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One or more keywords matched the following properties of Feder, Martin
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overview My research focuses on understanding adaptation to the environment from both a mechanistic and evolutionary perspective; i.e., how organisms function in natural environments, the mechanisms underlying this function, the evolutionary origin, maintenance, and constraint of this function, the evolutionary consequences of variation in function, and how all of these aspects are encoded or reflected in the genome. Thus, my research focuses at the intersection of the four disciplinary domains shown to the left; i.e., evolutionary and ecological functional genomics. My research program addresses this suite of issues through a multidisciplinary, problem-oriented approach. My present emphasis is on ecological and evolutionary physiology of the stress response [the induction of a specific suite of proteins (stress or heat-shock proteins) by extreme temperatures and other stresses]. Several projects are underway, with a common theme: HEAT-SHOCK PROTEINS AND GENES Specifically, my laboratory investigates the heat-shock protein Hsp70, its encoding genes, and its regulation in Drosophila as a model system for understanding evolutionary adaptation. Hsp70 is a molecular chaperone that deters stress-induced protein aggregation, but has numerous other functions. Hsp70 is necessary for full-strength tolerance (in terms of survival, normal development, normal function) of high temperature. Such tolerance is critical in nature, where non-adult Drosophila undergo harmful to lethal high temperatures. In nature, Drosophila populations vary in stress tolerance and Hsp70 levels. Our current major focus is on understanding the genomic basis for this variation. The number of hsp70 gene copies and evolution of the hsp70 coding sequence are partial or inadequate explanations. Evidently cis-regulatory regions such as proximal promoters underlie intraspecific variation in Hsp70 levels. Repeated insertion of mobile genetic elements into these promoters is a recurrent mechanism of evolution.
One or more keywords matched the following items that are connected to Feder, Martin
Item TypeName
Concept Body Temperature
Concept Body Temperature Regulation
Concept Hot Temperature
Concept Temperature
Academic Article Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster.
Academic Article Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae.
Academic Article Laboratory selection at different temperatures modifies heat-shock transcription factor (HSF) activation in Drosophila melanogaster.
Academic Article A Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression.
Academic Article Response to natural and laboratory selection at the Drosophila hsp70 genes.
Academic Article Hsp70 and thermal pretreatment mitigate developmental damage caused by mitotic poisons in Drosophila.
Academic Article Evolvability of Hsp70 expression under artificial election for inducible thermotolerance in independent populations of Drosophila melanogaster.
Academic Article Evolution of thermotolerance and the heat-shock response: evidence from inter/intraspecific comparison and interspecific hybridization in the virilis species group of Drosophila. I. Thermal phenotype.
Academic Article Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable elements.
Academic Article Dropping like flies: environmentally induced impairment and protection of locomotor performance in adult Drosophila melanogaster.
Academic Article Evolution and arrangement of the hsp70 gene cluster in two closely related species of the virilis group of Drosophila.
Academic Article Locomotion in response to shifting climate zones: not so fast.
Academic Article Location of P element insertions in the proximal promoter region of Hsp70A is consequential for gene expression and correlated with fecundity in Drosophila melanogaster.
Academic Article Acclimation to constant and variable temperatures in plethodontid salamanders--I. Rates of oxygen consumption.
Academic Article Effect of thermal acclimation on locomotor energetics and locomotor performance in a lungless salamander, Desmognathus ochrophaeus.
Academic Article Ecological and evolutionary physiology of heat shock proteins and the stress response in Drosophila: complementary insights from genetic engineering and natural variation.
Academic Article Temperatuer selection by the red-backed salamander, Plethodon c. cinereus (Green) (Caudata: Plethodontidae).
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