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Valerie Abadie

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Gastroenterology
AddressChicago IL 60637
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    We are a multidisciplinary team whose focus is to better understand how mucosal immune responses are dysregulated in the context of intestinal inflammatory disorders. We are particularly intrigued by B lymphocytes that can display many roles beyond antibodies production and can contribute to the pathogenesis of many autoimmune disorders. To get a better understanding of the role played by B lymphocytes in the context of Celiac Disease, we combined mouse and human studies to characterize those cells in health and disease and assess their function.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Khosla C, Jabri B, Abadie V. A Mouse Model of Celiac Disease. Curr Protoc. 2022 Aug; 2(8):e515. PMID: 35994521; PMCID: PMC10203737.
      Citations:    Fields:    Translation:HumansAnimals
    2. Polese B, Thurairajah B, Zhang H, Soo CL, McMahon CA, Fontes G, Hussain SNA, Abadie V, King IL. Prostaglandin E2 amplifies IL-17 production by ?d T cells during barrier inflammation. Cell Rep. 2021 07 27; 36(4):109456. PMID: 34320346.
      Citations: 7     Fields:    Translation:Animals
    3. Voisine J, Abadie V. Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease. Front Immunol. 2021; 12:674313. PMID: 34149709; PMCID: PMC8206552.
      Citations: 12     Fields:    Translation:HumansAnimals
    4. Lejeune T, Meyer C, Abadie V. B Lymphocytes Contribute to Celiac Disease Pathogenesis. Gastroenterology. 2021 06; 160(7):2608-2610.e4. PMID: 33667487; PMCID: PMC8647930.
      Citations: 7     Fields:    Translation:AnimalsCells
    5. Abadie V. [A new mouse model of coeliac disease with villous atrophy]. Med Sci (Paris). 2020 Nov; 36(11):969-972. PMID: 33151855.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Kim SM, Lejeune T, Palanski BA, Ernest JD, Tastet O, Voisine J, Discepolo V, Marietta EV, Hawash MBF, Ciszewski C, Bouziat R, Panigrahi K, Horwath I, Zurenski MA, Lawrence I, Dumaine A, Yotova V, Grenier JC, Murray JA, Khosla C, Barreiro LB, Jabri B, Abadie V. IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease. Nature. 2020 02; 578(7796):600-604. PMID: 32051586; PMCID: PMC7047598.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    7. Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B, Costes LM, Abadie V. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 04 07; 356(6333):44-50. PMID: 28386004; PMCID: PMC5506690.
      Citations: 175     Fields:    Translation:HumansAnimalsCells
    8. Jabri B, Abadie V. IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction. Nat Rev Immunol. 2015 12; 15(12):771-83. PMID: 26567920; PMCID: PMC5079184.
      Citations: 131     Fields:    Translation:HumansCells
    9. Tang F, Sally B, Lesko K, Discepolo V, Abadie V, Ciszewski C, Semrad C, Guandalini S, Kupfer SS, Jabri B. Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease. J Exp Med. 2015 Sep 21; 212(10):1487-95. PMID: 26304964; PMCID: PMC4577841.
      Citations: 12     Fields:    Translation:HumansCells
    10. Setty M, Discepolo V, Kamhawi S, Mayassi T, Kent A, Ciszewski C, Maglio M, Kistner E, Bhagat G, Semrad C, Kupfer SS, Green PH, Guandalini S, Troncone R, Murray JA, Turner JR, Jabri B, Abadie V. Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease. Gastroenterology. 2015 Sep; 149(3):681-91.e10. PMID: 26001928; PMCID: PMC4550536.
      Citations: 52     Fields:    Translation:HumansCells
    11. Jabri B, Abadie V. IL-15: a central regulator of celiac disease immunopathology. Immunol Rev. 2014 Jul; 260(1):221-34. PMID: 24942692; PMCID: PMC4066219.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    12. Tang F, Sally B, Ciszewski C, Abadie V, Curran SA, Groh V, Fitzgerald O, Winchester RJ, Jabri B. Interleukin 15 primes natural killer cells to kill via NKG2D and cPLA2 and this pathway is active in psoriatic arthritis. PLoS One. 2013; 8(9):e76292. PMID: 24086722; PMCID: PMC3783406.
