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Karczmar, Gregory

One or more keywords matched the following properties of Karczmar, Gregory

Property	Value
keywords	Breast cancer screening with MRI
keywords	Prostate cancer screening with MRI
overview	I have developed new approaches to functional and anatomic magnetic resonance imaging for over 30 years. I’ve applied these methods to improve detection and accurate diagnosis of cancer, and monitor cancer response to therapy. I am the Director of Magnetic Resonance Imaging Research at the University of Chicago, and Co-Director of the Advanced Imaging Program of the University of Chicago Comprehensive Cancer center. I’ve collaborated with our outstanding mammographic group and medical physics colleagues for many years to build internationally recognized research program in quantitative breast cancer MR imaging – which parallels and compliments a leading clinical program in breast cancer diagnosis and management. Similarly, I’ve collaborated with Dr. Oto and others to develop a leading translational research program focused on improving prostate cancer screening with MRI, and using MRI to guide therapye. With these collaborators, I’ve made pioneering contributions to MRI methods that improve prostate and breast cancer diagnosis and treatment. My research includes use of pre-clinical methods for breast and prostate cancer to improve understanding of cancer biology and guide the development of improved clinical methods.

One or more keywords matched the following items that are connected to Karczmar, Gregory

Item Type	Name
Concept	Breast Neoplasms
Concept	Endocrine Gland Neoplasms
Concept	Colonic Neoplasms
Concept	Uterine Cervical Neoplasms
Concept	Kidney Neoplasms
Concept	Mammary Neoplasms, Experimental
Concept	Liver Neoplasms
Concept	Neoplasm Transplantation
Concept	Neoplasm Staging
Concept	Lung Neoplasms
Concept	Prostatic Neoplasms
Concept	Head and Neck Neoplasms
Concept	Uterine Neoplasms
Concept	Soft Tissue Neoplasms
Concept	Biomarkers, Tumor
Concept	Tumor Necrosis Factor-alpha
Concept	Tumor Cells, Cultured
Concept	Neoplasm Metastasis
Concept	Neoplasms, Experimental
Concept	Tumor Burden
Concept	Colorectal Neoplasms
Concept	Mammary Neoplasms, Animal
Concept	Early Detection of Cancer
Concept	Muscle Neoplasms
Concept	Cell Line, Tumor
Concept	Neoplasm Grading
Concept	Neoplasm Invasiveness
Concept	Neoplasms
Concept	Neoplasm, Residual
Academic Article	Fast spectroscopic imaging of water and fat resonances to improve the quality of MR images.
Academic Article	Dynamic contrast measurements in rodent model tumors.
Academic Article	In vivo imaging of extraction fraction of low molecular weight MR contrast agents and perfusion rate in rodent tumors.
Academic Article	Applications of magnetic resonance in model systems: cancer therapeutics.
Academic Article	Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation.
Academic Article	Uptake of a superparamagnetic contrast agent imaged by MR with high spectral and spatial resolution.
Academic Article	Differentiation of nonmetastatic and metastatic rodent prostate tumors with high spectral and spatial resolution MRI.
Academic Article	A new method for imaging perfusion and contrast extraction fraction: input functions derived from reference tissues.
Academic Article	Imaging spin probe distribution in the tumor of a living mouse with 250 MHz EPR: correlation with BOLD MRI.
Academic Article	Spectrally inhomogeneous effects of contrast agents in breast lesion detected by high spectral and spatial resolution MRI.
Academic Article	MRI measurements correctly predict the relative effects of tumor oxygenating agents on hypoxic fraction in rodent BA1112 tumors.
Academic Article	MRI of the tumor microenvironment.
Academic Article	Breast MR imaging with high spectral and spatial resolutions: preliminary experience.
Academic Article	Functional and anatomic imaging of tumor vasculature: high-resolution MR spectroscopic imaging combined with a superparamagnetic contrast agent.
Academic Article	Selective depletion of tumor ATP by 2-deoxyglucose and insulin, detected by 31P magnetic resonance spectroscopy.
Academic Article	The effect of varying spectral resolution on the quality of high spectral and spatial resolution magnetic resonance images of the breast.
Academic Article	Effect of carbogen on tumor oxygenation: combined fluorine-19 and proton MRI measurements.
Academic Article	Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): methodology and comparison with blood oxygen level-dependent (BOLD) MRI.
Academic Article	Using high spectral and spatial resolution bold MRI to choose the optimal oxygenating treatment for individual cancer patients.
Academic Article	Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time.
Academic Article	Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors.
Academic Article	A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.
Academic Article	High spectral and spatial resolution MRI of breast lesions: preliminary clinical experience.
