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Peter Nagele

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBSD Academic Admin
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Nagele is an internationally recognized trauma anesthesiologist, researcher and educator. An authority on perioperative outcomes research, he focuses on to better predict, diagnose, prevent, and treat major cardiac events in surgical patients. He discovered that novel heart biomarkers may predict heart attacks in patients undergoing non-cardiac surgery.
    He has also conducted ground-breaking work suggesting that a brief inhalation of nitrous oxide, commonly known as laughing gas, improves severe symptoms of depression and suicidal thoughts.


    Collapse Biography 
    Collapse awards and honors
    2018Fellow, American Heart Association
    2016NARSAD Independent Investigator Grant, Brain & Behavior Research Foundation
    2016Ziskind-Somerfeld Research Award, Society for Biological Psychiatry
    2014Mentor of the Year, Clinical Research Training Center, Washington University School of Medicine
    2012Presidential Scholar Award, American Society of Anesthesiologists
    2011Billroth Prize, Vienna Medical Society (Austria)
    2007Elmer-Zsigmond Award, International Society for Anesthetic Pharmacology
    2006Otto-Kraupp-Prize
    2005Research Starter Grant , European Society of Anaesthesiology
    2005Resident’s Research Essay Contest Award, American Society for Anesthesiology

    Collapse Research 
    Collapse research activities and funding
    K23GM087534     (NAGELE, PETER)Jan 4, 2010 - Dec 31, 2013
    NIH
    Perioperative pharmacogenetics: Nitrous oxide and anesthetic outcomes
    Role: Principal Investigator

    R01HL126892     (NAGELE, PETER)Aug 1, 2015 - Apr 30, 2020
    NIH
    NOVEL STRATEGY FOR PERIOPERATIVE BETA-BLOCKER THERAPY
    Role: Principal Investigator

    R21MH108901     (CONWAY, CHARLES RICHARD)Jul 21, 2016 - Jun 30, 2018
    NIH
    NMDA RECEPTOR ANTAGONIST NITROUS OXIDE TARGETS AFFECTIVE BRAIN CIRCUITS
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Massalha S, Walpot J, Dey D, Guler EC, Clarkin O, Godkin L, Ratnayake I, Jayasinghe P, Hossain A, Crean A, Chan M, Butler C, Tandon V, Nagele P, Woodard PK, Mrkobrada M, Szczeklik W, Abdul Aziz YF, Biccard B, Devereaux PJ, Sheth T, Chow BJW. Epicardial Adipose Tissue: An Independent Predictor of Post-Operative Adverse Cardiovascular Events (CTA VISION Substudy). JACC Cardiovasc Imaging. 2019 Nov 06. PMID: 31734207.
      View in: PubMed
    2. Rubin DS, Huisingh-Scheetz M, Hung A, Ward RP, Nagele P, Arena R, Hedeker D. Accuracy of Physical Function Questions to Predict Moderate-Vigorous Physical Activity as Measured by Hip Accelerometry. Anesthesiology. 2019 11; 131(5):992-1003. PMID: 31490293.
      View in: PubMed
    3. Nagele P. Elevated cardiac troponin before surgery: perhaps not so benign. Br J Anaesth. 2019 Nov 01. PMID: 31685217.
      View in: PubMed
    4. Duma A, Nagele P. Cardiac Events after Electroconvulsive Therapy: Reply. Anesthesiology. 2019 Oct; 131(4):942. PMID: 31436543.
      View in: PubMed
    5. Buhre W, Disma N, Hendrickx J, De Hert S, Hollmann MW, Huhn R, Jakobsson J, Nagele P, Peyton P, Vutskits L. Response to comments on 'The European Society of Anaesthesiology Task Force review on the place of nitrous oxide in current clinical practice' (Br J Anaesth 2019; 122:587-604). Br J Anaesth. 2019 10; 123(4):e482-e483. PMID: 31371021.
