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Anna Biernacka

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Biernacka is a board-certified anatomic pathologist and cytopathologist with expertise in breast pathology. She works closely with other members of the Multidisciplinary Breast Program at the University of Chicago, providing comprehensive and coordinated care to breast cancer patients. Her clinical and research interests center on the morphologic and molecular features of breast diseases, with a special focus on apocrine lesions and androgen receptor signaling in breast cancer.


    Collapse Biography 
    Collapse education and training
    The Medical University of Lodz, PolandMD2006
    The Medical University of Lodz, PolandPhD2012
    Anderson Cancer CenterMD2010
    Albert Einstein College of MedicinePostdoctoral Fellowship2012
    Baylor College of MedicineResidency 2015Anatomic Pathology
    Dartmouth-HitchcockFellowship 2016Cytopathology
    Massachusetts General HospitalFellowship 2017Breast Pathology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhu Y, Biernacka A, Pardo B, Dojer N, Forey R, Skrzypczak M, Fongang B, Nde J, Yousefi R, Pasero P, Ginalski K, Rowicka M. qDSB-Seq is a general method for genome-wide quantification of DNA double-strand breaks using sequencing. Nat Commun. 2019 05 24; 10(1):2313. PMID: 31127121.
      View in: PubMed
    2. Jezela-Stanek A, Walczak A, Lazniewski M, Kosinska J, Stawinski P, Murcia Pienkowski V, Biernacka A, Rydzanicz M, Kostrzewa G, Krajewski P, Plewczynski D, Ploski R. Novel COL12A1 variant as a cause of mild familial extracellular matrix-related myopathy. Clin Genet. 2019 Jun; 95(6):736-738. PMID: 30920656.
      View in: PubMed
    3. Banach BS, Antic T, Bridge JA, Cipriani NA, Frye L, Krausz TN, Biernacka A. Fine-needle aspiration of dermatofibrosarcoma protuberans metastasizing to hemithorax with superior vena cava compression: Case report and literature review. Diagn Cytopathol. 2019 Aug; 47(8):797-802. PMID: 30919592.
      View in: PubMed
    4. Choy B, Venkataraman G, Biernacka A, Lastra RR, Mueller J, Setia N, Reeves W, Antic T. Correlation of cytopathology with flow cytometry and histopathology for the diagnosis of hematologic malignancies in young adults presenting with cervical lymphadenopathy. Diagn Cytopathol. 2019 Jun; 47(6):579-583. PMID: 30794347.
      View in: PubMed
    5. Smigiel R, Sherman DL, Rydzanicz M, Walczak A, Mikolajkow D, Krolak-Olejnik B, Kosinska J, Gasperowicz P, Biernacka A, Stawinski P, Marciniak M, Andrzejewski W, Boczar M, Krajewski P, Sasiadek MM, Brophy PJ, Ploski R. Homozygous mutation in the Neurofascin gene affecting the glial isoform of Neurofascin causes severe neurodevelopment disorder with hypotonia, amimia and areflexia. Hum Mol Genet. 2018 11 01; 27(21):3669-3674. PMID: 30124836.
      View in: PubMed
    6. Biernacka A, Zhu Y, Skrzypczak M, Forey R, Pardo B, Grzelak M, Nde J, Mitra A, Kudlicki A, Crosetto N, Pasero P, Rowicka M, Ginalski K. i-BLESS is an ultra-sensitive method for detection of DNA double-strand breaks. Commun Biol. 2018; 1:181. PMID: 30393778.
      View in: PubMed
    7. Murcia Pienkowski V, Kucharczyk M, Mlynek M, Szczaluba K, Rydzanicz M, Poszewiecka B, Skórka A, Sykulski M, Biernacka A, Koppolu AA, Posmyk R, Walczak A, Kosinska J, Krajewski P, Castaneda J, Obersztyn E, Jurkiewicz E, Smigiel R, Gambin A, Chrzanowska K, Krajewska-Walasek M, Ploski R. Mapping of breakpoints in balanced chromosomal translocations by shallow whole-genome sequencing points to EFNA5, BAHD1 and PPP2R5E as novel candidates for genes causing human Mendelian disorders. J Med Genet. 2019 Feb; 56(2):104-112. PMID: 30352868.
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    8. Szczaluba K, Chmielewska JJ, Sokolowska O, Rydzanicz M, Szymanska K, Feleszko W, Wlodarski P, Biernacka A, Murcia Pienkowski V, Walczak A, Bargel E, Królewczyk K, Nowacka A, Stawinski P, Nowis D, Dziembowska M, Ploski R. Neurodevelopmental phenotype caused by a de novo PTPN4 single nucleotide variant disrupting protein localization in neuronal dendritic spines. Clin Genet. 2018 Dec; 94(6):581-585. PMID: 30238967.
