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Peter Nagele

TitleProfessor
InstitutionUniversity of Chicago
DepartmentAnesthesia and Critical Care
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Nagele is an internationally recognized trauma anesthesiologist, researcher and educator. An authority on perioperative outcomes research, he focuses on to better predict, diagnose, prevent, and treat major cardiac events in surgical patients. He discovered that novel heart biomarkers may predict heart attacks in patients undergoing non-cardiac surgery.
    He has also conducted ground-breaking work suggesting that a brief inhalation of nitrous oxide, commonly known as laughing gas, improves severe symptoms of depression and suicidal thoughts.


    Collapse Biography 
    Collapse awards and honors
    2018Fellow, American Heart Association
    2016NARSAD Independent Investigator Grant, Brain & Behavior Research Foundation
    2016Ziskind-Somerfeld Research Award, Society for Biological Psychiatry
    2014Mentor of the Year, Clinical Research Training Center, Washington University School of Medicine
    2012Presidential Scholar Award, American Society of Anesthesiologists
    2011Billroth Prize, Vienna Medical Society (Austria)
    2007Elmer-Zsigmond Award, International Society for Anesthetic Pharmacology
    2006Otto-Kraupp-Prize
    2005Research Starter Grant , European Society of Anaesthesiology
    2005Resident’s Research Essay Contest Award, American Society for Anesthesiology

    Collapse Research 
    Collapse research activities and funding
    K23GM087534     (NAGELE, PETER)Jan 4, 2010 - Dec 31, 2013
    NIH
    Perioperative pharmacogenetics: Nitrous oxide and anesthetic outcomes
    Role: Principal Investigator

    R01HL126892     (NAGELE, PETER)Aug 1, 2015 - Apr 30, 2020
    NIH
    NOVEL STRATEGY FOR PERIOPERATIVE BETA-BLOCKER THERAPY
    Role: Principal Investigator

    R21MH108901     (CONWAY, CHARLES RICHARD)Jul 21, 2016 - Jun 30, 2018
    NIH
    NMDA RECEPTOR ANTAGONIST NITROUS OXIDE TARGETS AFFECTIVE BRAIN CIRCUITS
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Tank A, Hughey R, Ward RP, Nagele P, Rubin DS. Evaluation of Appropriate Use of Preoperative Echocardiography before Major Abdominal Surgery: A Retrospective Cohort Study. Anesthesiology. 2021 11 01; 135(5):854-863. PMID: 34543408.
      View in: PubMed
    2. Duma A, Maleczek M, Wagner C, Haslacher H, Szekeres T, Jaffe AS, Nagele P. NT-proBNP in young healthy adults undergoing non-cardiac surgery. Clin Biochem. 2021 Oct; 96:38-42. PMID: 34265286.
      View in: PubMed
    3. Nagele P, Palanca BJ, Gott B, Brown F, Barnes L, Nguyen T, Xiong W, Salloum NC, Espejo GD, Lessov-Schlaggar CN, Jain N, Cheng WWL, Komen H, Yee B, Bolzenius JD, Janski A, Gibbons R, Zorumski CF, Conway CR. A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. Sci Transl Med. 2021 06 09; 13(597). PMID: 34108247.
      View in: PubMed
    4. Puelacher C, Bollen Pinto B, Mills NL, Duceppe E, Popova E, Duma A, Nagele P, Omland T, Hammerer-Lercher A, Lurati Buse G. Expert consensus on peri-operative myocardial injury screening in noncardiac surgery: A literature review. Eur J Anaesthesiol. 2021 Jun 01; 38(6):600-608. PMID: 33653981.
      View in: PubMed
    5. Rubin DS, Huisingh-Scheetz M, Ferguson MK, Nagele P, Peden CJ, Lauderdale DS. U.S. trends in elective and emergent major abdominal surgical procedures from 2002 to 2014 in older adults. J Am Geriatr Soc. 2021 08; 69(8):2220-2230. PMID: 33969889.
      View in: PubMed
    6. Rubin DS, Hughey R, Gerlach RM, Ham SA, Ward RP, Nagele P. Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017. JAMA Cardiol. 2021 Jan 01; 6(1):13-20. PMID: 32997100.
