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Orlando DeLeon

TitleScholar
InstitutionUniversity of Chicago
DepartmentMedicine-Gastroenterology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Beckman TN, Volpatti LR, Norton de Matos S, Slezak AJ, Reda JW, Weinstock A, Ziolkowski L, Turk A, Budina E, Cao S, Borjas G, Kwon JW, deLeon O, Refvik KC, Lauterbach AL, Gomes S, Chang EB, Hubbell JA. A prometabolite strategy inhibits cardiometabolic disease in an ApoE-/- murine model of atherosclerosis. JCI Insight. 2025 Aug 08; 10(15). PMID: 40779455; PMCID: PMC12333940.
      Citations:    Fields:    Translation:HumansAnimals
    2. DeLeon O, Mocanu M, Tan A, Sidebottom AM, Koval J, Ceccato HD, Kralicek S, Colgan JJ, St George MM, Lake JM, Cooper M, Xu J, Moore J, Su Q, Xu Z, Ng SC, Chan FKL, Tun HM, Cham CM, Liu CY, Rubin DT, Martinez-Guryn K, Chang EB. Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects. Cell. 2025 Jul 24; 188(15):3927-3941.e13. PMID: 40482640; PMCID: PMC12330209.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    3. DeLeon O, Chang EB. Assessing the health of the gut microbial organ: why and how? J Clin Invest. 2025 Jun 02; 135(11). PMID: 40454478; PMCID: PMC12126215.
      Citations: 1     Fields:    
    4. Peng Y, Zhu J, Wang S, Liu Y, Liu X, DeLeon O, Zhu W, Xu Z, Zhang X, Zhao S, Liang S, Li H, Ho B, Ching JY, Cheung CP, Leung TF, Tam WH, Leung TY, Chang EB, Chan FKL, Zhang L, Ng SC, Tun HM. A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics. Cell Host Microbe. 2024 Dec 11; 32(12):2212-2230.e8. PMID: 39591974.
      Citations: 6     Fields:    Translation:HumansCells
    5. Müller S, DeLeon O, Atkinson SN, Saravia F, Kellogg S, Shank EA, Kirby JR. Thiocillin contributes to the ecological fitness of Bacillus cereus ATCC 14579 during interspecies interactions with Myxococcus xanthus. Front Microbiol. 2023; 14:1295262. PMID: 38075900; PMCID: PMC10704990.
      Citations:    
    6. Frazier K, Manzoor S, Carroll K, DeLeon O, Miyoshi S, Miyoshi J, St George M, Tan A, Chrisler EA, Izumo M, Takahashi JS, Rao MC, Leone VA, Chang EB. Gut microbes and the liver circadian clock partition glucose and lipid metabolism. J Clin Invest. 2023 09 15; 133(18). PMID: 37712426; PMCID: PMC10503806.
      Citations: 13     Fields:    Translation:Animals
    7. Kennedy MS, Zhang M, DeLeon O, Bissell J, Trigodet F, Lolans K, Temelkova S, Carroll KT, Fiebig A, Deutschbauer A, Sidebottom AM, Lake J, Henry C, Rice PA, Bergelson J, Chang EB. Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization. Cell Rep. 2023 08 29; 42(8):113009. PMID: 37598339; PMCID: PMC10528517.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    8. Fei N, Miyoshi S, Hermanson JB, Miyoshi J, Xie B, DeLeon O, Hawkins M, Charlton W, D'Souza M, Hart J, Sulakhe D, Martinez-Guryn KB, Chang EB, Charlton MR, Leone VA. Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model. bioRxiv. 2023 Jan 09. PMID: 36712061; PMCID: PMC9882021.
      Citations:    
    9. Lozada-Fernández VV, deLeon O, Kellogg SL, Saravia FL, Hadiono MA, Atkinson SN, Grobe JL, Kirby JR. Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice. mSystems. 2022 02 22; 7(1):e0023021. PMID: 35076278; PMCID: PMC8788325.
      Citations: 15     Fields:    Translation:HumansAnimals
    10. Bahr SM, Weidemann BJ, Castro AN, Walsh JW, deLeon O, Burnett CM, Pearson NA, Murry DJ, Grobe JL, Kirby JR. Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure. EBioMedicine. 2015 11; 2(11):1725-34. PMID: 26870798; PMCID: PMC4740326.
      Citations: 66     Fields:    Translation:Animals
    11. deLeon O, Puglise JM, Liu F, Smits J, ter Beest MB, Zegers MM. Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways. PLoS One. 2012; 7(7):e41039. PMID: 22815903; PMCID: PMC3399788.
      Citations: 6     Fields:    Translation:AnimalsCells
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