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Jeffrey Rathmell

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBen May Department of Cancer Research
AddressChicago IL 60637
ORCID ORCID Icon0000-0002-4106-3396 Additional info
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    Collapse Overview 
    Collapse overview
    The Rathmell lab aims to identify how metabolic pathways and nutrient microenvironments regulate lymphocyte metabolism, differentiation, and function. The activation of T lymphocytes remodels cell metabolism to support cell growth, proliferation, and signaling essential for effector differentiation and function. The field of immunometabolism explores mechanisms of this metabolic reprogramming and how metabolic pathways influence immune cell fate and function. The Rathmell lab uses genetic and metabolic techniques to discover mechanisms how (1) obesity affects cancer immunotherapy and (2) inflammatory microenvironments shape immune cell metabolism.

    Collapse Biography 
    Collapse education and training
    University of Northern Iowa, Cedar Falls, IAB.S.05/1991Biology
    Stanford University, Stanford, CAPhD05/1996Immunology
    University of Chicago, Chicago, ILPostdoc06/1999Cancer biology & metabolism
    University of Pennsylvania, Philadelphia, PAPostdoc05/2003Cancer biology & metabolism
    Collapse awards and honors
    2025Fred W. Alt Award for New Discoveries in Immunology, Cancer Research Institute
    2025Honorary Member, American Society for Clinical Investigator
    2024Waddell Walker Hancock Cancer Discovery Scholar, Vanderbilt University
    2022 - 24Clarivate Highly Cited Researcher
    2022Nature Milestones: Highlighted for discoveries in T cell immunometabolism, Nature Publishing
    2022Charles Randal Park Award for Outstanding Contributions to Research, Vanderbilt University
    2020 - 2021Molecular Pathology & Immunology Graduate Program Faculty Teaching Award, Vanderbilt University
    2019William E. Paul Distinguished Innovator Award, Lupus Research Alliance
    2019Fellow, American Association for the Advancement of Science
    2009Scholar, Leukemia and Lymphoma Society
    2008Bernard Osher Fellow, American Asthma Foundation
    2008Lisa Stafford Memorial Award for Excellence in Cancer Research, Duke University
    2007Research Scholar, American Cancer Society
    2004Research Scholar, V Foundation for Cancer Research
    2004Research Scholar, Sidney Kimmel Foundation
    1998 - 2001Postdoctoral Fellowship, Irvington Institute for Immunological Research
    1991 - 1993Graduate Research Fellowship, National Science Foundation
    1991Purple and Gold Award to top graduate in Biology, University of Northern Iowa
    1988Most Outstanding New Chemistry and New Biology Student, University of Northern Iowa

    Collapse Research 
    Collapse research activities and funding
    R13AI183475     (RATHMELL, JEFFREY C.)Mar 22, 2024 - Feb 28, 2025
    NIH
    2024 Immunometabolism in Health and Disease Gordon Research Conference and Gordon Research Seminar
    Role: Principal Investigator
    U01AI176244     (JAMES, JUDITH A)Mar 1, 2023 - Feb 29, 2028
    NIH
    Autoimmune Drivers and Protectors Team Science (ADAPTS)
    Role: Co-Principal Investigator
    R01AI153167     (RATHMELL, JEFFREY C.)May 20, 2020 - Apr 30, 2025
    NIH
    Targeting Tfh Cell Metabolic Regulation in SLE and SLE-Associated Atherosclerosis
    Role: Principal Investigator
    T32AI138932     (RATHMELL, JEFFREY C.)Aug 5, 2019 - Jul 31, 2025
    NIH
    Immunological Mechanisms of Disease Training Program
    Role: Principal Investigator
    R01CA217987     (RATHMELL, JEFFREY C)Apr 1, 2018 - Mar 31, 2028
    NIH
    Metabolic barriers to T cell activation in clear cell renal cell carcinoma
    Role: Principal Investigator
    R01HL136664     (RATHMELL, JEFFREY C.)Apr 6, 2017 - May 31, 2025
    NIH
    Targeting T cell glutamine metabolism in severe asthma
    Role: Principal Investigator
    R21CA194829     (RATHMELL, JEFFREY C.)Dec 1, 2015 - Nov 30, 2017
    NIH
    Metabolic regulation of T-ALL cellular proliferation and lifespan
    Role: Principal Investigator
    R01DK105550     (RATHMELL, JEFFREY C)Apr 1, 2015 - Jan 31, 2027
    NIH
    Exploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory disease
    Role: Principal Investigator
    R03AI106835     (RATHMELL, JEFFREY C.)Jun 1, 2013 - May 31, 2015
    NIH
    B cell metabolism in activation and autoantibody production
    Role: Principal Investigator
    R56AI102074     (RATHMELL, JEFFREY C.)Aug 1, 2012 - Jul 31, 2014
    NIH
    Glucose Transport in Regulation of T Cell Activation and Inflammation
    Role: Principal Investigator
    R01HL108006     (RATHMELL, JEFFREY C.)Apr 8, 2011 - Apr 29, 2016
    NIH
    T cell metabolism as a determinant of differentiation in allergic asthma
    Role: Principal Investigator
    R01CA123350     (RATHMELL, JEFFREY C.)Apr 1, 2007 - Jan 31, 2014
    NIH
    Glucose metabolism and cell death in cancer
    Role: Principal Investigator
    R01AI063345     (RATHMELL, JEFFREY C.)Feb 1, 2006 - Jan 31, 2012
    NIH
    Trophic Regulation in T Cell Homeostasis and Disease
    Role: Principal Investigator
    K01CA091905     (RATHMELL, JEFFREY C)Sep 22, 2001 - Aug 31, 2006
    NIH
    Control of lymphocyte trophic state by extrinsic signals
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Choi SC, Ge Y, Joshi MV, Jimenez D, Castellanos Garcia A, LaPlante C, Padilla LT, Ma C, Zhang N, Rathmell JC, Mohamadzadeh M, Morel L, Choi SC, Ge Y, Joshi MV, Jimenez D, Castellanos Garcia A, LaPlante C, Padilla LT, Ma C, Zhang N, Rathmell JC, Mohamadzadeh M, Morel L. Intrinsic T cell glutaminolysis promotes autoimmunity in lupus-prone mice. JCI Insight. 2025 Nov 10; 10(21). PMID: 40956613; PMCID: PMC12643493.
      Citations:    Fields:    Translation:AnimalsCells
    2. Clark LM, McAninch JC, McNitt DH, Padgett ML, Jenkins TW, Bass LE, Nichols CM, Rathmell JC, Bonami RH. BCL6 in T cells promotes type 1 diabetes by redirecting fates of insulin-autoreactive B lymphocytes. bioRxiv. 2025 Aug 28. PMID: 40909612; PMCID: PMC12407800.
      Citations:    
    3. Kimmel BR, Arora K, Chada NC, Bharti V, Kwiatkowski AJ, Finkelstein JE, Hanna A, Arner EN, Sheehy TL, Pastora LE, Yang J, Pagendarm HM, Stone PT, Hargrove-Wiley E, Taylor BC, Hubert LA, Fingleton BM, Gibson-Corley KN, May JC, McLean JA, Rathmell JC, Richmond A, Rathmell WK, Balko JM, Wilson JT. Potentiating cancer immunotherapies with modular albumin-hitchhiking nanobody-STING agonist conjugates. Nat Biomed Eng. 2025 Oct; 9(10):1719-1739. PMID: 40500332; PMCID: PMC12532571.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    4. Steiner KK, Young AC, Patterson AR, Sugiura A, Watson MJ, Preston SEJ, Zhelonkin A, Jennings EQ, Chi C, Heintzman DR, Pahnke AP, Toudji YT, Hatem Z, Madden MZ, Arner EN, Sewell AE, Blount AK, Okparaugo R, Fallman E, Krystofiak ES, Sheldon RD, Gibson-Corley KN, Voss K, Nowinski SM, Jones RG, Mogilenko DA, Rathmell JC. Mitochondrial fatty acid synthesis and MECR regulate CD4+ T cell function and oxidative metabolism. J Immunol. 2025 May 01; 214(5):958-976. PMID: 40204636; PMCID: PMC12123211.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Faneuff EE, Kim MJ, Blackman A, Karunakaran KA, Bader JE, Zhen X, Gallagher KS, Durst TJ, Connelly JA, Rathmell JC, Salina A, Martinez-Barricarte R, Serezani CH. PTEN inhibits scavenger receptor-mediated phagocytosis of methicillin-resistant Staphylococcus aureus. Immunohorizons. 2025 04 26; 9(6). PMID: 40288813; PMCID: PMC12034382.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Pierro EW, Cottam MA, An H, Lehmann BD, Pietenpol JA, Wellen KE, Makowski L, Rathmell JC, Fingleton B, Hasty AH. Comparison of Lean, Obese, and Weight-Loss Models Reveals TREM2 Deficiency Attenuates Breast Cancer Growth Uniquely in Lean Mice and Alters Clonal T-cell Populations. Cancer Res. 2025 Apr 03; 85(7):1219-1235. PMID: 39841585; PMCID: PMC11968228.
      Citations: 2     Fields:    Translation:HumansAnimals
    7. Marathe SJ, Grey EW, Bohm MS, Joseph SC, Ramesh AV, Cottam MA, Idrees K, Wellen KE, Hasty AH, Rathmell JC, Makowski L. Incretin triple agonist retatrutide (LY3437943) alleviates obesity-associated cancer progression. NPJ Metab Health Dis. 2025; 3(1):10. PMID: 40094000; PMCID: PMC11908972.
      Citations: 4     
    8. Fu H, Vuononvirta J, Fanti S, Bonacina F, D'Amati A, Wang G, Poobalasingam T, Fankhaenel M, Lucchesi D, Coleby R, Tarussio D, Thorens B, Hearnden RJ, Longhi MP, Grevitt P, Sheikh MH, Solito E, Godinho SA, Bombardieri M, Smith DM, Cooper D, Iqbal AJ, Rathmell JC, Schaefer S, Morales V, Bianchi K, Norata GD, Marelli-Berg FM. Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing. Nat Metab. 2025 Mar; 7(3):634. PMID: 40000839; PMCID: PMC11946881.
      Citations:    Fields:    
    9. Wilander BA, Rathmell JC. Metabolic and stress response adaptations in T cells to fever and physiological heat. Trends Immunol. 2025 Mar; 46(3):195-205. PMID: 39984354; PMCID: PMC11922645.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. Stier MT, Sewell AE, Mwizerwa EL, Sim CY, Tanner SM, Nichols CM, Durai HH, Jennings EQ, Lindau P, Wilfong EM, Newcomb DC, Bastarache JA, Ware LB, Rathmell JC. Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis. bioRxiv. 2025 Jan 29. PMID: 39975258; PMCID: PMC11838299.
