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Peter Nagele

TitleProfessor
InstitutionUniversity of Chicago
DepartmentAnesthesia and Critical Care
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Nagele is an internationally recognized trauma anesthesiologist, researcher and educator. An authority on perioperative outcomes research, he focuses on to better predict, diagnose, prevent, and treat major cardiac events in surgical patients. He discovered that novel heart biomarkers may predict heart attacks in patients undergoing non-cardiac surgery.
    He has also conducted ground-breaking work suggesting that a brief inhalation of nitrous oxide, commonly known as laughing gas, improves severe symptoms of depression and suicidal thoughts.

    Collapse Biography 
    Collapse awards and honors
    2022Fellow, American Association for the Advancement of Science
    2021Austrian Cross of Honor for Science and Arts , Republic of Austria
    2019FAER Academy of Research Mentors in Anesthesiology (elected), FAER
    2018Fellow, American Heart Association
    2016NARSAD Independent Investigator Grant, Brain & Behavior Research Foundation
    2016Ziskind-Somerfeld Research Award, Society for Biological Psychiatry
    2014Mentor of the Year, Clinical Research Training Center, Washington University School of Medicine
    2012Presidential Scholar Award, American Society of Anesthesiologists
    2011Billroth Prize, Vienna Medical Society (Austria)
    2007Elmer-Zsigmond Award, International Society for Anesthetic Pharmacology
    2006Otto-Kraupp-Prize
    2005Research Starter Grant , European Society of Anaesthesiology
    2005Resident’s Research Essay Contest Award, American Society for Anesthesiology

    Collapse Research 
    Collapse research activities and funding
    R21MH119531     (COCCARO, EMIL FRANK)Sep 1, 2020 - Aug 31, 2022
    NIH
    Nitrous Oxide and Cortico-Limbic Function in Aggression
    Role: Co-Principal Investigator
    R21MH108901     (CONWAY, CHARLES RICHARD)Jul 21, 2016 - Mar 31, 2020
    NIH
    NMDA RECEPTOR ANTAGONIST NITROUS OXIDE TARGETS AFFECTIVE BRAIN CIRCUITS
    Role: Co-Investigator
    R01HL126892     (NAGELE, PETER)Aug 1, 2015 - Apr 30, 2021
    NIH
    Novel Strategy for Perioperative Beta-Blocker Therapy
    Role: Principal Investigator
    K23GM087534     (NAGELE, PETER)Jan 4, 2010 - Dec 31, 2013
    NIH
    Perioperative pharmacogenetics: Nitrous oxide and anesthetic outcomes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. de Leon VC, Kumar A, Nagele P, Palanca BJ, Gott B, Janski A, Zorumski CF, Conway CR. Nitrous Oxide Reduced Suicidal Ideation in Treatment-Resistant Major Depression in Exploratory Analysis. J Clin Psychiatry. 2023 08 16; 84(5). PMID: 37585253.
      Citations:    Fields:    Translation:Humans
    2. Myles PS, Kulkarni J, Nagele P. Treatments for major depression. Lancet. 2023 06 24; 401(10394):2111. PMID: 37355289.
      Citations:    Fields:    Translation:Humans
    3. Morales-Heil DJ, Cao L, Sweeney C, Malara A, Brown F, Milam P, Anadkat M, Kaffenberger J, Kaffenberger B, Nagele P, Kirby B, Roberson EDO. Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa. HGG Adv. 2023 04 13; 4(2):100187. PMID: 37013170; PMCID: PMC10066561.
      Citations:    Translation:HumansCells
    4. Nagele P. Colonels and generals, chairs and deans: How the military educates its leaders and what we can learn in academic medicine. Front Health Serv. 2023; 3:1075543. PMID: 36926510; PMCID: PMC10012622.
      Citations:    
    5. Rubin DS, Lin AZ, Ward RP, Nagele P, Lin AZ, Ward RP, Nagele P. Trends and In-Hospital Mortality for Perioperative Myocardial Infarction After the Introduction of a Diagnostic Code for Type 2 Myocardial Infarction in the United States Between 2016 and 2018. Anesth Analg. 2024 Feb 01; 138(2):420-429. PMID: 36795598; PMCID: PMC10427730.
      Citations:    Fields:    Translation:Humans
    6. Palanca BJA, Conway CR, Zeffiro T, Gott BM, Nguyen T, Janski A, Jain N, Komen H, Burke BA, Zorumski CF, Nagele P. Persistent Brain Connectivity Changes in Healthy Volunteers Following Nitrous Oxide Inhalation. Biol Psychiatry Glob Open Sci. 2023 Oct; 3(4):698-704. PMID: 37881568; PMCID: PMC10593877.
