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Matthew Kaufman

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentOrg.Bio./Anatomy
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    My lab studies how populations of neurons implement decision making and motor control. We record and manipulate the activity of hundreds or thousands of neurons in mouse cortex, then use sophisticated analyses to understand how these areas compute variables that the animal needs in order to behave. With calcium imaging, we can identify each neuron's cell type, layer, or projection pattern, and use this information to better understand inter-area communication and the organization of computation within cortex. With optogenetics, we can close the causal loop to determine if the activity is necessary or the roles of cell types in computation. Finally, with pharmacological manipulations, we can begin to understand how psychiatric drugs drive their behavioral effects.


    Collapse Biography 
    Collapse education and training
    Stanford University, Stanford, CABS06/2005Symbolic Systems
    Stanford University, Stanford, CAPhD07/2011Neuroscience
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY02/2018Neuroscience
    Collapse awards and honors
    2006 - 2010NSF GRFP, Stanford University
    2013 - 2015Swartz Postdoctoral Fellowship, Cold Spring Harbor Laboratory
    2015 - 2015McKnight Foundation Allison Doupe Fellowship, Cold Spring Harbor Laboratory
    2015 - 2018Simons Collaboration on the Global Brain postdoctoral fellowship, Cold Spring Harbor Laboratory

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kaufman MT. Adapting Fine with a Little Help from the Null Space. Neuron. 2018 Nov 21; 100(4):771-773. PMID: 30465761.
      View in: PubMed
    2. Pandarinath C, O'Shea DJ, Collins J, Jozefowicz R, Stavisky SD, Kao JC, Trautmann EM, Kaufman MT, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV, Abbott LF, Sussillo D. Inferring single-trial neural population dynamics using sequential auto-encoders. Nat Methods. 2018 Oct; 15(10):805-815. PMID: 30224673.
      View in: PubMed
    3. O'Shea DJ, Kalanithi P, Ferenczi EA, Hsueh B, Chandrasekaran C, Goo W, Diester I, Ramakrishnan C, Kaufman MT, Ryu SI, Yeom KW, Deisseroth K, Shenoy KV. Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys. Sci Rep. 2018 Apr 30; 8(1):6775. PMID: 29712920.
      View in: PubMed
    4. Omrani M, Kaufman MT, Hatsopoulos NG, Cheney PD. Perspectives on classical controversies about the motor cortex. J Neurophysiol. 2017 Jun 14; jn.00795.2016. PMID: 28615340.
      View in: PubMed
    5. Licata AM, Kaufman MT, Raposo D, Ryan MB, Sheppard JP, Churchland AK. Posterior Parietal Cortex Guides Visual Decisions in Rats. J Neurosci. 2017 May 10; 37(19):4954-4966. PMID: 28408414.
      View in: PubMed
    6. Kaufman MT, Churchland AK. Many paths from state to state. Nat Neurosci. 2016 11 29; 19(12):1541-1542. PMID: 27898087.
      View in: PubMed
    7. Seely JS, Kaufman MT, Ryu SI, Shenoy KV, Cunningham JP, Churchland MM. Tensor Analysis Reveals Distinct Population Structure that Parallels the Different Computational Roles of Areas M1 and V1. PLoS Comput Biol. 2016 Nov; 12(11):e1005164. PMID: 27814353.
      View in: PubMed
    8. Elsayed GF, Lara AH, Kaufman MT, Churchland MM, Cunningham JP. Reorganization between preparatory and movement population responses in motor cortex. Nat Commun. 2016 10 27; 7:13239. PMID: 27807345.
      View in: PubMed
    9. Kaufman MT, Seely JS, Sussillo D, Ryu SI, Shenoy KV, Churchland MM. The Largest Response Component in the Motor Cortex Reflects Movement Timing but Not Movement Type. eNeuro. 2016 Jul-Aug; 3(4). PMID: 27761519.
      View in: PubMed
