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Daria Esterhazy

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    We study how tissue specific immunity is shaped in the digestive system under homeostatic conditions and how it can be perturbed to cause pathologies.

    Immunological niches in the digestive system

    Our goal is to understand what drives niche specific, or local, immunological differences between not only functional segments along the gut, but also the liver-biliary system and the pancreas. We postulate that this immune compartmentalization underlies the nature and site specificity of disease susceptibility, such as pathogen tropisms, food allergies, autoimmune diseases, chronic inflammatory diseases and cancers. Insight into how the immune system is wired in each niche will permit more tailored and potentially effective therapeutic strategies.

    Research area I: Driving forces and cellular substrates of tissue-specific lymph nodes in the digestive system

    Lymph nodes (LNs) are key sites for the initiation of tissue specific adaptive immunity. Along the gastrointestinal tract they are immunologically distinct (Esterhazy et al., Nature 2019), with the more proximal LNs being more tolerance-promoting and the more distal LNs more pro-inflammatory- but we wonder how extensive this paradigm is, what developmental, cellular and molecular forces underlie it, and how hardwired a LN tone is or if it can be re-established after a perturbation. Projects in the lab to address these questions include studying the active role of the gut tissue lymphatics and the lymph they carry, LN macrophages, and LN stromal cells in shaping LN niches.

    Research area II: Immune crosstalk between the gut, pancreas, and liver

    While the gut, pancreas, and liver are distinct organs, they are directly connected through shared LNs, vascular supply and ductal systems, such as the biliary and pancreatic ducts. This is due to their common developmental origin, and serves both metabolic and immunological co-ordination in response to common exposures. However, all three routes also offer unique modes of immune-modulation of one organ through more or less direct interaction with another branch of the digestive system. The extent of such reciprocal control of tissue-specific innate and adaptive immunity is our subject of investigation, with a particular focus on the impact on the pancreas and the implications for the etiology and control of pancreatic diseases such as type 1 and type 2 diabetes, pancreatitis, and pancreatic ductal adenocarcinoma.

    Techniques used

    We use a wide range of techniques in mice, including lymph node dissection, microsurgery, lymphatic vessel cannulation, pancreatic islet isolation, multimodal imaging, single cell gene expression analysis, gnotobiotics, and genetic manipulation of mice to model diseases or track immune events. We use a spectrum of gastrointestinal pathogens, and study human material to relate our work to human disease.
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    Collapse Biography 
    Collapse education and training
    ETH Zurich, Zurich, SwitzerlandPhD12/2010metabolism, pancreatic islet biology
    University of Cambridge, Cambridge, UKMSci06/2006Biochemistry
    University of Cambridge, Cambridge, UKBA06/2005Natural Sciences
    ETH Zurich, Switzerland2012Postdoctoral Fellowship
    Howard Hughes Medical Institute2013Postdoctoral Fellowship
    The Rockefeller University2018Postdoctoral Fellowship
    Collapse awards and honors
    2014 - 2016Advanced Postdoctoral Fellowship, Swiss National Science Foundation
    2013 - 2014Helmsley Trust Postdoctoral Fellowship, The Rockefeller University
    2012 - 2013Early Mobility Postdoctoral fellowship, Swiss National Science Foundation
    2012Young Scientist Research Prize, Swiss Diabetes Foundation
    2012ETH Medal for PhD Thesis, ETH Zurich
    2002 - 2006Gonville and Caius College Scholarship , University of Cambridge
    2002 - 2006Cambridge European Trust Scholarship, University of Cambridge