      View in: PubMed
    6. Samaha E, Avila A, Helwani MA, Ben Abdallah A, Jaffe AS, Scott MG, Nagele P. High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2019 Mar 19; 8(6):e008626. PMID: 30871395.
      View in: PubMed
    7. Buhre W, Disma N, Hendrickx J, DeHert S, Hollmann MW, Huhn R, Jakobsson J, Nagele P, Peyton P, Vutskits L. European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice. Br J Anaesth. 2019 May; 122(5):587-604. PMID: 30916011.
      View in: PubMed
    8. Duma A, Maleczek M, Panjikaran B, Herkner H, Karrison T, Nagele P. Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy: A Systematic Review and Meta-analysis. Anesthesiology. 2019 01; 130(1):83-91. PMID: 30557212.
      View in: PubMed
    9. Samaha E, Brown J, Brown F, Martinez SC, Scott M, Jaffe AS, Davila-Roman VG, Nagele P. High-sensitivity cardiac troponin T increases after stress echocardiography. Clin Biochem. 2019 Jan; 63:18-23. PMID: 30502318.
      View in: PubMed
    10. Hong HY, Karadaghy O, Kallogjeri D, Brown FT, Yee B, Piccirillo JF, Nagele P. Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2018 09 01; 144(9):781-787. PMID: 30073285.
      View in: PubMed
    11. Helwani MA, Amin A, Lavigne P, Rao S, Oesterreich S, Samaha E, Brown JC, Nagele P. Etiology of Acute Coronary Syndrome after Noncardiac Surgery. Anesthesiology. 2018 06; 128(6):1084-1091. PMID: 29481375.
      View in: PubMed
    12. Nagele P, Zorumski CF, Conway C. Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts. J Clin Psychopharmacol. 2018 Apr; 38(2):144-148. PMID: 29360650.
      View in: PubMed
    13. Duma A, Wagner C, Titz M, Maleczek M, Hüpfl M, Weihs VB, Samaha E, Herkner H, Szekeres T, Mittlboeck M, Scott MG, Jaffe AS, Nagele P. High-sensitivity cardiac troponin T in young, healthy adults undergoing non-cardiac surgery. Br J Anaesth. 2018 Feb; 120(2):291-298. PMID: 29406178.
      View in: PubMed
    14. Nagele P. Postoperative hypotension and troponin elevation: association or causation? Br J Anaesth. 2018 01; 120(1):4-5. PMID: 29397136.
      View in: PubMed
    15. Samaha E, Helwani MA, Brown JC, Brown F, Jaffe AS, Scott MG, Nagele P. Are high-sensitivity cardiac troponin I values stable between preoperative visit and day of non-cardiac surgery? Clin Biochem. 2018 Feb; 52:171-172. PMID: 29175409.
      View in: PubMed
    16. Brown JC, Samaha E, Rao S, Helwani MA, Duma A, Brown F, Gage BF, Miller JP, Jaffe AS, Apple FS, Scott MG, Nagele P. High-Sensitivity Cardiac Troponin T Improves the Diagnosis of Perioperative MI. Anesth Analg. 2017 11; 125(5):1455-1462. PMID: 28719430.
      View in: PubMed
    17. Duma A, Pal S, Johnston J, Helwani MA, Bhat A, Gill B, Rosenkvist J, Cartmill C, Brown F, Miller JP, Scott MG, Sanchez-Conde F, Jarvis M, Farber NB, Zorumski CF, Conway C, Nagele P. High-sensitivity Cardiac Troponin Elevation after Electroconvulsive Therapy: A Prospective, Observational Cohort Study. Anesthesiology. 2017 04; 126(4):643-652. PMID: 28166110.
      View in: PubMed
    18. Kopec M, Duma A, Helwani MA, Brown J, Brown F, Gage BF, Gibson DW, Miller JP, Novak E, Jaffe AS, Apple FS, Scott MG, Nagele P. Improving Prediction of Postoperative Myocardial Infarction With High-Sensitivity Cardiac Troponin T and NT-proBNP. Anesth Analg. 2017 02; 124(2):398-405. PMID: 28002165.