      Citations:    
    11. Arner EN, Jennings EQ, Crooks DR, Ricketts CJ, Wolf MM, Cottam MA, Fisher-Gupta EL, Lang M, Maio N, Shibata Y, Krystofiak ES, Vlach LM, Hatem Z, Blatt AM, Heintzman DR, Sewell AE, Hathaway ES, Steiner KK, Ye X, Schaefer S, Bacigalupa ZA, Linehan WM, Beckermann KE, Mason FM, Idrees K, Rathmell WK, Rathmell JC. Impaired oxidative phosphorylation drives primary tumor escape and metastasis. bioRxiv. 2025 Jan 09. PMID: 39829901; PMCID: PMC11741308.
      Citations:    
    12. Stone SH, Rathmell JC, Bader JE. Macrophages make "sense" of obesity-driven acidity in the TME. Cell Chem Biol. 2024 Dec 19; 31(12):2021-2023. PMID: 39706167; PMCID: PMC12784248.
      Citations:    Fields:    Translation:HumansAnimalsCells
    13. Zhen X, Betti MJ, Kars ME, Patterson AR, Medina-Torres EA, Scheffler Mendoza SC, Herrera Sánchez DA, Lopez-Herrera G, Svyryd Y, Mutchinick OM, Gamazon ER, Rathmell JC, Itan Y, Markle J, O'Farrill Romanillos P, Lugo-Reyes SO, Martinez-Barricarte R. Molecular and Clinical Characterization of a Founder Mutation Causing G6PC3 Deficiency. J Clin Immunol. 2024 12 04; 45(1):53. PMID: 39630167; PMCID: PMC11618172.
      Citations: 1     Fields:    Translation:HumansCells
    14. Choi SC, Ge Y, Joshi MV, Jimenez D, Padilla LT, LaPlante C, Rathmell JC, Mohamadzadeh M, Morel L. Glutaminolysis promotes the function of follicular helper T cells in lupus-prone mice. bioRxiv. 2024 Nov 25. PMID: 39651274; PMCID: PMC11623495.
      Citations:    
    15. Amancherla K, Schlendorf KH, Chow N, Sheng Q, Freedman JE, Rathmell JC. Single-cell RNA-sequencing identifies unique cell-specific gene expression profiles in high-grade cardiac allograft vasculopathy. J Heart Lung Transplant. 2025 Aug; 44(8):1321-1330. PMID: 39580136; PMCID: PMC12095613.
      Citations: 5     Fields:    Translation:HumansCells
    16. Islam M, Yang Y, Simmons AJ, Shah VM, Musale KP, Xu Y, Tasneem N, Chen Z, Trinh LT, Molina P, Ramirez-Solano MA, Sadien ID, Dou J, Rolong A, Chen K, Magnuson MA, Rathmell JC, Macara IG, Winton DJ, Liu Q, Zafar H, Kalhor R, Church GM, Shrubsole MJ, Coffey RJ, Lau KS. Temporal recording of mammalian development and precancer. Nature. 2024 Oct; 634(8036):1187-1195. PMID: 39478207; PMCID: PMC11525190.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    17. Chowdhury NU, Cephus JY, Henriquez Pilier E, Wolf MM, Madden MZ, Kuehnle SN, McKernan KE, Jennings EQ, Arner EN, Heintzman DR, Chi C, Sugiura A, Stier MT, Voss K, Ye X, Scales K, Krystofiak ES, Gandhi VD, Guzy RD, Cahill KN, Sperling AI, Peebles RS, Rathmell JC, Newcomb DC. Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation. J Clin Invest. 2024 Oct 15; 134(23). PMID: 39404231; PMCID: PMC11601904.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    18. Pierro EW, Cottam MA, An H, Lehmann BD, Pietenpol JA, Wellen KE, Makowski L, Rathmell JC, Fingleton B, Hasty AH. Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations. bioRxiv. 2024 Sep 27. PMID: 39386686; PMCID: PMC11463595.
      Citations:    
    19. Heintzman DR, Sinard RC, Fisher EL, Ye X, Patterson AR, Elasy JH, Voss K, Chi C, Sugiura A, Rodriguez-Garcia GJ, Chowdhury NU, Arner EN, Krystoviak ES, Mason FM, Toudji YT, Steiner KK, Khan W, Olson LM, Jones AL, Hong HS, Bass L, Beier KL, Deng W, Lyssiotis CA, Newcomb DC, Bick AG, Rathmell WK, Wilson JT, Rathmell JC. Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation. Sci Immunol. 2024 09 20; 9(99):eadp3475. PMID: 39303018; PMCID: PMC11607909.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    20. Hathaway ES, Jennings EQ, Rathmell JC. Immunometabolic Maladaptations to the Tumor Microenvironment. Cold Spring Harb Perspect Med. 2024 Sep 03; 14(9). PMID: 38438220; PMCID: PMC11368198.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Patterson AR, Needle GA, Sugiura A, Jennings EQ, Chi C, Steiner KK, Fisher EL, Robertson GL, Bodnya C, Markle JG, Sheldon RD, Jones RG, Gama V, Rathmell JC. Functional overlap of inborn errors of immunity and metabolism genes defines T cell metabolic vulnerabilities. Sci Immunol. 2024 08 16; 9(98):eadh0368. PMID: 39151020; PMCID: PMC11590014.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    22. Amancherla K, Schlendorf KH, Chow N, Sheng Q, Freedman JE, Rathmell JC. Single-cell RNA-sequencing identifies unique cell-specific gene expression profiles in high-grade cardiac allograft vasculopathy. bioRxiv. 2024 Jul 12. PMID: 39026730; PMCID: PMC11257508.
      Citations:    
    23. Steiner KK, Young AC, Patterson AR, Jennings EQ, Chi C, Hatem Z, Heintzman D, Sugiura A, Arner EN, Sewell AE, Madden MZ, Okparaugo R, Fallman EV, Gibson-Corley K, Voss K, Mogilenko D, Rathmell J. Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4+ T Cell Function and Oxidative Metabolism. bioRxiv. 2024 Jul 11. PMID: 39026793; PMCID: PMC11257487.
      Citations:    
    24. Zhen X, Betti M, Kars ME, Patterson A, Medina-Torres EA, Scheffler Mendoza SC, Herrera Sánchez DA, Lopez-Herrera G, Svyryd Y, Mutchinick O, Gamazon E, Rathmell J, Itan Y, Markle J, O'Farrill Romanillos P, Lugo-Reyes SO, Martinez-Barricarte R. Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency. Res Sq. 2024 Jul 11. PMID: 39041036; PMCID: PMC11261954.
      Citations:    
    25. De Martino M, Rathmell JC, Galluzzi L, Vanpouille-Box C. Author Correction: Cancer cell metabolism and antitumour immunity. Nat Rev Immunol. 2024 Jul; 24(7):537. PMID: 38806693.
      Citations: 7     Fields:    
    26. Voss K, Bartkowiak T, Sewell AE, Chi C, Landis MD, Schaefer S, Pua HH, Connelly JA, Irish JM, Rathmell JC, Kaviany S. Peripheral T Cell Development and Immunophenotyping of Twins with Heterozygous FOXN1 Mutations. Immunohorizons. 2024 07 01; 8(7):492-499. PMID: 39008056; PMCID: PMC11294276.
      Citations:    Fields:    Translation:HumansCells
    27. Bader JE, Wolf MM, Lupica-Tondo GL, Madden MZ, Reinfeld BI, Arner EN, Hathaway ES, Steiner KK, Needle GA, Hatem Z, Landis MD, Faneuff EE, Blackman A, Wolf EM, Cottam MA, Ye X, Bates ME, Smart K, Wang W, Pinheiro LV, Christofides A, Smith D, Boussiotis VA, Haake SM, Beckermann KE, Wellen KE, Reinhart-King CA, Serezani CH, Lee CH, Aubrey C, Chen H, Rathmell WK, Hasty AH, Rathmell JC. Author Correction: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity. Nature. 2024 Jul; 631(8022):E16. PMID: 38982216.
      Citations: 1     Fields:    
    28. Bacigalupa ZA, Arner EN, Vlach LM, Wolf MM, Brown WA, Krystofiak ES, Ye X, Hongo RA, Landis M, Amason EK, Beckermann KE, Rathmell WK, Rathmell JC. HIF-2a expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma. J Clin Invest. 2024 Jun 17; 134(12). PMID: 38941296; PMCID: PMC11178540.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    29. Bader JE, Wolf MM, Lupica-Tondo GL, Madden MZ, Reinfeld BI, Arner EN, Hathaway ES, Steiner KK, Needle GA, Hatem Z, Landis MD, Faneuff EE, Blackman A, Wolf EM, Cottam MA, Ye X, Bates ME, Smart K, Wang W, Pinheiro LV, Christofides A, Smith D, Boussiotis VA, Haake SM, Beckermann KE, Wellen KE, Reinhart-King CA, Serezani CH, Lee CH, Aubrey C, Chen H, Rathmell WK, Hasty AH, Rathmell JC. Obesity induces PD-1 on macrophages to suppress anti-tumour immunity. Nature. 2024 Jun; 630(8018):968-975. PMID: 38867043; PMCID: PMC11456854.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    30. Rodriguez-Garcia GJ, Graves DK, Mirza MB, Idrees K, Kim YJ, Korrer MJ, Rathmell JC. Cancer Cell Small Molecule Secretome Induces the Immune Checkpoint NKG2A and Dysfunction of Human CD8+ T Cells. Immunohorizons. 2024 06 01; 8(6):464-477. PMID: 38922288; PMCID: PMC11220743.
      Citations:    Fields:    Translation:HumansCells
    31. Tucker L, Ali U, Zent R, Lannigan DA, Rathmell JC, Tiriveedhi V. Chronic High-Salt Diet Activates Tumor-Initiating Stem Cells Leading to Breast Cancer Proliferation. Cells. 2024 05 25; 13(11). PMID: 38891044; PMCID: PMC11172022.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    32. Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell J, Vander Heiden MG. Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability. Elife. 2024 May 24; 13. PMID: 38787918; PMCID: PMC11126308.
