 Crohn Disease
"Crohn Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Descriptor ID |
D003424
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| MeSH Number(s) |
C06.405.205.731.500 C06.405.469.432.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Crohn Disease".
Below are MeSH descriptors whose meaning is more specific than "Crohn Disease".
This graph shows the total number of publications written about "Crohn Disease" by people in this website by year, and whether "Crohn Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 1 | 1 | 2 | | 1981 | 2 | 0 | 2 | | 1982 | 3 | 1 | 4 | | 1983 | 5 | 0 | 5 | | 1984 | 3 | 0 | 3 | | 1985 | 3 | 0 | 3 | | 1986 | 5 | 1 | 6 | | 1987 | 2 | 0 | 2 | | 1988 | 4 | 0 | 4 | | 1989 | 5 | 0 | 5 | | 1990 | 3 | 0 | 3 | | 1991 | 7 | 0 | 7 | | 1992 | 3 | 0 | 3 | | 1993 | 6 | 2 | 8 | | 1994 | 0 | 2 | 2 | | 1995 | 5 | 1 | 6 | | 1996 | 4 | 1 | 5 | | 1997 | 4 | 0 | 4 | | 1998 | 6 | 1 | 7 | | 1999 | 8 | 3 | 11 | | 2000 | 15 | 1 | 16 | | 2001 | 13 | 1 | 14 | | 2002 | 17 | 2 | 19 | | 2003 | 13 | 2 | 15 | | 2004 | 24 | 1 | 25 | | 2005 | 19 | 1 | 20 | | 2006 | 13 | 4 | 17 | | 2007 | 25 | 4 | 29 | | 2008 | 12 | 3 | 15 | | 2009 | 12 | 2 | 14 | | 2010 | 12 | 1 | 13 | | 2011 | 15 | 4 | 19 | | 2012 | 14 | 3 | 17 | | 2013 | 25 | 3 | 28 | | 2014 | 15 | 0 | 15 | | 2015 | 10 | 3 | 13 | | 2016 | 21 | 3 | 24 | | 2017 | 14 | 3 | 17 | | 2018 | 21 | 0 | 21 | | 2019 | 3 | 2 | 5 |
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Below are the most recent publications written about "Crohn Disease" by people in Profiles.
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Feld L, Glick LR, Cifu AS. Diagnosis and Management of Crohn Disease. JAMA. 2019 May 14; 321(18):1822-1823.
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Lu TX, Cohen RD. Maneuvering Clinical Pathways for Crohn's Disease. Curr Gastroenterol Rep. 2019 Apr 23; 21(5):20.
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Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles DA, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, Björkegren JLM, Im HK, Pasaniuc B, Rivas MA, Kundaje A. Opportunities and challenges for transcriptome-wide association studies. Nat Genet. 2019 04; 51(4):592-599.
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Feagan BG, Sandborn WJ, Colombel JF, Byrne SO, Khalid JM, Kempf C, Geransar P, Bhayat F, Rubin DT. Incidence of Arthritis/Arthralgia in Inflammatory Bowel Disease with Long-term Vedolizumab Treatment: Post Hoc Analyses of the GEMINI Trials. J Crohns Colitis. 2019 Jan 01; 13(1):50-57.
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Guandalini S, Sansotta N. Probiotics in the Treatment of Inflammatory Bowel Disease. Adv Exp Med Biol. 2019; 1125:101-107.
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Haberman Y, Schirmer M, Dexheimer PJ, Karns R, Braun T, Kim MO, Walters TD, Baldassano RN, Noe JD, Rosh J, Markowitz J, Crandall WV, Mack DR, Griffiths AM, Heyman MB, Baker SS, Kellermayer R, Moulton D, Patel AS, Gulati AS, Steiner SJ, LeLeiko N, Otley A, Oliva-Hemker M, Ziring D, Kirschner BS, Keljo DJ, Guthery SL, Cohen SA, Snapper S, Evans J, Dubinsky M, Aronow B, Hyams JS, Kugathasan S, Huttenhower C, Xavier RJ, Denson LA. Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal Immunol. 2019 03; 12(2):491-502.
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Uniken Venema WT, Voskuil MD, Vila AV, van der Vries G, Jansen BH, Jabri B, Faber KN, Dijkstra G, Xavier RJ, Wijmenga C, Graham DB, Weersma RK, Festen EA. Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets. Gastroenterology. 2019 02; 156(3):812-815.e22.
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Lindoso L, Mondal K, Venkateswaran S, Somineni HK, Ballengee C, Walters TD, Griffiths A, Noe JD, Crandall W, Snapper S, Rabizadeh S, Rosh JR, LeLeiko N, Guthery S, Mack D, Kellermayer R, Gulati AS, Pfefferkorn MD, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley A, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Stephens MC, Baldassano R, Dubinsky MC, Markowitz J, Denson LA, Hyams J, Kugathasan S, Ananthakrishnan AN. The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children. Am J Gastroenterol. 2018 10; 113(10):1524-1529.
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Colman RJ, Lawton RC, Dubinsky MC, Rubin DT. Methotrexate for the Treatment of Pediatric Crohn's Disease: A Systematic Review and Meta-analysis. Inflamm Bowel Dis. 2018 09 15; 24(10):2135-2141.
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Hanauer SB, Sandborn WJ, Lichtenstein GR. Evolving Considerations for Thiopurine Therapy for Inflammatory Bowel Diseases-A Clinical Practice Update: Commentary. Gastroenterology. 2019 01; 156(1):36-42.
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