      View in: PubMed
    19. Nagele P. Refining the Diagnosis of Type 2 Myocardial Infarction-Reply. JAMA Cardiol. 2017 01 01; 2(1):107. PMID: 27760250.
      View in: PubMed
    20. Nagele P. The Case for a Revised Definition of Myocardial Infarction-Resolving the Ambiguity of Type 2 Myocardial Infarction. JAMA Cardiol. 2016 06 01; 1(3):247-8. PMID: 27438099.
      View in: PubMed
    21. Duma A, Pal S, Helsten D, Stein PK, Miller JP, Nagele P. High-Fidelity Analysis of Perioperative QTc Prolongation. Anesth Analg. 2016 Feb; 122(2):439-48. PMID: 26505572.
      View in: PubMed
    22. Böttiger BW, Bernhard M, Knapp J, Nagele P. Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis. Crit Care. 2016 Jan 09; 20:4. PMID: 26747085.
      View in: PubMed
    23. Zorumski CF, Nagele P, Mennerick S, Conway CR. Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy. Front Psychiatry. 2015; 6:172. PMID: 26696909.
      View in: PubMed
    24. Duma A, Cartmill C, Blood J, Sharma A, Kharasch ED, Nagele P. The hematological effects of nitrous oxide anesthesia in pediatric patients. Anesth Analg. 2015 Jun; 120(6):1325-30. PMID: 25658315.
      View in: PubMed
    25. Sheth T, Chan M, Butler C, Chow B, Tandon V, Nagele P, Mitha A, Mrkobrada M, Szczeklik W, Faridah Y, Biccard B, Stewart LK, Heels-Ansdell D, Devereaux PJ. Prognostic capabilities of coronary computed tomographic angiography before non-cardiac surgery: prospective cohort study. BMJ. 2015 Apr 22; 350:h1907. PMID: 25902738.
      View in: PubMed
    26. Nagele P, Duma A, Kopec M, Gebara MA, Parsoei A, Walker M, Janski A, Panagopoulos VN, Cristancho P, Miller JP, Zorumski CF, Conway CR. Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial. Biol Psychiatry. 2015 Jul 01; 78(1):10-18. PMID: 25577164.
      View in: PubMed
    27. Selig HF, Nagele P, Lumenta DB, Voelckel WG, Trimmel H, Hüpfl M, Kamolz LP. [Thermal injuries in the OEAMTC air rescue service. Epidemiological characteristics of burns/scalds in children and adults]. Unfallchirurg. 2014 Apr; 117(4):334-40. PMID: 23420061.
      View in: PubMed
    28. Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G, Walsh M, Sapsford R, Schünemann HJ, Kurz A, Thomas S, Mrkobrada M, Thabane L, Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, Devereaux PJ, Sessler DI, Walsh M, Guyatt G, McQueen MJ, Bhandari M, Cook D, Bosch J, Buckley N, Yusuf S, Chow CK, Hillis GS, Halliwell R, Li S, Lee VW, Mooney J, Polanczyk CA, Furtado MV, Berwanger O, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA, Cavalcanti AB, Guimaraes HP, Jacka MJ, Graham M, McAlister F, McMurtry S, Townsend D, Pannu N, Bagshaw S, Bessissow A, Bhandari M, Duceppe E, Eikelboom J, Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D, Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C, Mizera R, O'Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V, Vanhelder T, Winemaker M, Gerstein H, McDonald S, O'Bryne P, Patel A, Paul J, Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C, Cook D, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S, Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N, Macneil D, Mrkobrada M, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius L, Siddiqui FS, Grocott HP, McKay A, Lee TW, Amadeo R, Funk D, McDonald H, Zacharias J, Villar JC, Cortés OL, Chaparro MS, Vásquez S, Castañeda A, Ferreira S, Coriat P, Monneret D, Goarin JP, Esteve CI, Royer C, Daas G, Chan MT, Choi GY, Gin T, Lit LC, Xavier D, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S, Abraham V, Afzal L, George P, Mala S, Schünemann H, Muti P, Vizza E, Wang CY, Ong GS, Mansor M, Tan AS, Shariffuddin