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One or more keywords matched the following properties of Awad, Issam
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overview Awad was recruited in 2010 to lead the Neurovascular Surgery Program at the University of Chicago Medicine, and is currently tenured in the Biological Sciences Division. He is the John Harper Seeley Professor of Neurological Sciences and Professor of Neurological Surgery, Neurology, the Grossman Institute of Neuroscience, Quantitative Biology and Human Behavior, and the (PhD granting) Committee on Neurobiology. He is a Senior Faculty Scholar at the Bucksbaum Institute for Clinical Excellence and directs the Safadi Program of Excellence in Clinical and Translational Neurosciences. Dr Awad is active in numerous professional and learned societies. He has served on the Executive Committee of the American Stroke Association, and on the Board of Governors of the American College of Surgeons. He was the Chairman of the Joint Cerebrovascular Section of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons, he has directed the Annual Course on Research Update in Neuroscience for Neurosurgeons, and he served as the 51st President of the Congress of Neurological Surgeons. Dr Awad is the Founding past-President of the World Association of Lebanese Neurosurgeons, and the Founding Chairman of Scientific Advisory Board of the patient advocacy group Angioma Alliance. Dr Awad has authored over 350 scientific papers and book chapters, and edited twelve books dealing with cerebrovascular surgery and other aspects of neurological surgery. He has presented over 500 papers and lectures at major meetings and symposia, has been a visiting professor at numerous institutions in the United States and abroad, was recognized among America’s Best Doctors, Best Teachers, and is the recipient of the Bucy Award for Excellence in Neurosurgical Education, the Arnold Award for Mentoring at Pritzker School of Medicine, and numerous other honors. Dr Awad has made numerous scientific contributions including the characterization of subcortical ischemic lesions in the aged, advances in the understanding of the natural history and biologic behavior of vascular malformations of the brain, numerous technical advances in neurovascular and epilepsy surgery, and is a recognized expert in the treatment of neurovascular disease, hemorrhagic stroke and neurosurgical critical care. His research has been cited by other researchers more than 79,000 times (H-index 91). Current research focuses on molecular mechanisms, biomarkers and therapeutic targets in cavernous angiomas (cerebral vascular malformations), the pathobiology of brain hemorrhage, and minimally invasive techniques for treating hemorrhagic stroke. Dr. Awad's research has been funded continuously from the National Institutes of Health since 1998, including a prestigious midcareer development grant in patient-oriented research (2000-2005), and current active R01, P01 and U01 funding through 2025. From 2016 to 2020, he served on the United States National Advisory Council for Neurological Disorders and Stroke. In 2019, he was elected to the Association of American Physicians. www.issamawad.com www.uchicagomedicine.org/ccm www.uchicagomedicine.org/hht http://safadiprogram.uchicago.edu
One or more keywords matched the following items that are connected to Awad, Issam
Item TypeName
Concept Cerebral Hemorrhage
Concept Subarachnoid Hemorrhage
Concept Intracranial Hemorrhage, Hypertensive
Concept Intracranial Hemorrhages
Concept Postoperative Hemorrhage
Concept Hemorrhage
Academic Article Mixed vascular malformations of the brain: clinical and pathogenetic considerations.
Academic Article Factors predisposing to clinical disability in patients with cavernous malformations of the brain.
Academic Article Comparison of the clinical presentation of symptomatic arteriovenous malformations (angiographically visualized) and occult vascular malformations.
Academic Article Misdiagnosis of symptomatic cerebral aneurysm. Prevalence and correlation with outcome at four institutions.
Academic Article Intracranial cavernous malformations: lesion behavior and management strategies.
Academic Article A comparison of the clinical profile of cavernous malformations with and without associated venous malformations.
Academic Article A quality-of-life instrument for young hemorrhagic stroke patients.
Academic Article Recommendations for the management of patients with unruptured intracranial aneurysms: A Statement for healthcare professionals from the Stroke Council of the American Heart Association.
Academic Article Hemorrhagic lesion at the tentorial incisura in a patient with facial nevus.
Academic Article Stereotactic computed tomographic-guided aspiration and thrombolysis of intracerebral hematoma : protocol and preliminary experience.
Academic Article AHA Scientific Statement: Recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the Stroke Council, American Stroke Association.
Academic Article Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion.
Academic Article Intracranial dural arteriovenous malformations: factors predisposing to an aggressive neurological course.
Academic Article Hemorrhage from cavernous malformations of the brain: definition and reporting standards. Angioma Alliance Scientific Advisory Board.
Academic Article Intraventricular hemorrhage secondary to intranidal aneurysm rupture-successful management by arteriovenous malformation embolization followed by intraventricular tissue plasminogen activator: case report.
