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One or more keywords matched the following properties of Sosnick, Tobin R.
PropertyValue
keywords Hydrogen exchange
overview My research program involves synergistic studies of protein folding and design, protein-RNA interactions, phosphorylation, signaling, and function with both experimental and computational components. The research is based on the premise that rigorous and innovative studies of basic processes have broad implications in many areas of biological research. My lab employs a range of experimental and computational methods including hydrogen exchange (HX), NMR, small-angle X-ray scattering (SAXS), rapid mixing methods, mass spectrometry, molecular dynamics and home-grown coarse-grain folding simulations and modeling. I am a very a strong believer in collaboration, having co-mentored over twenty students and post-doctoral fellows who produce over 60 papers in the last 20 years. I have a history of developing multi-approaches to bear on a problem. Since my Ph.D. in low temperature physics in 1989, I have entered many different areas, including delineating protein and RNA folding pathways and denatured states, de novo structure prediction, and the design of light-sensitive allosteric proteins.
One or more keywords matched the following items that are connected to Sosnick, Tobin R.
Item TypeName
Concept Hydrogen
Concept Hydrogen-Ion Concentration
Concept Hydrogen Bonding
Academic Article Mechanisms and uses of hydrogen exchange.
Academic Article Molecular collapse: the rate-limiting step in two-state cytochrome c folding.
Academic Article Hydrogen exchange: the modern legacy of Linderstrøm-Lang.
Academic Article Trifluoroethanol promotes helix formation by destabilizing backbone exposure: desolvation rather than native hydrogen bonding defines the kinetic pathway of dimeric coiled coil folding.
Academic Article D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding.
Academic Article Dynamics of hydrogen bond desolvation in protein folding.
Academic Article Large-scale context in protein folding: villin headpiece.
Academic Article Contribution of hydrogen bonding to protein stability estimated from isotope effects.
Academic Article Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects.
Academic Article Quantifying the structural requirements of the folding transition state of protein A and other systems.
Academic Article Barrier-limited, microsecond folding of a stable protein measured with hydrogen exchange: Implications for downhill folding.
Academic Article Psi-constrained simulations of protein folding transition states: implications for calculating.
Academic Article On docking, scoring and assessing protein-DNA complexes in a rigid-body framework.
Academic Article Protein folding intermediates: native-state hydrogen exchange.
Academic Article Minimalist representations and the importance of nearest neighbor effects in protein folding simulations.
Academic Article Benchmarking all-atom simulations using hydrogen exchange.
Academic Article Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange.
Academic Article Introduction of a polar core into the de novo designed protein Top7.
Academic Article Perplexing cooperative folding and stability of a low-sequence complexity, polyproline 2 protein lacking a hydrophobic core.
Academic Article Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response.
Academic Article A Membrane Burial Potential with H-Bonds and Applications to Curved Membranes and Fast Simulations.
Academic Article Water as a Good Solvent for Unfolded Proteins: Folding and Collapse are Fundamentally Different.
Academic Article Prediction and Validation of a Protein's Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence.
Academic Article HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain's allostery and unfolding upon B12 and TonB binding.
Academic Article Development of in vivo HDX-MS with applications to a TonB-dependent transporter and other proteins.
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