II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai HY, Ahmad WA, Razack AH, Malaga G, Valderrama-Victoria V, Loza-Herrera JD, De Los Angeles Lazo M, Rotta-Rotta A, Szczeklik W, Sokolowska B, Musial J, Gorka J, Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B, Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner D, Torborg A, Paniagua P, Urrutia G, Maestre ML, Santaló M, Gonzalez R, Font A, Martínez C, Pelaez X, De Antonio M, Villamor JM, García JA, Ferré MJ, Popova E, Alonso-Coello P, Garutti I, Cruz P, Fernández C, Palencia M, Díaz S, Del Castillo T, Varela A, de Miguel A, Muñoz M, Piñeiro P, Cusati G, Del Barrio M, Membrillo MJ, Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J, Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Pearse R, Ackland G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E, Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Del Arroyo AG, Sessler DI, Kurz A, Sun Z, Finnegan PS, Egan C, Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Nagele P, Blood J, Kalin M, Gibson D, Wildes T. Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology. 2014 Mar; 120(3):564-78. PMID: 24534856.
      View in: PubMed
    29. Nagele P, Brown F, Francis A, Scott MG, Gage BF, Miller JP. In reply. Anesthesiology. 2014 Feb; 120(2):515-6. PMID: 24448089.
      View in: PubMed
    30. Nagele P. Neuraxial block, death, and serious cardiovascular morbidity in the POISE trial. Br J Anaesth. 2014 Feb; 112(2):392. PMID: 24431369.
      View in: PubMed
    31. Duma A, Helsten D, Brown F, Bottros MM, Nagele P. The effect of nitrous oxide anesthesia on early postoperative opioid consumption and pain. Reg Anesth Pain Med. 2014 Jan-Feb; 39(1):31-6. PMID: 24310050.
      View in: PubMed
    32. Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG. Letter in response to "Use of preoperative cardiac troponin T to identify patients at risk for acute myocardial infraction and long-term mortality after major noncardiac surgery". Am Heart J. 2014 Feb; 167(2):e7. PMID: 24439992.
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    33. Nagele P. Exome sequencing: one small step for malignant hyperthermia, one giant step for our specialty--why exome sequencing matters to all of us, not just the experts. Anesthesiology. 2013 Nov; 119(5):1006-8. PMID: 24195944.
      View in: PubMed
    34. Parvizi D, Kamolz LP, Giretzlehner M, Haller HL, Trop M, Selig H, Nagele P, Lumenta DB. The potential impact of wrong TBSA estimations on fluid resuscitation in patients suffering from burns: things to keep in mind. Burns. 2014 Mar; 40(2):241-5. PMID: 24050977.
      View in: PubMed
    35. Nagele P, Brown F, Francis A, Scott MG, Gage BF, Miller JP. Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial. Anesthesiology. 2013 Jul; 119(1):19-28. PMID: 23856660.
      View in: PubMed
    36. Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG. High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery. Am Heart J. 2013 Aug; 166(2):325-332.e1. PMID: 23895816.
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    37. Johnston J, Pal S, Nagele P. Perioperative torsade de pointes: a systematic review of published case reports. Anesth Analg. 2013 Sep; 117(3):559-64. PMID: 23744954.
      View in: PubMed
    38. Blake CM, Kharasch ED, Schwab M, Nagele P. A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics. Clin Pharmacol Ther. 2013 Sep; 94(3):394-9. PMID: 23665868.
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    39. Nagele P, Pal S, Brown F, Blood J, Miller JP, Johnston J. Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia. Anesthesiology. 2012 Aug; 117(2):321-8. PMID: 22692379.
