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overview Dr. Pinto's research program has three major thematic goals: 1) To understand the effect of aging on sinonasal and sensory disorders 2) To determine how genetics, the environment, and social context (and their interaction) modulate susceptibility to these conditions 3) To use this information to develop and test novel treatments for these and other common conditions of the ear, nose, and throat He utilizes tools from the fields of demography, genetic epidemiology, genomics, public health and sociology to accomplish these goals. Dr. Pinto's research is funded by the National Institute on Aging and the National Institute of Allergy and Infectious Disease. Research Projects: Epidemiology of Presbyosmia (Age-Related Olfactory Decline) We are exploiting data from the National Social Life, Health, and Aging Project (NSHAP) (led by Linda Waite in Sociology), to study the demographic and other non-genetic factors that are associated with olfactory decline in aging. We have identified race as a key factor that is independently associated with olfactory function and demonstrated that anosmia predicts five year all cause mortality in US adults, providing some the first nationally representative data on this condition. We are also examining the rich array of health and social measures available in NSHAP, including state of the art biomeasures to determine underlying biological mechanisms and environmental determinants. Additional members of the Olfactory Research Group (the ORG) include Martha McClintock in Psychology and William Dale in Geriatric and Palliative Medicine, along with statisticians Kristin Wroblewski and Philip Schumm in Public Health Studies. Genetics of Presbyosmia ?We are employing genome wide association studies in a founder population to identify genetic variation that underlies age-related olfactory loss using quantitative trait loci mapping in collaboration with Carole Ober in Human Genetics. We published the first successful linkage study for an olfactory trait in humans and are pursuing other collaborations (David Bennett, Rush University) to identify genetic contributions to this important disorder. Genetics of Chronic Rhinosinusitis We are performing state of the art genetic, epigenetic, and genomic studies of CRS as part of the Chronic Rhinosinusitis Integrated Studies Program, a U19 award from the National Institute of Allergy and Infectious Disease in collaboration with Northwestern University (Robert Schleimer) and Johns Hopkins University/Geisinger Health System (Brian Schwartz). The project at The University of Chicago, in partnership with Carole Ober, focuses on genetic variation in pathogen response. Our project is the only National Institutes of Health-funded project on the genetics of this disorder. The Upper Airway Microbiome We have shown that the microbial ecology in the middle meatus of the sinuses is altered in allergic subjects, potentially predisposing to disease. We have several ongoing investigations into how the sinonasal microbiome predicts physiological changes in both the upper and lower airway, as well as factors that affect its composition and function. Collaborating on these projects are Robert Naclerio and Fuad Baroody in OHNS, along with Carole Ober and Yoav Gilad in Human Genetics. Rhinology Clinical Trials and Translational Research The Nasal Physiology Laboratory, a joint endeavor with Robert Naclerio and Fuad Baroody, runs ongoing clinical trials and translational studies of conditions such as allergic and non-allergic rhinitis, chronic rhinosinusitis, nasal polyposis, and other common conditions. Call 773-702-5889 for details on our current projects.

One or more keywords matched the following items that are connected to Pinto, Jayant M.