      Citations:    
    7. McKenzie NL, Ward RP, Nagele P, Rubin DS. Preoperative ß-Blocker Therapy and Stroke or Major Adverse Cardiac Events in Major Abdominal Surgery: A Retrospective Cohort Study. Anesthesiology. 2023 01 01; 138(1):42-54. PMID: 36227278; PMCID: PMC9771981.
      Citations: 2     Fields:    Translation:Humans
    8. Izumi Y, Hsu FF, Conway CR, Nagele P, Mennerick SJ, Zorumski CF. Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus. Biol Psychiatry. 2022 12 15; 92(12):964-972. PMID: 36050137; PMCID: PMC10107749.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Bass V, Brown F, Beiser DG, Peterson T, Gibbons RD, Nagele P. Preoperative Assessment of Anxiety and Depression Using Computerized Adaptive Screening Tools: A Pilot Prospective Cohort Study. Anesth Analg. 2022 04 01; 134(4):853-857. PMID: 34958316.
      Citations:    Fields:    Translation:Humans
    10. Nagele P. The Importance of Definitive Trials: The VIXIE Trial. Anesthesiology. 2022 03 01; 136(3):403-404. PMID: 35120197.
      Citations:    Fields:    
    11. Walpot J, Massalha S, Jayasinghe P, Sadaf M, Clarkin O, Godkin L, Sharma A, Ratnayake I, Godkin K, Jia K, Hossain A, Crean AM, Chan M, Butler C, Tandon V, Nagele P, Woodard PK, Mrkobrada M, Szczeklik W, Aziz YFA, Biccard B, Devereaux PJ, Sheth T, Chow BJW. Normalized Subendocardial Myocardial Attenuation on Coronary Computed Tomography Angiography Predicts Postoperative Adverse Cardiovascular Events: Coronary CTA VISION Substudy. Circ Cardiovasc Imaging. 2022 01; 15(1):e012654. PMID: 35041449.
      Citations:    Fields:    Translation:Humans
    12. Tank A, Hughey R, Ward RP, Nagele P, Rubin DS. Evaluation of Appropriate Use of Preoperative Echocardiography before Major Abdominal Surgery: A Retrospective Cohort Study. Anesthesiology. 2021 11 01; 135(5):854-863. PMID: 34543408; PMCID: PMC8511132.
      Citations:    Fields:    Translation:Humans
    13. Duma A, Maleczek M, Wagner C, Haslacher H, Szekeres T, Jaffe AS, Nagele P. NT-proBNP in young healthy adults undergoing non-cardiac surgery. Clin Biochem. 2021 Oct; 96:38-42. PMID: 34265286.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    14. Nagele P, Palanca BJ, Gott B, Brown F, Barnes L, Nguyen T, Xiong W, Salloum NC, Espejo GD, Lessov-Schlaggar CN, Jain N, Cheng WWL, Komen H, Yee B, Bolzenius JD, Janski A, Gibbons R, Zorumski CF, Conway CR. A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. Sci Transl Med. 2021 06 09; 13(597). PMID: 34108247.
      Citations: 17     Fields:    Translation:HumansCTClinical Trials
    15. Puelacher C, Bollen Pinto B, Mills NL, Duceppe E, Popova E, Duma A, Nagele P, Hammerer-Lercher A, Lurati Buse G, Omland T. Expert consensus on peri-operative myocardial injury screening in noncardiac surgery: A literature review. Eur J Anaesthesiol. 2021 Jun 01; 38(6):600-608. PMID: 33653981.
      Citations: 11     Fields:    Translation:Humans
    16. Rubin DS, Huisingh-Scheetz M, Ferguson MK, Nagele P, Peden CJ, Lauderdale DS. U.S. trends in elective and emergent major abdominal surgical procedures from 2002 to 2014 in older adults. J Am Geriatr Soc. 2021 08; 69(8):2220-2230. PMID: 33969889; PMCID: PMC8373714.
      Citations: 3     Fields:    Translation:Humans
    17. Rubin DS, Hughey R, Gerlach RM, Ham SA, Ward RP, Nagele P. Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017. JAMA Cardiol. 2021 01 01; 6(1):13-20. PMID: 32997100; PMCID: PMC7527943.
      Citations: 6     Fields:    Translation:Humans
    18. Beattie WS, Lalu M, Bocock M, Feng S, Wijeysundera DN, Nagele P, Fleisher LA, Kurz A, Biccard B, Leslie K, Howell S, Landoni G, Grocott H, Lamy A, Richards T, Myles P, StEP COMPAC Group, Patient Comfort, Clinical Indicators, Delirium Postoperative Cognitive Dysfunction Stroke, Cardiovascular, Data Extractors, Respiratory, Inflammation Sepsis, Acute Kidney Injury, Bleeding Complications Patient Blood Management, Healthcare Resource Utilisation, Patient-Centred Outcomes, Organ Failure and Survival, Cancer Surgery. Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes. Br J Anaesth. 2021 01; 126(1):56-66. PMID: 33092804.
