| Item Type | Name |
|
Academic Article
|
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
|
|
Academic Article
|
A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
|
|
Academic Article
|
Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
|
|
Academic Article
|
Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
|
|
Academic Article
|
Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
|
|
Academic Article
|
Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
|
|
Academic Article
|
Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
|
|
Academic Article
|
Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
|
|
Academic Article
|
Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
|
|
Academic Article
|
Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
|
|
Academic Article
|
Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
|
|
Academic Article
|
Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
|
|
Academic Article
|
Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
|
|
Academic Article
|
Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.
|
|
Academic Article
|
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
|
|
Academic Article
|
Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
|
|
Academic Article
|
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
|
|
Academic Article
|
Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
|
|
Academic Article
|
Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
|
|
Academic Article
|
Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases.
|
|
Academic Article
|
FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
|
|
Academic Article
|
PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
|
|
Academic Article
|
Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
|
|
Academic Article
|
Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
|
|
Academic Article
|
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
|
|
Academic Article
|
IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
|
|
Academic Article
|
Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
|
|
Academic Article
|
Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
|
|
Academic Article
|
IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
|
|
Academic Article
|
ß1 integrin is a crucial regulator of pancreatic ß-cell expansion.
|
|
Academic Article
|
Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
|
|
Academic Article
|
Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic ß-Cell Line INS-1* * This work was supported by grants from the NIH (GK-55267), the Juvenile Diabetes Foundation International, the German Research Society, and BetaGene, Inc.
|
|
Academic Article
|
Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes.
|
|
Academic Article
|
Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
|
|
Academic Article
|
Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
|
|
Academic Article
|
Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
|
|
Grant
|
Mitogenic Signal Transduction in Pancreatic Beta-Cells
|
|
Grant
|
Metabolic Control of Insulin Exocytosis
|
|
Grant
|
Central Control of Pancreatic Islet Function
|
|
Grant
|
Metabolic Control of Proinsulin Biosynthesis Translation
|
|
Grant
|
Metabolic Control of Proinsulin Biosynthesis Translation
|