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Honer M, Polara A, Kuwabara H, Jacobsen H, Hartung T, Caruso A, Esterhazy D, Stoffel M, Dannals RF, Wong DF, Borroni E, Gobbi LC, Pähler A. RO6807936 as a novel positron emission tomography (PET) radiotracer for in vitro and in vivo visualization and quantification of beta-site amyloid precursor protein cleaving enzyme (BACE1) in the rodent and baboon brain. J Labelled Comp Radiopharm. 2023 07; 66(9):222-236. PMID: 37095603.
      Citations:    Fields:    Translation:HumansAnimals
    2. Wang P, Chen L, McIntosh CM, Lane JI, Li R, Xie SZ, Sattar H, Esterhazy D, Chong AS, Alegre ML. Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation. Am J Transplant. 2022 10; 22(10):2348-2359. PMID: 35633180; PMCID: PMC9547964.
      Citations: 1     Fields:    Translation:Animals
    3. Canesso MCC, Mesin L, Muller PA, de Castro TBR, Lockhart A, ElJalby M, Mucida D, Esterházy D, Faria AMC. Compartmentalized gut lymph node drainage dictates adaptive immune responses. Nature. 2019 05; 569(7754):126-130. PMID: 30988509; PMCID: PMC6587593.
      Citations: 121     Fields:    Translation:AnimalsCells
    4. Mucida D, Esterházy D. Gut immune cells have a role in food metabolism. Nature. 2019 02; 566(7742):49-50. PMID: 30710125.
      Citations: 2     Fields:    Translation:HumansCells
    5. Mucida D, Esterhazy D. SnapShot: Gut Immune Niches. Cell. 2018 09 06; 174(6):1600-1600.e1. PMID: 30193116.
      Citations: 3     Fields:    Translation:Humans
    6. Cohen LJ, Esterhazy D, Kim SH, Lemetre C, Aguilar RR, Gordon EA, Pickard AJ, Cross JR, Emiliano AB, Han SM, Chu J, Vila-Farres X, Kaplitt J, Rogoz A, Calle PY, Hunter C, Bitok JK, Brady SF. Commensal bacteria make GPCR ligands that mimic human signalling molecules. Nature. 2017 09 07; 549(7670):48-53. PMID: 28854168; PMCID: PMC5777231.
      Citations: 180     Fields:    Translation:HumansAnimalsCells
    7. Loschko J, London M, Jove V, Oliveira TY, Mucida D, Esterházy D. Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance. Nat Immunol. 2016 May; 17(5):545-55. PMID: 27019226; PMCID: PMC4837106.
      Citations: 127     Fields:    Translation:AnimalsCellsPHPublic Health
    8. Loschko J, Schreiber HA, Rieke GJ, Meredith MM, Pedicord VA, Yao KH, Caballero S, Pamer EG, Mucida D, Nussenzweig MC, Esterházy D. Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation. J Exp Med. 2016 Apr 04; 213(4):517-34. PMID: 27001748; PMCID: PMC4821651.
      Citations: 62     Fields:    Translation:AnimalsCells
    9. Katafuchi T, Lemoff A, Ding X, Sondhi V, Kliewer SA, Mirzaei H, Mangelsdorf DJ, Esterházy D. Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry. Cell Metab. 2015 Jun 02; 21(6):898-904. PMID: 26039452; PMCID: PMC4454892.
      Citations: 28     Fields:    Translation:Animals
    10. Brown CC, Esterhazy D, Sarde A, London M, Pullabhatla V, Osma-Garcia I, Al-Bader R, Ortiz C, Elgueta R, Arno M, de Rinaldis E, Mucida D, Lord GM, Noelle RJ. Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program. Immunity. 2015 Mar 17; 42(3):499-511. PMID: 25769610; PMCID: PMC4372260.
      Citations: 70     Fields:    Translation:AnimalsCells
    11. Lee H, Ruane D, Law K, Ho Y, Garg A, Rahman A, Goljo E, Sikora AG, Mucida D, Chen BK, Govindraj S, Breton G, Mehandru S, Esterházy D, Cheong C. Phenotype and function of nasal dendritic cells. Mucosal Immunol. 2015 Sep; 8(5):1083-98. PMID: 25669151; PMCID: PMC4532662.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    12. Mucida D, Esterházy D. Serum amyloid A proteins take retinol for a ride. Trends Immunol. 2014 Nov; 35(11):505-6. PMID: 25443493; PMCID: PMC4380118.
      Citations: 1     Fields:    Translation:HumansAnimals
    13. Selevsek N, Schmidt A, Aebersold R, Stoffel M, Stützer I, Esterházy D. Systematic proteomic analysis identifies ß-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic ß-cells. J Biol Chem. 2013 Apr 12; 288(15):10536-47. PMID: 23430253; PMCID: PMC3624435.
      Citations: 49     Fields:    Translation:AnimalsCells
    14. Vats D, Wang H, Esterhazy D, Dikaiou K, Danzer C, Honer M, Stuker F, Matile H, Migliorini C, Fischer E, Ripoll J, Keist R, Krek W, Schibli R, Stoffel M, Rudin M. Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27). Diabetologia. 2012 Sep; 55(9):2407-16. PMID: 22790173; PMCID: PMC3411300.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    15. Akpinar P, Stoffel M, Esterházy D. Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2. Biol Chem. 2012 May; 393(6):473-84. PMID: 22628310.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    16. Stoffel M, Stützer I, Esterházy D. The pancreatic beta cell surface proteome. Diabetologia. 2012 Jul; 55(7):1877-89. PMID: 22460761; PMCID: PMC3369137.
      Citations: 14     Fields:    Translation:HumansCells
    17. Wang H, Rechsteiner MP, Beauchamp J, Hilpert H, Matile H, Prummer M, Schmidt A, Lieske N, Boehm B, Marselli L, Bosco D, Kerr-Conte J, Aebersold R, Spinas GA, Moch H, Migliorini C, Stoffel M, Esterházy D, Stützer I, Döbeli H. Bace2 is a ß cell-enriched protease that regulates pancreatic ß cell function and mass. Cell Metab. 2011 Sep 07; 14(3):365-77. PMID: 21907142.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    18. King MS, Yakovlev G, Hirst J, Esterházy D. Production of reactive oxygen species by complex I (NADH:ubiquinone oxidoreductase) from Escherichia coli and comparison to the enzyme from mitochondria. Biochemistry. 2008 Mar 25; 47(12):3964-71. PMID: 18307315.
      Citations: 39     Fields:    Translation:AnimalsCells
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