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Search Results to Marcus Ramsay Clark

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One or more keywords matched the following properties of Clark, Marcus Ramsay

overview Our laboratory has a long-standing interest in B cell antigen receptor (BCR) signaling and how BCR dependent processes regulate specific cell fate decisions. In the bone marrow, we have been working to understand how signals initiated through the pre-BCR, in conjunction with those delivered through the IL-7 receptor, coordinate cell cycle progression with immunoglobulin light chain gene recombination. These studies resulted in discovery of the epigenetic reader BRWD1 as critical for both regulating Ig-kappa accessibility and in coordinating broad transcriptional programs in early and late B lymphopoiesis. Recently, we have demonstrated that the pre-BCR initiates an IRF4-CXCR4 feedforward loop and that it is CXCR4 that directly signals Ig-kappa recombination. These latter findings fundamentally rewrite the canonical model of B lymphopoiesis. Furthermore, they are the first demonstration of a direct and independent role for CXCR4 in driving an important biological process. In the periphery, we have focused on the molecular control of germinal centers (GCs). Recently, we have recently defined two novel B cell populations within the dark zone that both allow compartmentalization of fundamental GC functions and reveal the molecular programs of the GC cycle. This new three population model fundamentally rewrites the GC paradigm. In all these areas, we have derived novel in vivo models, and have performed directed in vitro studies, to obtain definitive insights into these processes. Our translational studies have focused on how in situ adaptive immune responses drive tubulointerstitial inflammation in human lupus nephritis. For these studies, we have used deep machine learning to develop novel image analysis tools to quantify and identify functional relationships between different T cell and antigen presenting cell populations in situ. Remarkably, this bioinformatics platform approaches the sensitivity and specificity of two-photon excitation microscopy (TPEM). However, unlike TPEM, it can be applied to the study of human disease. We have also used single cell technologies to understand B cell selection at sites of inflammation and determine the interrelationships between transcriptional state and antigenic specificity.

One or more keywords matched the following items that are connected to Clark, Marcus Ramsay

Item TypeName
Concept Genes, Immunoglobulin
Concept Immunoglobulin Constant Regions
Concept Immunoglobulin Heavy Chains
Concept Immunoglobulin E
Concept Immunoglobulin Variable Region
Concept Immunoglobulin G
Concept Immunoglobulin Joining Region
Concept Immunoglobulin alpha-Chains
Concept Immunoglobulin lambda-Chains
Concept Immunoglobulin Class Switching
Concept Immunoglobulin Light Chains, Surrogate
Concept Immunoglobulin kappa-Chains
Concept Immunoglobulin Light Chains
Academic Article The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.
Academic Article A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling.
Academic Article B cell antigen receptor signaling and internalization are mutually exclusive events.
Academic Article Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression.
Academic Article Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.
Academic Article Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling.
Academic Article Self-reactive IgE exacerbates interferon responses associated with autoimmunity.
Academic Article Regulated Capture of V? Gene Topologically Associating Domains by Transcription Factories.
Academic Article Transcription factories in Ig? allelic choice and diversity.
Academic Article CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis.
Academic Article B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Academic Article Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation.
Academic Article Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation.
Academic Article Compartments and Connections Within the Germinal Center.
Academic Article Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection.

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  • Immunoglobulin G