      Citations: 18     Fields:    Translation:Humans
    19. Ranjeva SL, Tung A, Nagele P, Rubin DS. Morbidity and Mortality After Acute Myocardial Infarction After Elective Major Noncardiac Surgery. J Cardiothorac Vasc Anesth. 2021 Mar; 35(3):834-842. PMID: 33153868; PMCID: PMC7867597.
      Citations:    Fields:    Translation:Humans
    20. Titz M, Schwameis M, Kienbacher C, Buchtele N, Roth D, Duma A, Nagele P, Herkner H, Schörgenhofer C. Generalisability of randomised trials evaluating perioperative ß-blocker therapy in noncardiac surgery. Br J Anaesth. 2020 12; 125(6):926-934. PMID: 32888632.
      Citations: 3     Fields:    Translation:Humans
    21. Nagele P, Brown F, Bass V, Yohanna D. Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment. Front Psychiatry. 2020; 11:692. PMID: 32765325; PMCID: PMC7379369.
      Citations: 1     
    22. Nagele P. Perioperative Myocardial Injury and Infarction: Top-20 List of What We Know and What We Don't. Anesth Analg. 2020 07; 131(1):170-172. PMID: 32541590.
      Citations:    Fields:    Translation:Humans
    23. Varias A, van Roessel P, Parsiani M, Filippou-Frye M, Neylan TC, Nagele P, Yesavage J, Clark JD, Rodriguez CI. Does Nitrous Oxide Help Veterans With Posttraumatic Stress Disorder? A Case Series. J Clin Psychiatry. 2020 06 30; 81(4). PMID: 32609959; PMCID: PMC8218879.
      Citations: 4     Fields:    Translation:Humans
    24. Thomas S, Borges F, Bhandari M, De Beer J, Adili A, Winemaker M, Avram V, Chan MTV, Aguilera X, Alonso-Coello P, Jacka M, Wang CY, Berwanger O, Chow C, Srinathan S, Pettit S, Heels-Ansdell D, Rubery P, Devereaux PJ, VISION Investigators, Urrútia Cuchí G, Lamas C, Cruz P, Garutti I, Villar JC. Association Between Myocardial Injury and Cardiovascular Outcomes of Orthopaedic Surgery: A Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy. J Bone Joint Surg Am. 2020 May 20; 102(10):880-888. PMID: 32118652.
      Citations: 7     Fields:    Translation:Humans
    25. Nagele P. A Simplified Proposal to Redefine Acute Myocardial Infarction Versus Acute Myocardial Injury. Circulation. 2020 05 05; 141(18):1431-1433. PMID: 32364777; PMCID: PMC7202369.
      Citations: 3     Fields:    Translation:Humans
    26. Kalmoe MC, Janski AM, Zorumski CF, Nagele P, Palanca BJ, Conway CR. Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents. J Neurol Sci. 2020 05 15; 412:116778. PMID: 32240970.
      Citations: 21     Fields:    Translation:Humans
    27. Massalha S, Walpot J, Dey D, Guler EC, Clarkin O, Godkin L, Ratnayake I, Jayasinghe P, Hossain A, Crean A, Chan M, Butler C, Tandon V, Nagele P, Woodard PK, Mrkobrada M, Szczeklik W, Abdul Aziz YF, Biccard B, Devereaux PJ, Sheth T, Chow BJW. Epicardial Adipose Tissue: An Independent Predictor of Post-Operative Adverse Cardiovascular Events (CTA VISION Substudy). JACC Cardiovasc Imaging. 2020 03; 13(3):882-884. PMID: 31734207.
      Citations: 1     Fields:    Translation:Humans
    28. Nagele P. Elevated cardiac troponin before surgery: perhaps not so benign. Br J Anaesth. 2020 01; 124(1):6-7. PMID: 31685217.
      Citations: 2     Fields:    Translation:Humans
    29. Rubin DS, Huisingh-Scheetz M, Hung A, Ward RP, Nagele P, Arena R, Hedeker D. Accuracy of Physical Function Questions to Predict Moderate-Vigorous Physical Activity as Measured by Hip Accelerometry. Anesthesiology. 2019 11; 131(5):992-1003. PMID: 31490293; PMCID: PMC7025320.
      Citations:    Fields:    Translation:Humans
    30. Duma A, Nagele P. Cardiac Events after Electroconvulsive Therapy: Reply. Anesthesiology. 2019 10; 131(4):942. PMID: 31436543.
      Citations:    Fields:    
    31. Buhre W, Disma N, Hendrickx J, De Hert S, Hollmann MW, Jakobsson J, Nagele P, Peyton P, Huhn R, Vutskits L. Response to comments on 'The European Society of Anaesthesiology Task Force review on the place of nitrous oxide in current clinical practice' (Br J Anaesth 2019; 122:587-604). Br J Anaesth. 2019 10; 123(4):e482-e483. PMID: 31371021.