      Citations: 8     Fields:    Translation:Humans
    33. Zhen X, Betti MJ, Kars ME, Patterson A, Medina-Torres EA, Scheffler Mendoza SC, Herrera Sánchez DA, Lopez-Herrera G, Svyryd Y, Mutchinick OM, Gamazon E, Rathmell JC, Itan Y, Markle J, O'Farrill Romanillos P, Lugo-Reyes SO, Martinez-Barricarte R. Molecular and clinical characterization of a founder mutation causing G6PC3 deficiency. medRxiv. 2024 May 14. PMID: 38798393; PMCID: PMC11118594.
      Citations:    
    34. Wilson J, Kimmel B, Arora K, Chada N, Bharti V, Kwiatkowski A, Finklestein J, Hanna A, Arner E, Sheehy T, Pastora L, Yang J, Pagendarm H, Stone P, Taylor B, Hubert L, Gibson-Corley K, May J, McLean J, Rathmell J, Richmond A, Rathmell W, Balko J, Fingleton B, Hargrove-Wiley E. Programable Albumin-Hitchhiking Nanobodies Enhance the Delivery of STING Agonists to Potentiate Cancer Immunotherapy. Res Sq. 2024 May 08. PMID: 38766114; PMCID: PMC11100900.
      Citations:    
    35. Cross CE, Mayeda C, Medina S, Hayes MJ, Kaviany S, Connelly JA, Rathmell JC, Weaver KD, Thompson RC, Chambless LB, Ihrie RA, Irish JM. Velociraptor: Cross-Platform Quantitative Search Using Hallmark Cell Features. bioRxiv. 2024 May 04. PMID: 38746337; PMCID: PMC11092669.
      Citations:    
    36. De Martino M, Rathmell JC, Galluzzi L, Vanpouille-Box C. Cancer cell metabolism and antitumour immunity. Nat Rev Immunol. 2024 Sep; 24(9):654-669. PMID: 38649722; PMCID: PMC11365797.
      Citations: 101     Fields:    Translation:HumansAnimals
    37. Wolf MM, Madden MZ, Arner EN, Bader JE, Ye X, Vlach L, Tigue ML, Landis MD, Jonker PB, Hatem Z, Steiner KK, Gaines DK, Reinfeld BI, Hathaway ES, Xin F, Tantawy MN, Haake SM, Jonasch E, Muir A, Weiss VL, Beckermann KE, Rathmell WK, Rathmell JC. VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis. J Clin Invest. 2024 Apr 15; 134(8). PMID: 38618956; PMCID: PMC11014672.
      Citations: 10     Fields:    Translation:HumansAnimals
    38. Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell JC, Vander Heiden MG. Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability. bioRxiv. 2024 Apr 08. PMID: 38187626; PMCID: PMC10769456.
      Citations:    
    39. Monteith AJ, Ramsey HE, Silver AJ, Brown D, Greenwood D, Smith BN, Wise AD, Liu J, Olmstead SD, Watke J, Arrate MP, Gorska AE, Fuller L, Locasale JW, Stubbs MC, Rathmell JC, Savona MR. Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia. Cancer Res. 2024 04 01; 84(7):1101-1114. PMID: 38285895; PMCID: PMC10984779.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    40. Brookens SK, Cho SH, Paik Y, Meyer K, Raybuck AL, Park C, Greenwood DL, Rathmell JC, Boothby MR. Plasma Cell Differentiation, Antibody Quality, and Initial Germinal Center B Cell Population Depend on Glucose Influx Rate. J Immunol. 2024 01 01; 212(1):43-56. PMID: 37955416; PMCID: PMC10841396.
      Citations: 9     Fields:    Translation:Animals
    41. Chaib M, Holt JR, Fisher EL, Sipe LM, Bohm MS, Joseph SC, Simmons BW, Eugin Simon S, Yarbro JR, Tanveer U, Halle JL, Carson JA, Hollingsworth TJ, Wei Q, Rathmell JC, Thomas PG, Hayes DN, Makowski L. Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer. Sci Adv. 2023 12 22; 9(51):eadd3231. PMID: 38134280; PMCID: PMC10745701.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    42. Islam M, Yang Y, Simmons AJ, Shah VM, Pavan MK, Xu Y, Tasneem N, Chen Z, Trinh LT, Molina P, Ramirez-Solano MA, Sadien I, Dou J, Chen K, Magnuson MA, Rathmell JC, Macara IG, Winton D, Liu Q, Zafar H, Kalhor R, Church GM, Shrubsole MJ, Coffey RJ, Lau KS. Temporal recording of mammalian development and precancer. bioRxiv. 2023 Dec 19. PMID: 38187699; PMCID: PMC10769302.
      Citations:    
    43. Bacigalupa ZA, Landis MD, Rathmell JC. Nutrient inputs and social metabolic control of T cell fate. Cell Metab. 2024 01 02; 36(1):10-20. PMID: 38118440; PMCID: PMC10872404.
      Citations: 17     Fields:    Translation:Cells
    44. Fu H, Vuononvirta J, Fanti S, Bonacina F, D'Amati A, Wang G, Poobalasingam T, Fankhaenel M, Lucchesi D, Coleby R, Tarussio D, Thorens B, Hearnden RJ, Longhi MP, Grevitt P, Sheikh MH, Solito E, Godinho SA, Bombardieri M, Smith DM, Cooper D, Iqbal AJ, Rathmell JC, Schaefer S, Morales V, Bianchi K, Norata GD, Marelli-Berg FM. The glucose transporter 2 regulates CD8+ T cell function via environment sensing. Nat Metab. 2023 11; 5(11):1969-1985. PMID: 37884694; PMCID: PMC10663157.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    45. Brookens SK, Cho SH, Paik Y, Meyer K, Raybuck AL, Park C, Greenwood DL, Rathmell JC, Boothby MR. Plasma cell differentiation, antibody quality, and initial germinal center B cell population depend on glucose influx rate. bioRxiv. 2023 Sep 16. PMID: 37745429; PMCID: PMC10515901.
      Citations:    
    46. Sugiura A, Beier KL, Chi C, Heintzman DR, Ye X, Wolf MM, Patterson AR, Cephus JY, Hong HS, Lyssiotis CA, Newcomb DC, Rathmell JC. Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation. bioRxiv. 2023 Sep 13. PMID: 37745344; PMCID: PMC10515961.
      Citations: 1     
    47. Madden MZ, Ye X, Chi C, Fisher EL, Wolf MM, Needle GA, Bader JE, Patterson AR, Reinfeld BI, Landis MD, Hathaway ES, Muka JE, O'Neil RT, Karijolich J, Philip M, Rathmell JC. Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells. J Immunol. 2023 08 15; 211(4):563-575. PMID: 37341499; PMCID: PMC10526752.
      Citations: 16     Fields:    Translation:AnimalsCells
    48. Sekhar KR, Codreanu SG, Williams OC, Rathmell JC, Rathmell WK, McLean JA, Sherrod SD, Baregamian N. Metabolism of parathyroid organoids. Front Endocrinol (Lausanne). 2023; 14:1223312. PMID: 37492197; PMCID: PMC10364603.
      Citations: 6     Fields:    Translation:Humans
    49. Wang-Bishop L, Kimmel BR, Ngwa VM, Madden MZ, Baljon JJ, Florian DC, Hanna A, Pastora LE, Sheehy TL, Kwiatkowski AJ, Wehbe M, Wen X, Becker KW, Garland KM, Schulman JA, Shae D, Edwards D, Wolf MM, Delapp R, Christov PP, Beckermann KE, Balko JM, Rathmell WK, Rathmell JC, Chen J, Wilson JT. STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy. Sci Immunol. 2023 05 12; 8(83):eadd1153. PMID: 37146128; PMCID: PMC10226150.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    50. Hinshaw DC, Benavides GA, Metge BJ, Swain CA, Kammerud SC, Alsheikh HA, Elhamamsy A, Chen D, Darley-Usmar V, Rathmell JC, Welner RS, Samant RS, Shevde LA. Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer. Cancer Immunol Res. 2023 05 03; 11(5):687-702. PMID: 37058110; PMCID: PMC10159910.
      Citations: 18     Fields:    Translation:HumansCells
    51. Gong M, Choi SC, Park YP, Zou X, Elshikha AS, Gerriets VA, Rathmell JC, Mohamazadeh M, Morel L. Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice. iScience. 2023 May 19; 26(5):106774. PMID: 37216123; PMCID: PMC10197114.
      Citations: 10     
    52. Rathmell J. The good side of science: why I tweeted 31 reasons to love your career. Nature. 2023 Apr 07. PMID: 37029279.
      Citations:    Fields:    
    53. Li H, Guglielmetti C, Sei YJ, Zilberter M, Le Page LM, Shields L, Yang J, Nguyen K, Tiret B, Gao X, Bennett N, Lo I, Dayton TL, Kampmann M, Huang Y, Rathmell JC, Vander Heiden M, Chaumeil MM, Nakamura K. Neurons require glucose uptake and glycolysis in vivo. Cell Rep. 2023 04 25; 42(4):112335. PMID: 37027294; PMCID: PMC10556202.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    54. Cable J, Rathmell JC, Pearce EL, Ho PC, Haigis MC, Mamedov MR, Wu MJ, Kaech SM, Lynch L, Febbraio MA, Bapat SP, Hong HS, Zou W, Belkaid Y, Sullivan ZA, Keller A, Wculek SK, Green DR, Postic C, Amit I, Benitah SA, Jones RG, Reina-Campos M, Torres SV, Beyaz S, Brennan D, O'Neill LAJ, Perry RJ, Brenner D. Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report. Ann N Y Acad Sci. 2023 05; 1523(1):38-50. PMID: 36960914; PMCID: PMC10367315.
      Citations: 2     Fields:    Translation:Humans
    55. Arner EN, Rathmell JC. Metabolic programming and immune suppression in the tumor microenvironment. Cancer Cell. 2023 03 13; 41(3):421-433. PMID: 36801000; PMCID: PMC10023409.
      Citations: 284     Fields:    Translation:HumansCells
    56. Patterson AR, Needle GA, Sugiura A, Chi C, Steiner KK, Fisher EL, Robertson GL, Bodnya C, Markle JG, Gama V, Rathmell JC. Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities. bioRxiv. 2023 Jan 24. PMID: 36747715; PMCID: PMC9900827.