      View in: PubMed
    9. Clouaire T, Rocher V, Lashgari A, Arnould C, Aguirrebengoa M, Biernacka A, Skrzypczak M, Aymard F, Fongang B, Dojer N, Iacovoni JS, Rowicka M, Ginalski K, Côté J, Legube G. Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Mol Cell. 2018 10 18; 72(2):250-262.e6. PMID: 30270107.
      View in: PubMed
    10. Kuchta K, Towpik J, Biernacka A, Kutner J, Kudlicki A, Ginalski K, Rowicka M. Predicting proteome dynamics using gene expression data. Sci Rep. 2018 Sep 14; 8(1):13866. PMID: 30217992.
      View in: PubMed
    11. Pilch J, Koppolu AA, Walczak A, Murcia Pienkowski VA, Biernacka A, Skiba P, Machnik-Broncel J, Gasperowicz P, Kosinska J, Rydzanicz M, Emich-Widera E, Ploski R. Evidence for HNRNPH1 being another gene for Bain type syndromic mental retardation. Clin Genet. 2018 Oct; 94(3-4):381-385. PMID: 29938792.
      View in: PubMed
    12. Matuszewska KE, Badura-Stronka M, Smigiel R, Cabala M, Biernacka A, Kosinska J, Rydzanicz M, Winczewska-Wiktor A, Sasiadek M, Latos-Bielenska A, Zemojtel T, Ploski R. Phenotype of two Polish patients with Schaaf-Yang syndrome confirmed by identifying mutation in MAGEL2 gene. Clin Dysmorphol. 2018 Apr; 27(2):49-52. PMID: 29389715.
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    13. Olofson AM, Biernacka A, Li Z, Boonipat T, Gutmann EJ, Smith KD, Gardner TB, Gordon SR, Padmanabhan V, Marotti JD, Liu X. Indeterminate diagnoses in EUS-guided FNA of the pancreas: analysis of cytologist and clinician perceptions, cytologic features, and clinical outcomes. J Am Soc Cytopathol. 2018 Sep - Oct; 7(5):274-281. PMID: 31043287.
      View in: PubMed
    14. Smigiel R, Biernacka A, Biela M, Murcia-Pienkowski V, Szmida E, Gasperowicz P, Kosinska J, Kostrzewa G, Koppolu AA, Walczak A, Wawrzuta D, Rydzanicz M, Sasiadek M, Ploski R. Novel de novo mutation affecting two adjacent aminoacids in the EED gene in a patient with Weaver syndrome. J Hum Genet. 2018 Apr; 63(4):517-520. PMID: 29410511.
      View in: PubMed
    15. Szczaluba K, Szymanska K, Rydzanicz M, Ciara E, Walczak A, Piekutowska-Abramczuk D, Kosinska J, Jacoszek A, Czerska K, Biernacka A, Laure-Kamionowska M, Gasperowicz P, Pronicka E, Ploski R. A de novo loss-of-function DYNC1H1 mutation in a patient with parkinsonian features and a favourable response to levodopa. Clin Genet. 2018 05; 93(5):1107-1108. PMID: 29243232.
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    16. Szczaluba K, Biernacka A, Szymanska K, Gasperowicz P, Kosinska J, Rydzanicz M, Ploski R. Novel GNB1 de novo mutation in a patient with neurodevelopmental disorder and cutaneous mastocytosis: Clinical report and literature review. Eur J Med Genet. 2018 Mar; 61(3):157-160. PMID: 29174093.
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    17. Smigiel R, Biela M, Biernacka A, Stembalska A, Sasiadek M, Kosinska J, Rydzanicz M, Ploski R. New evidence for association of recessive IARS gene mutations with hepatopathy, hypotonia, intellectual disability and growth retardation. Clin Genet. 2017 12; 92(6):671-673. PMID: 29052218.
      View in: PubMed
    18. Truszkowska GT, Bilinska ZT, Muchowicz A, Pollak A, Biernacka A, Kozar-Kaminska K, Stawinski P, Gasperowicz P, Kosinska J, Zielinski T, Ploski R. Homozygous truncating mutation in NRAP gene identified by whole exome sequencing in a patient with dilated cardiomyopathy. Sci Rep. 2017 06 13; 7(1):3362. PMID: 28611399.
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    19. Shi W, Vu T, Boucher D, Biernacka A, Nde J, Pandita RK, Straube J, Boyle GM, Al-Ejeh F, Nag P, Jeffery J, Harris JL, Bain AL, Grzelak M, Skrzypczak M, Mitra A, Dojer N, Crosetto N, Cloonan N, Becherel OJ, Finnie J, Skaar JR, Walkley CR, Pandita TK, Rowicka M, Ginalski K, Lane SW, Khanna KK. Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. Blood. 2017 05 04; 129(18):2479-2492. PMID: 28270450.
