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Search Results to Tobin R. Sosnick

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One or more keywords matched the following properties of Sosnick, Tobin R.

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overview My research program involves synergistic studies of protein folding and design, protein-RNA interactions, phosphorylation, signaling, and function with both experimental and computational components. The research is based on the premise that rigorous and innovative studies of basic processes have broad implications in many areas of biological research. My lab employs a range of experimental and computational methods including hydrogen exchange (HX), NMR, small-angle X-ray scattering (SAXS), rapid mixing methods, mass spectrometry, molecular dynamics and home-grown coarse-grain folding simulations and modeling. I am a very a strong believer in collaboration, having co-mentored over twenty students and post-doctoral fellows who produce over 60 papers in the last 20 years. I have a history of developing multi-approaches to bear on a problem. Since my Ph.D. in low temperature physics in 1989, I have entered many different areas, including delineating protein and RNA folding pathways and denatured states, de novo structure prediction, and the design of light-sensitive allosteric proteins.

One or more keywords matched the following items that are connected to Sosnick, Tobin R.

Item TypeName
Concept RNA Precursors
Concept RNA, Fungal
Concept RNA, Transfer, Phe
Concept RNA, Bacterial
Concept RNA Probes
Concept RNA Polymerase I
Concept RNA
Concept DNA-Directed RNA Polymerases
Concept RNA Processing, Post-Transcriptional
Concept RNA, Transfer
Concept RNA, Catalytic
Concept RNA-Binding Proteins
Concept RNA, Untranslated
Concept RNA Folding
Concept RNA, Protozoan
Concept RNA Stability
Academic Article Applicability of urea in the thermodynamic analysis of secondary and tertiary RNA folding.
Academic Article Altering the intermediate in the equilibrium folding of unmodified yeast tRNAPhe with monovalent and divalent cations.
Academic Article Mg2+-dependent folding of a large ribozyme without kinetic traps.
Academic Article Mg2+-dependent compaction and folding of yeast tRNAPhe and the catalytic domain of the B. subtilis RNase P RNA determined by small-angle X-ray scattering.
Academic Article Intermediates and kinetic traps in the folding of a large ribozyme revealed by circular dichroism and UV absorbance spectroscopies and catalytic activity.
Academic Article Pathway modulation, circular permutation and rapid RNA folding under kinetic control.
Academic Article Folding of a large ribozyme during transcription and the effect of the elongation factor NusA.
Academic Article A thermodynamic framework and cooperativity in the tertiary folding of a Mg2+-dependent ribozyme.
Academic Article Application of circular dichroism to study RNA folding transitions.
Academic Article The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits.
Academic Article Modular construction of a tertiary RNA structure: the specificity domain of the Bacillus subtilis RNase P RNA.
Academic Article Getting hotter with RNA.
Academic Article Efficient fluorescence labeling of a large RNA through oligonucleotide hybridization.
Academic Article Mechanistic insights on the folding of a large ribozyme during transcription.
Academic Article RNA folding: models and perspectives.
Academic Article RNA folding during transcription.
Academic Article Folding of a universal ribozyme: the ribonuclease P RNA.
Academic Article A large collapsed-state RNA can exhibit simple exponential single-molecule dynamics.
Academic Article Kinetic barriers and the role of topology in protein and RNA folding.
Academic Article Reduced contact order and RNA folding rates.
Academic Article Characterization of tertiary folding of RNA by circular dichroism and urea.
Academic Article Single-molecule nonequilibrium periodic Mg2+-concentration jump experiments reveal details of the early folding pathways of a large RNA.
Academic Article Extended structures in RNA folding intermediates are due to nonnative interactions rather than electrostatic repulsion.
Academic Article Folding of noncoding RNAs during transcription facilitated by pausing-induced nonnative structures.
Academic Article Discrete structure of an RNA folding intermediate revealed by cryo-electron microscopy.
Academic Article Transcriptional pausing coordinates folding of the aptamer domain and the expression platform of a riboswitch.
Academic Article Structure of a folding intermediate reveals the interplay between core and peripheral elements in RNA folding.
Academic Article Structural basis for altering the stability of homologous RNAs from a mesophilic and a thermophilic bacterium.
Academic Article The rate-limiting step in the folding of a large ribozyme without kinetic traps.
Academic Article Stepwise conversion of a mesophilic to a thermophilic ribozyme.
Academic Article Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface.
Academic Article Ionic strength independence of charge distributions in solvation of biomolecules.
Academic Article A novel implicit solvent model for simulating the molecular dynamics of RNA.

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  • RNA