Academic Article Drainage efficiency with dual versus single catheters in severe intraventricular hemorrhage.
Academic Article Ventricular catheter location and the clearance of intraventricular hemorrhage.
Academic Article Resolution of intraventricular hemorrhage varies by ventricular region and dose of intraventricular thrombolytic: the Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) program.
Academic Article Fatal "hypertensive" intracerebral hemorrhage associated with a cerebral cavernous angioma: case report.
Academic Article Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
Academic Article Clinical vasospasm after subarachnoid hemorrhage: response to hypervolemic hemodilution and arterial hypertension.
Academic Article Thrombolytic evacuation of intracerebral and intraventricular hemorrhage.
Academic Article Subarachnoid hemorrhage and choir singing.
Academic Article Radiosurgery and venous malformations.
Academic Article Outcome predictors and spectrum of treatment eligibility with prospective protocolized management of intracerebral hemorrhage.
Academic Article Toward more rational prediction of outcome in patients with high-grade subarachnoid hemorrhage.
Academic Article Reporting terminology for brain arteriovenous malformation clinical and radiographic features for use in clinical trials.
Academic Article Natural history of the cavernous angioma.
Academic Article Ruptured superior cerebellar artery aneurysm in a child with bilateral fibromuscular hyperplasia of the renal arteries: case report and review of the literature.
Academic Article Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial.
Academic Article Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial.
Academic Article External ventricular drainage for intraventricular hemorrhage.
Academic Article Occurrence and impact of intracranial pressure elevation during treatment of severe intraventricular hemorrhage.
Academic Article Intensive care management of acute hemorrhagic leukoencephalitis with favorable neurologic outcome.
Academic Article Perioperative management and outcome after surgical treatment of anterior cerebral artery aneurysms.
Academic Article Proton magnetic resonance imaging in ischemic cerebrovascular disease.
Academic Article Endovascular therapeutic approach to peripheral aneurysms of the superior cerebellar artery.
Academic Article Intracranial cavernous angioma: a practical review of clinical and biological aspects.
Academic Article Surgery for intracerebral hemorrhage.
Academic Article Protocols and critical pathways for stroke care.
Academic Article Cerebral cavernous malformations and epilepsy.
Academic Article Current updates in perioperative management of intracerebral hemorrhage.
Academic Article Parenchymal perianeurysmal cystic changes in the brain: report of five cases.
Academic Article [Etiologic spectrum of intracerebral hemorrhage in young patients].
Academic Article Advances in the genetics of cerebrovascular disease and stroke.
Academic Article The Modified Graeb Score: an enhanced tool for intraventricular hemorrhage measurement and prediction of functional outcome.
Academic Article Primary intracerebral hemorrhage and subarachnoid hemorrhage.
Academic Article Radiosurgery for angiographically occult vascular malformations.
Academic Article Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema.
Academic Article Hemorrhagic stroke: introduction.
Academic Article Surgical trials in intracerebral hemorrhage.
Academic Article Current updates in perioperative management of intracerebral hemorrhage.
Academic Article When blood tickles the brain: where is the argument?
Academic Article Recommendations for the management of patients with unruptured intracranial aneurysms: A statement for healthcare professionals from the Stroke Council of the American Heart Association.
Academic Article Management of incidental cavernous malformations: a review.
Academic Article DBS reduced hemichorea associated with a developmental venous anomaly and microbleeding in STN.
Academic Article Spontaneous intracerebral and intraventricular hemorrhage: advances in minimally invasive surgery and thrombolytic evacuation, and lessons learned in recent trials.
Academic Article A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III).
Academic Article Bleeding and infection with external ventricular drainage: a systematic review in comparison with adjudicated adverse events in the ongoing Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR-III IHV) trial.
Academic Article Determinants of external ventricular drain placement and associated outcomes in patients with spontaneous intraventricular hemorrhage.
Academic Article Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III.
Academic Article Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations.
Academic Article Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial.
Academic Article Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.
Academic Article Spontaneous Intracerebral and Intraventricular Hemorrhage: Advances in Minimally Invasive Surgery and Thrombolytic Evacuation, and Lessons Learned in Recent Trials.
Academic Article Recombinant Human Coagulation Factor VIIa for Intracerebral Hemorrhage.
Academic Article Demographic Risk Factors for Vascular Lesions as Etiology of Intraventricular Hemorrhage in Prospectively Screened Cases.
Academic Article Surgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial.
Academic Article Permanent CSF shunting after intraventricular hemorrhage in the CLEAR III trial.
Academic Article CSF inflammatory response after intraventricular hemorrhage.
Academic Article Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage.