      Citations:    Fields:    
    32. Samaha E, Avila A, Helwani MA, Ben Abdallah A, Jaffe AS, Scott MG, Nagele P. High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2019 03 19; 8(6):e008626. PMID: 30871395; PMCID: PMC6475059.
      Citations: 11     Fields:    Translation:Humans
    33. Buhre W, Disma N, Hendrickx J, DeHert S, Hollmann MW, Jakobsson J, Nagele P, Peyton P, Huhn R, Vutskits L. European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice. Br J Anaesth. 2019 May; 122(5):587-604. PMID: 30916011.
      Citations: 17     Fields:    Translation:Humans
    34. Duma A, Maleczek M, Panjikaran B, Herkner H, Karrison T, Nagele P. Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy: A Systematic Review and Meta-analysis. Anesthesiology. 2019 01; 130(1):83-91. PMID: 30557212; PMCID: PMC6300062.
      Citations: 5     Fields:    Translation:Humans
    35. Samaha E, Brown J, Brown F, Martinez SC, Scott M, Jaffe AS, Davila-Roman VG, Nagele P. High-sensitivity cardiac troponin T increases after stress echocardiography. Clin Biochem. 2019 Jan; 63:18-23. PMID: 30502318.
      Citations: 5     Fields:    Translation:Humans
    36. Hong HY, Karadaghy O, Kallogjeri D, Brown FT, Yee B, Piccirillo JF, Nagele P. Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2018 09 01; 144(9):781-787. PMID: 30073285; PMCID: PMC6233619.
      Citations: 6     Fields:    Translation:Humans
    37. Helwani MA, Amin A, Lavigne P, Rao S, Oesterreich S, Samaha E, Brown JC, Nagele P. Etiology of Acute Coronary Syndrome after Noncardiac Surgery. Anesthesiology. 2018 06; 128(6):1084-1091. PMID: 29481375; PMCID: PMC5953771.
      Citations: 20     Fields:    Translation:Humans
    38. Nagele P, Zorumski CF, Conway C. Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts. J Clin Psychopharmacol. 2018 Apr; 38(2):144-148. PMID: 29360650; PMCID: PMC5825282.
      Citations: 16     Fields:    Translation:Humans
    39. Duma A, Wagner C, Titz M, Maleczek M, Weihs VB, Samaha E, Herkner H, Szekeres T, Mittlboeck M, Scott MG, Jaffe AS, Nagele P, Hüpfl M. High-sensitivity cardiac troponin T in young, healthy adults undergoing non-cardiac surgery. Br J Anaesth. 2018 Feb; 120(2):291-298. PMID: 29406178; PMCID: PMC6200098.
      Citations: 4     Fields:    Translation:Humans
    40. Nagele P. Postoperative hypotension and troponin elevation: association or causation? Br J Anaesth. 2018 01; 120(1):4-5. PMID: 29397136.
      Citations: 1     Fields:    Translation:Humans
    41. Samaha E, Helwani MA, Brown JC, Brown F, Jaffe AS, Scott MG, Nagele P. Are high-sensitivity cardiac troponin I values stable between preoperative visit and day of non-cardiac surgery? Clin Biochem. 2018 Feb; 52:171-172. PMID: 29175409; PMCID: PMC5805600.
      Citations:    Fields:    Translation:Humans
    42. Samaha E, Rao S, Helwani MA, Duma A, Brown F, Gage BF, Miller JP, Jaffe AS, Apple FS, Scott MG, Nagele P, Brown JC. High-Sensitivity Cardiac Troponin T Improves the Diagnosis of Perioperative MI. Anesth Analg. 2017 11; 125(5):1455-1462. PMID: 28719430; PMCID: PMC6435292.
      Citations: 8     Fields:    Translation:HumansCells
    43. Duma A, Pal S, Johnston J, Helwani MA, Bhat A, Gill B, Rosenkvist J, Cartmill C, Brown F, Miller JP, Scott MG, Sanchez-Conde F, Jarvis M, Farber NB, Zorumski CF, Conway C, Nagele P. High-sensitivity Cardiac Troponin Elevation after Electroconvulsive Therapy: A Prospective, Observational Cohort Study. Anesthesiology. 2017 04; 126(4):643-652. PMID: 28166110; PMCID: PMC5350051.
      Citations: 2     Fields:    Translation:Humans
    44. Duma A, Helwani MA, Brown J, Brown F, Gage BF, Gibson DW, Miller JP, Novak E, Jaffe AS, Apple FS, Scott MG, Nagele P, Kopec M. Improving Prediction of Postoperative Myocardial Infarction With High-Sensitivity Cardiac Troponin T and NT-proBNP. Anesth Analg. 2017 02; 124(2):398-405. PMID: 28002165; PMCID: PMC5243152.