      Citations:    
    57. Voss K, Sewell AE, Krystofiak ES, Gibson-Corley KN, Young AC, Basham JH, Sugiura A, Arner EN, Beavers WN, Kunkle DE, Dickson ME, Needle GA, Skaar EP, Rathmell WK, Ormseth MJ, Major AS, Rathmell JC. Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus. Sci Immunol. 2023 01 13; 8(79):eabq0178. PMID: 36638190; PMCID: PMC9936798.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    58. Song W, Postoak JL, Yang G, Guo X, Pua HH, Bader J, Rathmell JC, Kobayashi H, Haase VH, Leaptrot KL, Schrimpe-Rutledge AC, Sherrod SD, McLean JA, Zhang J, Wu L, Van Kaer L. Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases. Proc Natl Acad Sci U S A. 2023 01 03; 120(1):e2214874120. PMID: 36574710; PMCID: PMC9910429.
      Citations: 16     Fields:    Translation:AnimalsCells
    59. Pham L, Komalavilas P, Eddie AM, Thayer TE, Greenwood DL, Liu KH, Weinberg J, Patterson A, Fessel JP, Boyd KL, Schafer JC, Kuck JL, Shaver AC, Flaherty DK, Matlock BK, Wijers CDM, Serezani CH, Jones DP, Brittain EL, Rathmell JC, Noto MJ. Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid ß-oxidation. Commun Biol. 2022 12 13; 5(1):1366. PMID: 36513703; PMCID: PMC9747976.
      Citations: 16     Translation:HumansAnimalsCells
    60. Greenwood DL, Ramsey HE, Nguyen PTT, Patterson AR, Voss K, Bader JE, Sugiura A, Bacigalupa ZA, Schaefer S, Ye X, Dahunsi DO, Madden MZ, Wellen KE, Savona MR, Ferrell PB, Rathmell JC. Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk. Immunohorizons. 2022 12 01; 6(12):837-850. PMID: 36547387; PMCID: PMC9935084.
      Citations: 3     Fields:    Translation:AnimalsCells
    61. Axelrod ML, Meijers WC, Screever EM, Qin J, Carroll MG, Sun X, Tannous E, Zhang Y, Sugiura A, Taylor BC, Hanna A, Zhang S, Amancherla K, Tai W, Wright JJ, Wei SC, Opalenik SR, Toren AL, Rathmell JC, Ferrell PB, Phillips EJ, Mallal S, Johnson DB, Allison JP, Moslehi JJ, Balko JM. T cells specific for a-myosin drive immunotherapy-related myocarditis. Nature. 2022 11; 611(7937):818-826. PMID: 36385524; PMCID: PMC9930174.
      Citations: 183     Fields:    Translation:AnimalsCells
    62. Baregamian N, Sekhar KR, Krystofiak ES, Vinogradova M, Thomas G, Mannoh E, Solórzano CC, Kiernan CM, Mahadevan-Jansen A, Abumrad N, Freeman ML, Weiss VL, Rathmell JC, Rathmell WK. Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications. Surgery. 2023 Jan; 173(1):67-75. PMID: 36400581; PMCID: PMC9939934.
      Citations: 15     Fields:    Translation:Humans
    63. Wong HY, Sheng Q, Hesterberg AB, Croessmann S, Rios BL, Giri K, Jackson J, Miranda AX, Watkins E, Schaffer KR, Donahue M, Winkler E, Penson DF, Smith JA, Herrell SD, Luckenbaugh AN, Barocas DA, Kim YJ, Graves D, Giannico GA, Rathmell JC, Park BH, Gordetsky JB, Hurley PJ. Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease. Nat Commun. 2022 10 13; 13(1):6036. PMID: 36229464; PMCID: PMC9562361.
      Citations: 71     Fields:    Translation:Humans
    64. Zielke C, Gutierrez Ramirez AJ, Voss K, Ryan MS, Gholizadeh A, Rathmell JC, Abbyad P. Droplet Microfluidic Technology for the Early and Label-Free Isolation of Highly-Glycolytic, Activated T-Cells. Micromachines (Basel). 2022 Sep 01; 13(9). PMID: 36144067; PMCID: PMC9503730.
      Citations: 2     
    65. Beebout CJ, Robertson GL, Reinfeld BI, Blee AM, Morales GH, Brannon JR, Chazin WJ, Rathmell WK, Rathmell JC, Gama V, Hadjifrangiskou M. Uropathogenic Escherichia coli subverts mitochondrial metabolism to enable intracellular bacterial pathogenesis in urinary tract infection. Nat Microbiol. 2022 09; 7(9):1348-1360. PMID: 35995841; PMCID: PMC9756876.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    66. Groves SM, Ildefonso GV, McAtee CO, Ozawa PMM, Ireland AS, Stauffer PE, Wasdin PT, Huang X, Qiao Y, Lim JS, Bader J, Liu Q, Simmons AJ, Lau KS, Iams WT, Hardin DP, Saff EB, Holmes WR, Tyson DR, Lovly CM, Rathmell JC, Marth G, Sage J, Oliver TG, Weaver AM, Quaranta V. Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer. Cell Syst. 2022 09 21; 13(9):690-710.e17. PMID: 35981544; PMCID: PMC9615940.
      Citations: 32     Fields:    Translation:Humans
    67. Chen Z, Simon-Molas H, Cretenet G, Valle-Argos B, Smith LD, Forconi F, Schomakers BV, van Weeghel M, Bryant DJ, van Bruggen JAC, Peters FS, Rathmell JC, van der Windt GJW, Kater AP, Packham G, Eldering E. Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment. Blood. 2022 08 11; 140(6):630-643. PMID: 35486832; PMCID: PMC10118070.
      Citations: 26     Fields:    Translation:Humans
    68. Kaviany S, Bartkowiak T, Dulek DE, Khan YW, Hayes MJ, Schaefer SG, Ye X, Dahunsi DO, Connelly JA, Irish JM, Rathmell JC. Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1. Immunohorizons. 2022 07 15; 6(7):447-464. PMID: 35840326; PMCID: PMC9623573.
      Citations: 2     Fields:    Translation:HumansCells
    69. Peek CT, Ford CA, Eichelberger KR, Jacobse J, Torres TP, Maseda D, Latour YL, Piazuelo MB, Johnson JR, Byndloss MX, Wilson KT, Rathmell JC, Goettel JA, Cassat JE. Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss. Cell Mol Gastroenterol Hepatol. 2022; 14(4):731-750. PMID: 35835390; PMCID: PMC9420375.
      Citations: 10     Fields:    Translation:AnimalsCells
    70. Kramer KJ, Wilfong EM, Voss K, Barone SM, Shiakolas AR, Raju N, Roe CE, Suryadevara N, Walker LM, Wall SC, Paulo A, Schaefer S, Dahunsi D, Westlake CS, Crowe JE, Carnahan RH, Rathmell JC, Bonami RH, Georgiev IS, Irish JM. Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine. Nat Commun. 2022 06 16; 13(1):3466. PMID: 35710908; PMCID: PMC9201272.
      Citations: 31     Fields:    Translation:HumansCells
    71. Khandekar D, Dahunsi DO, Manzanera Esteve IV, Reid S, Rathmell JC, Titze J, Tiriveedhi V. Low-Salt Diet Reduces Anti-CTLA4 Mediated Systemic Immune-Related Adverse Events while Retaining Therapeutic Efficacy against Breast Cancer. Biology (Basel). 2022 May 25; 11(6). PMID: 35741331; PMCID: PMC9219826.
      Citations: 7     
    72. Thangavelu G, Andrejeva G, Bolivar-Wagers S, Jin S, Zaiken MC, Loschi M, Aguilar EG, Furlan SN, Brown CC, Lee YC, Hyman CM, Feser CJ, Panoskaltsis-Mortari A, Hippen KL, MacDonald KP, Murphy WJ, Maillard I, Hill GR, Munn DH, Zeiser R, Kean LS, Rathmell JC, Chi H, Noelle RJ, Blazar BR. Retinoic acid signaling acts as a rheostat to balance Treg function. Cell Mol Immunol. 2022 07; 19(7):820-833. PMID: 35581350; PMCID: PMC9243059.
      Citations: 8     Fields:    Translation:AnimalsCells
    73. Glass EB, Hoover AA, Bullock KK, Madden MZ, Reinfeld BI, Harris W, Parker D, Hufnagel DH, Crispens MA, Khabele D, Rathmell WK, Rathmell JC, Wilson AJ, Giorgio TD, Yull FE. Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer. BMC Cancer. 2022 May 06; 22(1):497. PMID: 35513776; PMCID: PMC9074180.
      Citations: 18     Fields:    Translation:HumansAnimals
    74. Huang Y, Zou Y, Jiao Y, Shi P, Nie X, Huang W, Xiong C, Choi M, Huang C, Macintyre AN, Nichols A, Li F, Li CY, MacIver NJ, Cardona DM, Brennan TV, Li Z, Chao NJ, Rathmell JC, Chen BJ. Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect. Front Immunol. 2022; 13:751296. PMID: 35296079; PMCID: PMC8920494.
      Citations: 9     Fields:    Translation:HumansCells
    75. Heintzman DR, Fisher EL, Rathmell JC. Microenvironmental influences on T cell immunity in cancer and inflammation. Cell Mol Immunol. 2022 03; 19(3):316-326. PMID: 35039633; PMCID: PMC8762638.
      Citations: 61     Fields:    Translation:HumansCells
    76. Monteith AJ, Miller JM, Williams JM, Voss K, Rathmell JC, Crofford LJ, Skaar EP. Altered Mitochondrial Homeostasis during Systemic Lupus Erythematosus Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating Staphylococcus aureus. J Immunol. 2022 01 15; 208(2):454-463. PMID: 34930781; PMCID: PMC8761356.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    77. Dudzinski SO, Bader JE, Beckermann KE, Young KL, Hongo R, Madden MZ, Abraham A, Reinfeld BI, Ye X, MacIver NJ, Giorgio TD, Rathmell JC. Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages. J Immunol. 2021 12 15; 207(12):3122-3130. PMID: 34772698; PMCID: PMC9095767.
      Citations: 22     Fields:    Translation:AnimalsCells
    78. Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ, Ye X, Beier KL, Chowdhury NU, Wolf MM, Young AC, Greenwood DL, Sewell AE, Shahi SK, Freedman SN, Cameron AM, Foerch P, Bourne T, Garcia-Canaveras JC, Karijolich J, Newcomb DC, Mangalam AK, Rabinowitz JD, Rathmell JC. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022 01 11; 55(1):65-81.e9. PMID: 34767747; PMCID: PMC8755618.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    79. Baechle JJ, Hanna DN, Sekhar KR, Rathmell JC, Rathmell WK, Baregamian N. Integrative computational immunogenomic profiling of cortisol-secreting adrenocortical carcinoma. J Cell Mol Med. 2021 11; 25(21):10061-10072. PMID: 34664400; PMCID: PMC8572764.