Academic Article	MRI of perfluorocarbon emulsion kinetics in rodent mammary tumours.
Academic Article	Fat suppression with spectrally selective inversion vs. high spectral and spatial resolution MRI of breast lesions: qualitative and quantitative comparisons.
Academic Article	Differentiation between benign and malignant breast lesions detected by bilateral dynamic contrast-enhanced MRI: a sensitivity and specificity study.
Academic Article	Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma.
Academic Article	Multiple reference tissue method for contrast agent arterial input function estimation.
Academic Article	Quantitative analysis of water proton spectral lineshape: a novel source of contrast in MRI.
Academic Article	DCEMRI of breast lesions: is kinetic analysis equally effective for both mass and nonmass-like enhancement?
Academic Article	New model for analysis of dynamic contrast-enhanced MRI data distinguishes metastatic from nonmetastatic transplanted rodent prostate tumors.
Academic Article	Detection of in situ mammary cancer in a transgenic mouse model: in vitro and in vivo MRI studies demonstrate histopathologic correlation.
Academic Article	P-31 spectroscopy study of response of superficial human tumors to therapy.
Academic Article	Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma.
Academic Article	Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study.
Academic Article	Relating dose of contrast media administered to uptake and washout of malignant lesions on DCEMRI of the breast.
Academic Article	Reproducibility assessment of a multiple reference tissue method for quantitative dynamic contrast enhanced-MRI analysis.
Academic Article	Kinetic curves of malignant lesions are not consistent across MRI systems: need for improved standardization of breast dynamic contrast-enhanced MRI acquisition.
Academic Article	Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model.
Academic Article	Comparison of high-resolution echo-planar spectroscopic imaging with conventional MR imaging of prostate tumors in mice.
Academic Article	Characterization of response to radiation mediated gene therapy by means of multimodality imaging.
Academic Article	Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage.
Academic Article	Fourier component imaging of water resonance in the human breast provides markers for malignancy.
Academic Article	Prostate cancer: differentiation of central gland cancer from benign prostatic hyperplasia by using diffusion-weighted and dynamic contrast-enhanced MR imaging.
Academic Article	Characterizing early contrast uptake of ductal carcinoma in situ with high temporal resolution dynamic contrast-enhanced MRI of the breast: a pilot study.
Academic Article	Diagnosis of suspicious breast lesions using an empirical mathematical model for dynamic contrast-enhanced MRI.
Academic Article	New vanadium-based magnetic resonance imaging probes: clinical potential for early detection of cancer.
Academic Article	Normal parenchymal enhancement patterns in women undergoing MR screening of the breast.
Academic Article	Early metabolic response to tumor necrosis factor in mouse sarcoma: a phosphorus-31 nuclear magnetic resonance study.
Academic Article	The diverse pathology and kinetics of mass, nonmass, and focus enhancement on MR imaging of the breast.
Academic Article	T(2)* relaxation times of intraductal murine mammary cancer, invasive mammary cancer, and normal mammary gland.
Academic Article	High-resolution MRI of excised human prostate specimens acquired with 9.4T in detection and identification of cancers: validation of a technique.
Academic Article	Diffusion-weighted and dynamic contrast-enhanced MRI of prostate cancer: correlation of quantitative MR parameters with Gleason score and tumor angiogenesis.
Academic Article	Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging.
Academic Article	Can DCEMRI assess the effect of green tea on the angiogenic properties of rodent prostate tumors?
Academic Article	Comparison of quantitative parameters in cervix cancer measured by dynamic contrast-enhanced MRI and CT.
Academic Article	In vivo MRI of early stage mammary cancers and the normal mouse mammary gland.
Academic Article	Improvement of the rotating frame experiment by detection of residual Z magnetization: a 31P MRS study of metabolite levels in a Meth-A sarcoma.
Academic Article	Comparing post-operative human breast specimen radiograph and MRI in lesion margin and volume assessment.
Academic Article	Hepatic cancers and their response to chemoembolization therapy. Quantitative image-guided 31P magnetic resonance spectroscopy.
Academic Article	Inhibition of tumor high-energy phosphate metabolism by insulin combined with rhodamine 123.
Academic Article	Clinical magnetic resonance spectroscopy of brain, heart, liver, kidney, and cancer. A quantitative approach.
Academic Article	Non-contrast enhanced MRI for evaluation of breast lesions: comparison of non-contrast enhanced high spectral and spatial resolution (HiSS) images versus contrast enhanced fat-suppressed images.
Academic Article	Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer.
Academic Article	Changes in T2*-weighted images during hyperoxia differentiate tumors from normal tissue.