      Citations: 17     Fields:    Translation:Humans
    45. Nagele P. Refining the Diagnosis of Type 2 Myocardial Infarction-Reply. JAMA Cardiol. 2017 01 01; 2(1):107. PMID: 27760250.
      Citations:    Fields:    Translation:Humans
    46. Nagele P. The Case for a Revised Definition of Myocardial Infarction-Resolving the Ambiguity of Type 2 Myocardial Infarction. JAMA Cardiol. 2016 06 01; 1(3):247-8. PMID: 27438099.
      Citations: 7     Fields:    Translation:Humans
    47. Pal S, Helsten D, Stein PK, Miller JP, Nagele P, Duma A. High-Fidelity Analysis of Perioperative QTc Prolongation. Anesth Analg. 2016 Feb; 122(2):439-48. PMID: 26505572.
      Citations: 5     Fields:    Translation:Humans
    48. Bernhard M, Nagele P, Böttiger BW, Knapp J. Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis. Crit Care. 2016 Jan 09; 20:4. PMID: 26747085; PMCID: PMC4706668.
      Citations: 28     Fields:    Translation:Humans
    49. Zorumski CF, Nagele P, Mennerick S, Conway CR. Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy. Front Psychiatry. 2015; 6:172. PMID: 26696909; PMCID: PMC4673867.
      Citations: 19     
    50. Cartmill C, Blood J, Sharma A, Kharasch ED, Nagele P, Duma A. The hematological effects of nitrous oxide anesthesia in pediatric patients. Anesth Analg. 2015 Jun; 120(6):1325-30. PMID: 25658315; PMCID: PMC4802492.
      Citations: 3     Fields:    Translation:HumansCells
    51. Sheth T, Chan M, Butler C, Chow B, Tandon V, Nagele P, Mitha A, Mrkobrada M, Szczeklik W, Faridah Y, Biccard B, Stewart LK, Heels-Ansdell D, Devereaux PJ, Coronary Computed Tomographic Angiography and Vascular Events in Noncardiac Surgery Patients Cohort . Prognostic capabilities of coronary computed tomographic angiography before non-cardiac surgery: prospective cohort study. BMJ. 2015 Apr 22; 350:h1907. PMID: 25902738; PMCID: PMC4413859.
      Citations: 32     Fields:    Translation:Humans
    52. Nagele P, Duma A, Kopec M, Gebara MA, Parsoei A, Walker M, Janski A, Panagopoulos VN, Cristancho P, Miller JP, Zorumski CF, Conway CR. Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial. Biol Psychiatry. 2015 Jul 01; 78(1):10-18. PMID: 25577164.
      Citations: 74     Fields:    Translation:HumansCTClinical Trials
    53. Nagele P, Lumenta DB, Voelckel WG, Trimmel H, Kamolz LP, Selig HF, Hüpfl M. [Thermal injuries in the OEAMTC air rescue service. Epidemiological characteristics of burns/scalds in children and adults]. Unfallchirurg. 2014 Apr; 117(4):334-40. PMID: 23420061.
      Citations:    Fields:    Translation:Humans
    54. Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G, Walsh M, Sapsford R, Kurz A, Thomas S, Mrkobrada M, Thabane L, Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, McQueen MJ, Bhandari M, Bosch J, Buckley N, Chow CK, Halliwell R, Li S, Lee VW, Mooney J, Furtado MV, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA, Cavalcanti AB, Guimaraes HP, Jacka MJ, McAlister F, McMurtry S, Townsend D, Pannu N, Bagshaw S, Bessissow A, Duceppe E, Eikelboom J, Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D, Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C, Mizera R, O'Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V, Vanhelder T, Winemaker M, McDonald S, O'Bryne P, Patel A, Paul J, Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S, Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N, Macneil D, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius L, Siddiqui FS, Grocott HP, McKay A, Lee TW, Amadeo R, Funk D, McDonald H, Zacharias J, Chaparro MS, Ferreira S, Coriat P, Monneret D, Goarin JP, Esteve CI, Royer C, Daas G, Choi GY, Gin T, Lit LC, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S, Afzal L, George P, Mala S, Muti P, Vizza E, Ong GS, Mansor M, Tan AS, Shariffuddin II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai HY, Ahmad WA, Razack AH, Valderrama-Victoria V, Loza-Herrera JD, De Los Angeles Lazo M, Rotta-Rotta A, Sokolowska B, Musial J, Gorka J, Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B, Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner D, Torborg A, Urrutia G, Maestre ML, Pelaez X, De Antonio M, Villamor JM, Popova E, Garutti I, Palencia M, Del Castillo T, Varela A, de Miguel A, Cusati G, Del Barrio M, Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J, Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Pearse R, Ackland G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E, Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Del Arroyo AG, Sun Z, Finnegan PS, Egan C, Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Blood J, Kalin M, Gibson D, Wildes T, Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Writing Group, on behalf o, Appendix 1. The Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Study Inve, Appendix 2. The Vascular events In noncardiac Surgery patIents cOhort evaluatioN Operations Committe, Vascular events In noncardiac Surgery patIents cOhort evaluatioN VISION Study Investigators, Botto F, Schünemann HJ, Cortés OL, Vásquez S, Castañeda A, Schünemann H, Santaló M, Gonzalez R, Font A, Martínez C, García JA, Ferré MJ, Fernández C, Díaz S, Muñoz M, Piñeiro P, Membrillo MJ. Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology. 2014 Mar; 120(3):564-78. PMID: 24534856.
