Item Type | Name |
Concept
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Cell Line, Tumor
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Academic Article
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Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction.
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Academic Article
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Overexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells.
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Academic Article
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Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer.
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Academic Article
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Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis.
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Academic Article
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Genome-wide gene expression profiles of thyroid carcinoma: Identification of molecular targets for treatment of thyroid carcinoma.
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Academic Article
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Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis.
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Academic Article
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Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.
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Academic Article
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Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke.
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Academic Article
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Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility.
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Academic Article
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Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer.
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Academic Article
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Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy.
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Academic Article
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Characterization of a cleavage stimulation factor, 3' pre-RNA, subunit 2, 64 kDa (CSTF2) as a therapeutic target for lung cancer.
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Academic Article
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IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.
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Academic Article
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Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patients.
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Academic Article
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Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression.
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Academic Article
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Identification of Epstein-Barr virus-induced gene 3 as a novel serum and tissue biomarker and a therapeutic target for lung cancer.
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Academic Article
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Genome-wide analysis of gene-expression profiles in chronic myeloid leukemia cells using a cDNA microarray.
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Academic Article
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Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis.
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Academic Article
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Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.
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Academic Article
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Involvement of C12orf32 overexpression in breast carcinogenesis.
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Academic Article
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Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray.
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Academic Article
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A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer.
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Academic Article
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Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
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Academic Article
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Serum REG4 level is a predictive biomarker for the response to preoperative chemoradiotherapy in patients with pancreatic cancer.
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Academic Article
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Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.
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Academic Article
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EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth.
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Academic Article
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Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells.
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Academic Article
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C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage.
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Academic Article
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Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.
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Academic Article
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Characterization of an Opa interacting protein 5 involved in lung and esophageal carcinogenesis.
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Academic Article
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Stanniocalcin 2 overexpression in castration-resistant prostate cancer and aggressive prostate cancer.
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Academic Article
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MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells.
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Academic Article
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Identification of a novel oncogene, MMS22L, involved in lung and esophageal carcinogenesis.
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Academic Article
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Genome-wide gene expression profiles of clear cell renal cell carcinoma: identification of molecular targets for treatment of renal cell carcinoma.
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Academic Article
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Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer.
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Academic Article
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Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis.
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Academic Article
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Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer.
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Academic Article
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Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis.
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Academic Article
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Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells.
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Academic Article
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Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk.
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Academic Article
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5alphaDH-DOC (5alpha-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer.
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Academic Article
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The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population.
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Academic Article
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Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis.
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Academic Article
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Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
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Academic Article
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p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.
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Academic Article
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Crosstalk of EDA-A2/XEDAR in the p53 signaling pathway.
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Academic Article
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Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells.
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Academic Article
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Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.
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Academic Article
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Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth.
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Academic Article
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Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis.
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Academic Article
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The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene.
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Academic Article
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The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer.
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Academic Article
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ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.
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Academic Article
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Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy.
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Academic Article
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Non-transmissible Sendai virus encoding granulocyte macrophage colony-stimulating factor is a novel and potent vector system for producing autologous tumor vaccines.
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Academic Article
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Aberrant laminin beta3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors.
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Academic Article
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Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase.
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Academic Article
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In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy.
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Academic Article
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Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).
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Academic Article
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WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck.
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Academic Article
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RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer.
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Academic Article
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Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity.
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Academic Article
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Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.
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Academic Article
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Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia.
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Academic Article
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Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis.
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Academic Article
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Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma.
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Academic Article
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Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.
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Academic Article
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Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas.
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Academic Article
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Identification of novel epigenetically inactivated gene PAMR1 in breast carcinoma.
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Academic Article
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Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells.
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Academic Article
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Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.
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Academic Article
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PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET.
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Academic Article
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Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas.
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Academic Article
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Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis.
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Academic Article
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Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis.
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Academic Article
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Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer.
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Academic Article
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WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation.
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Academic Article
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Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma.
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Academic Article
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A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis.
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Academic Article
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The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.
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Academic Article
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Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas.
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Academic Article
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A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.
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Academic Article
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Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer.
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Academic Article
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Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation.
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Academic Article
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Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex.
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Academic Article
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Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer.
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Academic Article
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The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.
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Academic Article
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Identification of candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines.
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Academic Article
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Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer.
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Academic Article
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Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10.
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Academic Article
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MRG-binding protein contributes to colorectal cancer development.
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Academic Article
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Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit.
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Academic Article
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Identification of an HLA-A2-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2).
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Academic Article
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Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer.
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Academic Article
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Activation of an oncogenic TBC1D7 (TBC1 domain family, member 7) protein in pulmonary carcinogenesis.