Academic Article	Effects of hyperoxia on T2* and resonance frequency weighted magnetic resonance images of rodent tumours.
Academic Article	The use of a reference tissue arterial input function with low-temporal-resolution DCE-MRI data.
Academic Article	Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry.
Academic Article	Spectroscopic imaging of the water resonance with short repetition time to study tumor response to hyperoxia.
Academic Article	Magnetic resonance measurement of response to hyperoxia differentiates tumors from normal tissue and may be sensitive to oxygen consumption.
Academic Article	Magnetic resonance imaging of rodent tumors using radiofrequency gradient echoes.
Academic Article	Spectrally inhomogeneous BOLD contrast changes detected in rodent tumors with high spectral and spatial resolution MRI.
Academic Article	Pure ductal carcinoma in situ: kinetic and morphologic MR characteristics compared with mammographic appearance and nuclear grade.
Academic Article	High spectral and spatial resolution MRI of age-related changes in murine prostate.
Academic Article	Sensitivity to tumor microvasculature without contrast agents in high spectral and spatial resolution MR images.
Academic Article	Response of tumors to therapy studied by 31P magnetic resonance spectroscopy.
Academic Article	HiSStology: high spectral and spatial resolution magnetic resonance imaging detection of vasculature validated by histology and micro-computed tomography.
Academic Article	Safety limitations of MR-HIFU treatment near interfaces: a phantom validation.
Academic Article	Hyperthermically induced changes in high spectral and spatial resolution MR images of tumor tissue--a pilot study.
Academic Article	MR imaging-guided focal laser ablation for prostate cancer: phase I trial.
Academic Article	Monitoring anti-angiogenic therapy in colorectal cancer murine model using dynamic contrast-enhanced MRI: comparing pixel-by-pixel with region of interest analysis.
Academic Article	Do we really need contrast agents?
Academic Article	Classification of breast lesions pre-contrast injection using water resonance lineshape analysis.
Academic Article	The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.
Academic Article	Mammary cancer initiation and progression studied with magnetic resonance imaging.
Academic Article	X-ray fluorescence microscopy demonstrates preferential accumulation of a vanadium-based magnetic resonance imaging contrast agent in murine colonic tumors.
Academic Article	Hybrid multidimensional T(2) and diffusion-weighted MRI for prostate cancer detection.
Academic Article	Potential of computer-aided diagnosis of high spectral and spatial resolution (HiSS) MRI in the classification of breast lesions.
Academic Article	Comparison of dynamic contrast-enhanced MRI parameters of breast lesions at 1.5 and 3.0?T: a pilot study.
Academic Article	Prostate volumes derived from MRI and volume-adjusted serum prostate-specific antigen: correlation with Gleason score of prostate cancer.
Academic Article	Dynamic contrast-enhanced MR imaging features of the normal central zone of the prostate.
Academic Article	High-resolution diffusion-weighted imaging of the prostate.
Academic Article	Residual analysis of the water resonance signal in breast lesions imaged with high spectral and spatial resolution (HiSS) MRI: a pilot study.
Academic Article	Preliminary assessment of dispersion versus absorption analysis of high spectral and spatial resolution magnetic resonance images in the diagnosis of breast cancer.
Academic Article	Correlation of In Vivo and Ex Vivo ADC and T2 of In Situ and Invasive Murine Mammary Cancers.
Academic Article	MRI accurately identifies early murine mammary cancers and reliably differentiates between in situ and invasive cancer: correlation of MRI with histology.
Academic Article	Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
Academic Article	Short-term reproducibility of apparent diffusion coefficient estimated from diffusion-weighted MRI of the prostate.
Academic Article	Arterial input functions (AIFs) measured directly from arteries with low and standard doses of contrast agent, and AIFs derived from reference tissues.
Academic Article	Benign Conditions That Mimic Prostate Carcinoma: MR Imaging Features with Histopathologic Correlation.
Academic Article	Ultrafast Bilateral DCE-MRI of the Breast with Conventional Fourier Sampling: Preliminary Evaluation of Semi-quantitative Analysis.
Academic Article	Pilot Study of the Use of Hybrid Multidimensional T2-Weighted Imaging-DWI for the Diagnosis of Prostate Cancer and Evaluation of Gleason Score.
Academic Article	Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Pharmacodynamic Biomarker for Pazopanib in Metastatic Renal Carcinoma.
Academic Article	Kinetic Analysis of Benign and Malignant Breast Lesions With Ultrafast Dynamic Contrast-Enhanced MRI: Comparison With Standard Kinetic Assessment.
Academic Article	Fast bilateral breast coverage with high spectral and spatial resolution (HiSS) MRI at 3T.
