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Search Results to Sean Pitroda

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One or more keywords matched the following properties of Pitroda, Sean

keywords Metastasis
overview Dr. Sean Pitroda investigates tumor mechanisms that restrict the potential curability of patients with limited metastatic disease following localized therapies, such as surgery or ablative radiotherapy. Dr. Pitroda's research utilizes integrative genome-wide molecular analyses of clinical metastases, molecular biology, CRISPR-Cas9 genome editing, animal models, immune analysis, and statistical modeling towards translational research goals. Recently, through analysis of independent clinical cohorts of colorectal cancer patients who underwent surgical resection of limited de novo liver metastases, he discovered a biological basis for curable metastasis (Pitroda SP et al, Nature Communications 2018). Specifically, patients with metastases exhibiting robust adaptive immune activation experienced a 10-year survival of ~95% following surgical resection. Building upon this finding, Dr. Pitroda's laboratory is characterizing tumor and host determinants of immune evasion. Studies employing prospectively collected patient tissue and blood specimens in parallel with tumor immunology murine models are expected to corroborate his hypotheses. In this way, his findings will shed light on strategies to augment antitumor immune function. Dr. Pitroda anticipates these findings will ultimately have important implications in the selection of local therapy for those patients with potentially curable metastatic disease from those whose few metastases are a part of a large cascade of widespread disease, thereby changing the paradigm for the treatment of metastatic cancers.

One or more keywords matched the following items that are connected to Pitroda, Sean

Item TypeName
Concept Neoplasm Metastasis
Academic Article MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment.
Academic Article STAT1 pathway mediates amplification of metastatic potential and resistance to therapy.
Academic Article Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells.
Academic Article microRNAs and oligometastasis.
Academic Article 14q32-encoded microRNAs mediate an oligometastatic phenotype.
Academic Article Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome.
Academic Article Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT).
Academic Article Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones.
Academic Article Ad.Egr-TNF and Local Ionizing Radiation Suppress Metastases by Interferon-ß-Dependent Activation of Antigen-specific CD8+ T Cells.
Academic Article Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.
Academic Article Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
Academic Article Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.
Academic Article Oligometastatic prostate cancer: Reality or figment of imagination?
Academic Article DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs.
Academic Article Staging the Metastatic Spectrum Through Integration of Clinical and Molecular Features.
Academic Article Integrated molecular and clinical staging defines the spectrum of metastatic cancer.
Academic Article Beyond Palliation: The Rationale for Metastasis-Directed Therapy for Metastatic Non-Small Cell Lung Cancer.
Academic Article Integration of radiotherapy and immunotherapy for treatment of oligometastases.
Academic Article Definition, Biology, and History of Oligometastatic and Oligoprogressive Disease.
Academic Article A Validated T Cell Radiomics Score Is Associated With Clinical Outcomes Following Multisite SBRT and Pembrolizumab.
Academic Article Cytoreduction and the Optimization Of Immune Checkpoint Inhibition with Radiation Therapy.
Academic Article Improved Survival Associated with Local Tumor Response Following Multisite Radiotherapy and Pembrolizumab: Secondary Analysis of a Phase I Trial.
Academic Article (Oligo)metastasis as a Spectrum of Disease.
Academic Article The Spectrum of Metastasis: An Opportunity for Cure?
Academic Article Treatment of Cancer with Radio-Immunotherapy: What We Currently Know and What the Future May Hold.
Academic Article Prospective Evaluation of Stereotactic Body Radiotherapy and Immunotherapy for Mediastinal and Hilar Lymph Node Metastases.
Academic Article Stereotactic Body Radiation Therapy and Immunotherapy in Abdominal and Pelvic Lymph Node Metastases.

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  • Neoplasm Metastasis