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Academic Article
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Methylation at CpG islands in intron 1 of EGR2 confers enhancer-like activity.
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Academic Article
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Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.
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Academic Article
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Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells.
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Academic Article
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Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses.
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Academic Article
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Critical roles of T-LAK cell-originated protein kinase in cytokinesis.
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Academic Article
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The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.
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Academic Article
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Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target.
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Academic Article
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VAV3 mediates resistance to breast cancer endocrine therapy.
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Academic Article
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The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6.
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Academic Article
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Identification of a nuclear protein, LRRC42, involved in lung carcinogenesis.
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Academic Article
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Adenovirus-mediated p53AIP1 gene transfer as a new strategy for treatment of p53-resistant tumors.
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Academic Article
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Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1.
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Academic Article
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A rare polymorphic variant of NBS1 reduces DNA repair activity and elevates chromosomal instability.
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Academic Article
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Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation.
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Academic Article
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Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray.
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Academic Article
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Serial analysis of gene expression in progressing and regressing mouse tumors implicates the involvement of RANTES and TARC in antitumor immune responses.
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Academic Article
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Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.
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Academic Article
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Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis.
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Academic Article
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The DNA binding site specificity and antiproliferative property of ternary Pt(II) and Zn(II) complexes of phenanthroline and N,N'-ethylenediaminediacetic acid.
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Academic Article
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The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1).
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Academic Article
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Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers.
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Academic Article
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Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers.
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Academic Article
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Identification of human leukocyte antigen-A24-restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy.
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Academic Article
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Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.
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Academic Article
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Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas.
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Academic Article
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FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
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Academic Article
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Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas.
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Academic Article
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Identification of the interleukin 4 receptor alpha gene as a direct target for p73.
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Academic Article
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PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer.
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Academic Article
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TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis.
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Academic Article
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Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer.
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Academic Article
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Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes.
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Academic Article
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SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells.
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Academic Article
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Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.
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Academic Article
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Identification of COX17 as a therapeutic target for non-small cell lung cancer.
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Academic Article
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Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.
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Academic Article
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Regulation of iron homeostasis by the p53-ISCU pathway.
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Academic Article
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PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.
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Academic Article
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SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells.
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Academic Article
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Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases.
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Academic Article
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Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
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Academic Article
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HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL.
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Academic Article
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Germline PARP4 mutations in patients with primary thyroid and breast cancers.
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Academic Article
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Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway.
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Academic Article
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Radioimmunotherapy of solid tumors targeting a cell-surface protein, FZD10: therapeutic efficacy largely depends on radiosensitivity.
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Academic Article
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Morphological Changes, Cadherin Switching, and Growth Suppression in Pancreatic Cancer by GALNT6 Knockdown.
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Academic Article
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Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation.
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Academic Article
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Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells.
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Academic Article
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Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor.
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Academic Article
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Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors.
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Academic Article
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Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma.
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Academic Article
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The forkhead box M1 transcription factor as a candidate of target for anti-cancer immunotherapy.
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Academic Article
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T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer.
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Academic Article
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GALNT6 Stabilizes GRP78 Protein by O-glycosylation and Enhances its Activity to Suppress Apoptosis Under Stress Condition.
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Academic Article
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Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.
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Academic Article
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Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells.
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Academic Article
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Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization.
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Academic Article
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The vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation.
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Academic Article
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a-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.
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Academic Article
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Critical Role of Estrogen Receptor Alpha O-Glycosylation by N-Acetylgalactosaminyltransferase 6 (GALNT6) in Its Nuclear Localization in Breast Cancer Cells.
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Academic Article
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Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma.
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Academic Article
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MELK inhibition targets cancer stem cells through downregulation of SOX2 expression in head and neck cancer cells.
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Academic Article
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Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models.
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Academic Article
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The GALNT6-LGALS3BP axis promotes breast cancer cell growth.
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Academic Article
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Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3.
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Academic Article
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High expression of maternal embryonic leucine-zipper kinase (MELK) impacts clinical outcomes in patients with ovarian cancer and its inhibition suppresses ovarian cancer cells growth ex vivo.
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Academic Article
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Established fibrous peritoneal metastasis in an immunocompetent mouse model similar to clinical immune microenvironment of gastric cancer.
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Academic Article
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FZD10-targeted a-radioimmunotherapy with 225 Ac-labeled OTSA101 achieves complete remission in a synovial sarcoma model.
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Academic Article
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Identification of RNF213 as a Potential Suppressor of Local Invasion in Intrahepatic Cholangiocarcinoma.
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