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Search Results to Michaela Gack

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overview Understanding host-virus interactions is an essential step in developing safe and effective antimicrobials against existing and newly emerging pathogens. The early detection of invading viruses by the host depends on a limited number of specific receptors that detect viral patterns and activate signaling cascades, thereby triggering interferon (IFN)-mediated antiviral defense mechanisms. Intracellular innate immune receptors, such as RIG-I-like receptors (RLRs) and the intracellular viral DNA sensors cGAS and IFI16, detect a variety of RNA and DNA viruses including influenza virus, measles virus, dengue virus and herpesviruses. In addition, members of the tripartite motif (TRIM) protein family play a major role in the antiviral host response. Research in the Gack laboratory seeks a better understanding of the cell-intrinsic mechanisms underlying the host innate immune response against viral infections. Another area of our research focuses on the detailed mechanisms by which viral pathogens – influenza viruses, measles virus, dengue virus and herpesviruses – suppress the innate immune system. The Gack laboratory uses an integrative approach that combines RNAi screens and proteomics with molecular, biochemical, and cell-biological approaches as well as viral infection studies including reverse genetics systems for the generation of recombinant mutant viruses.

One or more keywords matched the following items that are connected to Gack, Michaela

Item TypeName
Concept RNA, Ribosomal, 5S
Concept RNA, Viral
Concept RNA Viruses
Concept RNA
Concept RNA Interference
Concept RNA-Binding Proteins
Concept RNA, Double-Stranded
Concept DEAD-box RNA Helicases
Concept RNA Transport
Concept RNA, Small Interfering
Concept RNA Stability
Academic Article Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.
Academic Article Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
Academic Article RIG-I-like receptor regulation in virus infection and immunity.
Academic Article Conventional protein kinase C-a (PKC-a) and PKC-ß negatively regulate RIG-I antiviral signal transduction.
Academic Article Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.
Academic Article Ubiquitination in the antiviral immune response.
Academic Article Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
Academic Article Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.
Academic Article Regulation of RIG-I-like receptor signaling by host and viral proteins.
Academic Article Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.
Academic Article Phosphorylation-mediated negative regulation of RIG-I antiviral activity.
Academic Article Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production.
Academic Article TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
Academic Article RIG-I works double duty.
Academic Article The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25.
Academic Article Mechanisms of RIG-I-like receptor activation and manipulation by viral pathogens.
Academic Article Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.
Academic Article Intracellular detection of viral nucleic acids.
Academic Article A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.
Academic Article Viral evasion of intracellular DNA and RNA sensing.
Academic Article TRIM23 mediates virus-induced autophagy via activation of TBK1.
Academic Article Dusting for flu's fingerprints.
Academic Article Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.
Academic Article TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense.
Academic Article Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity.
Academic Article Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy.
Academic Article Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity.
Academic Article Evasion of Innate and Intrinsic Antiviral Pathways by the Zika Virus.
Academic Article RIG-I-like receptors: their regulation and roles in RNA sensing.
Academic Article Fixed single-cell RNA sequencing for understanding virus infection and host response.
Academic Article The BRCA1 Pseudogene Negatively Regulates Antitumor Responses through Inhibition of Innate Immune Defense Mechanisms.
Academic Article Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
Academic Article ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease.
Academic Article Nonsense-mediated decay controls the reactivation of the oncogenic herpesviruses EBV and KSHV.
Academic Article The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25's RNA Binding Ability.

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