      Citations: 11     Fields:    Translation:HumansCells
    80. Mohamed FA, Thangavelu G, Rhee SY, Sage PT, O'Connor RS, Rathmell JC, Blazar BR. Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease. Front Immunol. 2021; 12:757836. PMID: 34712243; PMCID: PMC8546182.
      Citations: 16     Fields:    Translation:HumansCells
    81. Yoo W, Zieba JK, Foegeding NJ, Torres TP, Shelton CD, Shealy NG, Byndloss AJ, Cevallos SA, Gertz E, Tiffany CR, Thomas JD, Litvak Y, Nguyen H, Olsan EE, Bennett BJ, Rathmell JC, Major AS, Bäumler AJ, Byndloss MX. High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide. Science. 2021 08 13; 373(6556):813-818. PMID: 34385401; PMCID: PMC8506909.
      Citations: 162     Fields:    Translation:AnimalsCells
    82. Kramer KJ, Wilfong EM, Voss K, Barone SM, Shiakolas AR, Raju N, Roe CE, Suryadevara N, Walker L, Wall SC, Paulo A, Schaefer S, Dahunsi D, Westlake CS, Crowe JE, Carnahan RH, Rathmell JC, Bonami RH, Georgiev IS, Irish JM. Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine. bioRxiv. 2021 Jul 28. PMID: 34341788; PMCID: PMC8328055.
      Citations:    
    83. De Melo P, Pineros Alvarez AR, Ye X, Blackman A, Alves-Filho JC, Medeiros AI, Rathmell J, Pua H, Serezani CH. Macrophage-Derived MicroRNA-21 Drives Overwhelming Glycolytic and Inflammatory Response during Sepsis via Repression of the PGE2/IL-10 Axis. J Immunol. 2021 08 01; 207(3):902-912. PMID: 34301845; PMCID: PMC8323968.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    84. Hinshaw DC, Hanna A, Lama-Sherpa T, Metge B, Kammerud SC, Benavides GA, Kumar A, Alsheikh HA, Mota M, Chen D, Ballinger SW, Rathmell JC, Ponnazhagan S, Darley-Usmar V, Samant RS, Shevde LA. Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages. Cancer Res. 2021 11 01; 81(21):5425-5437. PMID: 34289986; PMCID: PMC8563376.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    85. Baechle JJ, Hanna DN, Sekhar KR, Rathmell JC, Rathmell WK, Baregamian N. Multiplatform computational analysis of mast cells in adrenocortical carcinoma tumor microenvironment. Surgery. 2022 01; 171(1):111-118. PMID: 34261605; PMCID: PMC9941782.
      Citations: 6     Fields:    Translation:HumansCells
    86. Reinfeld BI, Rathmell WK, Kim TK, Rathmell JC. The therapeutic implications of immunosuppressive tumor aerobic glycolysis. Cell Mol Immunol. 2022 01; 19(1):46-58. PMID: 34239083; PMCID: PMC8752729.
      Citations: 59     Fields:    Translation:HumansCells
    87. Jia W, Poe JC, Su H, Anand S, Matsushima GK, Rathmell JC, Maillard I, Radojcic V, Imai K, Reyes NJ, Cardona DM, Li Z, Suthers AN, Curry-Chisolm IM, DiCioccio RA, Saban DR, Chen BJ, Chao NJ, Sarantopoulos S. BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation. Blood. 2021 05 06; 137(18):2544-2557. PMID: 33534893; PMCID: PMC8109011.
      Citations: 27     Fields:    Translation:AnimalsCells
    88. Voss K, Hong HS, Bader JE, Sugiura A, Lyssiotis CA, Rathmell JC. A guide to interrogating immunometabolism. Nat Rev Immunol. 2021 10; 21(10):637-652. PMID: 33859379; PMCID: PMC8478710.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    89. Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature. 2021 05; 593(7858):282-288. PMID: 33828302; PMCID: PMC8122068.
      Citations: 548     Fields:    Translation:HumansAnimalsCells
    90. Tiriveedhi V, Ivy MT, Myles EL, Zent R, Rathmell JC, Titze J. Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response. Cancers (Basel). 2021 Apr 02; 13(7). PMID: 33918403; PMCID: PMC8038238.
      Citations: 11     
    91. Madden MZ, Rathmell JC. The Complex Integration of T-cell Metabolism and Immunotherapy. Cancer Discov. 2021 07; 11(7):1636-1643. PMID: 33795235; PMCID: PMC8295173.
      Citations: 79     Fields:    Translation:HumansCells
    92. Rathmell JC. Obesity, Immunity, and Cancer. N Engl J Med. 2021 Mar 25; 384(12):1160-1162. PMID: 33761213; PMCID: PMC8053443.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    93. Shiuan E, Reddy A, Dudzinski SO, Lim AR, Sugiura A, Hongo R, Young K, Liu XD, Smith CC, O'Neal J, Dahlman KB, McAlister R, Chen B, Ruma K, Roscoe N, Bender J, Ward J, Kim JY, Vaupel C, Bordeaux J, Ganesan S, Mayer TM, Riedlinger GM, Vincent BG, Davis NB, Haake SM, Rathmell JC, Jonasch E, Rini BI, Rathmell WK, Beckermann KE. Clinical Features and Multiplatform Molecular Analysis Assist in Understanding Patient Response to Anti-PD-1/PD-L1 in Renal Cell Carcinoma. Cancers (Basel). 2021 Mar 23; 13(6). PMID: 33806963; PMCID: PMC8004696.
      Citations: 12     
    94. Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E. GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. Cancer Res. 2021 05 01; 81(9):2345-2357. PMID: 33753374; PMCID: PMC8137580.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    95. Levine LS, Hiam-Galvez KJ, Marquez DM, Tenvooren I, Madden MZ, Contreras DC, Dahunsi DO, Irish JM, Oluwole OO, Rathmell JC, Spitzer MH. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. Immunity. 2021 04 13; 54(4):829-844.e5. PMID: 33705706; PMCID: PMC8046726.
      Citations: 77     Fields:    Translation:AnimalsCells
    96. Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. J Clin Invest. 2021 02 15; 131(4). PMID: 33320840; PMCID: PMC7880417.
      Citations: 195     Fields:    Translation:HumansAnimalsCells
    97. Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC. Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. J Immunol. 2021 03 15; 206(6):1127-1139. PMID: 33558372; PMCID: PMC7946768.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    98. Rathmell JC, Rathmell WK. Pushing the boundaries with collision collaboration: the marriage of ideas. J Clin Invest. 2021 01 19; 131(2). PMID: 33463534; PMCID: PMC7810468.
      Citations:    Fields:    Translation:HumansCells
    99. Ramsey HE, Greenwood D, Zhang S, Childress M, Arrate MP, Gorska AE, Fuller L, Zhao Y, Stengel K, Fischer MA, Stubbs MC, Liu PCC, Boyd K, Rathmell JC, Hiebert SW, Savona MR. BET Inhibition Enhances the Antileukemic Activity of Low-dose Venetoclax in Acute Myeloid Leukemia. Clin Cancer Res. 2021 01 15; 27(2):598-607. PMID: 33148670.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    100. Wu H, Herr D, MacIver NJ, Rathmell JC, Gerriets VA. CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism. Int Immunopharmacol. 2020 Nov; 88:106922. PMID: 32866787; PMCID: PMC7657973.
      Citations: 21     Fields:    Translation:AnimalsCells
    101. Beckermann KE, Hongo R, Ye X, Young K, Carbonell K, Healey DCC, Siska PJ, Barone S, Roe CE, Smith CC, Vincent BG, Mason FM, Irish JM, Rathmell WK, Rathmell JC. CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation. JCI Insight. 2020 08 20; 5(16). PMID: 32814710; PMCID: PMC7455120.
      Citations: 58     Fields:    Translation:HumansCells
    102. Contat C, Ancey PB, Zangger N, Sabatino S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, Clerc-Rosset S, Knott GW, Rathmell JC, Abel ED, Meibom A, Meylan E. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. Elife. 2020 06 23; 9. PMID: 32571479; PMCID: PMC7311173.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    103. Bader JE, Voss K, Rathmell JC. Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy. Mol Cell. 2020 06 18; 78(6):1019-1033. PMID: 32559423; PMCID: PMC7339967.
      Citations: 582     Fields:    Translation:Humans
    104. Jiang X, Dudzinski S, Beckermann KE, Young K, McKinley E, J McIntyre O, Rathmell JC, Xu J, Gore JC. MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy. J Immunother Cancer. 2020 06; 8(1). PMID: 32581044; PMCID: PMC7312343.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    105. Lim AR, Rathmell WK, Rathmell JC. The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy. Elife. 2020 05 05; 9. PMID: 32367803; PMCID: PMC7200151.
      Citations: 172     Fields:    Translation:HumansAnimalsCells
    106. Makowski L, Chaib M, Rathmell JC. Immunometabolism: From basic mechanisms to translation. Immunol Rev. 2020 05; 295(1):5-14. PMID: 32320073; PMCID: PMC8056251.
      Citations: 214     Fields:    Translation:HumansAnimals
    107. Raddatz MA, Huffstater T, Bersi MR, Reinfeld BI, Madden MZ, Booton SE, Rathmell WK, Rathmell JC, Lindman BR, Madhur MS, Merryman WD. Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing. Arterioscler Thromb Vasc Biol. 2020 06; 40(6):e153-e165. PMID: 32295422; PMCID: PMC7285853.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    108. Li C, Zhu B, Son YM, Wang Z, Jiang L, Xiang M, Ye Z, Beckermann KE, Wu Y, Jenkins JW, Siska PJ, Vincent BG, Prakash YS, Peikert T, Edelson BT, Taneja R, Kaplan MH, Rathmell JC, Dong H, Hitosugi T, Sun J. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. Immunity. 2020 01 14; 52(1):201-202. PMID: 31940270; PMCID: PMC7004238.
      Citations: 11     Fields:    
    109. Fuseini H, Cephus JY, Wu P, Davis JB, Contreras DC, Gandhi VD, Rathmell JC, Newcomb DC. ERa Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation. Front Immunol. 2019; 10:2740. PMID: 31849948; PMCID: PMC6892971.
      Citations: 43     Fields:    Translation:AnimalsCells
    110. Li C, Zhu B, Son YM, Wang Z, Jiang L, Xiang M, Ye Z, Beckermann KE, Wu Y, Jenkins JW, Siska PJ, Vincent BG, Prakash YS, Peikert T, Edelson BT, Taneja R, Kaplan MH, Rathmell JC, Dong H, Hitosugi T, Sun J. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. Immunity. 2019 09 17; 51(3):491-507.e7. PMID: 31533057; PMCID: PMC6903704.
