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Priya Prakash

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentSurgery-Trauma and Acute Care
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    Hospital of the University of Pennsylvania Fellowship
    University of CincinnatiResidency
    University of CincinnatiInternship
    University of Cincinnati College of MedicineMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhou Y, Prakash PS, Liang H, Gorfe AA, Hancock JF. The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure. Proc Natl Acad Sci U S A. 2021 Feb 09; 118(6). PMID: 33526670.
      View in: PubMed
    2. Abbasi AB, Dumanian J, Okum S, Nwaudo D, Lee D, Prakash P, Bendix P. Association of a New Trauma Center With Racial, Ethnic, and Socioeconomic Disparities in Access to Trauma Care. JAMA Surg. 2021 Jan 01; 156(1):97-99. PMID: 33237319.
      View in: PubMed
    3. Sepuru KM, Nair V, Prakash P, Gorfe AA, Rajarathnam K. Long-Range Coupled Motions Underlie Ligand Recognition by a Chemokine Receptor. iScience. 2020 Dec 18; 23(12):101858. PMID: 33344917.
      View in: PubMed
    4. Prakash PS, Moore SA, Rezende-Neto JB, Trpcic S, Dunn JA, Smoot B, Jenkins DH, Cardenas T, Mukherjee K, Farnsworth J, Wild J, Young K, Schroeppel TJ, Coimbra R, Lee J, Skarupa DJ, Sabra MJ, Carrick MM, Moore FO, Ward J, Geng T, Lapham D, Piccinini A, Inaba K, Dodgion C, Gooley B, Schwartz T, Shraga S, Haan JM, Lightwine K, Burris J, Agrawal V, Seamon MJ, Cannon JW. Predictors of retained hemothorax in trauma: Results of an Eastern Association for the Surgery of Trauma multi-institutional trial. J Trauma Acute Care Surg. 2020 10; 89(4):679-685. PMID: 32649619.
      View in: PubMed
    5. Prakash P. A regulatory role of membrane by direct modulation of the catalytic kinase domain. Small GTPases. 2020 Jul 14; 1-11. PMID: 32663062.
      View in: PubMed
    6. Cone J, Williams B, Hampton D, Prakash P, Bendix P, Wilson K, Rogers S, Zakrison T. The Ethics and Politics of Gun Violence Research. J Laparoendosc Adv Surg Tech A. 2019 Dec 13. PMID: 31834854.
      View in: PubMed
    7. Prakash P, Gorfe AA. Probing the Conformational and Energy Landscapes of KRAS Membrane Orientation. J Phys Chem B. 2019 10 17; 123(41):8644-8652. PMID: 31554397.
      View in: PubMed
    8. Gupta AK, Wang X, Pagba CV, Prakash P, Sarkar-Banerjee S, Putkey J, Gorfe AA. Multi-target, ensemble-based virtual screening yields novel allosteric KRAS inhibitors at high success rate. Chem Biol Drug Des. 2019 08; 94(2):1441-1456. PMID: 30903639.
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    9. Prakash P, Hancock JF, Gorfe AA. Three distinct regions of cRaf kinase domain interact with membrane. Sci Rep. 2019 02 14; 9(1):2057. PMID: 30765804.
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    10. McCarthy MJ, Pagba CV, Prakash P, Naji AK, van der Hoeven D, Liang H, Gupta AK, Zhou Y, Cho KJ, Hancock JF, Gorfe AA. Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding. ACS Omega. 2019 Feb 28; 4(2):2921-2930. PMID: 30842983.
      View in: PubMed
    11. Prakash P, Litwin D, Liang H, Sarkar-Banerjee S, Dolino D, Zhou Y, Hancock JF, Jayaraman V, Gorfe AA. Dynamics of Membrane-Bound G12V-KRAS from Simulations and Single-Molecule FRET in Native Nanodiscs. Biophys J. 2019 01 22; 116(2):179-183. PMID: 30616834.
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    12. Zhou Y, Prakash P, Gorfe AA, Hancock JF. Ras and the Plasma Membrane: A Complicated Relationship. Cold Spring Harb Perspect Med. 2018 10 01; 8(10). PMID: 29229665.
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    13. Nunn A, Prakash P, Inaba K, Escalante A, Maher Z, Yamaguchi S, Kim DY, Maciel J, Chiu WC, Drumheller B, Hazelton JP, Mukherjee K, Luo-Owen X, Nygaard RM, Marek AP, Morse BC, Fitzgerald CA, Bosarge PL, Jawa RS, Rowell SE, Magnotti LJ, Ong AW, Brahmbhatt TS, Grossman MD, Seamon MJ. Occupational exposure during emergency department thoracotomy: A prospective, multi-institution study. J Trauma Acute Care Surg. 2018 07; 85(1):78-84. PMID: 29664893.
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    14. Chamieh J, Prakash P, Symons WJ. Management of Destructive Colon Injuries after Damage Control Surgery. Clin Colon Rectal Surg. 2018 Jan; 31(1):36-40. PMID: 29379406.