      Citations: 13     Fields:    Translation:HumansCells
    13. Benhabiles N, Boissonnas A, Liard C, Descours B, Reboulleau D, Bonduelle O, Verrier B, Van Rooijen N, Duffy D, Perrin H, Abadie V, Combadière C, Combadière B. Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells. Immunity. 2012 Nov 16; 37(5):917-29. PMID: 23142782.
      Citations: 78     Fields:    Translation:AnimalsCells
    14. Discepolo V, Jabri B, Abadie V. Intraepithelial lymphocytes in celiac disease immunopathology. Semin Immunopathol. 2012 Jul; 34(4):551-66. PMID: 22660791.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    15. Sollid LM, Barreiro LB, Jabri B, Abadie V. Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu Rev Immunol. 2011; 29:493-525. PMID: 21219178.
      Citations: 190     Fields:    Translation:HumansAnimals
    16. Badell E, Balloy V, Chignard M, Mistou MY, Winter N, Martino A, Abadie V, Combadière B, Combadière C. Mycobacterium bovis bacillus Calmette-Guérin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo T cell priming via IL-1R-dependent nitric oxide production. J Immunol. 2010 Feb 15; 184(4):2038-47. PMID: 20083674.
      Citations: 44     Fields:    Translation:AnimalsCells
    17. Bonduelle O, Duffy D, Parizot C, Verrier B, Abadie V, Combadière B. Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in mice. PLoS One. 2009 Dec 07; 4(12):e8159. PMID: 19997562; PMCID: PMC2785484.
      Citations: 22     Fields:    Translation:AnimalsCellsPHPublic Health
    18. Vogt A, Liard C, Duffy D, Bonduelle O, Boissonnas A, Sterry W, Verrier B, Blume-Peytavi U, Combadiere B, Mahe B, Abadie V. Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice. J Invest Dermatol. 2009 May; 129(5):1156-64. PMID: 19052565.
      Citations: 31     Fields:    Translation:AnimalsCells
    19. Iga M, Hartley O, Gorochov G, Dorgham K, Abadie V, Combadière B. Engineered CCR5 superagonist chemokine as adjuvant in anti-tumor DNA vaccination. Vaccine. 2008 Jun 19; 26(26):3252-60. PMID: 18479788.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    20. Badell E, Robledo M, Setterblad N, Gluckman JC, Gicquel B, Boudaly S, Winter N, Morel C, Abadie V. Mycobacterium bovis BCG-infected neutrophils and dendritic cells cooperate to induce specific T cell responses in humans and mice. Eur J Immunol. 2008 Feb; 38(2):437-47. PMID: 18203135.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    21. Pimentel M, Gicquel B, Reyrat JM, Winter N, Vultos TD, Méderlé I, Abadie V, Moniz-Pereira J. Modification of the mycobacteriophage Ms6 attP core allows the integration of multiple vectors into different tRNAala T-loops in slow- and fast-growing mycobacteria. BMC Mol Biol. 2006 Dec 15; 7:47. PMID: 17173678; PMCID: PMC1762012.
      Citations: 9     Fields:    Translation:Cells
    22. Badell E, Douillard P, Ensergueix D, Leenen PJ, Tanguy M, Fiette L, Saeland S, Gicquel B, Winter N, Abadie V. Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes. Blood. 2005 Sep 01; 106(5):1843-50. PMID: 15886329.
      Citations: 165     Fields:    Translation:AnimalsCells
    23. Etienne G, Montrozier H, Bordier C, Daffe M, Maridonneau-Parini I, Astarie-Dequeker C, Villeneuve C, Abadie V, Laval F. Surface-exposed glycopeptidolipids of Mycobacterium smegmatis specifically inhibit the phagocytosis of mycobacteria by human macrophages. Identification of a novel family of glycopeptidolipids. J Biol Chem. 2003 Dec 19; 278(51):51291-300. PMID: 14534313.
      Citations: 32     Fields:    Translation:HumansCells
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