      View in: PubMed
    7. Beattie WS, Lalu M, Bocock M, Feng S, Wijeysundera DN, Nagele P, Fleisher LA, Kurz A, Biccard B, Leslie K, Howell S, Landoni G, Grocott H, Lamy A, Richards T, Myles P. Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes. Br J Anaesth. 2021 01; 126(1):56-66. PMID: 33092804.
      View in: PubMed
    8. Ranjeva SL, Tung A, Nagele P, Rubin DS. Morbidity and Mortality After Acute Myocardial Infarction After Elective Major Noncardiac Surgery. J Cardiothorac Vasc Anesth. 2021 Mar; 35(3):834-842. PMID: 33153868.
      View in: PubMed
    9. Titz M, Schwameis M, Kienbacher C, Buchtele N, Roth D, Duma A, Nagele P, Schörgenhofer C, Herkner H. Generalisability of randomised trials evaluating perioperative ß-blocker therapy in noncardiac surgery. Br J Anaesth. 2020 12; 125(6):926-934. PMID: 32888632.
      View in: PubMed
    10. Nagele P, Brown F, Bass V, Yohanna D. Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment. Front Psychiatry. 2020; 11:692. PMID: 32765325.
      View in: PubMed
    11. Nagele P. Perioperative Myocardial Injury and Infarction: Top-20 List of What We Know and What We Don't. Anesth Analg. 2020 07; 131(1):170-172. PMID: 32541590.
      View in: PubMed
    12. Varias A, van Roessel P, Parsiani M, Filippou-Frye M, Neylan TC, Nagele P, Yesavage J, Clark JD, Rodriguez CI. Does Nitrous Oxide Help Veterans With Posttraumatic Stress Disorder? A Case Series. J Clin Psychiatry. 2020 06 30; 81(4). PMID: 32609959.
      View in: PubMed
    13. Thomas S, Borges F, Bhandari M, De Beer J, Urrútia Cuchí G, Adili A, Winemaker M, Avram V, Chan MTV, Lamas C, Cruz P, Aguilera X, Garutti I, Alonso-Coello P, Villar JC, Jacka M, Wang CY, Berwanger O, Chow C, Srinathan S, Pettit S, Heels-Ansdell D, Rubery P, Devereaux PJ. Association Between Myocardial Injury and Cardiovascular Outcomes of Orthopaedic Surgery: A Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy. J Bone Joint Surg Am. 2020 May 20; 102(10):880-888. PMID: 32118652.
      View in: PubMed
    14. Nagele P. A Simplified Proposal to Redefine Acute Myocardial Infarction Versus Acute Myocardial Injury. Circulation. 2020 05 05; 141(18):1431-1433. PMID: 32364777.
      View in: PubMed
    15. Kalmoe MC, Janski AM, Zorumski CF, Nagele P, Palanca BJ, Conway CR. Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents. J Neurol Sci. 2020 05 15; 412:116778. PMID: 32240970.
      View in: PubMed
    16. Massalha S, Walpot J, Dey D, Guler EC, Clarkin O, Godkin L, Ratnayake I, Jayasinghe P, Hossain A, Crean A, Chan M, Butler C, Tandon V, Nagele P, Woodard PK, Mrkobrada M, Szczeklik W, Abdul Aziz YF, Biccard B, Devereaux PJ, Sheth T, Chow BJW. Epicardial Adipose Tissue: An Independent Predictor of Post-Operative Adverse Cardiovascular Events (CTA VISION Substudy). JACC Cardiovasc Imaging. 2020 03; 13(3):882-884. PMID: 31734207.
      View in: PubMed
    17. Nagele P. Elevated cardiac troponin before surgery: perhaps not so benign. Br J Anaesth. 2020 01; 124(1):6-7. PMID: 31685217.
      View in: PubMed
    18. Rubin DS, Huisingh-Scheetz M, Hung A, Ward RP, Nagele P, Arena R, Hedeker D. Accuracy of Physical Function Questions to Predict Moderate-Vigorous Physical Activity as Measured by Hip Accelerometry. Anesthesiology. 2019 11; 131(5):992-1003. PMID: 31490293.