Item TypeName
Concept Adult
Concept Young Adult
Academic Article Treatment of nasal inflammation decreases the ability of subjects with asthma to condition inspired air.
Academic Article Alpha-adrenoreceptor blockade with phenoxybenzamine does not affect the ability of the nose to condition air.
Academic Article Familial aggregation of nasal conditioning capacity.
Academic Article Delayed maxillary sinusitis after orbital floor repair.
Academic Article Effect of changing airway pressure on the ability of the human nose to warm and humidify air.
Academic Article Elucidating the mechanism underlying the ocular symptoms associated with allergic rhinitis.
Academic Article Olfactory cleft inflammation is present in seasonal allergic rhinitis and is reduced with intranasal steroids.
Academic Article Recruitment factors which affect the outcome of a seasonal allergic rhinitis trial.
Academic Article Otolaryngology (urban) legend: the more programs to which you apply, the better the chances of matching.
Academic Article Peripheral blood and tissue T regulatory cells in chronic rhinosinusitis.
Academic Article A randomized, double-blind, placebo-controlled trial of anti-IgE for chronic rhinosinusitis.
Academic Article Serum 25-hydroxyvitamin D levels are lower in urban African American subjects with chronic rhinosinusitis.
Academic Article Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors.
Academic Article Surgical microanatomy of the müller muscle-conjunctival resection ptosis procedure.
Academic Article A genome-wide screen for hyposmia susceptibility Loci.
Academic Article A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.
Academic Article Current status of lymphography in the management of lymphomas.
Academic Article Ewing's sarcoma--5 years experience with chemotherapy.
Academic Article Systematic study of occult pulmonary thromboembolism in patients with deep venous thrombosis.
Academic Article Olfactory dysfunction predicts 5-year mortality in older adults.
Academic Article Gray matter volume reduction of olfactory cortices in patients with idiopathic olfactory loss.
Academic Article Racial disparities in olfactory loss among older adults in the United States.
Academic Article Seasonal allergic rhinitis affects sinonasal microbiota.
Academic Article Does airway surgery lower serum lipid levels in obstructive sleep apnea patients? A retrospective case review.
Academic Article Olfactory thresholds of the U.S. Population of home-dwelling older adults: development and validation of a short, reliable measure.
Academic Article Effect of prednisone on nasal symptoms and peripheral blood T-cell function in chronic rhinosinusitis.
Academic Article The effect of nasal structure on olfactory function in patients with OSA.
Academic Article Computer-assisted staging of chronic rhinosinusitis correlates with symptoms.
Academic Article Diagnostic algorithm for unilateral sinus disease: a 15-year retrospective review.
Academic Article Adequate continuous positive airway pressure therapy reduces mortality in Chinese patients with obstructive sleep apnea.
Academic Article The Rate of Age-Related Olfactory Decline Among the General Population of Older U.S. Adults.
Academic Article Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults.
Academic Article Can upper airway surgery for OSA protect against cardiovascular sequelae via effects on coagulation?
Academic Article Global Sensory Impairment in Older Adults in the United States.
Academic Article Nasal Microbiome Composition Is Associated with Chitotriosidase (Chit1) Activity in Adult Hutterites.
Academic Article Olfactory Dysfunction in Older Adults is Associated with Feelings of Depression and Loneliness.
Academic Article A clinical trial of a microcrystalline cellulose topical nasal spray on the acute response to allergen challenge.
Academic Article Gender difference in Chinese adults with post-viral olfactory disorder:a hospital-based study.
Academic Article Fine particulate matter exposure and olfactory dysfunction among urban-dwelling older US adults.
Academic Article Allergy and asthma medication use in home-dwelling U.S. older adults.
Academic Article Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.
Academic Article Chondrosarcoma--a roentgenographic and follow-up study.
Academic Article Factors Associated with Inaccurate Self-Reporting of Olfactory Dysfunction in Older US Adults.
Academic Article Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.
Academic Article Nitrogen dioxide pollution exposure is associated with olfactory dysfunction in older U.S. adults.
Academic Article The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults.
Academic Article Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults.
Academic Article Three-dimensional image analysis for staging chronic rhinosinusitis.
Academic Article Sensory Dysfunction and Sexuality in the U.S. Population of Older Adults.
Academic Article Patient and surgeon factors explain variation in the frequency of frontal sinus surgery.
Academic Article Evaluation of idiopathic olfactory loss with chemosensory event-related potentials and magnetic resonance imaging.
Academic Article Olfactory cortex and Olfactory bulb volume alterations in patients with post-infectious Olfactory loss.
Academic Article Cognitive Function and its Risk Factors Among Older US Adults Living at Home.
Academic Article A Retrospective Study to Compare the Use of the Mean Apnea-Hypopnea Duration and the Apnea-Hypopnea Index with Blood Oxygenation and Sleep Patterns in Patients with Obstructive Sleep Apnea Diagnosed by Polysomnography.
Academic Article Olfactory Dysfunction Predicts Subsequent Dementia in Older U.S. Adults.
Academic Article Sleep and Olfaction among Older Adults.
Academic Article Relationship Between Poor Olfaction and Mortality Among Community-Dwelling Older Adults: A Cohort Study.
Academic Article Radiologic sinus inflammation and symptoms of chronic rhinosinusitis in a population-based sample.
Academic Article Olfaction and Changes in Body Composition in a Large Cohort of Older U.S. Adults.
Academic Article IL-1Rahigh-IL-4low-IL-13low: A Novel Plasma Cytokine Signature Associated with Olfactory Dysfunction in Older US Adults.
Academic Article Odor Sensitivity Versus Odor Identification in Older US Adults: Associations With Cognition, Age, Gender, and Race.
Academic Article Hearing Impairment and Loneliness in Older Adults in the United States.
Academic Article Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex Reverse-Transcription Polymerase Chain Reaction.
Academic Article The Specter of Olfactory Impairment: Lessons About Mortality in Older US Adults.
Academic Article Olfactory Dysfunction Predicts the Development of Depression in Older US Adults.
Academic Article Sleep-Disordered Breathing Is Associated With Impaired Odor Identification in Older U.S. Adults.
Academic Article Olfaction Is Associated With Sexual Motivation and Satisfaction in Older Men and Women.
Academic Article Exposure to Particulate Matter Air Pollution and Anosmia.
Academic Article Long-Term Exposure to Particulate Matter Air Pollution and Chronic Rhinosinusitis in Nonallergic Patients.

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