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One or more keywords matched the following properties of Pinto, Jayant M.
overview Dr. Pinto's research program has three major thematic goals: 1) To understand the effect of aging on sinonasal and sensory disorders 2) To determine how genetics, the environment, and social context (and their interaction) modulate susceptibility to these conditions 3) To use this information to develop and test novel treatments for these and other common conditions of the ear, nose, and throat He utilizes tools from the fields of demography, genetic epidemiology, genomics, public health and sociology to accomplish these goals. Dr. Pinto's research is funded by the National Institute on Aging and the National Institute of Allergy and Infectious Disease. Research Projects: Epidemiology of Presbyosmia (Age-Related Olfactory Decline) We are exploiting data from the National Social Life, Health, and Aging Project (NSHAP) (led by Linda Waite in Sociology), to study the demographic and other non-genetic factors that are associated with olfactory decline in aging. We have identified race as a key factor that is independently associated with olfactory function and demonstrated that anosmia predicts five year all cause mortality in US adults, providing some the first nationally representative data on this condition. We are also examining the rich array of health and social measures available in NSHAP, including state of the art biomeasures to determine underlying biological mechanisms and environmental determinants. Additional members of the Olfactory Research Group (the ORG) include Martha McClintock in Psychology and William Dale in Geriatric and Palliative Medicine, along with statisticians Kristin Wroblewski and Philip Schumm in Public Health Studies. Genetics of Presbyosmia ?We are employing genome wide association studies in a founder population to identify genetic variation that underlies age-related olfactory loss using quantitative trait loci mapping in collaboration with Carole Ober in Human Genetics. We published the first successful linkage study for an olfactory trait in humans and are pursuing other collaborations (David Bennett, Rush University) to identify genetic contributions to this important disorder. Genetics of Chronic Rhinosinusitis We are performing state of the art genetic, epigenetic, and genomic studies of CRS as part of the Chronic Rhinosinusitis Integrated Studies Program, a U19 award from the National Institute of Allergy and Infectious Disease in collaboration with Northwestern University (Robert Schleimer) and Johns Hopkins University/Geisinger Health System (Brian Schwartz). The project at The University of Chicago, in partnership with Carole Ober, focuses on genetic variation in pathogen response. Our project is the only National Institutes of Health-funded project on the genetics of this disorder. The Upper Airway Microbiome We have shown that the microbial ecology in the middle meatus of the sinuses is altered in allergic subjects, potentially predisposing to disease. We have several ongoing investigations into how the sinonasal microbiome predicts physiological changes in both the upper and lower airway, as well as factors that affect its composition and function. Collaborating on these projects are Robert Naclerio and Fuad Baroody in OHNS, along with Carole Ober and Yoav Gilad in Human Genetics. Rhinology Clinical Trials and Translational Research The Nasal Physiology Laboratory, a joint endeavor with Robert Naclerio and Fuad Baroody, runs ongoing clinical trials and translational studies of conditions such as allergic and non-allergic rhinitis, chronic rhinosinusitis, nasal polyposis, and other common conditions. Call 773-702-5889 for details on our current projects.
One or more keywords matched the following items that are connected to Pinto, Jayant M.
Item TypeName
Concept Aging
Academic Article Olfactory function in Wave 2 of the National Social Life, Health, and Aging Project.
Academic Article Sensory function: insights from Wave 2 of the National Social Life, Health, and Aging Project.
Academic Article Olfactory thresholds of the U.S. Population of home-dwelling older adults: development and validation of a short, reliable measure.
Academic Article Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans.
Academic Article The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults.
Academic Article Sensory Dysfunction and Sexuality in the U.S. Population of Older Adults.
Academic Article Aging in the United States: Opportunities and Challenges for Otolaryngology-Head and Neck Surgery.
Academic Article Sleep and Olfaction among Older Adults.
Academic Article Hearing Impairment and Loneliness in Older Adults in the United States.
Academic Article Exploring Shared Effects of Multisensory Impairment, Physical Dysfunction, and Cognitive Impairment on Physical Activity: An Observational Study in a National Sample.
Academic Article Olfactory loss and aging: connections with health and well-being.
Academic Article Rapid olfactory decline during aging predicts dementia and GMV loss in AD brain regions.
Academic Article Sensory Health Among Older Adults in the United States: A Neighborhood Context Approach.
Search Criteria
  • Healthy Aging