Academic Article	Value of breast MRI for patients with a biopsy showing atypical ductal hyperplasia (ADH).
Academic Article	MRI ductography of contrast agent distribution and leakage in normal mouse mammary ducts and ducts with in situ cancer.
Academic Article	X-Ray Fluorescence Microscopy Demonstrates Preferential Accumulation of a Vanadium-Based Magnetic Resonance Imaging Contrast Agent in Murine Colonic Tumors.
Academic Article	MRI reveals increased tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer.
Academic Article	Multiparametric MRI Features and Pathologic Outcome of Wedge-Shaped Lesions in the Peripheral Zone on T2-Weighted Images of the Prostate.
Academic Article	Performance of T2 Maps in the Detection of Prostate Cancer.
Academic Article	Diagnosis of Prostate Cancer with Noninvasive Estimation of Prostate Tissue Composition by Using Hybrid Multidimensional MR Imaging: A Feasibility Study.
Academic Article	Performance of Ultrafast DCE-MRI for Diagnosis of Prostate Cancer.
Academic Article	Feasibility of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using Low-Dose Gadolinium: Comparative Performance With Standard Dose in Prostate Cancer Diagnosis.
Academic Article	MRI Findings After MRI-Guided Focal Laser Ablation of Prostate Cancer.
Academic Article	Ultrafast Dynamic Contrast-Enhanced Breast MRI: Kinetic Curve Assessment Using Empirical Mathematical Model Validated with Histological Microvessel Density.
Academic Article	Quantitative analysis of vascular properties derived from ultrafast DCE-MRI to discriminate malignant and benign breast tumors.
Academic Article	Comparison of arterial input functions measured from ultra-fast dynamic contrast enhanced MRI and dynamic contrast enhanced computed tomography in prostate cancer patients.
Academic Article	Comparison of region-of-interest-averaged and pixel-averaged analysis of DCE-MRI data based on simulations and pre-clinical experiments.
Academic Article	Fast Temporal Resolution Dynamic Contrast-Enhanced MRI: Histogram Analysis Versus Visual Analysis for Differentiating Benign and Malignant Breast Lesions.
Academic Article	Evaluation of Focal Laser Ablation of Prostate Cancer Using High Spectral and Spatial Resolution Imaging: A Pilot Study.
Academic Article	Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer in BRCA1 Mutation Carriers.
Academic Article	Comparison of T2-Weighted Imaging, DWI, and Dynamic Contrast-Enhanced MRI for Calculation of Prostate Cancer Index Lesion Volume: Correlation With Whole-Mount Pathology.
Academic Article	Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer.
Academic Article	Revisiting quantitative multi-parametric MRI of benign prostatic hyperplasia and its differentiation from transition zone cancer.
Academic Article	Diagnosis of Prostate Cancer by Use of MRI-Derived Quantitative Risk Maps: A Feasibility Study.
Academic Article	A compact solution for estimation of physiological parameters from ultrafast prostate dynamic contrast enhanced MRI.
Academic Article	Use of Indicator Dilution Principle to Evaluate Accuracy of Arterial Input Function Measured With Low-Dose Ultrafast Prostate Dynamic Contrast-Enhanced MRI.
Academic Article	Low-dose imaging technique (LITE) MRI: initial experience in breast imaging.
Academic Article	Effect of Echo Times on Prostate Cancer Detection on T2-Weighted Images.
Academic Article	Patient-Specific Characterization of Breast Cancer Hemodynamics Using Image-Guided Computational Fluid Dynamics.
Academic Article	Discrimination of benign from malignant breast lesions in dense breasts with model-based analysis of regions-of-interest using directional diffusion-weighted images.
Academic Article	T2*-weighted MRI as a non-contrast-enhanced method for assessment of focal laser ablation zone extent in prostate cancer thermotherapy.
Academic Article	Magnetic resonance angiography reveals increased arterial blood supply and tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer.
Academic Article	Signal intensity form of the Tofts model for quantitative analysis of prostate dynamic contrast enhanced MRI data.
Academic Article	Comparison of DCE-MRI of murine model cancers with a low dose and high dose of contrast agent.
Academic Article	Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images.
Academic Article	High spectral and spatial resolution MRI of prostate cancer: a pilot study.
Grant	MR Virtual Pathology of the Prostate
Academic Article	Robustness of radiomic features of benign breast lesions and hormone receptor positive/HER2-negative cancers across DCE-MR magnet strengths.
Academic Article	Effectiveness of Dynamic Contrast Enhanced MRI with a Split Dose of Gadoterate Meglumine for Detection of Prostate Cancer.