      View in: PubMed
    19. Duma A, Nagele P. Cardiac Events after Electroconvulsive Therapy: Reply. Anesthesiology. 2019 10; 131(4):942. PMID: 31436543.
      View in: PubMed
    20. Buhre W, Disma N, Hendrickx J, De Hert S, Hollmann MW, Huhn R, Jakobsson J, Nagele P, Peyton P, Vutskits L. Response to comments on 'The European Society of Anaesthesiology Task Force review on the place of nitrous oxide in current clinical practice' (Br J Anaesth 2019; 122:587-604). Br J Anaesth. 2019 10; 123(4):e482-e483. PMID: 31371021.
      View in: PubMed
    21. Samaha E, Avila A, Helwani MA, Ben Abdallah A, Jaffe AS, Scott MG, Nagele P. High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2019 03 19; 8(6):e008626. PMID: 30871395.
      View in: PubMed
    22. Buhre W, Disma N, Hendrickx J, DeHert S, Hollmann MW, Huhn R, Jakobsson J, Nagele P, Peyton P, Vutskits L. European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice. Br J Anaesth. 2019 May; 122(5):587-604. PMID: 30916011.
      View in: PubMed
    23. Duma A, Maleczek M, Panjikaran B, Herkner H, Karrison T, Nagele P. Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy: A Systematic Review and Meta-analysis. Anesthesiology. 2019 01; 130(1):83-91. PMID: 30557212.
      View in: PubMed
    24. Samaha E, Brown J, Brown F, Martinez SC, Scott M, Jaffe AS, Davila-Roman VG, Nagele P. High-sensitivity cardiac troponin T increases after stress echocardiography. Clin Biochem. 2019 Jan; 63:18-23. PMID: 30502318.
      View in: PubMed
    25. Hong HY, Karadaghy O, Kallogjeri D, Brown FT, Yee B, Piccirillo JF, Nagele P. Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2018 09 01; 144(9):781-787. PMID: 30073285.
      View in: PubMed
    26. Nagele P, Zorumski CF, Conway C. Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts. J Clin Psychopharmacol. 2018 Apr; 38(2):144-148. PMID: 29360650.
      View in: PubMed
    27. Duma A, Wagner C, Titz M, Maleczek M, Hüpfl M, Weihs VB, Samaha E, Herkner H, Szekeres T, Mittlboeck M, Scott MG, Jaffe AS, Nagele P. High-sensitivity cardiac troponin T in young, healthy adults undergoing non-cardiac surgery. Br J Anaesth. 2018 Feb; 120(2):291-298. PMID: 29406178.
      View in: PubMed
    28. Samaha E, Helwani MA, Brown JC, Brown F, Jaffe AS, Scott MG, Nagele P. Are high-sensitivity cardiac troponin I values stable between preoperative visit and day of non-cardiac surgery? Clin Biochem. 2018 Feb; 52:171-172. PMID: 29175409.
      View in: PubMed
    29. Brown JC, Samaha E, Rao S, Helwani MA, Duma A, Brown F, Gage BF, Miller JP, Jaffe AS, Apple FS, Scott MG, Nagele P. High-Sensitivity Cardiac Troponin T Improves the Diagnosis of Perioperative MI. Anesth Analg. 2017 11; 125(5):1455-1462. PMID: 28719430.
      View in: PubMed
    30. Duma A, Pal S, Johnston J, Helwani MA, Bhat A, Gill B, Rosenkvist J, Cartmill C, Brown F, Miller JP, Scott MG, Sanchez-Conde F, Jarvis M, Farber NB, Zorumski CF, Conway C, Nagele P. High-sensitivity Cardiac Troponin Elevation after Electroconvulsive Therapy: A Prospective, Observational Cohort Study. Anesthesiology. 2017 04; 126(4):643-652. PMID: 28166110.
