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Tang, Wei-Jen

One or more keywords matched the following items that are connected to Tang, Wei-Jen

Item Type	Name
Concept	Binding Sites
Academic Article	Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Academic Article	Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities.
Academic Article	Ubiquitin is a novel substrate for human insulin-degrading enzyme.
Academic Article	Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors.
Academic Article	Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
Academic Article	An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis.
Academic Article	Conversion of forskolin-insensitive to forskolin-sensitive (mouse-type IX) adenylyl cyclase.
Academic Article	Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site.
Academic Article	Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.
Academic Article	A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step.
Academic Article	Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.
Academic Article	Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme.
Academic Article	Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
Academic Article	The adenylyl cyclase activity of anthrax edema factor.
Academic Article	Three discrete regions of mammalian adenylyl cyclase form a site for Gsalpha activation.
Academic Article	Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Academic Article	Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
Academic Article	Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.
Academic Article	Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates.

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