    10. Sussillo D, Churchland MM, Kaufman MT, Shenoy KV. A neural network that finds a naturalistic solution for the production of muscle activity. Nat Neurosci. 2015 Jul; 18(7):1025-33. PMID: 26075643.
      View in: PubMed
    11. Kaufman MT, Churchland MM, Ryu SI, Shenoy KV. Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex. Elife. 2015 May 05; 4:e04677. PMID: 25942352.
      View in: PubMed
    12. Raposo D, Kaufman MT, Churchland AK. A category-free neural population supports evolving demands during decision-making. Nat Neurosci. 2014 Dec; 17(12):1784-1792. PMID: 25383902.
      View in: PubMed
    13. Kaufman MT, Churchland MM, Ryu SI, Shenoy KV. Cortical activity in the null space: permitting preparation without movement. Nat Neurosci. 2014 Mar; 17(3):440-8. PMID: 24487233.
      View in: PubMed
    14. Cowley BR, Kaufman MT, Butler ZS, Churchland MM, Ryu SI, Shenoy KV, Yu BM. DataHigh: graphical user interface for visualizing and interacting with high-dimensional neural activity. J Neural Eng. 2013 Dec; 10(6):066012. PMID: 24216250.
      View in: PubMed
    15. Kaufman MT, Churchland MM, Shenoy KV. The roles of monkey M1 neuron classes in movement preparation and execution. J Neurophysiol. 2013 Aug; 110(4):817-25. PMID: 23699057.
      View in: PubMed
    16. Kaufman MT, Churchland AK. Cognitive neuroscience: sensory noise drives bad decisions. Nature. 2013 Apr 11; 496(7444):172-3. PMID: 23579673.
      View in: PubMed
    17. Gilja V, Nuyujukian P, Chestek CA, Cunningham JP, Yu BM, Fan JM, Churchland MM, Kaufman MT, Kao JC, Ryu SI, Shenoy KV. A high-performance neural prosthesis enabled by control algorithm design. Nat Neurosci. 2012 Dec; 15(12):1752-7. PMID: 23160043.
      View in: PubMed
    18. Churchland MM, Cunningham JP, Kaufman MT, Foster JD, Nuyujukian P, Ryu SI, Shenoy KV. Neural population dynamics during reaching. Nature. 2012 Jul 05; 487(7405):51-6. PMID: 22722855.
      View in: PubMed
    19. Cowley BR, Kaufman MT, Churchland MM, Ryu SI, Shenoy KV, Yu BM. DataHigh: graphical user interface for visualizing and interacting with high-dimensional neural activity. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:4607-10. PMID: 23366954.
      View in: PubMed
    20. Chestek CA, Gilja V, Nuyujukian P, Foster JD, Fan JM, Kaufman MT, Churchland MM, Rivera-Alvidrez Z, Cunningham JP, Ryu SI, Shenoy KV. Long-term stability of neural prosthetic control signals from silicon cortical arrays in rhesus macaque motor cortex. J Neural Eng. 2011 Aug; 8(4):045005. PMID: 21775782.
      View in: PubMed
    21. Diester I, Kaufman MT, Mogri M, Pashaie R, Goo W, Yizhar O, Ramakrishnan C, Deisseroth K, Shenoy KV. An optogenetic toolbox designed for primates. Nat Neurosci. 2011 Mar; 14(3):387-97. PMID: 21278729.
      View in: PubMed
    22. Shenoy KV, Kaufman MT, Sahani M, Churchland MM. A dynamical systems view of motor preparation: implications for neural prosthetic system design. Prog Brain Res. 2011; 192:33-58. PMID: 21763517.
      View in: PubMed
    23. Churchland MM, Cunningham JP, Kaufman MT, Ryu SI, Shenoy KV. Cortical preparatory activity: representation of movement or first cog in a dynamical machine? Neuron. 2010 Nov 04; 68(3):387-400. PMID: 21040842.
      View in: PubMed
    24. Kaufman MT, Churchland MM, Santhanam G, Yu BM, Afshar A, Ryu SI, Shenoy KV. Roles of monkey premotor neuron classes in movement preparation and execution. J Neurophysiol. 2010 Aug; 104(2):799-810. PMID: 20538784.
      View in: PubMed
    25. Knutson B, Taylor J, Kaufman M, Peterson R, Glover G. Distributed neural representation of expected value. J Neurosci. 2005 May 11; 25(19):4806-12. PMID: 15888656.
      View in: PubMed
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