      View in: PubMed
    31. Kopec M, Duma A, Helwani MA, Brown J, Brown F, Gage BF, Gibson DW, Miller JP, Novak E, Jaffe AS, Apple FS, Scott MG, Nagele P. Improving Prediction of Postoperative Myocardial Infarction With High-Sensitivity Cardiac Troponin T and NT-proBNP. Anesth Analg. 2017 02; 124(2):398-405. PMID: 28002165.
      View in: PubMed
    32. Nagele P. Refining the Diagnosis of Type 2 Myocardial Infarction-Reply. JAMA Cardiol. 2017 01 01; 2(1):107. PMID: 27760250.
      View in: PubMed
    33. Nagele P. The Case for a Revised Definition of Myocardial Infarction-Resolving the Ambiguity of Type 2 Myocardial Infarction. JAMA Cardiol. 2016 06 01; 1(3):247-8. PMID: 27438099.
      View in: PubMed
    34. Duma A, Pal S, Helsten D, Stein PK, Miller JP, Nagele P. High-Fidelity Analysis of Perioperative QTc Prolongation. Anesth Analg. 2016 Feb; 122(2):439-48. PMID: 26505572.
      View in: PubMed
    35. Böttiger BW, Bernhard M, Knapp J, Nagele P. Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis. Crit Care. 2016 Jan 09; 20:4. PMID: 26747085.
      View in: PubMed
    36. Zorumski CF, Nagele P, Mennerick S, Conway CR. Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy. Front Psychiatry. 2015; 6:172. PMID: 26696909.
      View in: PubMed
    37. Duma A, Cartmill C, Blood J, Sharma A, Kharasch ED, Nagele P. The hematological effects of nitrous oxide anesthesia in pediatric patients. Anesth Analg. 2015 Jun; 120(6):1325-30. PMID: 25658315.
      View in: PubMed
    38. Sheth T, Chan M, Butler C, Chow B, Tandon V, Nagele P, Mitha A, Mrkobrada M, Szczeklik W, Faridah Y, Biccard B, Stewart LK, Heels-Ansdell D, Devereaux PJ. Prognostic capabilities of coronary computed tomographic angiography before non-cardiac surgery: prospective cohort study. BMJ. 2015 Apr 22; 350:h1907. PMID: 25902738.
      View in: PubMed
    39. Kaucikas M, Fitzpatrick A, Bryan E, Struve A, Henning R, Kosheleva I, Srajer V, Groenhof G, Van Thor JJ. Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa. Proteins. 2015 Mar; 83(3):397-402. PMID: 24050977.
      View in: PubMed
    40. Kaucikas M, Fitzpatrick A, Bryan E, Struve A, Henning R, Kosheleva I, Srajer V, Groenhof G, Van Thor JJ. Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa. Proteins. 2015 Mar; 83(3):397-402. PMID: 23420061.
      View in: PubMed
    41. Kaucikas M, Fitzpatrick A, Bryan E, Struve A, Henning R, Kosheleva I, Srajer V, Groenhof G, Van Thor JJ. Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa. Proteins. 2015 Mar; 83(3):397-402. PMID: 29397136.
      View in: PubMed
    42. Kaucikas M, Fitzpatrick A, Bryan E, Struve A, Henning R, Kosheleva I, Srajer V, Groenhof G, Van Thor JJ. Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa. Proteins. 2015 Mar; 83(3):397-402. PMID: 29481375.
      View in: PubMed
    43. Kaucikas M, Fitzpatrick A, Bryan E, Struve A, Henning R, Kosheleva I, Srajer V, Groenhof G, Van Thor JJ. Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa. Proteins. 2015 Mar; 83(3):397-402. PMID: 21691755.
      View in: PubMed
    44. Kaucikas M, Fitzpatrick A, Bryan E, Struve A, Henning R, Kosheleva I, Srajer V, Groenhof G, Van Thor JJ. Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa. Proteins. 2015 Mar; 83(3):397-402. PMID: 20951422.
      View in: PubMed
    45. Kaucikas M, Fitzpatrick A, Bryan E, Struve A, Henning R, Kosheleva I, Srajer V, Groenhof G, Van Thor JJ. Room temperature crystal structure of the fast switching M159T mutant of the fluorescent protein dronpa. Proteins. 2015 Mar; 83(3):397-402. PMID: 19339913.