Academic Article The Incidence of Catheter Tract Hemorrhage and Catheter Placement Accuracy in the CLEAR III Trial.
Academic Article Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.
Academic Article Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH).
Academic Article Symptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III): A Posthoc Root-Cause Analysis.
Academic Article Influence of Bleeding Pattern on Ischemic Lesions After Spontaneous Hypertensive Intracerebral Hemorrhage with Intraventricular Hemorrhage.
Academic Article Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations.
Academic Article Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.
Academic Article Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth.
Academic Article African American Screening and Enrollment in (Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage III) CLEAR III.
Academic Article Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial.
Academic Article Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Academic Article Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.
Academic Article A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III).
Academic Article Intracranial Hypertension and Cerebral Perfusion Pressure Insults in Adult Hypertensive Intraventricular Hemorrhage: Occurrence and Associations With Outcome.
Academic Article Biomarkers of cavernous angioma with symptomatic hemorrhage.
Grant Trial Readiness in Cavernous Angiomas with Symptomatic Hemorrhage
Grant Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial
Academic Article Surgery for intracerebral haemorrhage - Authors' reply.
Academic Article In Reply: Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.
Academic Article Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature.
Academic Article Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III.
Academic Article Primary intraventricular hemorrhage outcomes in the CLEAR III trial.
Academic Article Subclinical imaging changes in cerebral cavernous angiomas during prospective surveillance.
Academic Article Role of Temporal Sequence in Treating Intracerebral Hemorrhage.
Academic Article Novel Murine Models of Cerebral Cavernous Malformations.
Academic Article A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage.
Academic Article 3D Deep Neural Network Segmentation of Intracerebral Hemorrhage: Development and Validation for Clinical Trials.
Academic Article Thrombolysis for Evacuation of Intracerebral and Intraventricular Hemorrhage: A Guide to Surgical Protocols With Practical Lessons Learned From the MISTIE and CLEAR Trials.
Academic Article Impact of Intracranial Pressure Monitor-Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage.
Academic Article Temporal Evolution and Outcomes of Non-Traumatic Intracerebral Hemorrhage in Hospitalized Patients.
Academic Article A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).
Academic Article Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials.
Academic Article Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu.
Academic Article Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.
Academic Article Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage.
Academic Article Post-Trial Enhanced Deployment and Technical Performance with the MISTIE Procedure per Lessons Learned.
Academic Article In Reply: Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials.
Academic Article CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial.
Academic Article Post-Stroke Depression in Patients with Large Spontaneous Intracerebral Hemorrhage.
Academic Article COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation.
Academic Article Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project.
Academic Article Intracranial Pressure and Cerebral Perfusion Pressure in Large Spontaneous Intracranial Hemorrhage and Impact of Minimally Invasive Surgery.
Academic Article Perfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth.
Academic Article Association Between Intraventricular Alteplase Use and Parenchymal Hematoma Volume in Patients With Spontaneous Intracerebral Hemorrhage and Intraventricular Hemorrhage.
Academic Article Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials.
Academic Article Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis.
Academic Article Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions.
Academic Article Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume.
Academic Article Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis.
Academic Article One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability.
Concept Cerebral Intraventricular Hemorrhage
Grant Rock Inhibition as Therapy for Cerebral Cavernous Malformation
Grant IMMUNE RESPONSE IN HUMAN CEREBRAL CAVERNOUS MALFORMATIONS
Grant Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)
Grant Development of BA-1049 for treatment of cerebral cavernous malformation
Academic Article Impact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation.
Academic Article Cavernous Angioma Symptomatic Hemorrhage (CASH) Trial Readiness II: Imaging Biomarkers and Trial Modeling.
Academic Article Underlying intracranial atherosclerotic disease is associated with worse outcomes in acute large vessel occlusion undergoing endovascular thrombectomy.
Academic Article Catheter Tract Hemorrhages and Intracerebral Hemorrhage Outcomes in the Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Trial.
Academic Article Minimally Invasive Surgery With Thrombolysis for Intracerebral Hemorrhage Evacuation: Bayesian Reanalysis of a Randomized Controlled Trial.
Academic Article Mechanistic Evaluation of Diffusion Weighted Hyperintense Lesions After Large Spontaneous Intracerebral Hemorrhage: A Subgroup Analysis of MISTIE III.
Academic Article Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part II: Biomarkers and Trial Modeling.
Academic Article Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome.
Academic Article Association Between Hematoma Volume and Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis.
Academic Article Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta-Analysis, and Network Meta-Analysis.
Academic Article Pathologic Features of Brain Hemorrhage After Radiation Treatment: Case Series with Somatic Mutation Analysis.
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  • Hemorrhage