Academic Article	Can Pre-treatment Quantitative Multi-parametric MRI Predict the Outcome of Radiotherapy in Patients with Prostate Cancer?
Academic Article	Enhancement-constrained acceleration: A robust reconstruction framework in breast DCE-MRI.
Academic Article	Validation of Prostate Tissue Composition by Using Hybrid Multidimensional MRI: Correlation with Histologic Findings.
Academic Article	Histological validation of prostate tissue composition measurement using hybrid multi-dimensional MRI: agreement with pathologists' measures.
Academic Article	Differences Between Ipsilateral and Contralateral Early Parenchymal Enhancement Kinetics Predict Response of Breast Cancer to Neoadjuvant Therapy.
Academic Article	Towards Patient-Specific Optimization of Neoadjuvant Treatment Protocols for Breast Cancer Based on Image-Guided Fluid Dynamics.
Academic Article	Physically implausible signals as a quantitative quality assessment metric in prostate diffusion-weighted MR imaging.
Academic Article	The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth.
Academic Article	Directional and inter-acquisition variability in diffusion-weighted imaging and editing for restricted diffusion.
Academic Article	Comparing Radiologist Performance in Diagnosing Clinically Significant Prostate Cancer with Multiparametric versus Hybrid Multidimensional MRI.
Academic Article	Safely reducing unnecessary benign breast biopsies by applying non-mass and DWI directional variance filters to ADC thresholding.
Academic Article	Parametric maps of spatial two-tissue compartment model for prostate dynamic contrast enhanced MRI - comparison with the standard Tofts model in the diagnosis of prostate cancer.
Academic Article	Comparison of synthesized and acquired high b -value diffusion-weighted MRI for detection of prostate cancer.
Concept	Tumor Hypoxia
Concept	Triple Negative Breast Neoplasms
Grant	Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant Therapy
Grant	Detection of prostate Cancer Specific Signals with Hybrid Multi-Dimensional MRI
Grant	Microvessel Density With High Spectral/Spatial MRI
Grant	Assessment of Breast Cancer Risk with High Spectral and Spatial Resolution MRI
Grant	RESPONSE OF TUMORS TO TNF STUDIED BY MAGNETIC RESONANCE
Grant	Microvessel Density With High Spectral/Spatial MRI
Grant	High Spectral &Spatial Resolution MRI of Rodent Tumors
Grant	3T MRI Scanner for multidisciplinary imaging and image-guided therapy
Grant	Fast Spectroscopic MR Imaging of Breast Cancer
Grant	MRI of Early Non-invasive Rodent Mammary Cancers
Grant	High Spectral/Spatial Resolution Imaging Breast Cancer
Grant	Breast Cancer Screening with Quantitative Ultra-Fast DCEMRI and Clinical Risk Assessment
Grant	UPGRADE FOR 4.7 TESLA MR SCANNER
Grant	EFFECTS OF RADIOSENSITIZERS MEASURED BY MRI
Grant	Quantitative DCEMRI of Prostate Cancer Correlation with Gold Standards
Grant	A 7 Tesla magnet for the University of Chicago MRI research scanner
Academic Article	An Interactive App with Multi-parametric MRI - Whole-Mount Histology Correlation for Enhanced Prostate MRI Training of Radiology Residents.
Academic Article	Improving reader accuracy and specificity with the addition of hybrid multidimensional-MRI to multiparametric-MRI in diagnosing clinically significant prostate cancers.
Academic Article	Pharmacokinetic Analysis of Enhancement-Constrained Acceleration (ECA) reconstruction-based high temporal resolution breast DCE-MRI.
Academic Article	Parametric maps of spatial two-tissue compartment model for prostate dynamic contrast enhanced MRI - comparison with the standard tofts model in the diagnosis of prostate cancer.
Academic Article	Four-quadrant vector mapping of hybrid multidimensional MRI data for the diagnosis of prostate cancer.
Academic Article	Bilateral asymmetry of quantitative parenchymal kinetics at ultrafast DCE-MRI predict response to neoadjuvant chemotherapy in patients with HER2+ breast cancer.
Academic Article	Prostate Cancers Invisible on Multiparametric MRI: Pathologic Features in Correlation with Whole-Mount Prostatectomy.
Academic Article	External Evaluation of a Mammography-based Deep Learning Model for Predicting Breast Cancer in an Ethnically Diverse Population.
Grant	Chicago Alternative Prevention Study for BReast CAncer in Diverse Populations of High-Risk Women (CAPSBRACA)
Academic Article	Systematic evaluation of MRI-based characterization of tumor-associated vascular morphology and hemodynamics via a dynamic digital phantom.

Search Criteria

Neoplasms