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Ghosh, Asish
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Air-pollutant PM2.5
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Academic Interests: Google Scholar Citations: 7015.
Dr. Ghosh’s major research interest focuses on the molecular, genetic, and epigenetic regulation of chronological and stress-induced accelerated cellular senescence and aging-associated cardiovascular disease. Using genetic and pharmacologic approaches, Dr. Ghosh originally demonstrated the essential role of a major epigenetic regulator, acetyltransferase p300 in profibrogenic signal-induced collagen synthesis and fibrogenesis. Dr. Ghosh and colleagues further defined the significance of physical and functional interaction of p300 with several pro-fibrotic and anti-fibrotic regulators/transcription factors in controlling profibrogenic signaling and the synthesis of type I collagen, a major extracellular matrix protein in the fibrotic tissues. He is interested to investigate the impact of epigenetics in stressor-induced cellular senescence, and cardiac aging in an animal model of atrial fibrillation, and the underlying mechanisms using biochemical, immunocytochemistry, immunohistochemistry, transcriptomics and proteomics approaches. His goal is to continue doing innovative research on cardiac aging in collaboration with experts in the field of aging research, and to provide excellent guidance in research to students and trainees.
Dr. Ghosh's Scientific Research is Funded by the Grants from the American Heart Association, the National Institutes of Health and the National Scleroderma Foundation:
1. NIH R35HL161249. Title: "New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial Fibrillation.” Project Period: 1/2022-12/2028. Role: Co-Investigator
2. NIH R01HL152712. Title: "The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heart". Project Period: 01/2021-12/2024. Role: Co-Investigator
3. NIH 5R01HL14276. Title: "Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology". Project Period: 2019-2022. Role: Co-Investigator.
4. NIH 5R01HL051387. Title: " PAI-1 and Vascular Senescence". Project Period: 2018-2022. Role: Co-Investigator.
5. AHA 18IPA34170365. Innovative Project Award American Heart Association; Title: “Role of plasminogen activator system in air pollutants-induced cardiovascular disease.” Project Period: 2018-2021. Role: Principal-Investigator.
6. AHA 16GRNT31130010. Grant-in-Aid Award American Heart Association; Title: “Acetyltransferase p300 in myofibroblast differentiation and cardiac fibrosis." Project Period: 2016-2019. Role: Principal Investigator.
7. NIH 1P01HL108795. Program Project Grant (PPG). Title: "Cardiovascular Regenerative Medicine". Project Title: "Role of PAI-1 in Cardiovascular Repair and Fibrosis” Project Period: 2011-2016. Role: Co-Principal Investigator.
8. NIH R01 HL051387. Title: "Angiotensin, the Vascular Endothelium, and Fibrinolysis.” Project Period: 2008-2012. Role: Co-Investigator
9. National Scleroderma Foundation Project #007/06. Title: "Role of transcriptional coactivator p300 in Scleroderma”. Project Period: 2006-2008. Role: Co-Principal Investigator.
10. NIH 5R01AR042309. Title: "Molecular basis of fibrosis: regulation of collagen by TGF-beta.” Project Period: 1999-2008. Role: Co-Investigator.
11. National Scleroderma Foundation Project #004/04. Title: “Repression of TGF-beta signaling by PPAR-gamma: Novel approach to controlling fibrosis.” Project Period: 2004-2006. Role: Principal Investigator.
12. National Scleroderma Foundation grant. Project #005/01. Title: "Regulation of Type I collagen gene expression by tumor suppressor gene p53: implication in Scleroderma”. Project Period: 2001-2003. Role: Principal Investigator.
13. NIH 1R03AR046390. Title: "Cytokine Modulation of Collagen Gene Expression: Signal Integration by Coactivators.” Project Period: 1999-2002. Role: Principal Investigator.
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Ghosh, Asish