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    20. Aymard F, Aguirrebengoa M, Guillou E, Javierre BM, Bugler B, Arnould C, Rocher V, Iacovoni JS, Biernacka A, Skrzypczak M, Ginalski K, Rowicka M, Fraser P, Legube G. Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes. Nat Struct Mol Biol. 2017 04; 24(4):353-361. PMID: 28263325.
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    21. Hunt KK, Karakas C, Ha MJ, Biernacka A, Yi M, Sahin AA, Adjapong O, Hortobagyi GN, Bondy M, Thompson P, Cheung KL, Ellis IO, Bacus S, Symmans WF, Do KA, Keyomarsi K. Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer. Clin Cancer Res. 2017 Jun 15; 23(12):2991-3002. PMID: 27881578.
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    22. Biernacka A, Linos KD, DeLong PA, Suriawinata AA, Padmanabhan V, Liu X. A case of S-100 negative melanoma: A diagnostic pitfall in the workup of a poorly differentiated metastatic tumor of unknown origin. Cytojournal. 2016; 13:21. PMID: 27729935.
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    23. Karakas C, Biernacka A, Bui T, Sahin AA, Yi M, Akli S, Schafer J, Alexander A, Adjapong O, Hunt KK, Keyomarsi K. Cytoplasmic Cyclin E and Phospho-Cyclin-Dependent Kinase 2 Are Biomarkers of Aggressive Breast Cancer. Am J Pathol. 2016 07; 186(7):1900-1912. PMID: 27182644.
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    24. Biernacka A, Tsongalis PD, Peterson JD, de Abreu FB, Black CC, Gutmann EJ, Liu X, Tafe LJ, Amos CI, Tsongalis GJ. The potential utility of re-mining results of somatic mutation testing: KRAS status in lung adenocarcinoma. Cancer Genet. 2016 May; 209(5):195-8. PMID: 27068338.
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    25. Biernacka A, Cavalera M, Wang J, Russo I, Shinde A, Kong P, Gonzalez-Quesada C, Rai V, Dobaczewski M, Lee DW, Wang XF, Frangogiannis NG. Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice. Circ Heart Fail. 2015 Jul; 8(4):788-98. PMID: 25985794.
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    26. Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee DW, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis NG. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res. 2013 Dec 06; 113(12):1331-44. PMID: 24081879.
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    27. Duong MT, Akli S, Macalou S, Biernacka A, Debeb BG, Yi M, Hunt KK, Keyomarsi K. Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells. Cancer Res. 2013 Sep 01; 73(17):5556-68. PMID: 23955388.
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    28. Takahashi O, Komaki R, Smith PD, Jürgensmeier JM, Ryan A, Bekele BN, Wistuba II, Jacoby JJ, Korshunova MV, Biernacka A, Erez B, Hosho K, Herbst RS, O'Reilly MS. Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis. Clin Cancer Res. 2012 Mar 15; 18(6):1641-54. PMID: 22275507.
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    29. Xia Y, Dobaczewski M, Gonzalez-Quesada C, Chen W, Biernacka A, Li N, Lee DW, Frangogiannis NG. Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism. Hypertension. 2011 Nov; 58(5):902-11. PMID: 21947471.
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    30. Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-ß signaling in fibrosis. Growth Factors. 2011 Oct; 29(5):196-202. PMID: 21740331.
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    31. Biernacka A, Frangogiannis NG. Aging and Cardiac Fibrosis. Aging Dis. 2011 Apr; 2(2):158-173. PMID: 21837283.
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    32. Bagheri-Yarmand R, Biernacka A, Hunt KK, Keyomarsi K. Low molecular weight cyclin E overexpression shortens mitosis, leading to chromosome missegregation and centrosome amplification. Cancer Res. 2010 Jun 15; 70(12):5074-84. PMID: 20530685.
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    33. Bagheri-Yarmand R, Nanos-Webb A, Biernacka A, Bui T, Keyomarsi K. Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C. Cancer Res. 2010 Jun 15; 70(12):5085-95. PMID: 20530684.
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    34. Mittendorf EA, Liu Y, Tucker SL, McKenzie T, Qiao N, Akli S, Biernacka A, Liu Y, Meijer L, Keyomarsi K, Hunt KK. A novel interaction between HER2/neu and cyclin E in breast cancer. Oncogene. 2010 Jul 08; 29(27):3896-907. PMID: 20453888.
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    35. Akli S, Bui T, Wingate H, Biernacka A, Moulder S, Tucker SL, Hunt KK, Keyomarsi K. Low-molecular-weight cyclin E can bypass letrozole-induced G1 arrest in human breast cancer cells and tumors. Clin Cancer Res. 2010 Feb 15; 16(4):1179-90. PMID: 20145171.