      Citations: 233     Fields:    Translation:Humans
    55. Nagele P, Brown F, Francis A, Scott MG, Gage BF, Miller JP. In reply. Anesthesiology. 2014 Feb; 120(2):515-6. PMID: 24448089; PMCID: PMC4102494.
      Citations:    Fields:    Translation:Humans
    56. Nagele P. Neuraxial block, death, and serious cardiovascular morbidity in the POISE trial. Br J Anaesth. 2014 Feb; 112(2):392. PMID: 24431369.
      Citations:    Fields:    Translation:Humans
    57. Helsten D, Brown F, Bottros MM, Nagele P, Duma A. The effect of nitrous oxide anesthesia on early postoperative opioid consumption and pain. Reg Anesth Pain Med. 2014 Jan-Feb; 39(1):31-6. PMID: 24310050; PMCID: PMC3919543.
      Citations: 1     Fields:    Translation:Humans
    58. Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG. Letter in response to "Use of preoperative cardiac troponin T to identify patients at risk for acute myocardial infraction and long-term mortality after major noncardiac surgery". Am Heart J. 2014 Feb; 167(2):e7. PMID: 24439992.
      Citations:    Fields:    Translation:Humans
    59. Nagele P. Exome sequencing: one small step for malignant hyperthermia, one giant step for our specialty--why exome sequencing matters to all of us, not just the experts. Anesthesiology. 2013 Nov; 119(5):1006-8. PMID: 24195944; PMCID: PMC3980570.
      Citations: 1     Fields:    Translation:Humans
    60. Parvizi D, Kamolz LP, Giretzlehner M, Haller HL, Trop M, Selig H, Nagele P, Lumenta DB. The potential impact of wrong TBSA estimations on fluid resuscitation in patients suffering from burns: things to keep in mind. Burns. 2014 Mar; 40(2):241-5. PMID: 24050977.
      Citations: 11     Fields:    Translation:Humans
    61. Nagele P, Brown F, Francis A, Scott MG, Gage BF, Miller JP, VINO Study Team. Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial. Anesthesiology. 2013 Jul; 119(1):19-28. PMID: 23856660; PMCID: PMC3919550.
      Citations: 11     Fields:    Translation:Humans
    62. Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG. High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery. Am Heart J. 2013 Aug; 166(2):325-332.e1. PMID: 23895816; PMCID: PMC3728677.
      Citations: 46     Fields:    Translation:Humans
    63. Johnston J, Pal S, Nagele P. Perioperative torsade de pointes: a systematic review of published case reports. Anesth Analg. 2013 Sep; 117(3):559-564. PMID: 23744954; PMCID: PMC3750104.
      Citations: 9     Fields:    Translation:Humans
    64. Blake CM, Kharasch ED, Schwab M, Nagele P. A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics. Clin Pharmacol Ther. 2013 Sep; 94(3):394-9. PMID: 23665868; PMCID: PMC3818912.
      Citations: 48     Fields:    Translation:Humans
    65. Nagele P, Pal S, Brown F, Blood J, Miller JP, Johnston J. Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia. Anesthesiology. 2012 Aug; 117(2):321-8. PMID: 22692379; PMCID: PMC3406265.
      Citations: 26     Fields:    Translation:Humans
    66. Sheth T, Butler C, Chow B, Chan MT, Mitha A, Nagele P, Tandon V, Stewart L, Graham M, Choi GY, Kisten T, Woodard PK, Crean A, Abdul Aziz YF, Karthikeyan G, Chow CK, Szczeklik W, Markobrada M, Mastracci T, Devereaux PJ, CTA VISION Investigators. The coronary CT angiography vision protocol: a prospective observational imaging cohort study in patients undergoing non-cardiac surgery. BMJ Open. 2012; 2(4). PMID: 22855630; PMCID: PMC3449273.