      Citations: 144     Fields:    Translation:AnimalsCells
    111. Dudzinski SO, Cameron BD, Wang J, Rathmell JC, Giorgio TD, Kirschner AN. Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer. J Immunother Cancer. 2019 08 14; 7(1):218. PMID: 31412954; PMCID: PMC6694548.
      Citations: 54     Fields:    Translation:HumansAnimals
    112. Savona MR, Rathmell JC. Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade. Cancer Discov. 2019 Jul; 9(7):831-833. PMID: 31262744; PMCID: PMC8059329.
      Citations: 13     Fields:    Translation:Humans
    113. Babaer D, Amara S, McAdory BS, Johnson O, Myles EL, Zent R, Rathmell JC, Tiriveedhi V. Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells. Cancers (Basel). 2019 May 14; 11(5). PMID: 31091800; PMCID: PMC6562487.
      Citations: 9     
    114. van Bruggen JAC, Martens AWJ, Fraietta JA, Hofland T, Tonino SH, Eldering E, Levin MD, Siska PJ, Endstra S, Rathmell JC, June CH, Porter DL, Melenhorst JJ, Kater AP, van der Windt GJW. Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy. Blood. 2019 07 04; 134(1):44-58. PMID: 31076448; PMCID: PMC7022375.
      Citations: 121     Fields:    Translation:HumansCells
    115. Sinclair LV, Howden AJ, Brenes A, Spinelli L, Hukelmann JL, Macintyre AN, Liu X, Thomson S, Taylor PM, Rathmell JC, Locasale JW, Lamond AI, Cantrell DA, Howden AJM. Antigen receptor control of methionine metabolism in T cells. Elife. 2019 03 27; 8. PMID: 30916644; PMCID: PMC6497464.
      Citations: 121     Fields:    Translation:AnimalsCells
    116. Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL, Hoehn KL, Rathmell JC, Bullock TNJ. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. Sci Immunol. 2019 01 25; 4(31). PMID: 30683669; PMCID: PMC6824424.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    117. Freemerman AJ, Zhao L, Pingili AK, Teng B, Cozzo AJ, Fuller AM, Johnson AR, Milner JJ, Lim MF, Galanko JA, Beck MA, Bear JE, Rotty JD, Bezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale JW, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L. Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1. J Immunol. 2019 02 15; 202(4):1265-1286. PMID: 30659108; PMCID: PMC6360258.
      Citations: 76     Fields:    Translation:AnimalsCells
    118. Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature. 2018 11; 563(7733):714-718. PMID: 30464343; PMCID: PMC6331005.
      Citations: 205     Fields:    Translation:HumansAnimalsCells
    119. Greenplate AR, McClanahan DD, Oberholtzer BK, Doxie DB, Roe CE, Diggins KE, Leelatian N, Rasmussen ML, Kelley MC, Gama V, Siska PJ, Rathmell JC, Ferrell PB, Johnson DB, Irish JM. Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types. Cancer Immunol Res. 2019 01; 7(1):86-99. PMID: 30413431; PMCID: PMC6318034.
      Citations: 28     Fields:    Translation:HumansCells
    120. Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC. Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. Cell. 2018 12 13; 175(7):1780-1795.e19. PMID: 30392958; PMCID: PMC6361668.
      Citations: 402     Fields:    Translation:AnimalsCells
    121. Rathmell WK, Rathmell JC, Linehan WM. Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions. J Clin Oncol. 2018 10 29; JCO2018792309. PMID: 30372395; PMCID: PMC6488445.
      Citations: 42     Fields:    
    122. Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP. xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. Oncogene. 2018 09; 37(36):5007-5019. PMID: 29789716; PMCID: PMC6127081.
      Citations: 191     Fields:    Translation:HumansAnimalsCells
    123. Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018 05; 24(5):617-627. PMID: 29662201; PMCID: PMC6095711.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    124. Zhang Q, Jeppesen DK, Higginbotham JN, Demory Beckler M, Poulin EJ, Walsh AJ, Skala MC, McKinley ET, Manning HC, Hight MR, Schulte ML, Watt KR, Ayers GD, Wolf MM, Andrejeva G, Rathmell JC, Franklin JL, Coffey RJ. Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cell Mol Gastroenterol Hepatol. 2018; 5(4):627-629.e6. PMID: 29930982; PMCID: PMC6009797.
      Citations: 30     Fields:    
    125. Chen YH, Kratchmarov R, Lin WW, Rothman NJ, Yen B, Adams WC, Nish SA, Rathmell JC, Reiner SL. Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway. Cell Rep. 2018 01 23; 22(4):860-868. PMID: 29420173; PMCID: PMC5806629.
      Citations: 22     Fields:    Translation:HumansCells
    126. Sugiura A, Rathmell JC. Metabolic Barriers to T Cell Function in Tumors. J Immunol. 2018 01 15; 200(2):400-407. PMID: 29311381; PMCID: PMC5777533.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    127. Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat Med. 2018 02; 24(2):194-202. PMID: 29334372; PMCID: PMC5803339.
      Citations: 276     Fields:    Translation:HumansAnimalsCells
    128. Afzal J, Chan A, Karakas MF, Woldemichael K, Vakrou S, Guan Y, Rathmell J, Wahl R, Pomper M, Foster DB, Aon MA, Tsui B, O'Rourke B, Abraham MR. Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status. JACC Basic Transl Sci. 2017 Oct; 2(5):543-560. PMID: 29520378; PMCID: PMC5839118.
      Citations: 5     
    129. Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL. MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation. Cell Metab. 2017 Oct 03; 26(4):633-647.e7. PMID: 28978427; PMCID: PMC5650077.
      Citations: 362     Fields:    Translation:HumansAnimalsCells
    130. Liberti MV, Dai Z, Wardell SE, Baccile JA, Liu X, Gao X, Baldi R, Mehrmohamadi M, Johnson MO, Madhukar NS, Shestov AA, Chio IIC, Elemento O, Rathmell JC, Schroeder FC, McDonnell DP, Locasale JW. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017 Oct 03; 26(4):648-659.e8. PMID: 28918937; PMCID: PMC5629112.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    131. Andrejeva G, Rathmell JC. Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors. Cell Metab. 2017 Jul 05; 26(1):49-70. PMID: 28683294; PMCID: PMC5555084.
      Citations: 222     Fields:    Translation:HumansAnimalsCells
    132. MacIver NJ, Rathmell JC. Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate. Curr Opin Immunol. 2017 06; 46:viii-xi. PMID: 28684058; PMCID: PMC5648598.
      Citations: 10     Fields:    Translation:HumansCells
    133. Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. JCI Insight. 2017 Jun 15; 2(12). PMID: 28614802; PMCID: PMC5470888.
      Citations: 218     Fields:    
    134. Olenchock BA, Rathmell JC, Vander Heiden MG. Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. Immunity. 2017 05 16; 46(5):703-713. PMID: 28514672; PMCID: PMC5660630.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    135. Beckermann KE, Dudzinski SO, Rathmell JC. Dysfunctional T cell metabolism in the tumor microenvironment. Cytokine Growth Factor Rev. 2017 Jun; 35:7-14. PMID: 28456467; PMCID: PMC5710836.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    136. Rhoads JP, Major AS, Rathmell JC. Fine tuning of immunometabolism for the treatment of rheumatic diseases. Nat Rev Rheumatol. 2017 May; 13(5):313-320. PMID: 28381829; PMCID: PMC5502208.
      Citations: 44     Fields:    Translation:HumansAnimals
    137. Siska PJ, Johnpulle RAN, Zhou A, Bordeaux J, Kim JY, Dabbas B, Dakappagari N, Rathmell JC, Rathmell WK, Morgans AK, Balko JM, Johnson DB. Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling. Oncoimmunology. 2017; 6(4):e1305535. PMID: 28507813; PMCID: PMC5414873.
      Citations: 49     Fields:    
    138. Schmidt EA, Fee BE, Henry SC, Nichols AG, Shinohara ML, Rathmell JC, MacIver NJ, Coers J, Ilkayeva OR, Koves TR, Taylor GA. Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. J Biol Chem. 2017 03 17; 292(11):4651-4662. PMID: 28154172; PMCID: PMC5377780.
      Citations: 18     Fields:    Translation:AnimalsCells
    139. Adams WC, Chen YH, Kratchmarov R, Yen B, Nish SA, Lin WW, Rothman NJ, Luchsinger LL, Klein U, Busslinger M, Rathmell JC, Snoeck HW, Reiner SL. Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. Cell Rep. 2016 12 20; 17(12):3142-3152. PMID: 28009285; PMCID: PMC5189677.
      Citations: 68     Fields:    Translation:AnimalsCells
    140. Siska PJ, Rathmell JC. Metabolic Signaling Drives IFN-?. Cell Metab. 2016 11 08; 24(5):651-652. PMID: 27829134; PMCID: PMC5292925.
      Citations: 16     Fields:    Translation:HumansCells
    141. Johnson MO, Siska PJ, Contreras DC, Rathmell JC. Nutrients and the microenvironment to feed a T cell army. Semin Immunol. 2016 10; 28(5):505-513. PMID: 27712958; PMCID: PMC5154770.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    142. Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat Immunol. 2016 Dec; 17(12):1459-1466. PMID: 27695003; PMCID: PMC5215903.
      Citations: 351     Fields:    Translation:AnimalsCells
    143. Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H. mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. Immunity. 2016 09 20; 45(3):540-554. PMID: 27637146; PMCID: PMC5050556.
      Citations: 203     Fields:    Translation:AnimalsCells
    144. Siska PJ, Kim B, Ji X, Hoeksema MD, Massion PP, Beckermann KE, Wu J, Chi JT, Hong J, Rathmell JC. Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. J Immunol Methods. 2016 11; 438:51-58. PMID: 27594594; PMCID: PMC5065394.
      Citations: 36     Fields:    Translation:HumansCells
    145. Siska PJ, van der Windt GJ, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC. Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. J Immunol. 2016 09 15; 197(6):2532-40. PMID: 27511728; PMCID: PMC5010978.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    146. O'Neill LA, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nat Rev Immunol. 2016 09; 16(9):553-65. PMID: 27396447; PMCID: PMC5001910.
      Citations: 1645     Fields:    Translation:HumansAnimals
    147. Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metab. 2016 Apr 12; 23(4):649-62. PMID: 27076078; PMCID: PMC4832577.
