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One or more keywords matched the following properties of Kratsios, Paschalis
PropertyValue
keywords Transcription Factors
keywords chromatin factors
overview My lab uses the specific strengths of two model systems (C.elegans and mice) to reveal the gene regulatory mechanisms that control motor neuron development and function. To reveal such mechanisms we employ novel methodology, such as whole genome sequencing, CRISPR genome editing, ATAC-seq and cell type-specific transcriptome profiling. Our laboratory aims to systematically test whether the function of the gene regulatory factors we discover in C.elegans is conserved across phylogeny using mouse genetics and novel genomic approaches. A detailed understanding of how the motor neurons develop and function may provide novel entry points into the etiology, diagnosis or treatment of motor neuron disorders, such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). From the basic science perspective, our research will reveal novel transcription factors, their targets and the cis-regulatory elements (motifs) through which these factors act. Such decoding of cis-regulatory information is a vital step toward understanding genome function.
One or more keywords matched the following items that are connected to Kratsios, Paschalis
Item TypeName
Concept Age Factors
Concept Time Factors
Concept Basic Helix-Loop-Helix Transcription Factors
Academic Article Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart.
Academic Article Transcriptional coordination of synaptogenesis and neurotransmitter signaling.
Academic Article Direct conversion of C. elegans germ cells into specific neuron types.
Academic Article Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector gene.
Academic Article Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression.
Academic Article An intersectional gene regulatory strategy defines subclass diversity of C. elegans motor neurons.
Academic Article Nervous System Development: Flies and Worms Converging on Neuron Identity Control.
Academic Article An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.
Academic Article Transcriptional mechanisms of motor neuron development in vertebrates and invertebrates.
Academic Article A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life.
Academic Article Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function.
Academic Article Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity.
Academic Article Widespread employment of conserved C. elegans homeobox genes in neuronal identity specification.
Academic Article Maintenance of neurotransmitter identity by Hox proteins through a homeostatic mechanism.
Academic Article Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation.
Grant Gene regulatory mechanisms that assign and maintain motor neuron terminal differe
Grant Hox-dependent mechanisms for establishment and maintenance of motor neuron terminal identity
Grant Identification of the transcriptional targets of three conserved regulatory factors necessary for motor neuron subtype function - Resubmission 01
Grant Gene regulatory mechanisms that assign and maintain motor neuron terminal differe
Grant Molecular mechanisms of motor neuron terminal identity
Academic Article Maintenance of neuronal identity in C. elegans and beyond: Lessons from transcription and chromatin factors.
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