 Acetyl-CoA Carboxylase
"Acetyl-CoA Carboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.
| Descriptor ID |
D000103
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| MeSH Number(s) |
D08.811.464.257.050
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| Concept/Terms |
Acetyl-CoA Carboxylase- Acetyl-CoA Carboxylase
- Acetyl CoA Carboxylase
- Carboxylase, Acetyl-CoA
- Acetyl Coenzyme A Carboxylase
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Below are MeSH descriptors whose meaning is more general than "Acetyl-CoA Carboxylase".
Below are MeSH descriptors whose meaning is more specific than "Acetyl-CoA Carboxylase".
This graph shows the total number of publications written about "Acetyl-CoA Carboxylase" by people in this website by year, and whether "Acetyl-CoA Carboxylase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 0 | 2 | | 1994 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1999 | 2 | 0 | 2 | | 2001 | 3 | 0 | 3 | | 2002 | 3 | 0 | 3 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2015 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Acetyl-CoA Carboxylase" by people in Profiles.
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Loomba R, Kayali Z, Noureddin M, Ruane P, Lawitz EJ, Bennett M, Wang L, Harting E, Tarrant JM, McColgan BJ, Chung C, Ray AS, Subramanian GM, Myers RP, Middleton MS, Lai M, Charlton M, Harrison SA. GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology. 2018 11; 155(5):1463-1473.e6.
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Jang S, Gornicki P, Marjanovic J, Bass E, P Iurcotta T, Rodriguez P, Austin J, Haselkorn R. Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor. FEBS Lett. 2018 06; 592(12):2048-2058.
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Stein EA, Raal FJ. Lipid-Lowering Drug Therapy for CVD Prevention: Looking into the Future. Curr Cardiol Rep. 2015 Nov; 17(11):104.
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Jang S, Marjanovic J, Gornicki P. Resistance to herbicides caused by single amino acid mutations in acetyl-CoA carboxylase in resistant populations of grassy weeds. New Phytol. 2013 Mar; 197(4):1110-1116.
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Marjanovic J, Chalupska D, Patenode C, Coster A, Arnold E, Ye A, Anesi G, Lu Y, Okun I, Tkachenko S, Haselkorn R, Gornicki P. Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9093-8.
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Maeda S, Kobayashi MA, Araki S, Babazono T, Freedman BI, Bostrom MA, Cooke JN, Toyoda M, Umezono T, Tarnow L, Hansen T, Gaede P, Jorsal A, Ng DP, Ikeda M, Yanagimoto T, Tsunoda T, Unoki H, Kawai K, Imanishi M, Suzuki D, Shin HD, Park KS, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Parving HH, Bowden DW, Pedersen O, Nakamura Y. A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet. 2010 Feb 12; 6(2):e1000842.
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Chalupska D, Lee HY, Faris JD, Evrard A, Chalhoub B, Haselkorn R, Gornicki P. Acc homoeoloci and the evolution of wheat genomes. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9691-6.
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Liu W, Harrison DK, Chalupska D, Gornicki P, O'donnell CC, Adkins SW, Haselkorn R, Williams RR. Single-site mutations in the carboxyltransferase domain of plastid acetyl-CoA carboxylase confer resistance to grass-specific herbicides. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3627-32.
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Zuther E, Huang S, Jelenska J, Eilenberg H, Arnold EM, Su X, Sirikhachornkit A, Podkowinski J, Zilberstein A, Haselkorn R, Gornicki P. Complex nested promoters control tissue-specific expression of acetyl-CoA carboxylase genes in wheat. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1403-8.
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Gornicki P. Apicoplast fatty acid biosynthesis as a target for medical intervention in apicomplexan parasites. Int J Parasitol. 2003 Aug; 33(9):885-96.
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