      Citations: 2     Fields:    
    67. Selig HF, Nagele P, Voelckel WG, Trimmel H, Lumenta DB, Kamolz LP, Hüpfl M. The epidemiology of amputation injuries in the Austrian helicopter emergency medical service: a retrospective, nationwide cohort study. Eur J Trauma Emerg Surg. 2012 Dec; 38(6):651-7. PMID: 26814552.
      Citations: 2     Fields:    
    68. Nagele P. Notorious oxide. Anesthesiology. 2012 Jul; 117(1):3-5. PMID: 22569133; PMCID: PMC3769620.
      Citations: 1     Fields:    Translation:Humans
    69. Vascular Events In Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators, Devereaux PJ, Chan MT, Alonso-Coello P, Walsh M, Berwanger O, Villar JC, Wang CY, Garutti RI, Jacka MJ, Sigamani A, Srinathan S, Biccard BM, Chow CK, Abraham V, Tiboni M, Pettit S, Szczeklik W, Lurati Buse G, Botto F, Guyatt G, Heels-Ansdell D, Sessler DI, Thorlund K, Garg AX, Mrkobrada M, Thomas S, Rodseth RN, Pearse RM, Thabane L, McQueen MJ, VanHelder T, Bhandari M, Bosch J, Kurz A, Polanczyk C, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S. Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA. 2012 Jun 06; 307(21):2295-304. PMID: 22706835.
      Citations: 227     Fields:    Translation:Humans
    70. Selig HF, Trimmel H, Voelckel WG, Nagele P, Hüpfl M. Pediatric trauma in the Austrian Alps: the epidemiology of sport-related injuries in helicopter emergency medical service. High Alt Med Biol. 2012 Jun; 13(2):112-7. PMID: 22724614.
      Citations: 3     Fields:    Translation:Humans
    71. Nagele P. Perioperative genomics. Best Pract Res Clin Anaesthesiol. 2011 Dec; 25(4):549-55. PMID: 22099920; PMCID: PMC3222886.
      Citations: 2     Fields:    Translation:HumansCells
    72. Nagele P, Liggett SB. Genetic variation, ß-blockers, and perioperative myocardial infarction. Anesthesiology. 2011 Dec; 115(6):1316-27. PMID: 21918425; PMCID: PMC3226841.
      Citations: 10     Fields:    Translation:Humans
    73. Nagele P, Meissner K, Francis A, Saccone NL, Födinger M. Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification. Pharmacogenet Genomics. 2011 Jul; 21(7):426-31. PMID: 21597397; PMCID: PMC3116052.
      Citations: 14     Fields:    Translation:HumansAnimals
    74. Selig HF, Trimmel H, Voelckel WG, Trittenwein G, Nagele P, Hüpfl M. Prehospital pediatric emergencies in Austrian helicopter emergency medical service - a nationwide, population-based cohort study. Wien Klin Wochenschr. 2011 Sep; 123(17-18):552-8. PMID: 21691755.
      Citations: 4     Fields:    Translation:Humans
    75. Nagele P, Tallchief D, Blood J, Sharma A, Kharasch ED. Nitrous oxide anesthesia and plasma homocysteine in adolescents. Anesth Analg. 2011 Oct; 113(4):843-8. PMID: 21680854; PMCID: PMC3183370.
      Citations: 9     Fields:    Translation:HumansCells
    76. Kavsak PA, Walsh M, Srinathan S, Thorlacius L, Buse GL, Botto F, Pettit S, McQueen MJ, Hill SA, Thomas S, Mrkobrada M, Alonso-Coello P, Berwanger O, Biccard BM, Cembrowski G, Chan MT, Chow CK, de Miguel A, Garcia M, Graham MM, Jacka MJ, Kueh JH, Li SC, Lit LC, Naidoo P, Nagele P, Pearse RM, Rodseth RN, Sessler DI, Sigamani A, Szczeklik W, Tiboni M, Villar JC, Wang CY, Xavier D, Devereaux PJ, Martínez-Brú C. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study. Clin Biochem. 2011 Aug; 44(12):1021-4. PMID: 21640092.
      Citations: 29     Fields:    Translation:Humans
    77. Nagele P. Augmented CPR: rescue after the ResQ trial. Lancet. 2011 Jan 22; 377(9762):276-8. PMID: 21251706.
      Citations:    Fields:    Translation:Humans
    78. Selig HF, Nagele P, Hüpfl M. Chest-compression-only versus standard cardiopulmonary resuscitation: a meta-analysis. Lancet. 2010 Nov 06; 376(9752):1552-7. PMID: 20951422; PMCID: PMC2987687.
      Citations: 62     Fields:    Translation:Humans
    79. Nagele P, Rao LK, Penta M, Kallogjeri D, Spitznagel EL, Cavallone LF, Nussenbaum B, Piccirillo JF. Postoperative myocardial injury after major head and neck cancer surgery. Head Neck. 2011 Aug; 33(8):1085-91. PMID: 20886662; PMCID: PMC3017648.
