 IMP Dehydrogenase
"IMP Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.
| Descriptor ID |
D007168
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| MeSH Number(s) |
D08.811.682.047.485
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| Concept/Terms |
IMP Dehydrogenase- IMP Dehydrogenase
- Dehydrogenase, IMP
- Inosine-5-Monophosphate Dehydrogenase
- Dehydrogenase, Inosine-5-Monophosphate
- Inosine 5 Monophosphate Dehydrogenase
- Inosinic Acid Dehydrogenase
- Acid Dehydrogenase, Inosinic
- Dehydrogenase, Inosinic Acid
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Below are MeSH descriptors whose meaning is more general than "IMP Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "IMP Dehydrogenase".
This graph shows the total number of publications written about "IMP Dehydrogenase" by people in this website by year, and whether "IMP Dehydrogenase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2010 | 2 | 0 | 2 | | 2012 | 1 | 0 | 1 | | 2015 | 3 | 0 | 3 |
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Below are the most recent publications written about "IMP Dehydrogenase" by people in Profiles.
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Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. PLoS One. 2015; 10(10):e0138976.
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Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L. Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):531-8.
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Makowska-Grzyska M, Kim Y, Maltseva N, Osipiuk J, Gu M, Zhang M, Mandapati K, Gollapalli DR, Gorla SK, Hedstrom L, Joachimiak A. A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity. J Biol Chem. 2015 Feb 27; 290(9):5893-911.
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Makowska-Grzyska M, Kim Y, Wu R, Wilton R, Gollapalli DR, Wang XK, Zhang R, Jedrzejczak R, Mack JC, Maltseva N, Mulligan R, Binkowski TA, Gornicki P, Kuhn ML, Anderson WF, Hedstrom L, Joachimiak A. Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes. Biochemistry. 2012 Aug 07; 51(31):6148-63.
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Chen L, Petrelli R, Gao G, Wilson DJ, McLean GT, Jayaram HN, Sham YY, Pankiewicz KW. Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure. Bioorg Med Chem. 2010 Aug 15; 18(16):5950-64.
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Chen L, Wilson DJ, Xu Y, Aldrich CC, Felczak K, Sham YY, Pankiewicz KW. Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis. J Med Chem. 2010 Jun 24; 53(12):4768-78.
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Chen L, Wilson DJ, Labello NP, Jayaram HN, Pankiewicz KW. Mycophenolic acid analogs with a modified metabolic profile. Bioorg Med Chem. 2008 Oct 15; 16(20):9340-5.
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Chen L, Petrelli R, Olesiak M, Wilson DJ, Labello NP, Pankiewicz KW. Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 01; 16(15):7462-9.
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Chen L, Gao G, Bonnac L, Wilson DJ, Bennett EM, Jayaram HN, Pankiewicz KW. Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor. Bioorg Med Chem Lett. 2007 Jun 01; 17(11):3152-5.
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Becker BN, Becker YT, Leverson GE, Simmons WD, Sollinger HW, Pirsch JD. Reassessing the impact of cytomegalovirus infection in kidney and kidney-pancreas transplantation. Am J Kidney Dis. 2002 May; 39(5):1088-95.
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