"Acetyl-CoA Carboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.
| Descriptor ID |
D000103
|
| MeSH Number(s) |
D08.811.464.257.050 D08.811.641.249
|
| Concept/Terms |
Acetyl-CoA Carboxylase- Acetyl-CoA Carboxylase
- Acetyl CoA Carboxylase
- Carboxylase, Acetyl-CoA
- Acetyl Coenzyme A Carboxylase
|
Below are MeSH descriptors whose meaning is more general than "Acetyl-CoA Carboxylase".
Below are MeSH descriptors whose meaning is more specific than "Acetyl-CoA Carboxylase".
This graph shows the total number of publications written about "Acetyl-CoA Carboxylase" by people in this website by year, and whether "Acetyl-CoA Carboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 0 | 2 |
| 1994 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 2 | 0 | 2 |
| 2001 | 3 | 0 | 3 |
| 2002 | 3 | 0 | 3 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Acetyl-CoA Carboxylase" by people in Profiles.
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GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2018 11; 155(5):1463-1473.e6.
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Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor. FEBS Lett. 2018 06; 592(12):2048-2058.
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Lipid-Lowering Drug Therapy for CVD Prevention: Looking into the Future. Curr Cardiol Rep. 2015 Nov; 17(11):104.
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LKB1 couples glucose metabolism to insulin secretion in mice. Diabetologia. 2015 Jul; 58(7):1513-22.
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Resistance to herbicides caused by single amino acid mutations in acetyl-CoA carboxylase in resistant populations of grassy weeds. New Phytol. 2013 Mar; 197(4):1110-1116.
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Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9093-8.
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A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet. 2010 Feb 12; 6(2):e1000842.
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Acc homoeoloci and the evolution of wheat genomes. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9691-6.
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Single-site mutations in the carboxyltransferase domain of plastid acetyl-CoA carboxylase confer resistance to grass-specific herbicides. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3627-32.
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Complex nested promoters control tissue-specific expression of acetyl-CoA carboxylase genes in wheat. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1403-8.