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overview Our group works at the intersection of genetic, molecular, and environmental epidemiology. We are interested in how genetic variation influences or alters the effects of environmental exposures and biomarkers on human health and biology. Areas of ongoing research include (1) dynamic features of the genome that are biomarkers of aging, exposure, and disease risk, (2) genetic susceptibility and response to exposure to arsenic, a known carcinogen (3) methods for assessing causal relationships among risk factors, biomarkers, and disease phenotypes, and (4) genetic contributors to prostate cancer disparities. The long-term goals of our work are to understand toxicity mechanisms and disease biology and to improve our ability to predict disease and target interventions to high-risk sub-populations. Several ongoing projects are described below: • Arsenic and the Human Genome: Susceptibility and response to exposure: Over 100 million people worldwide consume arsenic-contaminated drinking water, which increases risk for a wide array of health conditions, including cancer. The goal of this project is to identify features of the human genome, both inherited (i.e., SNPs) and acquired/dynamic (i.e., telomere length, DNA methylation, somatic mutations), that reflect susceptibility to arsenic toxicity or response to arsenic exposure, using data from a large arsenic-exposed Bangladeshi cohort. Achieving these goals will reveal biological mechanisms of toxicity and susceptibility and provide strategies for identifying high risk individuals. • Genetics of Arsenic Metabolism: fine mapping and analysis of rare variants: Susceptibility to arsenic toxicity is partially determined by genetic variants on chromosome 10 which influence individuals’ ability to metabolize arsenic. Dr. Pierce directs a project that will comprehensively characterize the effects of these variants across three arsenic-exposed population groups (Bangladeshis, American Indians, and European Americans). • Telomere Length and Chromosomal Instability Across Various Tissue Types: Age-related telomere shortening may play a critical role in susceptibility to common age-related diseases, including cancer. Using tissue samples from the NHGRI’s Gene-Tissue Expression project (GTEx), Dr. Pierce’s team is assessing correlations among telomere length measurements taken across many cancer-prone tissues and determining if telomere length is correlated with DNA damage, aging-related DNA methylation features, as well as inherited genetic variation. • Identifying DNA Methylation Features That Underlie Prostate Cancer Disparities: In light of racial disparities in prostate cancer incidence and mortality in the U.S., Dr. Pierce is leading a project to determine if DNA methylation patterns in prostate tissue differ between African American and Caucasian patients and how such differences are related to clinical features, as well as genetic and environmental factors. This work will contribute to the identification ethnicity-specific biomarkers for prostate cancer aggressiveness.

One or more keywords matched the following items that are connected to Pierce, Brandon L.

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Concept Genetic Predisposition to Disease
Academic Article Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR.
Academic Article Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer.
Academic Article The impact of patents on the development of genome-based clinical diagnostics: an analysis of case studies.
Academic Article Clinical assessment incorporating a personal genome.
Academic Article Case-only genome-wide interaction study of disease risk, prognosis and treatment.
Academic Article Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data.
Academic Article Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus.
Academic Article Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.
Academic Article Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh.
Academic Article Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.
Academic Article Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants.
Academic Article Unidentified genetic variants influence pancreatic cancer risk: an analysis of polygenic susceptibility in the PanScan study.
Academic Article The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies.
Academic Article HOXD10 M319K mutation in a family with isolated congenital vertical talus.
Academic Article Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.
Academic Article Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction.
Academic Article A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
Academic Article Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study.
Academic Article Telomere structure and maintenance gene variants and risk of five cancer types.
Academic Article Screening for gene-environment (G×E) interaction using omics data from exposed individuals: an application to gene-arsenic interaction.
Academic Article Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.
Academic Article Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal.
Academic Article A meta-analysis approach with filtering for identifying gene-level gene-environment interactions.
Academic Article Lessons Learned From Past Gene-Environment Interaction Successes.
Academic Article Trans-ethnic predicted expression genome-wide association analysis identifies a gene for estrogen receptor-negative breast cancer.
Academic Article Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis.
Academic Article The effect of age on DNA methylation in whole blood among Bangladeshi men and women.
Academic Article Research Participants' Attitudes towards Receiving Information on Genetic Susceptibility to Arsenic Toxicity in Rural Bangladesh.

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