      View in: PubMed
    40. Sheth T, Butler C, Chow B, Chan MT, Mitha A, Nagele P, Tandon V, Stewart L, Graham M, Choi GY, Kisten T, Woodard PK, Crean A, Abdul Aziz YF, Karthikeyan G, Chow CK, Szczeklik W, Markobrada M, Mastracci T, Devereaux PJ. The coronary CT angiography vision protocol: a prospective observational imaging cohort study in patients undergoing non-cardiac surgery. BMJ Open. 2012; 2(4). PMID: 22855630.
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    41. Selig HF, Nagele P, Voelckel WG, Trimmel H, Hüpfl M, Lumenta DB, Kamolz LP. The epidemiology of amputation injuries in the Austrian helicopter emergency medical service: a retrospective, nationwide cohort study. Eur J Trauma Emerg Surg. 2012 Dec; 38(6):651-7. PMID: 26814552.
      View in: PubMed
    42. Nagele P. Notorious oxide. Anesthesiology. 2012 Jul; 117(1):3-5. PMID: 22569133.
      View in: PubMed
    43. Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA. 2012 Jun 06; 307(21):2295-304. PMID: 22706835.
      View in: PubMed
    44. Selig HF, Hüpfl M, Trimmel H, Voelckel WG, Nagele P. Pediatric trauma in the Austrian Alps: the epidemiology of sport-related injuries in helicopter emergency medical service. High Alt Med Biol. 2012 Jun; 13(2):112-7. PMID: 22724614.
      View in: PubMed
    45. Nagele P. Perioperative genomics. Best Pract Res Clin Anaesthesiol. 2011 Dec; 25(4):549-55. PMID: 22099920.
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    46. Nagele P, Liggett SB. Genetic variation, ß-blockers, and perioperative myocardial infarction. Anesthesiology. 2011 Dec; 115(6):1316-27. PMID: 21918425.
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    47. Nagele P, Meissner K, Francis A, Födinger M, Saccone NL. Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification. Pharmacogenet Genomics. 2011 Jul; 21(7):426-31. PMID: 21597397.
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    48. Selig HF, Trimmel H, Voelckel WG, Hüpfl M, Trittenwein G, Nagele P. Prehospital pediatric emergencies in Austrian helicopter emergency medical service - a nationwide, population-based cohort study. Wien Klin Wochenschr. 2011 Sep; 123(17-18):552-8. PMID: 21691755.
      View in: PubMed
    49. Nagele P, Tallchief D, Blood J, Sharma A, Kharasch ED. Nitrous oxide anesthesia and plasma homocysteine in adolescents. Anesth Analg. 2011 Oct; 113(4):843-8. PMID: 21680854.
      View in: PubMed
    50. Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ, Hill SA, Thomas S, Mrkobrada M, Alonso-Coello P, Berwanger O, Biccard BM, Cembrowski G, Chan MT, Chow CK, de Miguel A, Garcia M, Graham MM, Jacka MJ, Kueh JH, Li SC, Lit LC, Martínez-Brú C, Naidoo P, Nagele P, Pearse RM, Rodseth RN, Sessler DI, Sigamani A, Szczeklik W, Tiboni M, Villar JC, Wang CY, Xavier D, Devereaux PJ. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study. Clin Biochem. 2011 Aug; 44(12):1021-4. PMID: 21640092.
      View in: PubMed
    51. Nagele P. Augmented CPR: rescue after the ResQ trial. Lancet. 2011 Jan 22; 377(9762):276-8. PMID: 21251706.
      View in: PubMed
    52. Hüpfl M, Selig HF, Nagele P. Chest-compression-only versus standard cardiopulmonary resuscitation: a meta-analysis. Lancet. 2010 Nov 06; 376(9752):1552-7. PMID: 20951422.
      View in: PubMed
    53. Nagele P, Rao LK, Penta M, Kallogjeri D, Spitznagel EL, Cavallone LF, Nussenbaum B, Piccirillo JF. Postoperative myocardial injury after major head and neck cancer surgery. Head Neck. 2011 Aug; 33(8):1085-91. PMID: 20886662.
