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Gilad, Yoav
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overview The Gilad lab focuses on studying genetic and regulatory differences between humans and our close evolutionary relatives. Our long term goal is to identify the genetic basis of human-specific traits, including genetic variation that underlies higher susceptibility to certain diseases and disorders in humans than in other primates.
One or more keywords matched the following items that are connected to Gilad, Yoav
Item TypeName
Concept Herpesvirus 4, Human
Concept Humans
Concept Genome, Human
Academic Article Sex-specific genetic architecture of human disease.
Academic Article Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data.
Academic Article Sex-specific and lineage-specific alternative splicing in primates.
Academic Article Understanding mechanisms underlying human gene expression variation with RNA sequencing.
Academic Article Accurate inference of transcription factor binding from DNA sequence and chromatin accessibility data.
Academic Article Noisy splicing drives mRNA isoform diversity in human cells.
Academic Article The effects of EBV transformation on gene expression levels and methylation profiles.
Academic Article Exon-specific QTLs skew the inferred distribution of expression QTLs detected using gene expression array data.
Academic Article Characterizing natural variation using next-generation sequencing technologies.
Academic Article Genomics: ENCODE explained.
Academic Article Dissecting the regulatory architecture of gene expression QTLs.
Academic Article Time-dependent transcriptional profiling links gene expression to mitogen-activated protein kinase kinase 4 (MKK4)-mediated suppression of omental metastatic colonization.
Academic Article The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels.
Academic Article Revealing the architecture of gene regulation: the promise of eQTL studies.
Academic Article Expression quantitative trait loci detected in cell lines are often present in primary tissues.
Academic Article The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
Academic Article Using genomic tools to study regulatory evolution.
Academic Article DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines.
Academic Article A genome-wide study of DNA methylation patterns and gene expression levels in multiple human and chimpanzee tissues.
Academic Article False positive peaks in ChIP-seq and other sequencing-based functional assays caused by unannotated high copy number regions.
Academic Article Comment on "Widespread RNA and DNA sequence differences in the human transcriptome".
Academic Article Regulatory element copy number differences shape primate expression profiles.
Academic Article Functional comparison of innate immune signaling pathways in primates.
Academic Article Gene expression differences among primates are associated with changes in a histone epigenetic modification.
Academic Article A genome sequence resource for the aye-aye (Daubentonia madagascariensis), a nocturnal lemur from Madagascar.
Academic Article Comparative RNA sequencing reveals substantial genetic variation in endangered primates.
Academic Article DNase?I sensitivity QTLs are a major determinant of human expression variation.
Academic Article High-resolution mapping of expression-QTLs yields insight into human gene regulation.
Academic Article Gene regulation in primates evolves under tissue-specific selection pressures.
Academic Article Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
Academic Article Controls of nucleosome positioning in the human genome.
Academic Article General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations.
Academic Article Comparative studies of gene regulatory mechanisms.
Academic Article The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines.
Academic Article Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels.
Academic Article Social environmental effects on gene regulation.
Academic Article Epigenetic modifications are associated with inter-species gene expression variation in primates.
Academic Article Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature.
Academic Article The genetic and mechanistic basis for variation in gene regulation.
Academic Article Genomic variation. Impact of regulatory variation from RNA to protein.
Academic Article Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes.
Academic Article Identification of genetic variants that affect histone modifications in human cells.
Academic Article Primate transcript and protein expression levels evolve under compensatory selection pressures.
Academic Article Does a unique olfactory genome imply a unique olfactory world?
Academic Article Seasonal variation in human gut microbiome composition.
Academic Article The functional consequences of variation in transcription factor binding.
Academic Article Host genetic variation influences gene expression response to rhinovirus infection.
Academic Article Comparative metabolomics in primates reveals the effects of diet and gene regulatory variation on metabolic divergence.
Academic Article RNA-seq: impact of RNA degradation on transcript quantification.
Academic Article A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.
Academic Article msCentipede: Modeling Heterogeneity across Genomic Sites and Replicates Improves Accuracy in the Inference of Transcription Factor Binding.
Academic Article Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
Academic Article WASP: allele-specific software for robust molecular quantitative trait locus discovery.
Academic Article Genome-Wide Association Studies of the Human Gut Microbiota.
Academic Article Mycobacterial infection induces a specific human innate immune response.
Academic Article Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
Academic Article Synthesis, biological studies and molecular dynamics of new anticancer RGD-based peptide conjugates for targeted drug delivery.
Academic Article Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs.
Academic Article RNA splicing is a primary link between genetic variation and disease.
Academic Article Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling.
Academic Article The human olfactory transcriptome.
Academic Article Integrated analyses of gene expression and genetic association studies in a founder population.
Academic Article DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Academic Article Gene expression in local stroma reflects breast tumor states and predicts patient outcome.
Academic Article Batch effects and the effective design of single-cell gene expression studies.
Academic Article Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.
Academic Article Reducing mitochondrial reads in ATAC-seq using CRISPR/Cas9.
Academic Article Impact of regulatory variation across human iPSCs and differentiated cells.
Academic Article Silencing of transposable elements may not be a major driver of regulatory evolution in primate iPSCs.
Academic Article A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes.
Academic Article Human genomics: Cracking the regulatory code.
Academic Article A comparative study of endoderm differentiation in humans and chimpanzees.
Academic Article A Comparative Assessment of Human and Chimpanzee iPSC-derived Cardiomyocytes with Primary Heart Tissues.
Academic Article Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells.
Academic Article Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes.
Academic Article A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees.
Academic Article Discovery and characterization of variance QTLs in human induced pluripotent stem cells.
Academic Article Dynamic genetic regulation of gene expression during cellular differentiation.
Academic Article Reorganization of 3D genome structure may contribute to gene regulatory evolution in primates.
Academic Article A comparison of gene expression and DNA methylation patterns across tissues and species.
Academic Article Systematic Comparison of High-throughput Single-Cell and Single-Nucleus Transcriptomes during Cardiomyocyte Differentiation.
Academic Article Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis.
Academic Article Effective study design for comparative functional genomics.
Academic Article Prime time for primate functional genomics.
Academic Article Alternative polyadenylation mediates genetic regulation of gene expression.
Academic Article Where Are the Disease-Associated eQTLs?
Academic Article Gene expression variability in human and chimpanzee populations share common determinants.
Academic Article A TAD Skeptic: Is 3D Genome Topology Conserved?
Academic Article Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes.
Academic Article Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzees.
Academic Article Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions.
Academic Article Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation.
Academic Article Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation.
Academic Article Human embryoid bodies as a novel system for genomic studies of functionally diverse cell types.
Grant Development of iPSCs for comparative genomics in primates
Grant Analysis and interpretation of noncoding regulatory variation
Grant A National iPS Cell Network with Deep Phenotyping for Translational Research
Grant eQTL mapping in iPSC-derived differentiated cardiomyocytes
Grant Mapping QTLs Associated with Variation in RNA Decay Rates
Grant Characterizing and mapping gene regulatory robustness in cardiomyoctes
Grant Characterizing and Understanding Variation in Gene Regulatory Mechanisms Within and Between Species'
Grant The evolution of human specific regulatory pathways
Grant Using single cell RNA-seq to study regulatory noise and robustness
Grant Natural Selection on Gene Regulation in Humans
Grant Genes, genomes, and genotoxicity: in vivo epigenetic toxicology of 1,3-butadiene
Academic Article The relationship between regulatory changes in cis and trans and the evolution of gene expression in humans and chimpanzees.
Academic Article Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility.
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  • Humans