      Citations: 146     Fields:    Translation:HumansAnimalsCells
    148. Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP. ERRa-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Rep. 2016 Apr 12; 15(2):323-35. PMID: 27050525; PMCID: PMC4833658.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    149. Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG. Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev Cell. 2016 Mar 07; 36(5):540-9. PMID: 26954548; PMCID: PMC4766004.
      Citations: 364     Fields:    Translation:HumansAnimalsCells
    150. McFadden K, Hafez AY, Kishton R, Messinger JE, Nikitin PA, Rathmell JC, Luftig MA. Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. Proc Natl Acad Sci U S A. 2016 Feb 09; 113(6):E782-90. PMID: 26802124; PMCID: PMC4760815.
      Citations: 74     Fields:    Translation:HumansCells
    151. Johnson MO, Rathmell JC. AIF Is "Always In Fashion" for T Cells. Immunity. 2016 Jan 19; 44(1):11-13. PMID: 26789917; PMCID: PMC5660629.
      Citations: 4     Fields:    Translation:AnimalsCells
    152. Hu J, Sun T, Wang H, Chen Z, Wang S, Yuan L, Liu T, Li HR, Wang P, Feng Y, Wang Q, McLendon RE, Friedman AH, Keir ST, Bigner DD, Rathmell J, Fu XD, Li QJ, Wang H, Wang XF. MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. Cancer Cell. 2016 Jan 11; 29(1):49-60. PMID: 26766590; PMCID: PMC4871949.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    153. Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015 Dec; 35 Suppl:S276-S304. PMID: 26590477; PMCID: PMC4819002.
      Citations: 114     Fields:    Translation:HumansCells
    154. Kang S, Keener AB, Jones SZ, Benschop RJ, Caro-Maldonado A, Rathmell JC, Clarke SH, Matsushima GK, Whitmire JK, Vilen BJ. IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF. J Immunol. 2016 Jan 01; 196(1):196-206. PMID: 26621863; PMCID: PMC4684997.
      Citations: 10     Fields:    Translation:AnimalsCells
    155. Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE, Target Validation Team. Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol. 2015 Dec; 35 Suppl:S129-S150. PMID: 26454069; PMCID: PMC4656121.
      Citations: 185     Fields:    Translation:HumansCells
    156. Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV. MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metab. 2015 Dec 01; 22(6):1009-19. PMID: 26387865; PMCID: PMC4818967.
      Citations: 173     Fields:    Translation:HumansCells
    157. Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. 2015 Sep 10; 162(6):1217-28. PMID: 26321681; PMCID: PMC4567953.
      Citations: 858     Fields:    Translation:AnimalsCells
    158. Murray PJ, Rathmell J, Pearce E. SnapShot: Immunometabolism. Cell Metab. 2015 Jul 07; 22(1):190-190.e1. PMID: 26154058.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    159. Siska PJ, Rathmell JC. PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1. Mol Cell. 2015 Jun 04; 58(5):711-2. PMID: 26046643; PMCID: PMC4704109.
      Citations: 10     Fields:    Translation:HumansAnimals
    160. Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, Rathmell JC, Dewhirst MW, Kirsch DG. HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. Radiat Res. 2015 Jun; 183(6):594-609. PMID: 25973951; PMCID: PMC4800000.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    161. Siska PJ, Rathmell JC. T cell metabolic fitness in antitumor immunity. Trends Immunol. 2015 Apr; 36(4):257-64. PMID: 25773310; PMCID: PMC4393792.
      Citations: 190     Fields:    Translation:HumansAnimalsCells
    162. Kishton RJ, Rathmell JC. Novel therapeutic targets of tumor metabolism. Cancer J. 2015 Mar-Apr; 21(2):62-9. PMID: 25815845; PMCID: PMC4380246.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    163. Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol. 2015 Feb; 16(2):188-96. PMID: 25559257; PMCID: PMC4297515.
      Citations: 275     Fields:    Translation:AnimalsCells
    164. Stathem M, Marimuthu S, O'Neal J, Rathmell JC, Chesney JA, Beverly LJ, Siskind LJ. Glucose availability and glycolytic metabolism dictate glycosphingolipid levels. J Cell Biochem. 2015 Jan; 116(1):67-80. PMID: 25145677; PMCID: PMC4229434.
      Citations: 14     Fields:    Translation:HumansCells
    165. Kountikov EI, Poe JC, Maclver NJ, Rathmell JC, Tedder TF. A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. Am J Pathol. 2015 Mar; 185(3):617-30. PMID: 25542773; PMCID: PMC4348474.
      Citations: 4     Fields:    Translation:AnimalsCells
    166. Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, Wood KC. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Sci Signal. 2014 12 23; 7(357):ra121. PMID: 25538079; PMCID: PMC4353587.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    167. Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, Smith PA, Schneider MA, MacIver NJ, Locasale JW, Newgard CB, Shinohara ML, Rathmell JC. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J Clin Invest. 2015 Jan; 125(1):194-207. PMID: 25437876; PMCID: PMC4382238.
      Citations: 439     Fields:    Translation:AnimalsCells
    168. Wang B, Liu TY, Lai CH, Rao YH, Choi MC, Chi JT, Dai JW, Rathmell JC, Yao TP. Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. Mol Biol Cell. 2014 Nov 01; 25(21):3300-7. PMID: 25187650; PMCID: PMC4214777.
      Citations: 28     Fields:    Translation:AnimalsCells
    169. Cao Y, Rathmell JC, Macintyre AN. Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. PLoS One. 2014; 9(8):e104104. PMID: 25090630; PMCID: PMC4121309.
      Citations: 89     Fields:    Translation:AnimalsCells
    170. Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 2014 Jul 01; 20(1):61-72. PMID: 24930970; PMCID: PMC4079750.
      Citations: 686     Fields:    Translation:HumansAnimalsCells
    171. Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK. HIF1a and HIF2a exert distinct nutrient preferences in renal cells. PLoS One. 2014; 9(5):e98705. PMID: 24879016; PMCID: PMC4039535.
      Citations: 11     Fields:    Translation:AnimalsCells
    172. Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 2014 Apr 15; 192(8):3626-36. PMID: 24616478; PMCID: PMC3984038.
      Citations: 299     Fields:    Translation:HumansAnimalsCells
    173. Saucillo DC, Gerriets VA, Sheng J, Rathmell JC, Maciver NJ. Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol. 2014 Jan 01; 192(1):136-44. PMID: 24273001; PMCID: PMC3872216.
      Citations: 161     Fields:    Translation:AnimalsCells
    174. Green DR, Rathmell J. Sweet nothings: sensing of sugar metabolites controls T cell function. Cell Metab. 2013 Jul 02; 18(1):7-8. PMID: 23823473; PMCID: PMC3749232.
      Citations: 2     Fields:    Translation:AnimalsCells
    175. Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, Koretzky GA. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat Immunol. 2013 Jun; 14(6):611-8. PMID: 23644504; PMCID: PMC3711189.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    176. McCarthy SA, Mufson RA, Pearce EJ, Rathmell JC, Howcroft TK. Metabolic reprogramming of the immune response in the tumor microenvironment. Cancer Biol Ther. 2013 Apr; 14(4):315-8. PMID: 23358474; PMCID: PMC3667870.
      Citations: 10     Fields:    Translation:HumansAnimals
    177. Macintyre AN, Rathmell JC. Activated lymphocytes as a metabolic model for carcinogenesis. Cancer Metab. 2013 Jan 23; 1(1):5. PMID: 24280044; PMCID: PMC3834493.
      Citations: 51     
    178. Kurokawa M, Ito T, Yang CS, Zhao C, Macintyre AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S. Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2300-5. PMID: 23324740; PMCID: PMC3568344.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    179. MacIver NJ, Michalek RD, Rathmell JC. Metabolic regulation of T lymphocytes. Annu Rev Immunol. 2013; 31:259-83. PMID: 23298210; PMCID: PMC3606674.
      Citations: 768     Fields:    Translation:HumansAnimalsCells
    180. Caro-Maldonado A, Gerriets VA, Rathmell JC. Matched and mismatched metabolic fuels in lymphocyte function. Semin Immunol. 2012 Dec; 24(6):405-13. PMID: 23290889; PMCID: PMC3582857.
      Citations: 28     Fields:    Translation:HumansCells
    181. Altman BJ, Rathmell JC. Metabolic stress in autophagy and cell death pathways. Cold Spring Harb Perspect Biol. 2012 Sep 01; 4(9):a008763. PMID: 22952396; PMCID: PMC3428762.
      Citations: 109     Fields:    
    182. Rathmell JC. Metabolism and autophagy in the immune system: immunometabolism comes of age. Immunol Rev. 2012 Sep; 249(1):5-13. PMID: 22889211; PMCID: PMC3576876.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    183. Bhatt AP, Jacobs SR, Freemerman AJ, Makowski L, Rathmell JC, Dittmer DP, Damania B. Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11818-23. PMID: 22752304; PMCID: PMC3406848.
      Citations: 109     Fields:    Translation:HumansCells
    184. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bourquin JP, Boya P, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, Ghosh P, Giammarioli AM, Giatromanolaki AN, Gibson SB, Gilkerson RW, Ginger ML, Ginsberg HN, Golab J, Goligorsky MS, Golstein P, Gomez-Manzano C, Goncu E, Gonzalez CD, Gonzalez R, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490; PMCID: PMC3404883.
      Citations: 1882     Fields:    Translation:HumansAnimals
    185. Gerriets VA, Rathmell JC. Metabolic pathways in T cell fate and function. Trends Immunol. 2012 Apr; 33(4):168-73. PMID: 22342741; PMCID: PMC3319512.
      Citations: 230     Fields:    Translation:HumansAnimalsCells
    186. Rathmell JC. T cell Myc-tabolism. Immunity. 2011 Dec 23; 35(6):845-6. PMID: 22195738; PMCID: PMC3267318.
      Citations: 18     Fields:    
    187. Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, Rathmell JC. Estrogen-related receptor-a is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):18348-53. PMID: 22042850; PMCID: PMC3215012.
      Citations: 131     Fields:    Translation:AnimalsCells
    188. Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP. The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. Endocrinology. 2011 Dec; 152(12):4691-705. PMID: 21933863; PMCID: PMC3230052.
      Citations: 59     Fields:    Translation:AnimalsCells
    189. MacIver NJ, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, Jones RG. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J Immunol. 2011 Oct 15; 187(8):4187-98. PMID: 21930968; PMCID: PMC3206094.
