft rejection in the deficiency of protein kinase c-theta.
Academic Article Reversing endogenous alloreactive B cell GC responses with anti-CD154 or CTLA-4Ig.
Academic Article AST Cutting Edge of Transplantation 2013 Meeting Report: a comprehensive look at B cells and antibodies in transplantation.
Academic Article Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs.
Academic Article New kid on the pretransplant block: IgG recognizing apoptotic cells.
Academic Article The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation.
Academic Article Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients.
Academic Article Phenotypic analyses of lymphokine-activated killer cells that release interferon gamma and tumor necrosis factor alpha.
Academic Article Importance of B Lymphocytes and the IgG-Binding Protein Sbi in Staphylococcus aureus Skin Infection.
Academic Article High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article Cytotoxicity of prion protein peptide (PrP106-126) differs in mechanism from the cytotoxic activity of the Alzheimer's disease amyloid peptide, A beta 25-35.
Academic Article Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection.
Academic Article Tracing Donor-MHC Class II Reactive B cells in Mouse Cardiac Transplantation: Delayed CTLA4-Ig Treatment Prevents Memory Alloreactive B-Cell Generation.
Academic Article Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.
Academic Article Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft.
Academic Article Transplantation tolerance: don't forget about the B cells.
Academic Article Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice.
Academic Article Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.
Academic Article Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.
Academic Article Active immunotherapy for TNF-mediated inflammation using self-assembled peptide nanofibers.
Academic Article Modification of the clonogenic assay for the detection of lymphokine activated killer cell activity.
Academic Article The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate.
Academic Article An optimized protocol to quantify signaling in human transitional B cells by phospho flow cytometry.
Academic Article Ability of cell-sized beads bearing tumor cell membrane proteins to stimulate LAK cells to secrete interferon-gamma and tumor necrosis factor-alpha.
Academic Article Alone Again, Naturally: B Cells Encountering Antigen Without T cells.
Academic Article Nonimmune lymphocyte-macrophage interaction. II. Evidence that the interaction involves sulfated polysaccharide recognition.
Academic Article MyD88 in antigen-presenting cells is not required for CD4+ T-cell responses during peptide nanofiber vaccination.
Academic Article New insights into the development of B cell responses: Implications for solid organ transplantation.
Academic Article Regulation of tumor necrosis factor secretion in leukocytes from alpha-1-antitrypsin deficient humans.
Academic Article Cytostatic and cytotoxic activity of lymphokine-activated killer cell supernatants.
Academic Article Activation of extracellular signal-regulated kinases potentiates hemin toxicity in astrocyte cultures.
Academic Article Heterogeneity of memory B cells.
Academic Article Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8+ T cell responses.
Academic Article The pursuit of transplantation tolerance: new mechanistic insights.
Academic Article Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection.
Academic Article Skin-restricted commensal colonization accelerates skin graft rejection.
Academic Article B Cell Recruitment Follows Kidney Injury and Maladaptive Repair.
Academic Article Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article B cells as antigen-presenting cells in transplantation rejection and tolerance.
Academic Article Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination.
Academic Article Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells.
Academic Article Mechanisms of organ transplant injury mediated by B cells and antibodies: Implications for antibody-mediated rejection.
Academic Article Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice.
Academic Article Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection.

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