      View in: PubMed
    15. Duchesne JC, Tatum D, Jones G, Davis B, Robledo R, DeMoya M, O'Keeffe T, Ferrada P, Jacome T, Schroll R, Wlodarczyk J, Prakash P, Smith B, Inaba K, Khor D, Duke M, Khan M. Multi-institutional analysis of neutrophil-to-lymphocyte ratio (NLR) in patients with severe hemorrhage: A new mortality predictor value. J Trauma Acute Care Surg. 2017 11; 83(5):888-893. PMID: 28837540.
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    16. Sarkar-Banerjee S, Sayyed-Ahmad A, Prakash P, Cho KJ, Waxham MN, Hancock JF, Gorfe AA. Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes. J Am Chem Soc. 2017 09 27; 139(38):13466-13475. PMID: 28863262.
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    17. Sayyed-Ahmad A, Prakash P, Gorfe AA. Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants. Proteins. 2017 Sep; 85(9):1618-1632. PMID: 28498561.
      View in: PubMed
    18. Chreiman KM, Prakash PS, Martin ND, Kim PK, Mehta S, McGinnis K, Gallagher JJ, Reilly PM. Staying connected: Service-specific orientation can be successfully achieved using a mobile application for onboarding care providers. Trauma Surg Acute Care Open. 2017; 2(1):e000085. PMID: 29766089.
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    19. Prakash P, Sayyed-Ahmad A, Cho KJ, Dolino DM, Chen W, Li H, Grant BJ, Hancock JF, Gorfe AA. Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers. Sci Rep. 2017 01 09; 7:40109. PMID: 28067274.
      View in: PubMed
    20. Zhou Y, Prakash P, Liang H, Cho KJ, Gorfe AA, Hancock JF. Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output. Cell. 2017 Jan 12; 168(1-2):239-251.e16. PMID: 28041850.
      View in: PubMed
    21. Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF. AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2. Mol Cell Biol. 2016 12 15; 36(24):3086-3099. PMID: 27697864.
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    22. Prakash P, Gorfe AA. Membrane orientation dynamics of lipid-modified small GTPases. Small GTPases. 2017 07 03; 8(3):129-138. PMID: 27715448.
      View in: PubMed
    23. Prakash P, Zhou Y, Liang H, Hancock JF, Gorfe AA. Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis. Biophys J. 2016 Mar 08; 110(5):1125-38. PMID: 26958889.
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    24. Gupta T, Mujib M, Agarwal P, Prakash P, Garg A, Sharma N, Aronow WS, Nabors C. Association Between Opioid Abuse/Dependence and Outcomes in Hospitalized Heart Failure Patients. Am J Ther. 2016 Mar-Apr; 23(2):e350-6. PMID: 25611362.
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    25. Prakash P, Sayyed-Ahmad A, Gorfe AA. pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound Proteins. PLoS Comput Biol. 2015 Oct; 11(10):e1004469. PMID: 26506102.
      View in: PubMed
    26. McCarthy M, Prakash P, Gorfe AA. Computational allosteric ligand binding site identification on Ras proteins. Acta Biochim Biophys Sin (Shanghai). 2016 Jan; 48(1):3-10. PMID: 26487442.
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    27. Prakash P, Hancock JF, Gorfe AA. Binding hotspots on K-ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis. Proteins. 2015 May; 83(5):898-909. PMID: 25740554.
      View in: PubMed
    28. Prakash P, Gorfe AA. Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras. Mol Simul. 2014; 40(10-11):839-847. PMID: 26491216.
      View in: PubMed
    29. Prakash P, Gorfe AA. Lessons from computer simulations of Ras proteins in solution and in membrane. Biochim Biophys Acta. 2013 Nov; 1830(11):5211-8. PMID: 23906604.
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    30. O'Connor OJ, Prakash P, Cronin CG, McDermott S, Blake MA. PET/CT in the imaging of ovarian Cancer. Front Biosci (Elite Ed). 2013 Jan 01; 5:141-53. PMID: 23276977.
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    31. Prakash P, Sayyed-Ahmad A, Zhou Y, Volk DE, Gorenstein DG, Dial E, Lichtenberger LM, Gorfe AA. Aggregation behavior of ibuprofen, cholic acid and dodecylphosphocholine micelles. Biochim Biophys Acta. 2012 Dec; 1818(12):3040-7. PMID: 22885171.
      View in: PubMed
    32. Prakash PS, Caldwell CC, Lentsch AB, Pritts TA, Robinson BR. Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response. J Trauma Acute Care Surg. 2012 Aug; 73(2):401-6; discussion 406-7. PMID: 22846946.
      View in: PubMed
    33. Prakash P, Sayyed-Ahmad A, Gorfe AA. The role of conserved waters in conformational transitions of Q61H K-ras. PLoS Comput Biol. 2012; 8(2):e1002394. PMID: 22359497.
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    34. Prakash P, Kalra MK, Sharma A, Shepard JA, Digumarthy SR. FDG PET/CT in assessment of pulmonary lymphangitic carcinomatosis. AJR Am J Roentgenol. 2010 Jan; 194(1):231-6. PMID: 20028927.
      View in: PubMed
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