      Citations: 155     Fields:    Translation:AnimalsCells
    190. Macintyre AN, Rathmell JC. PKM2 and the tricky balance of growth and energy in cancer. Mol Cell. 2011 Jun 24; 42(6):713-4. PMID: 21700216; PMCID: PMC3267323.
      Citations: 34     Fields:    
    191. Coloff JL, Macintyre AN, Nichols AG, Liu T, Gallo CA, Plas DR, Rathmell JC. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer Res. 2011 Aug 01; 71(15):5204-13. PMID: 21670080; PMCID: PMC3148426.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    192. Wang X, Eno CO, Altman BJ, Zhu Y, Zhao G, Olberding KE, Rathmell JC, Li C. ER stress modulates cellular metabolism. Biochem J. 2011 Apr 01; 435(1):285-96. PMID: 21241252; PMCID: PMC3072169.
      Citations: 52     Fields:    Translation:AnimalsCells
    193. Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S. Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Mol Biol Cell. 2011 Apr 15; 22(8):1207-16. PMID: 21325626; PMCID: PMC3078078.
      Citations: 62     Fields:    Translation:HumansCells
    194. Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, Sullivan SA, Nichols AG, Rathmell JC. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol. 2011 Mar 15; 186(6):3299-303. PMID: 21317389; PMCID: PMC3198034.
      Citations: 1208     Fields:    Translation:AnimalsCells
    195. Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. J Biol Chem. 2011 Feb 18; 286(7):5921-33. PMID: 21159778; PMCID: PMC3037705.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    196. Mason EF, Zhao Y, Goraksha-Hicks P, Coloff JL, Gannon H, Jones SN, Rathmell JC. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Res. 2010 Oct 15; 70(20):8066-76. PMID: 20876800; PMCID: PMC2955844.
      Citations: 27     Fields:    Translation:HumansCells
    197. Mason EF, Rathmell JC. Cell metabolism: an essential link between cell growth and apoptosis. Biochim Biophys Acta. 2011 Apr; 1813(4):645-54. PMID: 20816705; PMCID: PMC3010257.
      Citations: 93     Fields:    Translation:HumansAnimals
    198. Michalek RD, Rathmell JC. The metabolic life and times of a T-cell. Immunol Rev. 2010 Jul; 236:190-202. PMID: 20636818; PMCID: PMC2983473.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    199. Ke H, Harris R, Coloff JL, Jin JY, Leshin B, Miliani de Marval P, Tao S, Rathmell JC, Hall RP, Zhang JY. The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. Cancer Res. 2010 Apr 15; 70(8):3080-8. PMID: 20354187; PMCID: PMC2855785.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    200. Jacobs SR, Michalek RD, Rathmell JC. IL-7 is essential for homeostatic control of T cell metabolism in vivo. J Immunol. 2010 Apr 01; 184(7):3461-9. PMID: 20194717; PMCID: PMC2980949.
      Citations: 98     Fields:    Translation:AnimalsCells
    201. Calamito M, Juntilla MM, Thomas M, Northrup DL, Rathmell J, Birnbaum MJ, Koretzky G, Allman D. Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood. 2010 May 20; 115(20):4043-50. PMID: 20042722; PMCID: PMC2875094.
      Citations: 52     Fields:    Translation:AnimalsCells
    202. Goraksha-Hicks P, Rathmell JC. TGF-beta: a new role for an old AktTOR. Dev Cell. 2009 Jul; 17(1):6-8. PMID: 19619487; PMCID: PMC2789270.
      Citations: 3     Fields:    Translation:AnimalsCells
    203. Rathmell JC, Newgard CB. Biochemistry. A glucose-to-gene link. Science. 2009 May 22; 324(5930):1021-2. PMID: 19460991; PMCID: PMC2788238.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    204. Altman BJ, Rathmell JC. Autophagy: not good OR bad, but good AND bad. Autophagy. 2009 May; 5(4):569-70. PMID: 19398886; PMCID: PMC2788432.
      Citations: 13     Fields:    Translation:HumansAnimals
    205. Wieman HL, Horn SR, Jacobs SR, Altman BJ, Kornbluth S, Rathmell JC. An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. Biochem J. 2009 Mar 01; 418(2):345-67. PMID: 19016655; PMCID: PMC2637307.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    206. Altman BJ, Wofford JA, Zhao Y, Coloff JL, Ferguson EC, Wieman HL, Day AE, Ilkayeva O, Rathmell JC. Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. Mol Biol Cell. 2009 Feb; 20(4):1180-91. PMID: 19109422; PMCID: PMC2642748.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    207. Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Mol Endocrinol. 2009 Mar; 23(3):388-401. PMID: 19106193; PMCID: PMC2654518.
      Citations: 54     Fields:    Translation:HumansCells
    208. Zhao Y, Coloff JL, Ferguson EC, Jacobs SR, Cui K, Rathmell JC. Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. J Biol Chem. 2008 Dec 26; 283(52):36344-53. PMID: 18990690; PMCID: PMC2606014.
      Citations: 69     Fields:    Translation:AnimalsCells
    209. Michalek RD, Rathmell JC. Methed-up FOXOs can't in-Akt-ivate. Mol Cell. 2008 Oct 24; 32(2):160-2. PMID: 18951081; PMCID: PMC2603568.
      Citations: 1     Fields:    Translation:HumansCells
    210. Ferguson EC, Rathmell JC. New roles for pyruvate kinase M2: working out the Warburg effect. Trends Biochem Sci. 2008 Aug; 33(8):359-62. PMID: 18603432; PMCID: PMC2590867.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    211. Maciver NJ, Jacobs SR, Wieman HL, Wofford JA, Coloff JL, Rathmell JC. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J Leukoc Biol. 2008 Oct; 84(4):949-57. PMID: 18577716; PMCID: PMC2638731.
      Citations: 232     Fields:    Translation:HumansAnimalsCells
    212. Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, Rathmell JC. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol. 2008 Apr 01; 180(7):4476-86. PMID: 18354169; PMCID: PMC2593791.
      Citations: 494     Fields:    Translation:AnimalsCells
    213. Zhao Y, Wieman HL, Jacobs SR, Rathmell JC. Mechanisms and methods in glucose metabolism and cell death. Methods Enzymol. 2008; 442:439-57. PMID: 18662583; PMCID: PMC2605583.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    214. Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood. 2008 Feb 15; 111(4):2101-11. PMID: 18042802; PMCID: PMC2234050.
      Citations: 236     Fields:    Translation:AnimalsCells
    215. Juntilla MM, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA. Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12105-10. PMID: 17609365; PMCID: PMC1924580.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    216. Rathmell JC, Kornbluth S. Filling a GAP(DH) in caspase-independent cell death. Cell. 2007 Jun 01; 129(5):861-3. PMID: 17540167; PMCID: PMC2592604.
      Citations: 6     Fields:    Translation:HumansCells
    217. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Mol Cell Biol. 2007 Jun; 27(12):4328-39. PMID: 17371841; PMCID: PMC1900055.
      Citations: 103     Fields:    Translation:AnimalsCells
    218. Wieman HL, Wofford JA, Rathmell JC. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell. 2007 Apr; 18(4):1437-46. PMID: 17301289; PMCID: PMC1838986.
      Citations: 341     Fields:    Translation:AnimalsCells
    219. Coloff JL, Rathmell JC. Metabolic regulation of Akt: roles reversed. J Cell Biol. 2006 Dec 18; 175(6):845-7. PMID: 17158959; PMCID: PMC2064693.
      Citations: 12     Fields:    Translation:HumansCells
    220. Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portocarrero CP, Keister BA, Belka GK, Cho H, Rathmell JC, Thompson CB, Birnbaum MJ, Chodosh LA. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metab. 2006 Dec; 4(6):475-90. PMID: 17141631.
      Citations: 52     Fields:    Translation:Animals
    221. Deming PB, Rathmell JC. Mitochondria, cell death, and B cell tolerance. Curr Dir Autoimmun. 2006; 9:95-119. PMID: 16394657.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    222. Jacobs SR, Rathmell JC. Lymphocyte selection by starvation: glucose metabolism and cell death. Trends Immunol. 2006 Jan; 27(1):4-7. PMID: 16300996.
      Citations: 4     Fields:    Translation:AnimalsCells
    223. Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC, Kornbluth S. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell. 2005 Oct 07; 123(1):89-103. PMID: 16213215; PMCID: PMC2788768.
      Citations: 113     Fields:    Translation:AnimalsCells
    224. Cinalli RM, Herman CE, Lew BO, Wieman HL, Thompson CB, Rathmell JC. T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. Eur J Immunol. 2005 Mar; 35(3):786-95. PMID: 15719365; PMCID: PMC2628485.
      Citations: 11     Fields:    Translation:AnimalsCells
    225. Bauer DE, Harris MH, Plas DR, Lum JJ, Hammerman PS, Rathmell JC, Riley JL, Thompson CB. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB J. 2004 Aug; 18(11):1303-5. PMID: 15180958; PMCID: PMC4458073.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    226. Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol. 2004 May 01; 172(9):5287-96. PMID: 15100267; PMCID: PMC2842445.
      Citations: 130     Fields:    Translation:AnimalsCells
    227. Rathmell JC. B-cell homeostasis: digital survival or analog growth? Immunol Rev. 2004 Feb; 197:116-28. PMID: 14962191.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    228. Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol. 2003 Oct; 23(20):7315-28. PMID: 14517300; PMCID: PMC230333.
      Citations: 269     Fields:    Translation:AnimalsCells
    229. Rathmell JC, Elstrom RL, Cinalli RM, Thompson CB. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur J Immunol. 2003 Aug; 33(8):2223-32. PMID: 12884297.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    230. Rathmell JC. Apoptosis and B cell tolerance. Curr Dir Autoimmun. 2003; 6:38-60. PMID: 12408046.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    231. Rathmell JC, Lindsten T, Zong WX, Cinalli RM, Thompson CB. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol. 2002 Oct; 3(10):932-9. PMID: 12244308.
      Citations: 134     Fields:    Translation:AnimalsCells
    232. Plas DR, Rathmell JC, Thompson CB. Homeostatic control of lymphocyte survival: potential origins and implications. Nat Immunol. 2002 Jun; 3(6):515-21. PMID: 12032565.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    233. Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, Elstrom RL, June CH, Thompson CB. The CD28 signaling pathway regulates glucose metabolism. Immunity. 2002 Jun; 16(6):769-77. PMID: 12121659.
      Citations: 793     Fields:    Translation:HumansCells
    234. Rathmell JC, Thompson CB. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell. 2002 Apr; 109 Suppl:S97-107. PMID: 11983156.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
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