      View in: PubMed
    54. Pehböck D, Wenzel V, Voelckel W, Jonsson K, Herff H, Mittlböck M, Nagele P. Effects of preoxygenation on desaturation time during hemorrhagic shock in pigs. Anesthesiology. 2010 Sep; 113(3):593-9. PMID: 20683251.
      View in: PubMed
    55. Rao LK, Francis AM, Wilcox U, Miller JP, Nagele P. Pre-operative vitamin B infusion and prevention of nitrous oxide-induced homocysteine increase. Anaesthesia. 2010 Jul; 65(7):710-5. PMID: 20477781.
      View in: PubMed
    56. Nagele P, Zeugswetter B, Eberle C, Hüpfl M, Mittlböck M, Födinger M. A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia. Pharmacogenet Genomics. 2009 May; 19(5):325-9. PMID: 19339913.
      View in: PubMed
    57. Nagele P, Zeugswetter B, Wiener C, Burger H, Hüpfl M, Mittlböck M, Födinger M. Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia. Anesthesiology. 2008 Jul; 109(1):36-43. PMID: 18580170.
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    58. Hüpfl M, Schmatzer I, Buzath A, Burger H, Hörauf K, Ihra G, Marhofer P, Nagele P. The effects of aminophylline on bispectral index during inhalational and total intravenous anaesthesia. Anaesthesia. 2008 Jun; 63(6):583-7. PMID: 18279487.
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    59. Thies KC, Nagele P. [Advanced Trauma Life Support--a standard of care for Germany? No substantial improvement of care can be expected]. Anaesthesist. 2007 Nov; 56(11):1147-54. PMID: 17882389.
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    60. Nagele P, Mendel JB, Placzek WJ, Scott BA, D'Avignon DA, Crowder CM. Volatile anesthetics bind rat synaptic snare proteins. Anesthesiology. 2005 Oct; 103(4):768-78. PMID: 16192769.
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    61. Nagele P, Metz LB, Crowder CM. Xenon acts by inhibition of non-N-methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in Caenorhabditis elegans. Anesthesiology. 2005 Sep; 103(3):508-13. PMID: 16129975.
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    62. Hüpfl M, Duma A, Uray T, Maier C, Fiegl N, Bogner N, Nagele P. Over-the-head cardiopulmonary resuscitation improves efficacy in basic life support performed by professional medical personnel with a single rescuer: a simulation study. Anesth Analg. 2005 Jul; 101(1):200-5, table of contents. PMID: 15976232.
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    63. Nagele P, Hüpfl M, Kroesen G. Epidemiology and outcome of pediatric trauma treated by an emergency-physician-staffed advanced life-support unit. Wien Klin Wochenschr. 2004 Jun 30; 116(11-12):398-403. PMID: 15291294.
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    64. Nagele P, Metz LB, Crowder CM. Nitrous oxide (N(2)O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8791-6. PMID: 15159532.
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    65. Nagele P. Misuse of standard error of the mean (SEM) when reporting variability of a sample. A critical evaluation of four anaesthesia journals. Br J Anaesth. 2003 Apr; 90(4):514-6. PMID: 12644429.
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    66. Rossaint R, Reyle-Hahn M, Schulte Am Esch J, Scholz J, Scherpereel P, Vallet B, Giunta F, Del Turco M, Erdmann W, Tenbrinck R, Hammerle AF, Nagele P. Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery. Anesthesiology. 2003 Jan; 98(1):6-13. PMID: 12502972.
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    67. Nagele P, Kroesen G. [Pediatric emergencies. An epidemiologic study of mobile care units in Innsbruck]. Anaesthesist. 2000 Aug; 49(8):725-31. PMID: 11013776.
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    68. Nagele P, Hammerle AF. Sevoflurane and mivacurium in a patient with Huntington's chorea. Br J Anaesth. 2000 Aug; 85(2):320-1. PMID: 10992848.
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