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Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.
2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.
2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells.
2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells.
Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells.