Matthew Kaufman
Title | Assistant Professor |
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Institution | University of Chicago |
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Department | Organismal Biology and Anatomy |
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Address | Chicago IL 60637
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Email |  |
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vCard | Download vCard |
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Overview My lab studies how populations of neurons implement decision making and motor control. We record and manipulate the activity of hundreds or thousands of neurons in mouse cortex, then use sophisticated analyses to understand how these areas compute variables that the animal needs in order to behave. With calcium imaging, we can identify each neuron's cell type, layer, or projection pattern, and use this information to better understand inter-area communication and the organization of computation within cortex. With optogenetics, we can close the causal loop to determine if the activity is necessary or the roles of cell types in computation. Finally, with pharmacological manipulations, we can begin to understand how psychiatric drugs drive their behavioral effects.
Biography Stanford University, Stanford, CA | BS | 06/2005 | Symbolic Systems | Stanford University, Stanford, CA | PhD | 07/2011 | Neuroscience | Cold Spring Harbor Laboratory, Cold Spring Harbor, NY | | 02/2018 | Neuroscience |
2006 - 2010 | NSF GRFP, Stanford University | 2013 - 2015 | Swartz Postdoctoral Fellowship, Cold Spring Harbor Laboratory | 2015 - 2015 | McKnight Foundation Allison Doupe Fellowship, Cold Spring Harbor Laboratory | 2015 - 2018 | Simons Collaboration on the Global Brain postdoctoral fellowship, Cold Spring Harbor Laboratory |
ORNG Applications Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Huang L, Kebschull JM, Fürth D, Musall S, Kaufman MT, Churchland AK, Zador AM. BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals. Cell. 2020 Dec 23; 183(7):2040. PMID: 33357401.
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Suresh AK, Goodman JM, Okorokova EV, Kaufman M, Hatsopoulos NG, Bensmaia SJ. Neural population dynamics in motor cortex are different for reach and grasp. Elife. 2020 11 17; 9. PMID: 33200745.
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Huang L, Kebschull JM, Fürth D, Musall S, Kaufman MT, Churchland AK, Zador AM. BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals. Cell. 2020 07 09; 182(1):177-188.e27. PMID: 32619423.
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O'Shea DJ, Kalanithi P, Ferenczi EA, Hsueh B, Chandrasekaran C, Goo W, Diester I, Ramakrishnan C, Kaufman MT, Ryu SI, Yeom KW, Deisseroth K, Shenoy KV. Publisher Correction: Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys. Sci Rep. 2019 Dec 05; 9(1):18775. PMID: 31801956.
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Musall S, Kaufman MT, Juavinett AL, Gluf S, Churchland AK. Single-trial neural dynamics are dominated by richly varied movements. Nat Neurosci. 2019 10; 22(10):1677-1686. PMID: 31551604.
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Trautmann EM, Stavisky SD, Lahiri S, Ames KC, Kaufman MT, O'Shea DJ, Vyas S, Sun X, Ryu SI, Ganguli S, Shenoy KV. Accurate Estimation of Neural Population Dynamics without Spike Sorting. Neuron. 2019 07 17; 103(2):292-308.e4. PMID: 31171448.
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Kaufman MT. Adapting Fine with a Little Help from the Null Space. Neuron. 2018 11 21; 100(4):771-773. PMID: 30465761.
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Pandarinath C, O'Shea DJ, Collins J, Jozefowicz R, Stavisky SD, Kao JC, Trautmann EM, Kaufman MT, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV, Abbott LF, Sussillo D. Inferring single-trial neural population dynamics using sequential auto-encoders. Nat Methods. 2018 10; 15(10):805-815. PMID: 30224673.
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O'Shea DJ, Kalanithi P, Ferenczi EA, Hsueh B, Chandrasekaran C, Goo W, Diester I, Ramakrishnan C, Kaufman MT, Ryu SI, Yeom KW, Deisseroth K, Shenoy KV. Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys. Sci Rep. 2018 04 30; 8(1):6775. PMID: 29712920.
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Omrani M, Kaufman MT, Hatsopoulos NG, Cheney PD. Perspectives on classical controversies about the motor cortex. J Neurophysiol. 2017 09 01; 118(3):1828-1848. PMID: 28615340.
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Licata AM, Kaufman MT, Raposo D, Ryan MB, Sheppard JP, Churchland AK. Posterior Parietal Cortex Guides Visual Decisions in Rats. J Neurosci. 2017 05 10; 37(19):4954-4966. PMID: 28408414.
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Kaufman MT, Churchland AK. Many paths from state to state. Nat Neurosci. 2016 11 29; 19(12):1541-1542. PMID: 27898087.
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Seely JS, Kaufman MT, Ryu SI, Shenoy KV, Cunningham JP, Churchland MM. Tensor Analysis Reveals Distinct Population Structure that Parallels the Different Computational Roles of Areas M1 and V1. PLoS Comput Biol. 2016 Nov; 12(11):e1005164. PMID: 27814353.
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Elsayed GF, Lara AH, Kaufman MT, Churchland MM, Cunningham JP. Reorganization between preparatory and movement population responses in motor cortex. Nat Commun. 2016 10 27; 7:13239. PMID: 27807345.
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Kaufman MT, Seely JS, Sussillo D, Ryu SI, Shenoy KV, Churchland MM. The Largest Response Component in the Motor Cortex Reflects Movement Timing but Not Movement Type. eNeuro. 2016 Jul-Aug; 3(4). PMID: 27761519.
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Sussillo D, Churchland MM, Kaufman MT, Shenoy KV. A neural network that finds a naturalistic solution for the production of muscle activity. Nat Neurosci. 2015 Jul; 18(7):1025-33. PMID: 26075643.
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Kaufman MT, Churchland MM, Ryu SI, Shenoy KV. Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex. Elife. 2015 May 05; 4:e04677. PMID: 25942352.
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Raposo D, Kaufman MT, Churchland AK. A category-free neural population supports evolving demands during decision-making. Nat Neurosci. 2014 Dec; 17(12):1784-1792. PMID: 25383902.
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Kaufman MT, Churchland MM, Ryu SI, Shenoy KV. Cortical activity in the null space: permitting preparation without movement. Nat Neurosci. 2014 Mar; 17(3):440-8. PMID: 24487233.
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Cowley BR, Kaufman MT, Butler ZS, Churchland MM, Ryu SI, Shenoy KV, Yu BM. DataHigh: graphical user interface for visualizing and interacting with high-dimensional neural activity. J Neural Eng. 2013 Dec; 10(6):066012. PMID: 24216250.
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Kaufman MT, Churchland MM, Shenoy KV. The roles of monkey M1 neuron classes in movement preparation and execution. J Neurophysiol. 2013 Aug; 110(4):817-25. PMID: 23699057.
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Kaufman MT, Churchland AK. Cognitive neuroscience: sensory noise drives bad decisions. Nature. 2013 Apr 11; 496(7444):172-3. PMID: 23579673.
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Gilja V, Nuyujukian P, Chestek CA, Cunningham JP, Yu BM, Fan JM, Churchland MM, Kaufman MT, Kao JC, Ryu SI, Shenoy KV. A high-performance neural prosthesis enabled by control algorithm design. Nat Neurosci. 2012 Dec; 15(12):1752-7. PMID: 23160043.
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Churchland MM, Cunningham JP, Kaufman MT, Foster JD, Nuyujukian P, Ryu SI, Shenoy KV. Neural population dynamics during reaching. Nature. 2012 Jul 05; 487(7405):51-6. PMID: 22722855.
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Cowley BR, Kaufman MT, Churchland MM, Ryu SI, Shenoy KV, Yu BM. DataHigh: graphical user interface for visualizing and interacting with high-dimensional neural activity. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:4607-10. PMID: 23366954.
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Chestek CA, Gilja V, Nuyujukian P, Foster JD, Fan JM, Kaufman MT, Churchland MM, Rivera-Alvidrez Z, Cunningham JP, Ryu SI, Shenoy KV. Long-term stability of neural prosthetic control signals from silicon cortical arrays in rhesus macaque motor cortex. J Neural Eng. 2011 Aug; 8(4):045005. PMID: 21775782.
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Diester I, Kaufman MT, Mogri M, Pashaie R, Goo W, Yizhar O, Ramakrishnan C, Deisseroth K, Shenoy KV. An optogenetic toolbox designed for primates. Nat Neurosci. 2011 Mar; 14(3):387-97. PMID: 21278729.
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Shenoy KV, Kaufman MT, Sahani M, Churchland MM. A dynamical systems view of motor preparation: implications for neural prosthetic system design. Prog Brain Res. 2011; 192:33-58. PMID: 21763517.
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Churchland MM, Cunningham JP, Kaufman MT, Ryu SI, Shenoy KV. Cortical preparatory activity: representation of movement or first cog in a dynamical machine? Neuron. 2010 Nov 04; 68(3):387-400. PMID: 21040842.
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Kaufman MT, Churchland MM, Santhanam G, Yu BM, Afshar A, Ryu SI, Shenoy KV. Roles of monkey premotor neuron classes in movement preparation and execution. J Neurophysiol. 2010 Aug; 104(2):799-810. PMID: 20538784.
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Knutson B, Taylor J, Kaufman M, Peterson R, Glover G. Distributed neural representation of expected value. J Neurosci. 2005 May 11; 25(19):4806-12. PMID: 15888656.
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Year | Publications |
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2005 | 1 | 2010 | 2 | 2011 | 3 | 2012 | 3 | 2013 | 3 | 2014 | 2 | 2015 | 2 | 2016 | 4 | 2017 | 2 | 2018 | 3 | 2019 | 3 | 2020 | 3 |
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