      View in: PubMed
    46. Nagele P, Duma A, Kopec M, Gebara MA, Parsoei A, Walker M, Janski A, Panagopoulos VN, Cristancho P, Miller JP, Zorumski CF, Conway CR. Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial. Biol Psychiatry. 2015 Jul 01; 78(1):10-18. PMID: 25577164.
      View in: PubMed
    47. Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G, Walsh M, Sapsford R, Schünemann HJ, Kurz A, Thomas S, Mrkobrada M, Thabane L, Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, Devereaux PJ, Sessler DI, Walsh M, Guyatt G, McQueen MJ, Bhandari M, Cook D, Bosch J, Buckley N, Yusuf S, Chow CK, Hillis GS, Halliwell R, Li S, Lee VW, Mooney J, Polanczyk CA, Furtado MV, Berwanger O, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA, Cavalcanti AB, Guimaraes HP, Jacka MJ, Graham M, McAlister F, McMurtry S, Townsend D, Pannu N, Bagshaw S, Bessissow A, Bhandari M, Duceppe E, Eikelboom J, Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D, Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C, Mizera R, O'Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V, Vanhelder T, Winemaker M, Gerstein H, McDonald S, O'Bryne P, Patel A, Paul J, Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C, Cook D, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S, Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N, Macneil D, Mrkobrada M, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius L, Siddiqui FS, Grocott HP, McKay A, Lee TW, Amadeo R, Funk D, McDonald H, Zacharias J, Villar JC, Cortés OL, Chaparro MS, Vásquez S, Castañeda A, Ferreira S, Coriat P, Monneret D, Goarin JP, Esteve CI, Royer C, Daas G, Chan MT, Choi GY, Gin T, Lit LC, Xavier D, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S, Abraham V, Afzal L, George P, Mala S, Schünemann H, Muti P, Vizza E, Wang CY, Ong GS, Mansor M, Tan AS, Shariffuddin II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai HY, Ahmad WA, Razack AH, Malaga G, Valderrama-Victoria V, Loza-Herrera JD, De Los Angeles Lazo M, Rotta-Rotta A, Szczeklik W, Sokolowska B, Musial J, Gorka J, Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B, Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner D, Torborg A, Paniagua P, Urrutia G, Maestre ML, Santaló M, Gonzalez R, Font A, Martínez C, Pelaez X, De Antonio M, Villamor JM, García JA, Ferré MJ, Popova E, Alonso-Coello P, Garutti I, Cruz P, Fernández C, Palencia M, Díaz S, Del Castillo T, Varela A, de Miguel A, Muñoz M, Piñeiro P, Cusati G, Del Barrio M, Membrillo MJ, Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J, Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Pearse R, Ackland G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E, Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Del Arroyo AG, Sessler DI, Kurz A, Sun Z, Finnegan PS, Egan C, Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Nagele P, Blood J, Kalin M, Gibson D, Wildes T. Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology. 2014 Mar; 120(3):564-78. PMID: 24534856.
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    48. Nagele P, Brown F, Francis A, Scott MG, Gage BF, Miller JP. In reply. Anesthesiology. 2014 Feb; 120(2):515-6. PMID: 24448089.
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    49. Nagele P. Neuraxial block, death, and serious cardiovascular morbidity in the POISE trial. Br J Anaesth. 2014 Feb; 112(2):392. PMID: 24431369.
      View in: PubMed
    50. Duma A, Helsten D, Brown F, Bottros MM, Nagele P. The effect of nitrous oxide anesthesia on early postoperative opioid consumption and pain. Reg Anesth Pain Med. 2014 Jan-Feb; 39(1):31-6. PMID: 24310050.
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    51. Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG. Letter in response to "Use of preoperative cardiac troponin T to identify patients at risk for acute myocardial infraction and long-term mortality after major noncardiac surgery". Am Heart J. 2014 Feb; 167(2):e7. PMID: 24439992.
