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One or more keywords matched the following properties of Pitroda, Sean
keywords Metastasis
overview My long-term vision is to improve the treatment of metastatic disease through clinical research. I believe this can only be achieved through challenging the prevailing view that metastases are always widespread and incurable. My laboratory utilizes integrative molecular analyses of clinical metastases, bioinformatics and computational tools, tumor models, molecular biology, immunologic analyses, and statistical modeling to investigate: (1) biological mechanisms that restrict the potential curability of patients with limited metastatic disease following localized therapies, such as surgery and ablative radiotherapy, and (2) the interplay between ablative radiotherapy and immune checkpoint blockade in patients with metastatic disease. We discovered the first biological basis for curable metastasis in patients with colorectal cancer who underwent surgical resection of limited de novo liver metastases, whereby robust adaptive immune activation in concert with favorable clinical factors was associated with a 10-year overall survival of ~95% following surgery (Nature Communications 2018). Recently, we discovered that concurrent administration of ablative radiotherapy with immunotherapy augmented local tumor immunity and improved survival in patients with highly aneuploid non-small cell lung cancer (Nature Cancer 2022). In addition, we validated a tumor aneuploidy score as a novel biomarker of immunotherapy response across multiple human cancers (Nature Genetics 2022). I anticipate these findings will ultimately have important implications in the delineation of those patients with potentially curable metastatic disease from those whose few metastases are part of a large cascade of widespread disease, thereby advancing the paradigm for the treatment of metastatic cancers.
One or more keywords matched the following items that are connected to Pitroda, Sean
Item TypeName
Concept Neoplasm Metastasis
Academic Article MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment.
Academic Article STAT1 pathway mediates amplification of metastatic potential and resistance to therapy.
Academic Article Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells.
Academic Article microRNAs and oligometastasis.
Academic Article 14q32-encoded microRNAs mediate an oligometastatic phenotype.
Academic Article Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome.
Academic Article Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT).
Academic Article Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones.
Academic Article Ad.Egr-TNF and Local Ionizing Radiation Suppress Metastases by Interferon-ß-Dependent Activation of Antigen-specific CD8+ T Cells.
Academic Article Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.
Academic Article Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
Academic Article Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.
Academic Article Oligometastatic prostate cancer: Reality or figment of imagination?
Academic Article DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs.
Academic Article Staging the Metastatic Spectrum Through Integration of Clinical and Molecular Features.
Academic Article Integrated molecular and clinical staging defines the spectrum of metastatic cancer.
Academic Article Beyond Palliation: The Rationale for Metastasis-Directed Therapy for Metastatic Non-Small Cell Lung Cancer.
Academic Article Integration of radiotherapy and immunotherapy for treatment of oligometastases.
Academic Article Definition, Biology, and History of Oligometastatic and Oligoprogressive Disease.
Academic Article A Validated T Cell Radiomics Score Is Associated With Clinical Outcomes Following Multisite SBRT and Pembrolizumab.
Academic Article Cytoreduction and the Optimization Of Immune Checkpoint Inhibition with Radiation Therapy.
Academic Article Improved Survival Associated with Local Tumor Response Following Multisite Radiotherapy and Pembrolizumab: Secondary Analysis of a Phase I Trial.
Academic Article (Oligo)metastasis as a Spectrum of Disease.
Academic Article The Spectrum of Metastasis: An Opportunity for Cure?
Academic Article Treatment of Cancer with Radio-Immunotherapy: What We Currently Know and What the Future May Hold.
Academic Article Prospective Evaluation of Stereotactic Body Radiotherapy and Immunotherapy for Mediastinal and Hilar Lymph Node Metastases.
Academic Article Stereotactic Body Radiation Therapy and Immunotherapy in Abdominal and Pelvic Lymph Node Metastases.
Academic Article The oligometastatic spectrum in the era of improved detection and modern systemic therapy.
Academic Article Beyond the Visible Spectrum: Considering the Oligometastatic Hypothesis in the Light of a New Era.
Academic Article A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy.
Search Criteria
  • Neoplasm Metastasis