      Citations: 5     Fields:    Translation:Humans
    80. Wenzel V, Voelckel W, Jonsson K, Herff H, Nagele P, Pehböck D, Mittlböck M. Effects of preoxygenation on desaturation time during hemorrhagic shock in pigs. Anesthesiology. 2010 Sep; 113(3):593-9. PMID: 20683251.
      Citations: 7     Fields:    Translation:Animals
    81. Rao LK, Francis AM, Wilcox U, Miller JP, Nagele P. Pre-operative vitamin B infusion and prevention of nitrous oxide-induced homocysteine increase. Anaesthesia. 2010 Jul; 65(7):710-5. PMID: 20477781; PMCID: PMC3732777.
      Citations: 3     Fields:    Translation:Humans
    82. Nagele P, Zeugswetter B, Eberle C, Hüpfl M, Mittlböck M, Födinger M. A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia. Pharmacogenet Genomics. 2009 May; 19(5):325-9. PMID: 19339913.
      Citations: 1     Fields:    Translation:HumansCells
    83. Nagele P, Zeugswetter B, Wiener C, Burger H, Hüpfl M, Mittlböck M, Födinger M. Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia. Anesthesiology. 2008 Jul; 109(1):36-43. PMID: 18580170.
      Citations: 21     Fields:    Translation:Humans
    84. Schmatzer I, Buzath A, Burger H, Ihra G, Marhofer P, Nagele P, Hüpfl M, Hörauf K. The effects of aminophylline on bispectral index during inhalational and total intravenous anaesthesia. Anaesthesia. 2008 Jun; 63(6):583-7. PMID: 18279487.
      Citations: 6     Fields:    Translation:Humans
    85. Thies KC, Nagele P. [Advanced Trauma Life Support--a standard of care for Germany? No substantial improvement of care can be expected]. Anaesthesist. 2007 Nov; 56(11):1147-54. PMID: 17882389.
      Citations: 7     Fields:    Translation:Humans
    86. Nagele P, Mendel JB, Placzek WJ, Scott BA, Crowder CM, D'Avignon DA. Volatile anesthetics bind rat synaptic snare proteins. Anesthesiology. 2005 Oct; 103(4):768-78. PMID: 16192769.
      Citations: 21     Fields:    Translation:AnimalsCells
    87. Nagele P, Metz LB, Crowder CM. Xenon acts by inhibition of non-N-methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in Caenorhabditis elegans. Anesthesiology. 2005 Sep; 103(3):508-13. PMID: 16129975.
      Citations: 10     Fields:    Translation:AnimalsCells
    88. Duma A, Uray T, Maier C, Fiegl N, Bogner N, Nagele P, Hüpfl M. Over-the-head cardiopulmonary resuscitation improves efficacy in basic life support performed by professional medical personnel with a single rescuer: a simulation study. Anesth Analg. 2005 Jul; 101(1):200-5, table of contents. PMID: 15976232.
      Citations: 6     Fields:    Translation:Humans
    89. Nagele P, Kroesen G, Hüpfl M. Epidemiology and outcome of pediatric trauma treated by an emergency-physician-staffed advanced life-support unit. Wien Klin Wochenschr. 2004 Jun 30; 116(11-12):398-403. PMID: 15291294.
      Citations: 3     Fields:    Translation:Humans
    90. Nagele P, Metz LB, Crowder CM. Nitrous oxide (N(2)O) requires the N-methyl-D-aspartate receptor for its action in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8791-6. PMID: 15159532; PMCID: PMC423274.
      Citations: 19     Fields:    Translation:AnimalsCells
    91. Nagele P. Misuse of standard error of the mean (SEM) when reporting variability of a sample. A critical evaluation of four anaesthesia journals. Br J Anaesth. 2003 Apr; 90(4):514-6. PMID: 12644429.
      Citations: 36     Fields:    
    92. Rossaint R, Reyle-Hahn M, Schulte Am Esch J, Scholz J, Scherpereel P, Vallet B, Giunta F, Del Turco M, Erdmann W, Tenbrinck R, Hammerle AF, Nagele P, Xenon Study Group. Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery. Anesthesiology. 2003 Jan; 98(1):6-13. PMID: 12502972.
      Citations: 41     Fields:    Translation:HumansCTClinical Trials
    93. Kroesen G, Nagele P. [Pediatric emergencies. An epidemiologic study of mobile care units in Innsbruck]. Anaesthesist. 2000 Aug; 49(8):725-31. PMID: 11013776.
      Citations: 6     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    94. Nagele P, Hammerle AF. Sevoflurane and mivacurium in a patient with Huntington's chorea. Br J Anaesth. 2000 Aug; 85(2):320-1. PMID: 10992848.
      Citations: 2     Fields:    Translation:Humans
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