      View in: PubMed
    52. Nagele P. Exome sequencing: one small step for malignant hyperthermia, one giant step for our specialty--why exome sequencing matters to all of us, not just the experts. Anesthesiology. 2013 Nov; 119(5):1006-8. PMID: 24195944.
      View in: PubMed
    53. Nagele P, Brown F, Francis A, Scott MG, Gage BF, Miller JP. Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial. Anesthesiology. 2013 Jul; 119(1):19-28. PMID: 23856660.
      View in: PubMed
    54. Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG. High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery. Am Heart J. 2013 Aug; 166(2):325-332.e1. PMID: 23895816.
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    55. Johnston J, Pal S, Nagele P. Perioperative torsade de pointes: a systematic review of published case reports. Anesth Analg. 2013 Sep; 117(3):559-564. PMID: 23744954.
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    56. Blake CM, Kharasch ED, Schwab M, Nagele P. A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics. Clin Pharmacol Ther. 2013 Sep; 94(3):394-9. PMID: 23665868.
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    57. Nagele P, Pal S, Brown F, Blood J, Miller JP, Johnston J. Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia. Anesthesiology. 2012 Aug; 117(2):321-8. PMID: 22692379.
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    58. Sheth T, Butler C, Chow B, Chan MT, Mitha A, Nagele P, Tandon V, Stewart L, Graham M, Choi GY, Kisten T, Woodard PK, Crean A, Abdul Aziz YF, Karthikeyan G, Chow CK, Szczeklik W, Markobrada M, Mastracci T, Devereaux PJ. The coronary CT angiography vision protocol: a prospective observational imaging cohort study in patients undergoing non-cardiac surgery. BMJ Open. 2012; 2(4). PMID: 22855630.
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    59. Selig HF, Nagele P, Voelckel WG, Trimmel H, Hüpfl M, Lumenta DB, Kamolz LP. The epidemiology of amputation injuries in the Austrian helicopter emergency medical service: a retrospective, nationwide cohort study. Eur J Trauma Emerg Surg. 2012 Dec; 38(6):651-7. PMID: 26814552.
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    60. Nagele P. Notorious oxide. Anesthesiology. 2012 Jul; 117(1):3-5. PMID: 22569133.
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    61. Selig HF, Hüpfl M, Trimmel H, Voelckel WG, Nagele P. Pediatric trauma in the Austrian Alps: the epidemiology of sport-related injuries in helicopter emergency medical service. High Alt Med Biol. 2012 Jun; 13(2):112-7. PMID: 22724614.
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    62. Nagele P. Perioperative genomics. Best Pract Res Clin Anaesthesiol. 2011 Dec; 25(4):549-55. PMID: 22099920.
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    63. Nagele P, Liggett SB. Genetic variation, ß-blockers, and perioperative myocardial infarction. Anesthesiology. 2011 Dec; 115(6):1316-27. PMID: 21918425.
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    64. Nagele P, Meissner K, Francis A, Födinger M, Saccone NL. Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification. Pharmacogenet Genomics. 2011 Jul; 21(7):426-31. PMID: 21597397.
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    65. Nagele P, Tallchief D, Blood J, Sharma A, Kharasch ED. Nitrous oxide anesthesia and plasma homocysteine in adolescents. Anesth Analg. 2011 Oct; 113(4):843-8. PMID: 21680854.
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    66. Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ, Hill SA, Thomas S, Mrkobrada M, Alonso-Coello P, Berwanger O, Biccard BM, Cembrowski G, Chan MT, Chow CK, de Miguel A, Garcia M, Graham MM, Jacka MJ, Kueh JH, Li SC, Lit LC, Martínez-Brú C, Naidoo P, Nagele P, Pearse RM, Rodseth RN, Sessler DI, Sigamani A, Szczeklik W, Tiboni M, Villar JC, Wang CY, Xavier D, Devereaux PJ. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study. Clin Biochem. 2011 Aug; 44(12):1021-4. PMID: 21640092.
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    67. Nagele P. Augmented CPR: rescue after the ResQ trial. Lancet. 2011 Jan 22; 377(9762):276-8. PMID: 21251706.