      View in: PubMed
    36. Wasilewska A, Zoch-Zwierz W, Jadeszko I, Porowski T, Biernacka A, Niewiarowska A, Korzeniecka-Kozerska A. Assessment of serum cystatin C in children with congenital solitary kidney. Pediatr Nephrol. 2006 May; 21(5):688-93. PMID: 16572341.
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    37. Biernacka A, Zoch-Zwierz WM, Wasilewska A, Porowski T, Niewiarowska A, Tenderenda E. [Urinary TGF-beta1 excretion in children with renal cysts]. Przegl Lek. 2006; 63 Suppl 3:94-6. PMID: 16898500.
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    38. Wasilewska A, Tomaszewska B, Zoch-Zwierz W, Biernacka A, Klewinowska K, Koput A. Serum and urine leptin concentration in children with nephrotic syndrome. Pediatr Nephrol. 2005 May; 20(5):597-602. PMID: 15782310.
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    39. Wasilewska A, Zoch-Zwierz W, Tomaszewska B, Biernacka A. [Reference values of 24-hour ambulatory blood pressure in healthy children by height]. Pol Merkur Lekarski. 2004 Nov; 17(101):451-6. PMID: 15754630.
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    40. Wasilewska AM, Zoch-Zwierz WM, Tomaszewska B, Biernacka A. Platelet-derived growth factor and platelet profiles in childhood nephrotic syndrome. Pediatr Nephrol. 2005 Jan; 20(1):36-41. PMID: 15490251.
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    41. Wasilewska A, Zoch-Zwierz WM, Tomaszewska B, Wiercinski R, Biernacka A, Porowski T. [Reference values of arterial pressure depending on age, assessed by 24-hour ambulatory monitoring]. Pol Merkur Lekarski. 2003 Jul; 15(85):29-33. PMID: 14593955.
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    42. Zoch-Zwierz W, Biernacka A, Tomaszewska B, Wasilewska A, Wiercinski R, Winiecka W, Niewiarowska A, Smólko M, Korzeniecka-Kozerska A. [Vasculitis of cerebral vessels, probable cause of neurological complications in a child with Schonlein-Henoch purpura]. Pol Merkur Lekarski. 2002 Apr; 12(70):306-8. PMID: 12089895.
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    43. Wiercinski R, Zoch-Zwierz W, Wasilewska A, Tomaszewska B, Winiecka W, Stasiak-Barmuta A, Porowski T, Biernacka A. [Lymphocyte subpopulations of peripheral blood in children with Schönlein-Henoch purpura and IgA nephropathy]. Pol Merkur Lekarski. 2001 Apr; 10(58):244-6. PMID: 11434167.
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    44. Zoch-Zwierz W, Wasilewska A, Biernacka A, Tomaszewska B, Winiecka W, Wiercinski R, Porowski T. [The course of post-streptococcal glomerulonephritis depending on methods of treatment for the preceding respiratory tract infection]. Wiad Lek. 2001; 54(1-2):56-63. PMID: 11344703.
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    45. Zoch-Zwierz W, Tomaszewska B, Wiercinski R, Winiecka W, Wasilewska A, Mysliwiec B, Niewiarowska A, Biernacka A. [Use of salazopyrin in Schonlein-Henoch disease]. Wiad Lek. 1995 Jan-Jun; 48(1-12):63-5. PMID: 9638208.
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    46. Zoch-Zwierz W, Winiecka W, Smólko M, Zadrozna-Tolwinska B, Iwaszkiewicz-Pawlowska A, Biernacka A. [Anomalies of the cervical spine in children]. Wiad Lek. 1993 Sep; 46(17-18):714-7. PMID: 7975613.
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    47. Iwaszkiewicz-Pawlowska A, Zoch-Zwierz W, Biernacka A. [Primary hyperlipoproteinemia type V]. Pol Tyg Lek. 1992 Nov 16-30; 47(46-48):1067-8. PMID: 1305725.
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    48. Zoch-Zwierz W, Wiercinski R, Tomaszewska B, Winiecka W, Biernacka A, Puchnarewicz A. [Acute renal failure in a child with fulminant purpura]. Wiad Lek. 1990 Jul 15; 43(14):738-41. PMID: 2267799.
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    49. Zoch-Zwierz W, Slowikowski K, Kadziela H, Lukaszewicz D, Biernacka A. [Familial occurrence of central diabetes insipidus]. Wiad Lek. 1990 Jun 15; 43(12):619-21. PMID: 2260322.
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    50. Iwaszkiewicz-Pawlowska A, Winiecka W, Biernacka A. [A case od rare location of Ewing's sarcoma in a 6-year-old boy]. Wiad Lek. 1990 Apr 01; 43(7):285-8. PMID: 2402910.
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