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    68. Nagele P, Rao LK, Penta M, Kallogjeri D, Spitznagel EL, Cavallone LF, Nussenbaum B, Piccirillo JF. Postoperative myocardial injury after major head and neck cancer surgery. Head Neck. 2011 Aug; 33(8):1085-91. PMID: 20886662.
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    69. Pehböck D, Wenzel V, Voelckel W, Jonsson K, Herff H, Mittlböck M, Nagele P. Effects of preoxygenation on desaturation time during hemorrhagic shock in pigs. Anesthesiology. 2010 Sep; 113(3):593-9. PMID: 20683251.
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    70. Rao LK, Francis AM, Wilcox U, Miller JP, Nagele P. Pre-operative vitamin B infusion and prevention of nitrous oxide-induced homocysteine increase. Anaesthesia. 2010 Jul; 65(7):710-5. PMID: 20477781.
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    71. Nagele P, Zeugswetter B, Wiener C, Burger H, Hüpfl M, Mittlböck M, Födinger M. Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia. Anesthesiology. 2008 Jul; 109(1):36-43. PMID: 18580170.
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    72. Hüpfl M, Schmatzer I, Buzath A, Burger H, Hörauf K, Ihra G, Marhofer P, Nagele P. The effects of aminophylline on bispectral index during inhalational and total intravenous anaesthesia. Anaesthesia. 2008 Jun; 63(6):583-7. PMID: 18279487.
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    73. Thies KC, Nagele P. [Advanced Trauma Life Support--a standard of care for Germany? No substantial improvement of care can be expected]. Anaesthesist. 2007 Nov; 56(11):1147-54. PMID: 17882389.
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    74. Nagele P, Mendel JB, Placzek WJ, Scott BA, D'Avignon DA, Crowder CM. Volatile anesthetics bind rat synaptic snare proteins. Anesthesiology. 2005 Oct; 103(4):768-78. PMID: 16192769.
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    75. Nagele P, Metz LB, Crowder CM. Xenon acts by inhibition of non-N-methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in Caenorhabditis elegans. Anesthesiology. 2005 Sep; 103(3):508-13. PMID: 16129975.
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    76. Hüpfl M, Duma A, Uray T, Maier C, Fiegl N, Bogner N, Nagele P. Over-the-head cardiopulmonary resuscitation improves efficacy in basic life support performed by professional medical personnel with a single rescuer: a simulation study. Anesth Analg. 2005 Jul; 101(1):200-5, table of contents. PMID: 15976232.
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    77. Nagele P, Hüpfl M, Kroesen G. Epidemiology and outcome of pediatric trauma treated by an emergency-physician-staffed advanced life-support unit. Wien Klin Wochenschr. 2004 Jun 30; 116(11-12):398-403. PMID: 15291294.
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    78. Nagele P, Metz LB, Crowder CM. Nitrous oxide (N(2)O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8791-6. PMID: 15159532.
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    79. Zhong R, Wan J, Jin R, Lamppa G. A pea antisense gene for the chloroplast stromal processing peptidase yields seedling lethals in Arabidopsis: survivors show defective GFP import in vivo. Plant J. 2003 Jun; 34(6):802-12. PMID: 22706835.
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    80. Nagele P. Misuse of standard error of the mean (SEM) when reporting variability of a sample. A critical evaluation of four anaesthesia journals. Br J Anaesth. 2003 Apr; 90(4):514-6. PMID: 12644429.
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    81. Rossaint R, Reyle-Hahn M, Schulte Am Esch J, Scholz J, Scherpereel P, Vallet B, Giunta F, Del Turco M, Erdmann W, Tenbrinck R, Hammerle AF, Nagele P. Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery. Anesthesiology. 2003 Jan; 98(1):6-13. PMID: 12502972.
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    82. Nagele P, Kroesen G. [Pediatric emergencies. An epidemiologic study of mobile care units in Innsbruck]. Anaesthesist. 2000 Aug; 49(8):725-31. PMID: 11013776.
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    83. Nagele P, Hammerle AF. Sevoflurane and mivacurium in a patient with Huntington's chorea. Br J Anaesth. 2000 Aug; 85(2):320-1. PMID: 10992848.
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